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it has been described to reach proportions of up to 22&#37; of cases in some series<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A radiograph and an ultrasound examination were ordered due to the need to make a differential diagnosis between bone infarction and osteomyelitis&#46; Both showed nonspecific inflammatory soft tissue changes in the anterior region of the left tibia and neither allowed differentiation of the disease&#46; Empirical intravenous antibiotherapy was initiated&#44; and a bone scintigraphy was ordered&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient underwent a bone scintigraphy scan&#44; with capture of static images in the blood pool phase &#40;at 5<span class="elsevierStyleHsp" style=""></span>min&#41; and the metabolic phase &#40;2<span class="elsevierStyleHsp" style=""></span>h&#41; following intravenous injection of 335<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-HDP&#46; 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with decreased uptake in the two proximal thirds of the ipsilateral tibial shaft &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The scintigraphic pattern was compatible with osteomyelitis in the tuberosity of the left tibia and with bone infarction in the two proximal thirds of the ipsilateral tibial diaphysis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Early in the course of disease&#44; it is difficult to differentiate between osteomyelitis and bone infarction based on clinical or radiological features&#46; Nevertheless&#44; plain radiography is used as the initial imaging technique to rule out other diseases &#40;tumours and fractures&#41;&#46; The characteristic radiologic findings cannot be detected until at least 10 days have elapsed since the onset of symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">An ultrasound examination may be useful in sites that can be accessed with this technique&#44; mainly for the detection of collections and abscesses in soft tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Dual-tracer bone scintigraphy can differentiate between bone infarction and osteomyelitis&#46; On scintigraphy&#44; osteomyelitis presents with increased tracer uptake &#40;there may be decreased uptake in the early stages&#41;&#46; Increased uptake is also observed in cases of bone infarction during the revascularization phase&#44; starting from the third day from onset &#40;uptake may be normal or decreased before the third day&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">It is during the revascularization phase that bone marrow scintigraphy can differentiate between the two diseases&#44; as bone infarction continues to exhibit decreased uptake&#44; whereas osteomyelitis exhibits normal tracer uptake&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Bone marrow scanning targets the reticuloendothelial system of bone marrow&#44; while bone scanning reflects the reparative osteoblastic response&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Bone scintigraphy is abnormal in both osteomyelitis and bone infarction&#44; whereas bone marrow scintigraphy is normal in osteomyelitis&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In the context of sickle-cell disease&#44; it is important to take into account the medical history&#44; as previous bone infarctions may continue to exhibit decreased uptake<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and it is not possible to determine whether they are new or old lesions by means of scintigraphy&#44; which requires consideration of current manifestations and the previous history in their assessment&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In conclusion&#44; currently available nuclear medicine techniques can be very useful&#44; as dual-tracer bone scintigraphy makes possible the early differential diagnosis of bone infarction versus osteomyelitis through non-invasive means&#44; which is important in children with sickle cell disease in who both diseases overlap&#46;</p></span>"
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Scientific Letter
Role of nuclear medicine in the differential diagnosis of bone infarction and osteomyelitis in drepanocytosis
Papel de la medicina nuclear en el diagnóstico diferencial entre infarto óseo y osteomielitis en el contexto de drepanocitosis
Cristina Sandoval-Morenoa,
Corresponding author
, Lourdes Castillejos-Rodrígueza, M. Pilar García-Alonsoa, Bárbara Rubio-Gribbleb, Francisco Javier Penín-Gonzáleza
a Servicio de Medicina Nuclear, Hospital Universitario de Getafe, Getafe, Madrid, Spain
b Servicio de Pediatría, Hospital Universitario de Getafe, Getafe, Madrid, Spain
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">During the blood pool phase&#44; the bone scan showed an increased diffusion of the radiotracer in the vascular-interstitial compartment in the left tibial tuberosity&#46; In the metabolic phase and the colloid study&#58; focal increased uptake in the left tibial tuberosity&#44; with normal uptake in the colloid study&#46; Slightly increased diffuse uptake in the two proximal thirds of the left tibial diaphysis&#44; with decreased uptake in the colloid study&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sickle cell disease is an autosomal recessive disease in which red blood cells with abnormal haemoglobin S take on a sickle shape&#44; causing obstruction of capillary blood blow and haemolysis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Vaso-occlusive crises with bone involvement &#40;bone infarction&#41; are the most common clinical manifestation&#44; mainly in the humerus&#44; tibia and femur&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Tissue devitalization after vaso-occlusive crises&#44; the saturation of macrophages with products derived from chronic haemolysis and splenic dysfunction predispose to bone infection&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and <span class="elsevierStyleItalic">Salmonella</span> is the most frequent causative agent&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Clinical manifestations are similar in both cases &#40;tenderness&#44; warmth&#44; erythema and swelling&#41;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and the findings of conventional imaging techniques &#40;radiography and ultrasonography&#41; are frequently inconclusive&#46; In the field of nuclear medicine&#44; dual-tracer bone scintigraphy &#40;with diphosphonate and colloid tracers&#41; is available for the purpose of differential diagnosis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a boy aged 12 years with sickle cell disease that visited the emergency department with pain in the proximal region of the left tibia lasting 48<span class="elsevierStyleHsp" style=""></span>h in the absence of trauma&#46; The patient initially improved with analgesic treatment &#40;morphine hydrochloride&#41; but worsened on the third day&#44; with exacerbation of pain&#44; local oedema and elevation of acute phase reactants and procalcitonin&#46; The patient did not have leukocytosis or fever &#40;although the absence of fever is infrequent&#44; it has been described to reach proportions of up to 22&#37; of cases in some series<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A radiograph and an ultrasound examination were ordered due to the need to make a differential diagnosis between bone infarction and osteomyelitis&#46; Both showed nonspecific inflammatory soft tissue changes in the anterior region of the left tibia and neither allowed differentiation of the disease&#46; Empirical intravenous antibiotherapy was initiated&#44; and a bone scintigraphy was ordered&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient underwent a bone scintigraphy scan&#44; with capture of static images in the blood pool phase &#40;at 5<span class="elsevierStyleHsp" style=""></span>min&#41; and the metabolic phase &#40;2<span class="elsevierStyleHsp" style=""></span>h&#41; following intravenous injection of 335<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-HDP&#46; The images revealed increased distribution in the vascular and interstitial compartment and increased osteogenic activity in the left tibial tuberosity&#44; with very faint and diffuse tracer uptake in the two proximal thirds of the ipsilateral tibial diaphysis&#44; and no other abnormalities in the rest of the examined structures&#46; This scintigraphic pattern may appear in bone infarcts as well as osteomyelitis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">A bone marrow scintigraphy was performed at 24<span class="elsevierStyleHsp" style=""></span>h to differentiate between the two diseases&#46; Images were captured in a similar position 20<span class="elsevierStyleHsp" style=""></span>min after the intravenous injection of 201<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-sulfur colloid&#46; Imaging showed normal uptake in the tuberosity of the left tibia&#44; with decreased uptake in the two proximal thirds of the ipsilateral tibial shaft &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The scintigraphic pattern was compatible with osteomyelitis in the tuberosity of the left tibia and with bone infarction in the two proximal thirds of the ipsilateral tibial diaphysis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Early in the course of disease&#44; it is difficult to differentiate between osteomyelitis and bone infarction based on clinical or radiological features&#46; Nevertheless&#44; plain radiography is used as the initial imaging technique to rule out other diseases &#40;tumours and fractures&#41;&#46; The characteristic radiologic findings cannot be detected until at least 10 days have elapsed since the onset of symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">An ultrasound examination may be useful in sites that can be accessed with this technique&#44; mainly for the detection of collections and abscesses in soft tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Dual-tracer bone scintigraphy can differentiate between bone infarction and osteomyelitis&#46; On scintigraphy&#44; osteomyelitis presents with increased tracer uptake &#40;there may be decreased uptake in the early stages&#41;&#46; Increased uptake is also observed in cases of bone infarction during the revascularization phase&#44; starting from the third day from onset &#40;uptake may be normal or decreased before the third day&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">It is during the revascularization phase that bone marrow scintigraphy can differentiate between the two diseases&#44; as bone infarction continues to exhibit decreased uptake&#44; whereas osteomyelitis exhibits normal tracer uptake&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Bone marrow scanning targets the reticuloendothelial system of bone marrow&#44; while bone scanning reflects the reparative osteoblastic response&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Bone scintigraphy is abnormal in both osteomyelitis and bone infarction&#44; whereas bone marrow scintigraphy is normal in osteomyelitis&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In the context of sickle-cell disease&#44; it is important to take into account the medical history&#44; as previous bone infarctions may continue to exhibit decreased uptake<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and it is not possible to determine whether they are new or old lesions by means of scintigraphy&#44; which requires consideration of current manifestations and the previous history in their assessment&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In conclusion&#44; currently available nuclear medicine techniques can be very useful&#44; as dual-tracer bone scintigraphy makes possible the early differential diagnosis of bone infarction versus osteomyelitis through non-invasive means&#44; which is important in children with sickle cell disease in who both diseases overlap&#46;</p></span>"
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Article information
ISSN: 23412879
Original language: English
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Idiomas
Anales de Pediatría (English Edition)
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