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Given the presence of a brain lesion probably caused by inflammation&#44; the patient was screened for autoimmune diseases&#44; and the antinuclear antibodies&#44; complement and antineutrophil cytoplasmic antibodies tests were all negative&#46; The patient underwent genetic testing for hereditary autoinflammatory diseases &#40;familial Mediterranean fever&#44; periodic fever syndrome due to mevalonate kinase deficiency&#44; TRAPS&#44; BLAU syndrome&#47;early-onset sarcoidosis&#41; that found no mutation associated with her disease&#46; The test for HLA-B51 was negative&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Beh&#231;et&#39;s disease was suspected based on the clinical presentation and imaging findings&#44; leading to initiation of empirical immunosuppressive therapy with corticosteroids &#40;first with intravenous methylprednisolone bolus injection at 30<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day for 3 days&#44; and then by the oral route at 2<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#41;&#44; colchicine &#40;0&#46;5<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>h by the oral route&#41; and azathioprine &#40;1&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day by the oral route&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient responded well to the treatment&#44; with a gradual improvement of symptoms that allowed the progressive tapering and eventual discontinuation of corticosteroids&#46; The followup MRI at six months after initiation of treatment did not show any pathological changes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; At present&#44; the patient continues treatment with azathioprine and colchicine&#44; with good results&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Beh&#231;et&#39;s disease is diagnosed based on clinical manifestations&#44; and there are no validated classification criteria for the paediatric population&#46; Kon&#233;-Paut et al&#46; created an international registry of paediatric patients with BD with the purpose of defining the characteristics of paediatric patients with the disease and subsequently developing classification criteria adapted to this population&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> In 26&#37; of cases of BD&#44; the onset occurs before age 16 years&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Neurological involvement has been described in 5&#37; to 30&#37; of BD cases in children&#44; most frequently with central nervous system involvement in the form of thrombosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Parenchymal involvement is typically found at the level of the brainstem&#44; appearing as a single inflammatory oedematous lesion that is hyperintense on T2 and iso- to hypointense on T1&#44; associated with meningitis&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">To date&#44; no randomised clinical trials have been conducted for the treatment of BD&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> The goals of treatment are symptom control and preventing damage to the affected organ&#44; usually by administration of corticosteroids or immunosuppressants such as azathioprine&#44; ciclosporin or anti-TNF alpha&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Advances in the knowledge of the pathophysiology of BD will help define a more specific therapeutic approach&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Neurological involvement is an exceptional initial presentation in childhood BD&#46; The characteristic neuroimaging findings and the accompanying characteristic symptoms guide the clinical diagnosis&#46;</p></span>"
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Scientific Letter
Meningoencephalitis as a presentation form of Behçet
Meningoencefalitis de tronco como presentación de Behçet
D. Rodàa,
Corresponding author
droda@hsjdbcn.org

Corresponding author.
, A. Martínez-Monsenya, M. Rebollob, E. Iglesiasc
a Servicio de Pediatría, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues de Llobregat, Barcelona, Spain
b Servicio de Radiología, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues de Llobregat, Barcelona, Spain
c Unidad de Reumatología Pediátrica, Servicio de Pediatría, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues de Llobregat, Barcelona, Spain
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eye fundus examination &#40;<span class="elsevierStyleItalic">N</span>&#41;&#44; lumbar puncture &#40;predominantly mononuclear pleocytosis with 950 white blood cells&#47;mL&#59; <span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>10&#41;&#44; cerebrospinal fluid protein &#40;mildly elevated at 68<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#59; <span class="elsevierStyleItalic">N</span>&#44; 15&#8211;40&#41; and glucose &#40;<span class="elsevierStyleItalic">N</span>&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Meningoencephalitis was suspected and empirical treatment with intravenous acyclovir initiated while awaiting the results of PCR tests for herpes simplex virus 1 and 2&#44; which turned out negative&#46; The patient was tested for infectious agents &#40;Mantoux test&#44; antibody testing for HIV&#44; <span class="elsevierStyleItalic">Borrelia</span>&#44; <span class="elsevierStyleItalic">Listeria</span> and syphilis&#41; and cancer &#40;chest radiograph&#44; blood differential test and LDH&#41;&#44; and no abnormalities were found&#46; Faecal calprotectin was measured to rule out intestinal inflammatory disease&#44; and was found to be normal&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">During hospitalisation&#44; she experienced palsy of the VI cranial nerves with ongoing fluctuations in the level of consciousness&#44; leading to performance of a head CT scan with contrast that showed no abnormalities&#46; Forty-eight hours later&#44; the patient underwent a cranial MRI scan that showed a hyperintense T2 signal at the level of the brainstem&#44; centred at the midbrain and extending towards the cerebral peduncles and the pons&#44; with leptomeningeal enhancement and an uptaking punctiform focus at the level of the right cerebellar peduncle &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A and B&#41;&#46; Given the presence of a brain lesion probably caused by inflammation&#44; the patient was screened for autoimmune diseases&#44; and the antinuclear antibodies&#44; complement and antineutrophil cytoplasmic antibodies tests were all negative&#46; The patient underwent genetic testing for hereditary autoinflammatory diseases &#40;familial Mediterranean fever&#44; periodic fever syndrome due to mevalonate kinase deficiency&#44; TRAPS&#44; BLAU syndrome&#47;early-onset sarcoidosis&#41; that found no mutation associated with her disease&#46; The test for HLA-B51 was negative&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Beh&#231;et&#39;s disease was suspected based on the clinical presentation and imaging findings&#44; leading to initiation of empirical immunosuppressive therapy with corticosteroids &#40;first with intravenous methylprednisolone bolus injection at 30<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day for 3 days&#44; and then by the oral route at 2<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#41;&#44; colchicine &#40;0&#46;5<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>h by the oral route&#41; and azathioprine &#40;1&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day by the oral route&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient responded well to the treatment&#44; with a gradual improvement of symptoms that allowed the progressive tapering and eventual discontinuation of corticosteroids&#46; The followup MRI at six months after initiation of treatment did not show any pathological changes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; At present&#44; the patient continues treatment with azathioprine and colchicine&#44; with good results&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Beh&#231;et&#39;s disease is diagnosed based on clinical manifestations&#44; and there are no validated classification criteria for the paediatric population&#46; Kon&#233;-Paut et al&#46; created an international registry of paediatric patients with BD with the purpose of defining the characteristics of paediatric patients with the disease and subsequently developing classification criteria adapted to this population&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> In 26&#37; of cases of BD&#44; the onset occurs before age 16 years&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Neurological involvement has been described in 5&#37; to 30&#37; of BD cases in children&#44; most frequently with central nervous system involvement in the form of thrombosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Parenchymal involvement is typically found at the level of the brainstem&#44; appearing as a single inflammatory oedematous lesion that is hyperintense on T2 and iso- to hypointense on T1&#44; associated with meningitis&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">To date&#44; no randomised clinical trials have been conducted for the treatment of BD&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> The goals of treatment are symptom control and preventing damage to the affected organ&#44; usually by administration of corticosteroids or immunosuppressants such as azathioprine&#44; ciclosporin or anti-TNF alpha&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Advances in the knowledge of the pathophysiology of BD will help define a more specific therapeutic approach&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Neurological involvement is an exceptional initial presentation in childhood BD&#46; The characteristic neuroimaging findings and the accompanying characteristic symptoms guide the clinical diagnosis&#46;</p></span>"
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ISSN: 23412879
Original language: English
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