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                      "titulo" => "Calendario de Vacunaci&#243;n de la Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a&#46; Recomendaciones"
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                            2 => "J&#46; Ar&#237;stegui Fern&#225;ndez"
                            3 => "M&#46;J&#46; Cilleruelo Ortega"
                            4 => "J&#46;M&#46; Corretger Rauet"
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Scientific Letter
More is not always better. Individual guideline or systematic vaccination against pneumococcus
Más no siempre es mejor. Pauta individual o calendario sistemático en vacuna antineumocócica
An Lieve Dirk Boonea,
Corresponding author
boone_an@gva.es

Corresponding author.
, María Besó-Delgadoa, Ana María Alguacil-Ramosb, Eliseo Pastor-Villalbab, Antonio Portero-Alonsob
a Servicio de Medicina Preventiva, Hospital Clínico Universitario de Valencia, Valencia, Spain
b Servicio de Coordinación y Promoción de la Salud y Prevención en las Etapas de la Vida, Dirección General de Salud Pública, Valencia, Spain
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Sociedad Valenciana de Pediatr&#237;a &#40;Valencian Association of Paediatrics&#41;&#44; Asociaci&#243;n Valenciana de Pediatr&#237;a en Atenci&#243;n Primaria &#40;Valencian Association of Primary Care Paediatrics&#41;&#44; Asociaci&#243;n de Pediatr&#237;a Extrahospitalaria de Alicante &#40;Association of Outpatient Paediatrics of Alicante&#41; and the Advisory Committee on Vaccines of the ACV&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Despite these recommendations&#44; some paediatricians continue to recommend the 3<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1 schedule in all children and not only those in risk groups&#44; because they believe it is necessary to achieve herd immunity&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">For this reason&#44; we set out to determine the PCV13 coverage rates and dose schedules used from the time it was included in the routine immunization schedule of the ACV<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> in children born between January 1 and September 30&#44; 2015&#44; and assessing potential additional costs for parents and the health care system&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We conducted a cross-sectional descriptive study using data collected from the Vaccine Information System &#40;Sistema de Informaci&#243;n Vacunal &#91;SIV&#93;&#41;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> of both the Nominal Vaccine Register &#40;Registro de Vacunas Nominal &#91;RVN&#93;&#41; and the Vaccine Repository Register &#40;Registro de Vacunas de Almac&#233;n &#91;RVA&#93;&#41;&#44; using the Population Information System &#40;Sistema de Informaci&#243;n Poblacional &#91;SIP&#93;&#41; or public health card as a population register&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We studied the following variables&#58; health area and basic health zone&#44; age&#44; number of administered doses&#44; vaccine lot number&#44; and risk-group membership&#46; We performed the statistical analysis with Microsoft Excel<span class="elsevierStyleSup">&#174;</span> 2003&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In the period under study&#44; 31<span class="elsevierStyleHsp" style=""></span>815 children were born&#44; and 42<span class="elsevierStyleHsp" style=""></span>005 PCV13 doses administered&#44; out of which 23<span class="elsevierStyleHsp" style=""></span>670 were first doses&#44; 16<span class="elsevierStyleHsp" style=""></span>096 second doses and 2239 third doses&#46; The mean age-adjusted vaccine coverage rate was 93&#46;6&#37; for the first dose &#40;95&#37; IC&#44; 93&#46;5&#8211;93&#46;7&#41;&#44; 88&#46;5&#37; for the second dose &#40;95&#37; CI&#44; 88&#46;3&#8211;88&#46;6&#41; and 20&#46;4&#37; for the third dose &#40;95&#37; CI&#44; 20&#46;1&#8211;20&#46;7&#41;&#46; Of the children that received a third dose&#44; 92&#46;6&#37; did not belong to any risk groups&#46; The proportion of children with no risk that received the first dose was 98&#46;3&#37;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the percentage of children born in 2015 that belonged to risk groups and received a third dose of PCV13 by health area&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Of the 24 health areas of the ACV&#44; four had coverage rates for a third dose of PCV13 vaccine that exceeded 49&#37; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">In these health areas&#44; 91&#46;9&#37; of the third doses were not supplied by the public health system&#44; so we assume that these doses were purchased at pharmacies by parents&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The total expenditure in third doses for children that did not belong to any risk group in the ACV amounted to 158<span class="elsevierStyleHsp" style=""></span>176&#46;48&#8364;&#44; of which 43<span class="elsevierStyleHsp" style=""></span>304&#46;80&#8364; corresponded to the Valencian Public Health System for vaccination events that were covered under the tax laws<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> of the Government of the ACV&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The PCV13 vaccine coverage rate in the ACV in 2014&#44; before the vaccine was included in the routine immunization schedule&#44; was 67&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> which already sufficed to achieve herd immunity&#46; Therefore&#44; a third dose at age 6 months is not justified by the vaccination coverage rates either before or after the inclusion of the PCV13 vaccine in the routine schedule&#44; save in children belonging to risk groups&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">High coverage rates have been achieved since the PCV13 vaccine was first included in the routine immunization schedule&#44; so a third dose at 6 months would not be indicated except in at-risk children&#46; The additional and inefficient costs for both parents and the Department of Public Health are considerable&#46; When it comes to vaccination&#44; more is not always better&#44; so we must apply the best and most efficient scientific evidence that is currently available for the benefit of the population and immunization programmes&#46;</p></span>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">92&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">220&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#46;6&#8211;57&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">210&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">662&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">632&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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Article information
ISSN: 23412879
Original language: English
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