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"titulo" => "Frequent users in paediatric emergency departments. Who are they? Why do they consult?" 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[ 0 => array:4 [ "autoresLista" => "Begoña Rodríguez-Azor, José Miguel Ramos-Fernández, Sonia Sánchiz-Cárdenas, Ana Cordón-Martínez, Begoña Carazo-Gallego, David Moreno-Pérez, Antonio Urda-Cardona" "autores" => array:7 [ 0 => array:3 [ "nombre" => "Begoña" "apellidos" => "Rodríguez-Azor" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "José Miguel" "apellidos" => "Ramos-Fernández" "email" => array:2 [ 0 => "dr.jmramos@gmail.com" 1 => "josem.ramos.sspa@juntadeandalucia.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Sonia" "apellidos" => "Sánchiz-Cárdenas" 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"referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Unidad de Gestión Clínica de Pediatría, Hospital Materno-Infantil, Hospital Regional Universitario de Málaga, Málaga, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Sección de Lactantes, Unidad de Gestión Clínica de Pediatría, Hospital Materno-Infantil, Hospital Regional Universitario de Málaga, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Grupo de Investigación IBIMA, Málaga, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Departamento de Pediatría y Farmacología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Sección de Infectología, Unidad de Gestión Clínica de Pediatría, Hospital Regional Universitario Materno-Infantil, Málaga, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cicatrices renales en menores de 36 meses ingresados por pielonefritis aguda" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The approach to the diagnosis and management of urinary tract infection (UTI) in children is complex, especially in young infants that may have especially severe forms of disease, with a high percentage of patients developing sequelae in the form of renal scarring that have variable impact in the long-term. The indications for imaging tests have been changing in recent years with the publication of different clinical guidelines.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1–4</span></a> The main changes have been based on systematic literature reviews, taking into account the association of microbiological, ultrasound and cystography findings with long-term sequelae and UTI recurrence. Several practical approaches that have been proposed recently illustrate the difficulty in reaching a consensus about decision making in the management of UTIs during acute infection and after treatment to assess the impact on renal function. These approaches also identify the presence of underlying disease and prevent potential recurrences.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2–5</span></a> There are few studies on this subject,<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">6,7</span></a> especially in our region.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> In this study, we reviewed the outcomes of children aged less than 36 months admitted for severe UTI, analysing the presence of renal scarring in relation to clinical manifestations, medical history and imaging test results.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">We conducted a retrospective study by reviewing the medical records of patients aged less than 36 months admitted to a tertiary care hospital that met the criteria for a first episode of upper urinary tract infection: probable acute pyelonephritis (APN) defined as leukocyturia and evidence of urinary pathogen growth in urine collected by catheter following previously established criteria,<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4,9</span></a> in the presence of fever and/or decline of general health status and/or elevated levels of acute phase reactants<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a> (C reactive protein [CRP]<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>mg/L and/or procalcitonin [PCT]<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.5<span class="elsevierStyleHsp" style=""></span>ng/mL), with a minimum duration of followup of at least 6 months. The study comprehended the period between January 2010 and December 2014. The standardized antibiotherapy approach consisted of treating infants aged less than 3 months with ampicillin and gentamicin, and older children with gentamicin alone until antimicrobial susceptibility test results became available. The exclusion criteria were: UTI occurring in the context of surgery, nosocomial infection, previous or current urinary catheterization, and UTI secondary to a confirmed obstructive uropathy or limited to the lower urinary tract. We also excluded newborns aged less than 4 weeks, as UTI in these cases could be considered a manifestation of a potential generalized neonatal infection.</p><p id="par0015" class="elsevierStylePara elsevierViewall">We collected data for the following variables in each patient: age; sex; duration of symptoms in days at time of admission; fever at admission; nephrourologic abnormalities in prenatal ultrasound (dilation anywhere in the urinary tract or structural malformations); acute phase reactant levels (CRP measured by turbidimetric immunoassay; PCT measured by enzyme-linked fluorescent immunoassay, creatinine at time of admission by means of the modified Jaffé kinetic method [bichromatic spectrophotometry, 510 and 600<span class="elsevierStyleHsp" style=""></span>nm]); abnormal findings in basic urinalysis; pathogen isolated in culture of urine specimen obtained by catheter; results of blood culture, urinary tract ultrasound and serial voiding cystourethrography (VCUG) performed early during admission; recurrent UTI episodes in the months following admission; and dimercaptosuccinic acid (DMSA) scintigraphy at least 6 months after the resolution of the first episode of APN.</p><p id="par0020" class="elsevierStylePara elsevierViewall">We categorized a few quantitative variables for the purpose of analysis. We divided age into three categories: less than 3 months, 3–6 months, and greater than 6 months. We categorized PCT levels into less than 0.5<span class="elsevierStyleHsp" style=""></span>ng/mL, 0.5–1<span class="elsevierStyleHsp" style=""></span>ng/mL, and greater than 1<span class="elsevierStyleHsp" style=""></span>ng/mL. We categorized C reactive protein by quartiles. Urologic ultrasound comprised three categories: urinary tract dilation, lobar nephronia/renal abscesses, and complex malformations. The results of VCUG were divided into three categories: normal, reflux grade I–III, and reflux grade IV–V. Bacteriological results were divided into two categories: <span class="elsevierStyleItalic">Escherichia coli (E. coli)</span> and pathogen other than <span class="elsevierStyleItalic">E. coli</span>. Duration of symptoms was divided into less than one day and more than one day.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Following the general guidelines that applied during the period under study,<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,3–5</span></a> VCUG was indicated in patients with clinical sepsis, isolated pathogen other than <span class="elsevierStyleItalic">E. coli</span>, sonographic abnormalities or siblings with urinary tract abnormalities. DMSA scintigraphy was indicated in infants aged less than 6 months and all patients with abnormal ultrasound findings, pathogen other than <span class="elsevierStyleItalic">E. coli</span>, septic appearance, persistent fever more than 48<span class="elsevierStyleHsp" style=""></span>h after initiating antibiotherapy, micturition abnormalities, dehydration or elevated creatinine at least 6 months after infection. Imaging studies were considered abnormal when cortical tracer uptake was reduced. The results were divided in two categories: normal and abnormal.</p><p id="par0030" class="elsevierStylePara elsevierViewall">We present quantitative data as mean and standard deviation, and qualitative data as frequency percentages. We analyzed the association between qualitative variables and the presence of lesions in DMSA scintigraphy by means of the <span class="elsevierStyleItalic">χ</span><span class="elsevierStyleSup">2</span>-test. Variables for which the association corresponded to a <span class="elsevierStyleItalic">p</span>-value of less than .20 were included in a binomial logistic regression analysis with the purpose of identifying independent risk factors for the presence of abnormalities in DMSA scintigraphy. We conducted the statistical analysis with the PSPP statistical software (GNU<span class="elsevierStyleSup">©</span> General Public License by the Free Software Foundation).</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">The study included a total of 125 healthy patients. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> presents patient data for quantitative variables. Sixty percent of the patients were male; 52.8% were aged less than 3 months, 72.0% less than 6 months and 87% less than 12 months. Eight percent of cases had onset without fever. In 46.7%, symptom duration at admission was less than one day. As for diagnostic tests, the reagent strip test was positive (defined as a result corresponding to two or more crosses) for leukocyte esterase in 84% of cases, and for nitrites in 45%.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The pathogen isolated in 125 of the urine cultures was <span class="elsevierStyleItalic">E. coli</span> (74.6%), followed by <span class="elsevierStyleItalic">Klebsiella pneumoniae</span> (8.9%), <span class="elsevierStyleItalic">Enterococcus faecalis</span> (7.3%), <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> (3.2%), <span class="elsevierStyleItalic">Proteus mirabilis</span> (1.6%), <span class="elsevierStyleItalic">Enterobacter cloacae</span> (1.6%) and other. Of the total blood cultures performed (108), 7.4% were positive.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Ultrasound detected nephronia, renal abscess or complex malformations in 16.7% and some type of urinary tract dilation in 21.9%. A VCUG was ordered in 70 patients; 54.3% had normal results, 12.8% had reflux grade I–III, and 32.9% reflux grade IV–V. Six patients had grade IV–V vesicoureteral reflux (VUR) with normal ultrasound results, and four of these patients developed renal scarring. Investigation with a DMSA scan was indicated in 80% of cases of APN, but was only performed in 61% of these cases due to parental non-adherence. Out of the sixty cases in which it was finally performed, some degree of renal scarring was found in 44%. In our case series, 13.4% of the patients had a history of abnormal findings in the urinary tract on prenatal ultrasound. We found a recurrence rate in the first six months of follow-up of 15.2%.</p><p id="par0050" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the comparative analysis of abnormalities in the DSMA scintigraphy examination at six months. We found a statistically significant association with the presence of abnormalities in prenatal ultrasound, involvement of a pathogen other than <span class="elsevierStyleItalic">E. coli</span>, and recurrent UTI. We did not find an association between the presence of renal lesions and patient age or elevation of acute phase reactants.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The logistic regression analysis identified the presence of reflux of grade IV–V in VCUG and UTI recurrence as risk factors, while the peak temperature of fever was identified as a weak protective factor (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">The potential for developing sequelae in the form of renal scarring is the leading factor in current guidelines for deciding the diagnostic tests to be performed in cases of severe UTI, which are more frequent during childhood. Few studies make reference to the potential long-term sequelae or the probability of recurrence of these diseases in our region. Thus, we thought it would be interesting to determine the potential correlation of development of renal scarring with updated local microbiology and ultrasound and scintigraphy findings in order to establish an appropriate protocol for treatment and for determining the need for diagnostic and follow-up tests, for the purpose of optimizing long-term outcomes in adulthood while avoiding performance of unnecessary tests.</p><p id="par0065" class="elsevierStylePara elsevierViewall">There had been abnormal ultrasound findings in 38.6% of cases. Most frequent among them were nephronia and dilation of the urinary tract, which was consistent with the previous literature.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">10–15</span></a> The findings of DMSA scintigraphy were abnormal in 44% of the patients. Therefore, we estimated the overall percentage of patients with some type of long-term renal damage at 22%, somewhat higher than the figure reported in a previous systematic review,<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a> although the latter included patients up to age 19 years with any type of UTI, febrile and afebrile, of whom 57% had a history of previous abnormal findings on DMSA scintigraphy. When no other indication criteria are applied, the percentage of cases of febrile UTI in which there is evidence of renal damage in acute phase DMSA scintigraphy is as high as 73%.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> Case series that focus on children aged less than 36 months,<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> as our study did, have found a lower percentage of renal damage on DMSA scintigraphy of around 12%, but these series involved ambulatory patients and approaches in which the sole indication for DMSA scintigraphy is the presence of abnormal findings in ultrasound. In our opinion, this results in a clear selection bias, and we believe that other criteria such as those applied in our study should be indications for DMSA scintigraphy.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a> We also attribute the incidence of scarring that we found to the sample selected for our study, with a predominance of young infants with probable APN that presented with fever and a marked elevation of acute phase reactants. Although PCT has been described as a marker of renal damage with development of scarring in the long term,<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> we did not find this association in our series. In this regard, there is no wide consensus regarding the routine measurement of acute phase reactants for assessment of acute disease.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> In research on infants with febrile UTI, DMSA scintigraphy showed renal lesions at 3 months in 51% of the patients, while VUR was found in 25%.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> It is possible that some of the lesions detected by DMSA scintigraphy will have no long-term impact, as suggested by some authors,<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> but the circumstances under which this test can be forgone have yet to be established.</p><p id="par0070" class="elsevierStylePara elsevierViewall">In our case series, the association between abnormal findings in VCUG and high-grade (IV–V) reflux and DMSA scan abnormalities remained significant in the multivariate analysis, suggesting that reflux is a predisposing factor for APN but that the latter, in itself, can account for renal scarring regardless of its cause. The authors of the systematic review referred above noted that the presumed association of VCUG and DMSA gammagraphy could be due to confounding factors,<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a> as nearly all studies find that high-grade reflux is found in only approximately 2.5% of cases of APN, and yet the mean percentage of cases with sequelae detected by DMSA gammagraphy is 25%. In our series, the association emerged as an independent factor in the logistic regression analysis (OR, 6.419). For decades, the presence of VUR has been the focus of interest in the follow-up of UTI, although it is evident that the presence of VUR is neither necessary nor sufficient to develop renal scarring.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The absence of an association between the development of scarring and isolation of a bacterium other than <span class="elsevierStyleItalic">E. coli</span> in the multivariate analysis is consistent with the recommendations of the most recent clinical practice guidelines for the management of UTI in children, according to which the results of microbial testing are no longer a criteria for the indication of VCUG.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,2,4,5</span></a> Perhaps the criterion of the involved bacterium for the indication of DMSA scintigraphy should also be reconsidered.</p><p id="par0080" class="elsevierStylePara elsevierViewall">There has been previous discussion that the association between the abnormalities found in prenatal ultrasound and DMSA scintigraphy may result from a cause of cortical dysplasia that predated UTI and manifests with renal damage detectable in DMSA scintigraphy that may progress to renal failure regardless of the subsequent treatment of the associated VUR, which is usually of a high grade.<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">17,18</span></a> A larger sample of cases may be able to evince the association that is suggested by the χ<span class="elsevierStyleSup">2</span>-test.</p><p id="par0085" class="elsevierStylePara elsevierViewall">As reported in other series, we found a statistically significant association between recurrence of APN and renal damage, and recurrence was identified as a risk factor (OR, 7.52). We do not know the role that the genetic susceptibility to UTI previously described in the literature<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a> may have played in our series. In this regard, the best preventive measure is early detection of reinfection and its prompt treatment, as has been proposed,<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,4,5</span></a> while the need for antibiotic prophylaxis in reflux cases is increasingly disputed.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5,20</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Lastly, we would like to mention the protective effect (albeit a weak one) of fever in relation to the development of scarring, as a mechanism that is a nonspecific response to infection. We have not found any studies that analyzed or referred to this aspect.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Some of the limitations of the study were the lack of long-term follow-up of the impact of the detected renal scarring, as well as the lack of data on recurrence beyond the first six months from the first episode of APN. The sample consisted of severe cases with a predominance of infants younger than 6 months of age with a marked elevation of acute phase reactants, and thus our conclusions apply to this specific subset of patients with APN, on whom, as we mentioned before, few data are available.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusions</span><p id="par0100" class="elsevierStylePara elsevierViewall">The presence of renal scarring at 6 months reached 44% with the selection criteria for DMSA scintigraphy applied in our study of patients hospitalised with severe disease. In our study, recurrence and high-grade VUR were risk factors for abnormal DMSA scintigraphy findings. Raised body temperature in the fever variable appeared as a weak protective factor. We did not find an association with the isolation of pathogens other than <span class="elsevierStyleItalic">E. coli</span>. We think it is justified to propose eliminating the isolation of a pathogen other than <span class="elsevierStyleItalic">E. coli</span> as an indication for ordering a DMSA scan.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interests</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres794527" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Method" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec792850" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres794526" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Método" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec792851" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interests" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-12-22" "fechaAceptado" => "2016-03-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec792850" "palabras" => array:4 [ 0 => "Renal scar" 1 => "Pyelonephritis" 2 => "Voiding cystourethrography" 3 => "DMSA-scintigraphy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec792851" "palabras" => array:4 [ 0 => "Cicatriz renal" 1 => "Pielonefritis" 2 => "Cistourografía miccional seriada" 3 => "Gammagrafía DMSA" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Acute pyelonephritis (APN) is one of the most common causes of serious bacterial infection in infants. Renal scarring is the most prevalent long-term complication.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To review the incidence of renal scarring within 6 months after an episode of APN in children under 36 months and its relationship with imaging studies, clinical settings, and bacteriology.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Method</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A retrospective study of previously healthy patients aged one to 36 months, admitted for a first episode of APN, with a minimum follow-up of 6 months. Demographic and clinical variables were collected along with bacteriology, renal and bladder ultrasound scan, voiding cystourethrography, DMSA-scintigraphy, and re-infection events.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A total of 125 patients were included in the study, of which 60% were male, the large majority (92%) febrile, and due to <span class="elsevierStyleItalic">Escherichia coli</span> (74.6%). There was a history of prenatal ultrasound scan changes in 15.4%. Ultrasound scan found dilation of the urinary tract in 22.1%. Voiding cystourethrography was performed on 70 patients: 54.3% no abnormalities, 12.8% vesicoureteral reflux (VUR) grade <span class="elsevierStyleSmallCaps">i</span>-<span class="elsevierStyleSmallCaps">iii</span>, and 32.9% <span class="elsevierStyleSmallCaps">iv</span>-<span class="elsevierStyleSmallCaps">v</span> grade VUR. Six patients had <span class="elsevierStyleSmallCaps">iv</span>-<span class="elsevierStyleSmallCaps">v</span> grade VUR with a normal ultrasound scan. Adherence to DMSA-scintigraphy at 6 months was only 61% of that indicated. Renal scarring was found in 44.3% of those in which it was performed (60 cases).</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Almost half (44%) DMSA-scintigraphy in children aged one to 36 months hospitalised for APN show renal scarring at 6 months, which was found to be associated with the re-infection events and the <span class="elsevierStyleSmallCaps">iv</span>-<span class="elsevierStyleSmallCaps">v</span> grade VUR. There was no relationship between scarring and the bacteriology or the elevations of inflammatory biochemical markers.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Method" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Una de las causas más frecuentes de infección bacteriana grave en lactantes es la pielonefritis aguda (PNFA), cuya secuela más prevalente a largo plazo es la instauración de cicatrices renales.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Revisar la incidencia de cicatrices renales a los 6 meses de un episodio de PNFA en niños menores de 36 meses y su relación con la clínica, las pruebas de imagen y la bacteriología.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Método</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de pacientes de uno a 36 meses previamente sanos ingresados por un primer episodio de PNFA, con un seguimiento mínimo de 6 meses. Se recogieron las variables demográficas junto con bacteriología, ecografía, cistourografía miccional seriada, recidivas y gammagrafía-DMSA.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 125 pacientes, 60% varones, la mayoría febriles al ingreso (92%), debido a <span class="elsevierStyleItalic">E. coli</span> (74,6%). Existía antecedente de alteración ecográfica prenatal solo en el 15,4%. La ecografía detectó dilatación de la vía urinaria en el 22,1%. En 70 pacientes se indicó cistourografía miccional seriada: 54,3% sin anomalías, 12,8% con reflujo vesicoureteral (RVU) grado <span class="elsevierStyleSmallCaps">i</span>-<span class="elsevierStyleSmallCaps">iii</span> y 32,9% con RVU <span class="elsevierStyleSmallCaps">iv</span>-<span class="elsevierStyleSmallCaps">v</span>. Seis pacientes presentaban RVU <span class="elsevierStyleSmallCaps">iv</span>-<span class="elsevierStyleSmallCaps">v</span> con ecografías normales. La adherencia a la gammagrafía DMSA a los 6 meses fue solo del 61% de los indicados. De los efectuados (60 casos), en un 44,3% se hallaron cicatrices renales, relacionadas significativamente con la recurrencia y el RVU <span class="elsevierStyleSmallCaps">iv</span>-<span class="elsevierStyleSmallCaps">v,</span> pero no con la bacteriología ni con la elevación de reactantes.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El 44% de las gammagrafías-DMSA de pacientes de uno a 36 meses hospitalizados por PNFA desarrolla cicatrices renales a los 6 meses. Estas se relacionaron con las recurrencias y el RVU grave, pero no con la bacteriología y los reactantes inflamatorios.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Método" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Rodríguez-Azor B, Ramos-Fernández JM, Sánchiz-Cárdenas S, Cordón-Martínez A, Carazo-Gallego B, Moreno-Pérez D, et al. Cicatrices renales en menores de 36 meses ingresados por pielonefritis aguda. An Pediatr (Barc). 2017;86:76–80.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Minimum \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Maximum \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Standard deviation \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age (months) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">125 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.68 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fever (°C) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">120 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">41.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.84 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">117 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.42 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C reactive protein (mg/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">121 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">358 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">98.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">82.35 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Procalcitonin (ng/mL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.82 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plasma creatinine (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.22 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1328982.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Main descriptive statistical results for the data collected at the time of hospital admission for the first episode of upper urinary tract infection.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">CRP, C reactive protein; PCT, procalcitonin; VCUG: voiding cystourethrography.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.490 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Prenatal ultrasound: abnormal findings \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fever \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of symptoms (days) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.089 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.377 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CRP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.973 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leukocyturia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.396 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nitrituria \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.107 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bacteriuria \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.770 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pathogen other than <span class="elsevierStyleItalic">E. coli</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ultrasound at diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serial VCUG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Recurrence \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1328981.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Statistical significance of comparison by <span class="elsevierStyleItalic">χ</span><span class="elsevierStyleSup">2</span> test of abnormal dimercaptosuccinic acid scintigraphy findings and other variables under study.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">CI, confidence interval; OR: odds ratio; VCUG: voiding cystourethrography; VUR, vesicoureteral reflux.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Significance: <span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fever \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.967 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.945–0.990 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">VCUG: VUR grade IV–V \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.419 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.688–24.413 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Recurrence \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.592 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.433–40.213 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1328980.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Variables that were statistically significant in the logistic regression analysis, odds ratio and 95% confidence interval.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0105" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Technical report – diagnosis and management of an initial UTI in febrile infants and young children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.M. Finnell" 1 => "A.E. Carroll" 2 => "S.M. Downs" 3 => "Subcommittee on Urinary Tract Infection" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.2011-1332" "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "2011" "volumen" => "128" "paginaInicial" => "e749" "paginaFinal" => "e770" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21873694" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0110" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "KHA-CARI guideline: diagnosis and treatment of urinary tract infection in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. McTaggart" 1 => "M. Danchin" 2 => "M. Ditchfield" 3 => "I. Hewitt" 4 => "J. Kausman" 5 => "S. Kennedy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nephrology (Carlton)" "fecha" => "2015" "volumen" => "20" "paginaInicial" => "55" "paginaFinal" => "60" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0115" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and management of urinary tract infection in children: summary of NICE guidance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Mori" 1 => "M. Lakhanpaul" 2 => "K. Verrier-Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.39286.700891.AD" "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "2007" "volumen" => "335" "paginaInicial" => "395" "paginaFinal" => "397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17717369" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0120" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Grupo de trabajo de la Guía de Práctica Clínica sobre Infección del Tracto Urinario en la Población Pediátrica. Guía de práctica clínica sobre infección del tracto urinario en la población pediátrica. Plan de Calidad para el Sistema Nacional de Salud del Ministerio de Sanidad, Política Social e Igualdad. Instituto Aragonés de Ciencias de la Salud; 2011. Guías de Práctica Clínica en el SNS: I<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>CS N.o 2009/01." ] ] ] 4 => array:3 [ "identificador" => "bib0125" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.G. Village" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.2011-1330" "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "2011" "volumen" => "128" "paginaInicial" => "595" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21873693" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0130" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A UK multicentre study of the antimicrobial susceptibility of bacterial pathogens causing urinary tract infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.J. Farrell" 1 => "I. Morrissey" 2 => "D. de Rubeis" 3 => "M. Robbins" 4 => "D. Felmingham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect" "fecha" => "2003" "volumen" => "46" "paginaInicial" => "94" "paginaFinal" => "100" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12634070" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0135" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antimicrobial resistance patterns of urinary tract pathogens and rationale for empirical therapy in Turkish children for the years 2000–2006" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Catal" 1 => "N. Bavbek" 2 => "O. Bayrak" 3 => "M. Karabel" 4 => "D. Karabel" 5 => "E. Odemis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11255-008-9445-5" "Revista" => array:6 [ "tituloSerie" => "Int Urol Nephrol" "fecha" => "2009" "volumen" => "41" "paginaInicial" => "953" "paginaFinal" => "957" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18704743" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0140" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infecciones del tracto urinario: sensibilidad antimicrobiana y seguimiento clínico" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. De Lucas Collantes" 1 => "J. Cela Alvargonzalez" 2 => "A.M. Angulo Chacón" 3 => "M. García Ascaso" 4 => "R. Piñeiro Pérez" 5 => "M.J. Cilleruelo Ortega" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Pediatr (Barc)" "fecha" => "2012" "volumen" => "76" "paginaInicial" => "224" "paginaFinal" => "228" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0145" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urinary tract infections in infants and children: diagnosis and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.L. Robinson" 1 => "J.C. Finlay" 2 => "M.E. Lang" 3 => "R. Bortolussi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Paediatr Child Health" "fecha" => "2014" "volumen" => "19" "paginaInicial" => "315" "paginaFinal" => "325" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25332662" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0150" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Shaikh" 1 => "J.L. Borrell" 2 => "J. Evron" 3 => "M. Leeflang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/14651858.CD009185.pub2" "Revista" => array:5 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2015" "volumen" => "1" "paginaInicial" => "CD009185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25603480" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0155" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dimercapto-succinic acid scintigraphy instead of voiding cystourethrography for infants with urinary tract infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Hansson" 1 => "M. Dhamey" 2 => "O. Sigström" 3 => "R. Sixt" 4 => "E. Stokland" 5 => "M. Wennerström" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000135337.71154.60" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2004" "volumen" => "172" "paginaInicial" => "1071" "paginaFinal" => "1074" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15311040" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0160" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "5-Year prospective results of dimercapto-succinic acid imaging in children with febrile urinary tract infection: proof that the top-down approach works" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Herz" 1 => "P. Merguerian" 2 => "L. McQuiston" 3 => "C. Danielson" 4 => "M. Gheen" 5 => "L. Brenfleck" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2010.04.050" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2010" "volumen" => "184" "numero" => "4 Suppl." "paginaInicial" => "1703" "paginaFinal" => "1709" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20728131" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0165" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Update on recent guidelines for the management of urinary tract infections in children: the shifting paradigm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Paintsil" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MOP.0b013e32835c14cc" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pediatr" "fecha" => "2013" "volumen" => "25" "paginaInicial" => "88" "paginaFinal" => "94" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23241875" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0170" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Managing children under 36 months of age with febrile urinary tract infection: a new approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Pennesi" 1 => "I. L’Erario" 2 => "L. Travan" 3 => "A. Ventura" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00467-011-2087-3" "Revista" => array:7 [ "tituloSerie" => "Pediatr Nephrol" "fecha" => "2012" "volumen" => "27" "paginaInicial" => "611" "paginaFinal" => "615" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22234625" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S2352301815002118" "estado" => "S300" "issn" => "23523018" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0175" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of renal scarring in children with a first urinary tract infection: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Shaikh" 1 => "A.L. Ewing" 2 => "S. Bhatnagar" 3 => "A. Hoberman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.2010-0685" "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "2010" "volumen" => "126" "paginaInicial" => "1084" "paginaFinal" => "1091" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21059720" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0180" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Procalcitonin as a predictor of renal scarring in infants and young children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Bressan" 1 => "B. Andreola" 2 => "P. Zucchetta" 3 => "G. Montini" 4 => "M. Burei" 5 => "G. Perilongo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00467-009-1125-x" "Revista" => array:6 [ "tituloSerie" => "Pediatr Nephrol" "fecha" => "2009" "volumen" => "24" "paginaInicial" => "1199" "paginaFinal" => "1204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19205751" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0185" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.C. Craig" 1 => "L.M. Irwig" 2 => "J.F. Knight" 3 => "L.P. Roy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Pediatrics" "fecha" => "2000" "volumen" => "105" "paginaInicial" => "1236" "paginaFinal" => "1241" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10835063" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673615000562" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0190" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital reflux nephropathy: a follow-up of 108 cases diagnosed perinatally" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.M. Assael" 1 => "S. Guez" 2 => "G. Marra" 3 => "E. Secco" 4 => "G. Manzoni" 5 => "M. Bosio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1998" "volumen" => "82" "paginaInicial" => "252" "paginaFinal" => "257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9722762" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0195" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Innate immunity and genetic determinants of urinary tract infection susceptibility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Godaly" 1 => "I. Ambite" 2 => "C. Svanborg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QCO.0000000000000127" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Infect Dis" "fecha" => "2015" "volumen" => "28" "paginaInicial" => "88" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25539411" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0200" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Montini" 1 => "L. Rigon" 2 => "P. Zucchetta" 3 => "F. Fregonese" 4 => "A. Toffolo" 5 => "D. Gobber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.2007-3770" "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "2008" "volumen" => "122" "paginaInicial" => "1064" "paginaFinal" => "1071" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18977988" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000008600000002/v1_201701260047/S2341287916301582/v1_201701260047/en/main.assets" "Apartado" => array:4 [ "identificador" => "26005" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000008600000002/v1_201701260047/S2341287916301582/v1_201701260047/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287916301582?idApp=UINPBA00005H" ]
Year/Month | Html | Total | |
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2024 November | 14 | 18 | 32 |
2024 October | 100 | 36 | 136 |
2024 September | 141 | 34 | 175 |
2024 August | 141 | 61 | 202 |
2024 July | 166 | 41 | 207 |
2024 June | 159 | 33 | 192 |
2024 May | 136 | 36 | 172 |
2024 April | 114 | 34 | 148 |
2024 March | 93 | 24 | 117 |
2024 February | 110 | 33 | 143 |
2024 January | 129 | 22 | 151 |
2023 December | 130 | 26 | 156 |
2023 November | 115 | 25 | 140 |
2023 October | 123 | 23 | 146 |
2023 September | 107 | 19 | 126 |
2023 August | 98 | 16 | 114 |
2023 July | 98 | 22 | 120 |
2023 June | 111 | 27 | 138 |
2023 May | 127 | 23 | 150 |
2023 April | 94 | 25 | 119 |
2023 March | 128 | 24 | 152 |
2023 February | 76 | 15 | 91 |
2023 January | 96 | 27 | 123 |
2022 December | 78 | 27 | 105 |
2022 November | 83 | 37 | 120 |
2022 October | 93 | 61 | 154 |
2022 September | 78 | 26 | 104 |
2022 August | 70 | 72 | 142 |
2022 July | 63 | 47 | 110 |
2022 June | 64 | 38 | 102 |
2022 May | 55 | 42 | 97 |
2022 April | 77 | 23 | 100 |
2022 March | 142 | 49 | 191 |
2022 February | 89 | 43 | 132 |
2022 January | 102 | 39 | 141 |
2021 December | 84 | 49 | 133 |
2021 November | 88 | 47 | 135 |
2021 October | 142 | 76 | 218 |
2021 September | 75 | 37 | 112 |
2021 August | 103 | 44 | 147 |
2021 July | 73 | 37 | 110 |
2021 June | 97 | 53 | 150 |
2021 May | 108 | 42 | 150 |
2021 April | 308 | 93 | 401 |
2021 March | 205 | 29 | 234 |
2021 February | 148 | 29 | 177 |
2021 January | 137 | 47 | 184 |
2020 December | 90 | 24 | 114 |
2020 November | 86 | 21 | 107 |
2020 October | 67 | 15 | 82 |
2020 September | 50 | 26 | 76 |
2020 August | 50 | 16 | 66 |
2020 July | 53 | 19 | 72 |
2020 June | 44 | 16 | 60 |
2020 May | 46 | 22 | 68 |
2020 April | 37 | 23 | 60 |
2020 March | 38 | 17 | 55 |
2020 February | 31 | 19 | 50 |
2020 January | 35 | 24 | 59 |
2019 December | 52 | 27 | 79 |
2019 November | 39 | 18 | 57 |
2019 October | 37 | 14 | 51 |
2019 September | 55 | 24 | 79 |
2019 August | 59 | 26 | 85 |
2019 July | 28 | 26 | 54 |
2019 June | 27 | 21 | 48 |
2019 May | 69 | 23 | 92 |
2019 April | 87 | 18 | 105 |
2019 March | 44 | 11 | 55 |
2019 February | 43 | 18 | 61 |
2019 January | 39 | 20 | 59 |
2018 December | 47 | 31 | 78 |
2018 November | 86 | 32 | 118 |
2018 October | 174 | 19 | 193 |
2018 September | 61 | 5 | 66 |
2018 August | 1 | 0 | 1 |
2018 July | 2 | 0 | 2 |
2018 June | 3 | 0 | 3 |
2018 May | 4 | 0 | 4 |
2018 April | 22 | 0 | 22 |
2018 March | 27 | 0 | 27 |
2018 February | 12 | 0 | 12 |
2018 January | 21 | 0 | 21 |
2017 December | 24 | 0 | 24 |
2017 November | 13 | 0 | 13 |
2017 October | 18 | 0 | 18 |
2017 September | 17 | 0 | 17 |
2017 August | 17 | 0 | 17 |
2017 July | 23 | 0 | 23 |
2017 June | 28 | 21 | 49 |
2017 May | 27 | 10 | 37 |
2017 April | 110 | 89 | 199 |
2017 March | 17 | 25 | 42 |
2017 February | 27 | 28 | 55 |
2017 January | 7 | 19 | 26 |
2016 December | 0 | 1 | 1 |