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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Tuberculosis &#40;TB&#41; is one of the most prevalent infectious diseases worldwide&#46; Paediatric patients are at significantly higher risk than adults of progressing to tuberculosis disease and developing disseminated and extrapulmonary forms of TB&#46; In addition&#44; in recent years we have witnessed an emergence of multidrug-resistant &#40;MDR&#41; strains of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> &#40;MTB&#41; in Spain&#44; especially in immigrants from highly endemic countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;3</span></a> Extrapulmonary forms of TB&#44; and osteoarticular TB in particular&#44; pose a considerable diagnostic challenge on account of their insidious course and atypical manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a> Osteoarticular TB amounts to approximately 1&#8211;5&#37; of all cases of paediatric TB&#44; and to 10&#8211;17&#37; of extrapulmonary TB cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;4</span></a> However&#44; few case series have been published on this form in the literature&#44; and most of these studies were conducted in highly endemic countries&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The aim of our study was to define the characteristics of paediatric osteoarticular TB in Spain&#46; We made a retrospective review of cases of osteoarticular TB diagnosed in patients aged less than 14 years in the Hospital Universitario La Paz over a period of 20 years &#40;January 1996&#8211;Debember 2015&#41;&#46; We collected epidemiologic&#44; clinical&#44; radiologic&#44; microbiologic&#44; treatment and outcome data&#46; We considered that skin tuberculin tests were positive when the induration was 5<span class="elsevierStyleHsp" style=""></span>mm or greater at 48&#8211;72<span class="elsevierStyleHsp" style=""></span>h from the intradermal injection of 2 units of RT-23 tuberculin in 0&#46;1<span class="elsevierStyleHsp" style=""></span>mL solution &#40;Statens Serum Institut&#59; Copenhagen&#44; Denmark&#41;&#46; We entered and analysed the data in Excel &#40;Microsoft&#59; Redmond&#44; USA&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We identified 213 cases of children with confirmed TB&#44; of which 11 &#40;5&#46;2&#37;&#41; presented with osteoarticular involvement&#46; This presentation was the third most frequent following pulmonary TB &#40;132 cases&#44; 62&#37;&#41; and tuberculous lymphadenitis &#40;41 cases&#44; 19&#37;&#41;&#46; Of the 11 patients with osteoarticular involvement&#44; 4 &#40;36&#46;4&#37;&#41; received a diagnosis of spinal TB &#40;3 dorsal&#44; 1 lumbar&#41;&#59; 5 &#40;45&#46;4&#37;&#41; of articular TB &#40;2 in the knee&#44; 1 in the hip&#44; 1 in the ankle&#44; and 1 with polyarticular TB with hip&#44; knee and shoulder involvement&#41;&#59; and 2 &#40;18&#46;2&#37;&#41; of isolated osteomyelitis &#40;1 in the femur&#44; 1 in the mastoid process&#41;&#46; Five cases &#40;45&#37;&#41; presented with concomitant pulmonary involvement&#46; The male to female ratio was 1&#46;2&#58;1&#44; and the mean age at diagnosis was 5&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;6 years&#46; The median delay in diagnosis was 12 months &#40;range&#44; 2 weeks-3 years&#41;&#46; The most frequent reason that led to suspicion of TB was the presence of characteristic findings on magnetic resonance &#40;bone destruction with cold abscesses or synovial hypertrophy&#41; in children of immigrants from countries with a high TB burden &#40;9 patients&#44; 82&#37;&#41;&#46; All the patients were immunocompetent&#46; The investigation of contacts identified the index case in 4 patients &#40;36&#46;4&#37;&#41; and relatives with latent tuberculosis infection in 5&#44; and was negative in 2&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The most frequent presenting symptom was functional impairment &#40;64&#37;&#41; accompanied by pain in 45&#37; of cases&#44; and fever in 36&#37; of cases&#46; All patients had a positive tuberculin skin test&#46; The presence of <span class="elsevierStyleItalic">M&#46; tuberculosis</span> was confirmed in 82&#37; &#40;9&#47;11&#41;&#58; 2 in joint fluid &#40;PCR and culture&#41; and 7 in a synovial&#44; bone or perilesional abscess biopsy specimens &#40;1 by culture&#44; 6 by PCR and culture&#41;&#44; with the additional detection of growth in the gastric aspirate culture of 2 of these patients&#46; The most frequent radiologic findings were bone destruction &#40;82&#37;&#41;&#44; cold abscesses &#40;36&#37;&#41; and synovial hypertrophy &#40;27&#37;&#41;&#46; Two strains of MDR-MBT were isolated&#44; both in children born in Spain but with index cases from highly endemic countries&#58; one patient had travelled to China and stayed with a grandfather that had TB&#59; the other one was living with a Moroccan man that died of the disease&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The duration of treatment ranged from 9 to 12 months&#44; except in patients with MDR strains&#44; who were treated for 24 months&#46; One boy needed to switch treatments due to acute drug-induced liver failure&#46; Forty-five percent of patients required surgical intervention &#40;3 to drain the lesion&#44; 2 to stabilise the joint&#41;&#46; Forty-five percent developed sequelae in the long term&#58; 3 patients developed kyphosis&#44; 1 leg-length inequality and 1 limited mobility&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In our case series&#44; paediatric osteoarticular TB was the third most frequent form of disease presentation&#44; which was similar to what has been described in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> We would like to highlight the diagnostic delay and the high percentage of children that required surgical intervention and had sequelae in our study&#46; These findings underscore the importance of including tuberculosis disease in the differential diagnosis of osteoarticular lesions with a slow course&#44; accompanied by pain or with prolonged functional impairment&#44; even in the absence of fever&#44; and especially in immigrant children or children in contact with immigrants from highly endemic countries&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Furthermore&#44; the prevalence of MDR-MBT is higher in these patients&#44; so it is essential that adequate samples are collected to take advantage of the available molecular diagnostic techniques for the early detection of drug resistances&#46;</p></span>"
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                      "titulo" => "Pediatric extrapulmonary tuberculosis&#58; clinical spectrum&#44; risk factors and diagnostic challenges in a low prevalence region"
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                          "autores" => array:6 [
                            0 => "B&#46; Santiago"
                            1 => "D&#46; Bl&#225;zquez-Gamero"
                            2 => "F&#46; Baquero-Artigao"
                            3 => "J&#46; Ruiz-Contreras"
                            4 => "J&#46;M&#46; Bell&#243;n"
                            5 => "M&#46;A&#46; Mu&#241;oz-Fern&#225;ndez"
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Scientific Letter
Osteoarticular tuberculosis in paediatrics: A review of 20 years of cases in a tertiary hospital
Tuberculosis osteoarticular en la edad pediátrica, revisión de casos en 20 años en un hospital terciario
María José Pérez Durána,
Corresponding author
mjopduran@gmail.com

Corresponding author.
, Bárbara Moreno Sanz-Gadeaa, Teresa del Rosal Ravesb, María José Mellado Peñab, Fernando Baquero-Artigaob
a Hospital Universitario La Paz, Madrid, Spain
b Servicio de Pediatría-Enfermedades infecciosas y Tropicales, Hospital Universitario La Paz, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Tuberculosis &#40;TB&#41; is one of the most prevalent infectious diseases worldwide&#46; Paediatric patients are at significantly higher risk than adults of progressing to tuberculosis disease and developing disseminated and extrapulmonary forms of TB&#46; In addition&#44; in recent years we have witnessed an emergence of multidrug-resistant &#40;MDR&#41; strains of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> &#40;MTB&#41; in Spain&#44; especially in immigrants from highly endemic countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;3</span></a> Extrapulmonary forms of TB&#44; and osteoarticular TB in particular&#44; pose a considerable diagnostic challenge on account of their insidious course and atypical manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a> Osteoarticular TB amounts to approximately 1&#8211;5&#37; of all cases of paediatric TB&#44; and to 10&#8211;17&#37; of extrapulmonary TB cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;4</span></a> However&#44; few case series have been published on this form in the literature&#44; and most of these studies were conducted in highly endemic countries&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The aim of our study was to define the characteristics of paediatric osteoarticular TB in Spain&#46; We made a retrospective review of cases of osteoarticular TB diagnosed in patients aged less than 14 years in the Hospital Universitario La Paz over a period of 20 years &#40;January 1996&#8211;Debember 2015&#41;&#46; We collected epidemiologic&#44; clinical&#44; radiologic&#44; microbiologic&#44; treatment and outcome data&#46; We considered that skin tuberculin tests were positive when the induration was 5<span class="elsevierStyleHsp" style=""></span>mm or greater at 48&#8211;72<span class="elsevierStyleHsp" style=""></span>h from the intradermal injection of 2 units of RT-23 tuberculin in 0&#46;1<span class="elsevierStyleHsp" style=""></span>mL solution &#40;Statens Serum Institut&#59; Copenhagen&#44; Denmark&#41;&#46; We entered and analysed the data in Excel &#40;Microsoft&#59; Redmond&#44; USA&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We identified 213 cases of children with confirmed TB&#44; of which 11 &#40;5&#46;2&#37;&#41; presented with osteoarticular involvement&#46; This presentation was the third most frequent following pulmonary TB &#40;132 cases&#44; 62&#37;&#41; and tuberculous lymphadenitis &#40;41 cases&#44; 19&#37;&#41;&#46; Of the 11 patients with osteoarticular involvement&#44; 4 &#40;36&#46;4&#37;&#41; received a diagnosis of spinal TB &#40;3 dorsal&#44; 1 lumbar&#41;&#59; 5 &#40;45&#46;4&#37;&#41; of articular TB &#40;2 in the knee&#44; 1 in the hip&#44; 1 in the ankle&#44; and 1 with polyarticular TB with hip&#44; knee and shoulder involvement&#41;&#59; and 2 &#40;18&#46;2&#37;&#41; of isolated osteomyelitis &#40;1 in the femur&#44; 1 in the mastoid process&#41;&#46; Five cases &#40;45&#37;&#41; presented with concomitant pulmonary involvement&#46; The male to female ratio was 1&#46;2&#58;1&#44; and the mean age at diagnosis was 5&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;6 years&#46; The median delay in diagnosis was 12 months &#40;range&#44; 2 weeks-3 years&#41;&#46; The most frequent reason that led to suspicion of TB was the presence of characteristic findings on magnetic resonance &#40;bone destruction with cold abscesses or synovial hypertrophy&#41; in children of immigrants from countries with a high TB burden &#40;9 patients&#44; 82&#37;&#41;&#46; All the patients were immunocompetent&#46; The investigation of contacts identified the index case in 4 patients &#40;36&#46;4&#37;&#41; and relatives with latent tuberculosis infection in 5&#44; and was negative in 2&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The most frequent presenting symptom was functional impairment &#40;64&#37;&#41; accompanied by pain in 45&#37; of cases&#44; and fever in 36&#37; of cases&#46; All patients had a positive tuberculin skin test&#46; The presence of <span class="elsevierStyleItalic">M&#46; tuberculosis</span> was confirmed in 82&#37; &#40;9&#47;11&#41;&#58; 2 in joint fluid &#40;PCR and culture&#41; and 7 in a synovial&#44; bone or perilesional abscess biopsy specimens &#40;1 by culture&#44; 6 by PCR and culture&#41;&#44; with the additional detection of growth in the gastric aspirate culture of 2 of these patients&#46; The most frequent radiologic findings were bone destruction &#40;82&#37;&#41;&#44; cold abscesses &#40;36&#37;&#41; and synovial hypertrophy &#40;27&#37;&#41;&#46; Two strains of MDR-MBT were isolated&#44; both in children born in Spain but with index cases from highly endemic countries&#58; one patient had travelled to China and stayed with a grandfather that had TB&#59; the other one was living with a Moroccan man that died of the disease&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The duration of treatment ranged from 9 to 12 months&#44; except in patients with MDR strains&#44; who were treated for 24 months&#46; One boy needed to switch treatments due to acute drug-induced liver failure&#46; Forty-five percent of patients required surgical intervention &#40;3 to drain the lesion&#44; 2 to stabilise the joint&#41;&#46; Forty-five percent developed sequelae in the long term&#58; 3 patients developed kyphosis&#44; 1 leg-length inequality and 1 limited mobility&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In our case series&#44; paediatric osteoarticular TB was the third most frequent form of disease presentation&#44; which was similar to what has been described in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> We would like to highlight the diagnostic delay and the high percentage of children that required surgical intervention and had sequelae in our study&#46; These findings underscore the importance of including tuberculosis disease in the differential diagnosis of osteoarticular lesions with a slow course&#44; accompanied by pain or with prolonged functional impairment&#44; even in the absence of fever&#44; and especially in immigrant children or children in contact with immigrants from highly endemic countries&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Furthermore&#44; the prevalence of MDR-MBT is higher in these patients&#44; so it is essential that adequate samples are collected to take advantage of the available molecular diagnostic techniques for the early detection of drug resistances&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; P&#233;rez Dur&#225;n MJ&#44; Moreno Sanz-Gadea B&#44; del Rosal Raves T&#44; Mellado Pe&#241;a MJ&#44; Baquero-Artigao F&#46; Tuberculosis osteoarticular en la edad pedi&#225;trica&#44; revisi&#243;n de casos en 20 a&#241;os en un hospital terciario&#46; An Pediatr &#40;Barc&#41;&#46; 2017&#59;87&#58;291&#8211;292&#46;</p>"
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