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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The newborn may have a variety of haemodynamic problems with a variable and complex pathophysiology&#44; that at times have limited clinical manifestations&#46; This cardiovascular vulnerability stems from particular features of the newborn&#44; such as incomplete myocardial development&#44; the presence of foetal shunts&#44; changes in systemic and pulmonary vascular resistance&#44; and more generally the complex haemodynamic changes that take place during transition to extrauterine life&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Despite progressive technological advances in neonatal intensive care&#44; in most cases haemodynamic monitoring in newborns is still based on assessment of continuous heart rate&#44; blood pressure &#40;BP&#41;&#44; acid&#8211;base status&#44; urine output&#44; or poorly validated clinical signs such as capillary refill time&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> While these measures provide important and useful information to the clinician&#44; they are just variables associated in varying degrees to tissue perfusion&#44; which is the key haemodynamic parameter&#44; and for which an adequate monitoring method has yet to be developed&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> One potentially interesting option would be measurement of regional oxygen saturation by means of near-infrared spectroscopy&#44; although further research is required to confirm this&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Many publications have demonstrated that the correlation between BP and cardiac output is weak&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6</span></a> It is not uncommon to find situations in which BP is normal and peripheral blood flow is below normal range&#46; This can have important implications&#44; as low peripheral blood flow in the first hours of life has been associated with the development of brain damage and neurodevelopmental abnormalities in premature infants&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> On the other hand&#44; there is no clear definition of what constitutes a normal BP in newborns&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> The use of clinical assessment and the classic parameters mentioned before to elucidate the underlying pathophysiology in haemodynamic disturbances can lead to incorrect assumptions and therapeutic decisions&#44; which may even cause harm&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In the neonate&#44; echocardiography is commonly performed by a cardiologist to assess structure and function of the heart&#46; Usually&#44; a single study is done to rule out congenital heart disease or global myocardial dysfunction&#44; and the time at which it is performed often depends on the availability of a cardiologist&#46; This can be an important factor in units that have limited access to a cardiologist&#44; or in situations in which serial assessment is needed to evaluate response to treatment or the haemodynamic changes that take place during transition from foetal to postnatal circulation&#46; It is important to consider that these changes can be very different from what might be assumed clinically based on conventional assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Functional echocardiography&#44; or neonatologist-performed cardiac ultrasound&#44; depending on the terminology suggested by different authors&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;12</span></a> is being introduced progressively in neonatal intensive care units &#40;NICU&#41; as a tool to help guide treatment choices&#46; Functional echocardiography &#40;FnECHO&#41; adds to the assessment of classic clinical parameters in an attempt to provide individualised treatment based on the specific pathophysiology at hand&#46; It must be used as an adjunct to clinical assessment and not as a substitute for assessment by a cardiologist&#44; as their purposes are different and complementary&#46; The neonatologist can use FnECHO to obtain information about haemodynamic function in real time and to make longitudinal assessments as needed&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The aims of FnECHO are assessment of myocardial function&#44; systemic and pulmonary blood flow&#44; intracardiac and extracardiac shunts&#44; and tissue perfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Functional echocardiography is commonly used to assess haemodynamic status during the transition from foetal to postnatal circulation in the extremely premature neonate&#44; to assess for the presence and significance of PDA&#44; to determine the underlying pathophysiology in patients with haemodynamic instability&#44; and in neonates with high oxygen requirements&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;13&#8211;15</span></a> It has shown a positive impact on the management of adult patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#8211;18</span></a> However&#44; there is no clear evidence associating the use of FnECHO with improved outcomes of neonates admitted to the NICU&#44; although some publications show a positive effect in this regard&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;19&#44;20</span></a> As far as we know&#44; there are no publications on the use of FnECHO in Spanish NICUs&#46; We present the results of a retrospective study on the use of FnECHO in a Spanish NICU during a 1-year period&#44; in which we analysed frequency of FnECHO use&#44; type of patient receiving it&#44; indications for FnECHO&#44; and effects on the management of patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">We performed a retrospective study of every FnECHO done in newborns admitted to the NICU of the Hospital Cl&#237;nico San Carlos of Madrid between January 2012 and January 2013&#46; This 11-bed unit provides treatment for all types of neonatal disease except for heart surgery and ECMO &#40;Level <span class="elsevierStyleSmallCaps">IIIB</span>&#41;&#46; All the studies were performed at the request of the physicians in charge by 2 NICU neonatologists &#40;AC and LA&#41; that have more than 5-year experience in FnECHO&#46; The ultrasound assessments and measurements were performed according to a standardised procedure that has been previously described and is presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;21</span></a> The indications for the ultrasound scans and their results were documented in the medical record of each patient&#46; When an ultrasound was done&#44; the results were discussed with the physicians in charge to decide on the therapeutic approach&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">We collected the following general data on patients&#58; gestational age &#40;GA&#41;&#44; birth weight&#44; and principal diagnosis&#46; The following clinical data were recorded from the ultrasound tests&#58; heart rate&#44; presence of a murmur&#44; presence of a gradient between preductal and postductal haemoglobin oxygen saturation &#62;10&#37;&#44; mean BP &#40;MBP&#59; mmHg&#41;&#44; lactate levels &#40;mmol&#47;L&#41; and presence of oliguria &#40;diuresis &#60;1<span class="elsevierStyleHsp" style=""></span>ml&#47;kg&#47;h&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The data about the echocardiographic examinations included&#58; days of life at the time of examination&#44; number of ultrasound studies per patient&#44; and indication for examination&#46; We documented whether the results of FnECHO led to treatment modification&#44; and if so&#44; what changes were made&#46; Our analysis excluded ultrasound examinations performed in newborns with a suspected or confirmed structural congenital cardiopathy &#40;CC&#41;&#46; Although neonatologist-performed FnECHO&#44; our unit is also used to localise catheters&#44; assess for the presence of pleural effusion and its evacuation&#44; the study of brain blood flow&#44; or screening for gross brain injury&#44; our study only took into account echocardiographic examinations&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Analysed ultrasound parameters&#58; all echocardiograms were done with a portable ultrasound machine with a neonatal probe &#40;Titan&#44; SonoSite Inc&#46;&#44; Bothell&#44; USA&#44; probe C11&#47;5&#8211;8<span class="elsevierStyleHsp" style=""></span>MHz&#41;&#58; &#40;1&#41; assessment of ductus presence&#47;consequences&#58; presence&#44; diameter in colour or 2D Doppler&#59; shunt direction&#44; ratio of left atrium to aorta&#44; ductal Doppler pattern&#59; &#40;2&#41; assessment of myocardial function and systemic blood flow&#58; ejection fraction &#40;EF&#41;&#44; shortening fraction &#40;SF&#41;&#44; left ventricle &#40;LV&#41; and right ventricle &#40;RV&#41; cardiac output&#44; superior vena cava blood flow and &#40;3&#41; assessment of pulmonary hypertension&#58; calculation of pulmonary artery pressure in the presence of tricuspid regurgitation&#44; interventricular septal shape&#44; shunt direction&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Qualitative variables are expressed as absolute and relative frequencies&#44; and quantitative variables as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation or median and interquartile range in case of asymmetrical distribution or high dispersion of the data&#46; We used the statistical package STATA 12 to do the analysis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">A total of 168 ultrasound examinations were performed in 50 patients during the period under study&#44; with a mean of 3&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;83 examinations per patient&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the general characteristics of the patients&#46; The mean GA of the patients was 31&#46;3 weeks&#44; with a range of 24&#46;1&#8211;40&#46;2 weeks&#44; and the mean birth weight was 1549<span class="elsevierStyleHsp" style=""></span>g &#40;590&#8211;4160<span class="elsevierStyleHsp" style=""></span>g&#41;&#46; Seventy percent of patients were born before 32 weeks of gestation&#46; The most frequent admission diagnosis was extreme prematurity and&#47;or extremely low weight at birth &#40;38&#37;&#41;&#46; Very low birth weight occurred in 34&#37; of the patients &#40;1000&#8211;1500<span class="elsevierStyleHsp" style=""></span>g&#41;&#46; Other principal diagnoses &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; at the time of admission were hypoxic ischaemic encephalopathy to be treated with hypothermia &#40;10&#37;&#41;&#44; respiratory distress syndrome &#40;8&#37;&#41;&#44; transient tachypnoea &#40;6&#37;&#41; and other &#40;4&#37;&#41;&#46; The median days of life at the time of ultrasound examination was 6 days &#40;2&#8211;19 days&#41;&#46; The most frequent indication for echocardiography was assessment of the presence and significance of PDA&#44; accounting for 58&#46;3&#37; of examinations &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; Other indications included haemodynamic instability &#40;22&#46;2&#37;&#41;&#44; presence of heart murmur &#40;8&#46;3&#37;&#41;&#44; assessment of transition from foetal to postnatal circulation in extremely preterm neonates &#40;5&#46;4&#37;&#41;&#44; pulmonary hypertension screening &#40;1&#46;2&#37;&#41;&#44; and other &#40;4&#46;8&#37;&#41;&#46; As for the impact of FnECHO on patient management&#44; the echocardiography results led to treatment modification in 62 patients &#40;36&#46;9&#37;&#41;&#46; The most common modifications involved the management of PDA&#46; Thus&#44; treatment with ibuprofen was initiated in 17&#46;4&#37; of patients following the ultrasound test&#44; while in 1&#46;2&#37; of patients treatment with this drug was discontinued early&#46; As for haemodynamic support&#44; ultrasound results led to changes in the management of 10&#46;8&#37; of the patients&#46; The changes involved volume expansion therapy &#40;0&#46;6&#37;&#41;&#44; initiation or modification of inotropic therapy &#40;9&#46;6&#37;&#41; or initiation of hydrocortisone therapy &#40;0&#46;6&#37;&#41;&#46; Out of all ultrasound scans&#44; 36&#46;3&#37; were done in patients who had no murmur&#44; arterial hypotension&#44; oliguria&#44; increased lactate levels&#44; tachycardia&#44; or presence of an oxygen saturation gradient&#46; Of all these examinations&#44; 21&#46;7&#37; corresponded to routine studies in the early days of life&#46; Another 78&#46;3&#37; were follow-up studies in patients who had been previously assessed&#46; In 14 of these ultrasounds &#40;22&#46;9&#37;&#41; the results led to a modification of treatment&#46; Twelve corresponded to PDA&#46; The analysis of echocardiography parameters included the assessment of the presence and significance of PDA in 100&#37; of the patients&#46; Myocardial function was assessed by means of the EF&#47;FA ratio in 23&#46;8&#37;&#44; LV output in 24&#46;4&#37; and RV output in 21&#46;4&#37; of patients&#46; Systemic blood flow in the superior vena cava was measured in 42&#37; of the examinations&#46; The presence of pulmonary hypertension was assessed in 7&#46;7&#37; of patients&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">This study is the first to describe the use of FnECHO in a Spanish NICU&#46; The results suggest that this technique is used frequently and that it leads to treatment modification in a significant percentage of cases&#46; A similar study published recently describes the performance of 512 FnECHOs in a Canadian unit over a period of 3&#46;5 years&#44; which works out at an average of 142 examinations a year&#44; a figure that is very close to the one described in this work of 168 examinations in 12 months&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> That study also observed an increasing use of this technique during the period under analysis&#44; which confirms the interest in FnECHO and its progressive implantation in neonatology units&#46; A survey-based study shows that as early as 10 years ago 41&#37; of the level 3 neonatology units in Australia and New Zealand had at least 1 neonatologist with FnECHO skills&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> This figure had increased by more than 90&#37; in 2010&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> The neonatologist in our unit started to use FnECHO 10 years ago and used it mostly as a diagnostic tool and to monitor response to treatment of PDA&#46; Since then&#44; the range of indications has increased to the point that it has nearly turned into an additional part of the clinical assessment of haemodynamic disturbances&#46; According to our study&#44; the most frequent indication for FnECHO is diagnosis or monitoring of PDA &#40;58&#46;3&#37; of patients&#41;&#44; followed by assessment of pathophysiology underlying haemodynamic instability &#40;22&#46;2&#37;&#41;&#46; This is consistent with the data of the study by El-Kuffash et al&#46;&#44; in which PDA assessment amounted for 51&#37; of FnECHO indications&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In our study&#44; the results of 36&#46;9&#37; of FnECHO examinations led to changes in the management of the patient&#44; a figure that is very close to the one reported by El-Kuffash&#44; with a 41&#37; rate of management changes following the ultrasound examination&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Studies in adults suggest that FnECHO results in treatment changes in up to 51&#46;4&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> This supports the definition of FnECHO as a tool that guides therapeutic decision making&#46; In the study presented here&#44; 36&#46;3&#37; of the ultrasounds were performed in patients with no other abnormal haemodynamic parameters or heart murmur&#44; despite which the management of 22&#46;9&#37; of them changed after the examination&#46; Almost all of these patients had PDA&#46; We already mentioned that FnECHO findings are not always predictable based on traditional clinical assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Thus&#44; El-Kuffash et al&#46; found 6&#37; of unexpected diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> In fact&#44; in FnECHO study performed in adult intensive care units&#44; previously undetected severe abnormalities were found in up to 7&#46;5&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> In our study&#44; an average of 3&#46;4 ultrasounds were made per patient&#44; with some patients receiving up to 16 ultrasounds&#46; This shows how FnECHO can be used for patient follow-up or to monitor response to treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">While it is clear that this technique is useful in practise&#44; strong evidence of the positive impact of the use of FnECHO in the NICU on patient outcomes is still lacking&#46; But several retrospective studies<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;19&#44;20</span></a> and a few clinical trials<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> suggest that FnECHO is beneficial in this way&#46; In any case&#44; randomised studies need to be performed to see whether the FnECHO has an effect on patient outcomes&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The main controversy surrounding performance of echocardiography by a neonatologist is based on the potential danger of missing a CC or making an incorrect diagnosis and starting the wrong treatment in a patient with CC&#46; However&#44; while this is a real danger&#44; in most cases an existing structural cardiopathy is detected by FnECHO&#44; even if a complete diagnostic assessment is not made&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#44;28</span></a> Either way&#44; cardiologists and neonatologists must work in close collaboration&#44; and a cardiology consult must be requested whenever there are doubts&#46; Adequate training in FnECHO is essential to minimise these risks&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Yet&#44; despite the increasingly widespread use of this technique worldwide&#44; many countries&#44; including Spain&#44; do not have a standardised training programme&#46; In this case&#44; training depends on personal interest&#44; is performed at the same time as the working routine and relies on the collaboration of the cardiologists and&#47;or the availability of specific materials like text books or CDs&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> This has been how training in FnECHO has been done in our unit&#44; and it would not have been possible without the collaboration of paediatric cardiologists who understood that this technique is used by the neonatologist as an adjunct in clinical assessment&#44; and not an intrusion in their field&#46; Other countries like Australia&#44; New Zealand&#44; the United States&#44; Canada&#44; and some European countries have accredited training programmes&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;29&#44;30</span></a> The American Society of Echocardiography&#44; in collaboration with the European Association of Echocardiography and the Association for European Pediatric Cardiologists&#44; has recently published specific recommendations for the training of neonatologists in FnECHO&#44; which explain in detail what the training and accrediting process should entail&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> recommendations that have been modified by other authors&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Given the growing interest in this technique and its widespread use&#44; training and accreditation programmes should be developed in Spain with the support of the Sociedad Espa&#241;ola de Neonatolog&#237;a &#40;Spanish Society of Neonatologists&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">There are several limitations to this study&#44; most of which derive from its retrospective nature&#46; For instance&#44; treatment modification following FnECHO ultimately depended on the decision of the physician in charge of the patient&#44; and not only on the data obtained from the ultrasound&#44; which may have affected the perceived influence of this technique on the management of neonates&#44; making it smaller or greater than it is&#46; On the other hand&#44; this study cannot determine whether therapeutic choices would have been different if FnECHO had not been available&#44; nor whether those choices were the correct ones&#46; Furthermore&#44; the very decision of performing the ultrasound test&#44; or not&#44; also rested with the physician in charge rather than being determined by a study protocol&#44; which could have a considerable effect on the observed frequency of use&#46; Also&#44; the echocardiographic view may constitute an important limitation in some patients&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Although this study did not collect information on this variable in a systematic manner&#44; technical limitations associated to the view and the use of a 5&#8211;8<span class="elsevierStyleHsp" style=""></span>MHz probe rather than a probe with a higher frequency &#40;8&#8211;12<span class="elsevierStyleHsp" style=""></span>MHz&#41;&#44; which would be ideal&#44; may have affected the quality of some of these ultrasound studies&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusions</span><p id="par0070" class="elsevierStylePara elsevierViewall">Functional echocardiography is a useful tool employed widely in the NICU&#46; It provides complementary information that aids in making therapeutic decisions&#46; Its use is spreading in neonatology units&#44; although clinical trials need to be done to assess its impact on patient outcomes&#46; Structured training and accreditation programmes based on existing recommendations need to be developed to ensure the correct and safe use of this technique&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Several publications highlight the usefulness of functional echocardiography &#40;FnECHO&#41; in neonatal intensive care&#46; Data are lacking on its use in neonatal units in Spain&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To evaluate frequency of use&#44; patient characteristics&#44; indications&#44; measurements&#44; and impact on patient management of FnECHO in a neonatal intensive care unit &#40;NICU&#41; in Spain over a 1-year period&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A retrospective study conducted in NICU patients during 1 year&#46; Variables&#58; gestational age&#44; birthweight&#44; admission criteria&#44; days of life at examination&#44; indication for FnECHO&#44; parameters assessed&#44; and treatment modifications&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">168 echocardiographic studies were performed in 50 patients &#40;mean 3&#46;4&#59; SD 2&#46;83&#41;&#46; The most frequent indication was patent ductus &#40;PDA&#41; assessment &#40;58&#46;3&#37;&#41;&#44; followed by haemodynamic instability &#40;22&#46;2&#37;&#41;&#46; The results of FnECHO modified treatment in 62 cases &#40;36&#46;9&#37;&#41;&#46; In 17&#46;4&#37; of them treatment with ibuprofen was initiated&#44; and in 1&#46;2&#37; it was discontinued&#46; In 10&#46;8&#37; of the cases&#44; the results of FnECHO modified haemodynamic support&#46; Echocardiographic evaluation included&#58; assessment of presence&#47;haemodynamic significance of PDA &#40;100&#37;&#41;&#59; myocardiac function&#58; ejection fraction&#47;shortening fraction &#40;EF&#47;SF&#41; 23&#46;8&#37;&#44; left ventricular output 24&#46;4&#37;&#44; right ventricular output 21&#46;4&#37;&#44; systemic blood flow 42&#46;3&#37;&#59; and signs of pulmonary hypertension 7&#46;7&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">FnECHO is frequently used in the NICU&#44; and in many cases it guides treatment&#46; PDA assessment and haemodynamic instability are the most frequent indications&#46; It still needs to be elucidated if the use of FnECHO modifies patient outcomes&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numerosas publicaciones destacan la utilidad de la ecocardiograf&#237;a funcional &#40;EcoFn&#41; en neonatolog&#237;a&#46; No existen datos sobre su uso en unidades espa&#241;olas&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluar la frecuencia de uso&#44; pacientes&#44; indicaciones&#44; mediciones y repercusi&#243;n sobre el tratamiento de la EcoFn en un a&#241;o en una unidad de cuidados intensivos neonatales &#40;UCIN&#41; espa&#241;ola&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo retrospectivo en pacientes ingresados en UCIN en un a&#241;o&#46; Variables&#58; edad gestacional&#44; peso&#44; diagn&#243;stico principal&#44; d&#237;as de vida en el momento del estudio&#44; indicaci&#243;n&#44; par&#225;metros medidos y modificaciones del tratamiento&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se realizaron 168 ecograf&#237;as en 50 pacientes&#44; con una media &#177; desviaci&#243;n est&#225;ndar de 3&#44;4 &#177; 2&#44;83 por paciente&#46; Las indicaciones m&#225;s frecuentes fueron la valoraci&#243;n del ductus &#40;58&#44;3&#37;&#41; seguida de la inestabilidad hemodin&#225;mica &#40;22&#44;2&#37;&#41;&#46; El resultado de la ecograf&#237;a modific&#243; el tratamiento en 62 casos &#40;36&#44;9&#37;&#41;&#46; En un 17&#44;4&#37; se inici&#243; tratamiento con ibuprofeno y en un 1&#44;2&#37; de los casos se adelant&#243; el fin de este&#46; En un 10&#44;8&#37; de los casos&#44; la ecograf&#237;a modific&#243; el soporte hemodin&#225;mico&#46; Los par&#225;metros principales valorados fueron&#58; valoraci&#243;n de presencia&#47;repercusi&#243;n del ductus 100&#37;&#59; funci&#243;n mioc&#225;rdica&#58; fracci&#243;n de eyecci&#243;n&#47;acortamiento 23&#44;8&#37;&#44; gasto ventr&#237;culo del izquierdo 24&#44;4&#37;&#44; gasto del ventr&#237;culo derecho 21&#44;4&#37;&#59; flujo sist&#233;mico 42&#44;3&#37;&#59; signos de hipertensi&#243;n pulmonar 7&#44;7&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La EcoFn es utilizada frecuentemente en UCIN y en muchos casos gu&#237;a el tratamiento de los pacientes&#46; La valoraci&#243;n del ductus y de la inestabilidad hemodin&#225;mica son las indicaciones m&#225;s frecuentes&#46; Queda por determinar si el uso de la EcoFn modifica la evoluci&#243;n de los pacientes de UCIN&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Corredera A&#44; Rodr&#237;guez MJ&#44; Ar&#233;valo P&#44; Llorente B&#44; Moro M&#44; Arruza L&#46; Ecocardiograf&#237;a funcional en cuidados intensivos neonatales&#58; experiencia en una unidad espa&#241;ola a lo largo de un a&#241;o&#46; An Pediatr &#40;Barc&#41;&#46; 2014&#59;81&#58;167&#8211;173&#46;</p>"
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Component&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">View&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of ductus arteriosus</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Diameter &#40;narrowest dimension of duct&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2D or colour Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ductal&#47;suprasternal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Shunt directionality</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colour&#47;CW&#47;PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ductal&#47;suprasternal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Systolic and diastolic flow velocity through ductus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CW&#47;PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ductal&#47;suprasternal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">LV systolic function</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SF&#47;EF&#58; LV end-diastolic and end-systolic diameter</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of overall myocardial function</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV Tei index</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Time interval between end and onset of transmitral flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical four-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>LV ejection time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical five-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV Tei index</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Time interval between end and onset of transtricuspid flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical four-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>RV ejection time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of pulmonary hypertension</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Peak tricuspid regurgitation velocity</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colour Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical four-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Interventricular septum morphology</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal short axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of atrial-level shunt</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Directionality</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colour&#47;PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subxiphoid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">LV cardiac index</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV outflow tract diameter</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2D&#47;M mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Velocity&#8211;time integral of PW in LV outflow tract</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical five-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">RV cardiac index</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV outflow tract diameter</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Velocity&#8211;time integral of PW in RV outflow tract</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">SVC flow</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SVC diameter &#40;mean of systolic and diastolic diameter&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">High parasternal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Velocity&#8211;time integral of SVC &#40;mean of 5 cycles&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subxiphoid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of RV function</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Tricuspid annular plane systolic excursion &#40;TAPSE&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical four-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab556671.png"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Components of functional echocardiography and techniques used for their assessment&#46;</p>"
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      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Characteristic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gestational age</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;32 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;70&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>32&#8211;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;12&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Weight</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;1500<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;72&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1500&#8211;2499<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;14&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805;2500<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;14&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Gestational age and weight of the patients&#46;</p>"
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      2 => array:7 [
        "identificador" => "tbl0015"
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        "tabla" => array:1 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Principal diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Extreme prematurity&#47;extreme low weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;38&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Respiratory distress syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypoxic ischaemic encephalopathy&#47;therapeutic hypothermia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate prematurity&#47;very low weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;34&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Transient tachypnoea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Principal diagnoses of studied patients&#46;</p>"
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      3 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Results are expressed as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation&#44; percentage&#44; or median with interquartile range&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Ao&#58; aorta&#59; LA&#58; left atrium&#59; PDA&#58; patent ductus arteriosus&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Patients who underwent assessment for PDA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gestational age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;2 &#40;2&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1196&#46;5 &#40;410&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Median days of life at first ultrasound&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#8211;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Murmur&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Treatment modification&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Start of ibuprofen treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ductus diameter&#44; mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7 &#40;0&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LA&#58;Ao ratio&nbsp;\t\t\t\t\t\t\n
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic and cerebral hemodynamics during the transitional period after premature birth"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Noori"
                            1 => "T&#46;A&#46; Stavroudis"
                            2 => "I&#46; Seri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clp.2009.07.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Perinatol"
                        "fecha" => "2009"
                        "volumen" => "36"
                        "paginaInicial" => "723"
                        "paginaFinal" => "736"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19944832"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional echocardiography&#58; an emerging clinical tool for the neonatologist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Kluckow"
                            1 => "I&#46; Seri"
                            2 => "N&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2006.10.056"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2007"
                        "volumen" => "150"
                        "paginaInicial" => "125"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17236886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical detection of low upper body blood flow in very premature infants using blood pressure&#44; capillary refill time&#44; and central-peripheral temperature difference"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;A&#46; Osborn"
                            1 => "N&#46; Evans"
                            2 => "M&#46; Kluckow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child Fetal Neonatal Ed"
                        "fecha" => "2004"
                        "volumen" => "89"
                        "paginaInicial" => "F168"
                        "paginaFinal" => "F173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14977905"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemodynamic monitoring in neonates&#58; advances and challenges"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Soleymani"
                            1 => "M&#46; Borzage"
                            2 => "I&#46; Seri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jp.2010.101"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "2010"
                        "volumen" => "30"
                        "numero" => "Suppl&#46;"
                        "paginaInicial" => "S38"
                        "paginaFinal" => "S45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20877406"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Greisen"
                            1 => "T&#46; Leung"
                            2 => "M&#46; Wolf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1098/rsta.2011.0261"
                      "Revista" => array:6 [
                        "tituloSerie" => "Philos Trans A Math Phys Eng Sci"
                        "fecha" => "2011"
                        "volumen" => "369"
                        "paginaInicial" => "4440"
                        "paginaFinal" => "4451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22006900"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between cardiac output&#44; cerebral electrical activity&#44; cerebral fractional oxygen extraction and peripheral blood flow in premature newborn infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Victor"
                            1 => "R&#46;E&#46; Appleton"
                            2 => "M&#46; Beirne"
                            3 => "A&#46;G&#46; Marson"
                            4 => "A&#46;M&#46; Weindling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1203/01.pdr.0000238379.67720.19"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Res"
                        "fecha" => "2006"
                        "volumen" => "60"
                        "paginaInicial" => "456"
                        "paginaFinal" => "460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16940235"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low superior vena cava flow and intraventricular haemorrhage in preterm infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Kluckow"
                            1 => "N&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child Fetal Neonatal Ed"
                        "fecha" => "2000"
                        "volumen" => "82"
                        "paginaInicial" => "F188"
                        "paginaFinal" => "F194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10794784"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low superior vena cava flow and effect of inotropes on neurodevelopment to 3 years in preterm infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;A&#46; Osborn"
                            1 => "N&#46; Evans"
                            2 => "M&#46; Kluckow"
                            3 => "J&#46;R&#46; Bowen"
                            4 => "I&#46; Rieger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2006-3398"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2007"
                        "volumen" => "120"
                        "paginaInicial" => "372"
                        "paginaFinal" => "380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17671064"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood pressure measurements in the newborn"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Nuntnarumit"
                            1 => "W&#46; Yang"
                            2 => "H&#46;S&#46; Bada-Ellzey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Perinatol"
                        "fecha" => "1999"
                        "volumen" => "26"
                        "paginaInicial" => "981"
                        "paginaFinal" => "996"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10572732"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mean arterial pressures during the first 24<span class="elsevierStyleHsp" style=""></span>hours of life in &#60; or &#61;600-gram birth weight infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Cordero"
                            1 => "C&#46;J&#46; Timan"
                            2 => "H&#46;H&#46; Waters"
                            3 => "L&#46;A&#46; Sachs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.jp.7210736"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "2002"
                        "volumen" => "22"
                        "paginaInicial" => "348"
                        "paginaFinal" => "353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12082467"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does point-of-care functional echocardiography enhance cardiovascular care in the NICU&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Sehgal"
                            1 => "P&#46;J&#46; McNamara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jp.2008.100"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "2008"
                        "volumen" => "28"
                        "paginaInicial" => "729"
                        "paginaFinal" => "735"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18633423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neonatology concerns about the TNE consensus statement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Evans"
                            1 => "M&#46; Kluckow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.echo.2011.11.006"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Soc Echocardiogr"
                        "fecha" => "2012"
                        "volumen" => "25"
                        "paginaInicial" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22169045"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeted neonatal echocardiography in the neonatal intensive care unit&#58; practice guidelines and recommendations for training"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Mertens"
                            1 => "I&#46; Seri"
                            2 => "J&#46; Marek"
                            3 => "R&#46; Arlettaz"
                            4 => "P&#46; Barker"
                            5 => "P&#46; McNamara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ejechocard/jer181"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Echocardiogr"
                        "fecha" => "2011"
                        "volumen" => "12"
                        "paginaInicial" => "715"
                        "paginaFinal" => "736"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21998460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional echocardiography in assessment of the cardiovascular system in asphyxiated neonates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Kluckow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2010.11.007"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2011"
                        "volumen" => "158"
                        "numero" => "2 Suppl&#46;"
                        "paginaInicial" => "e13"
                        "paginaFinal" => "e18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21238700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Range of echocardiographic findings in term neonates with high oxygen requirements"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46; Evans"
                            1 => "M&#46; Kluckow"
                            2 => "A&#46; Currie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child Fetal Neonatal Ed"
                        "fecha" => "1998"
                        "volumen" => "78"
                        "paginaInicial" => "F105"
                        "paginaFinal" => "F111"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9577279"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Routine transthoracic echocardiography in a general Intensive Care Unit&#58; an 18 month survey in 704 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;A&#46; Marcelino"
                            1 => "S&#46;M&#46; Marum"
                            2 => "A&#46;P&#46; Fernandes"
                            3 => "N&#46; Germano"
                            4 => "M&#46;G&#46; Lopes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejim.2008.09.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Intern Med"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "e37"
                        "paginaFinal" => "e42"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19393476"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Feasibility and potential clinical utility of goal-directed transthoracic echocardiography performed by noncardiologist intensivists using a small hand-carried device &#40;SonoHeart&#41; in critically ill patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;R&#46; Manasia"
                            1 => "H&#46;M&#46; Nagaraj"
                            2 => "R&#46;B&#46; Kodali"
                            3 => "L&#46;B&#46; Croft"
                            4 => "J&#46;M&#46; Oropello"
                            5 => "R&#46; Kohli-Seth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiothorac Vasc Anesth"
                        "fecha" => "2005"
                        "volumen" => "19"
                        "paginaInicial" => "155"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15868520"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic accuracy of left ventricular function for identifying sepsis among emergency department patients with nontraumatic symptomatic undifferentiated hypotension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;E&#46; Jones"
                            1 => "P&#46;A&#46; Craddock"
                            2 => "V&#46;S&#46; Tayal"
                            3 => "J&#46;A&#46; Kline"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Shock"
                        "fecha" => "2005"
                        "volumen" => "24"
                        "paginaInicial" => "513"
                        "paginaFinal" => "517"
                        "link" => array:1 [
                          0 => array:2 [
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                ]
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                            4 => "E&#46;J&#46; Molloy"
                          ]
                        ]
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                    ]
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                        "paginaInicial" => "574"
                        "paginaFinal" => "578"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18394102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation"
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                          "etal" => false
                          "autores" => array:6 [
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                      ]
                    ]
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                        "paginaFinal" => "589&#46;e1"
                        "link" => array:1 [
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                      ]
                    ]
                  ]
                ]
              ]
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                      "titulo" => "Neonatologist-performed functional echocardiography in the neonatal intensive care unit"
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                        "paginaInicial" => "50"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Targeted neonatal echocardiography &#40;TnECHO&#41; service in a Canadian neonatal intensive care unit&#58; a 4-year experience"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "C&#46; Herbozo"
                            2 => "A&#46; Jain"
                            3 => "A&#46; Lapointe"
                            4 => "P&#46;J&#46; McNamara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jp.2013.42"
                      "Revista" => array:3 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "2013"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23624969"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiography on neonatal intensive care units in Australia and New Zealand"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46; Evans"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Paediatr Child Health"
                        "fecha" => "2000"
                        "volumen" => "36"
                        "paginaInicial" => "169"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10760017"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variation in the management of persistent pulmonary hypertension of the newborn&#58; a survey of physicians in Canada&#44; Australia&#44; and New Zealand"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Shivananda"
                            1 => "L&#46; Ahliwahlia"
                            2 => "M&#46; Kluckow"
                            3 => "J&#46; Luc"
                            4 => "R&#46; Jankov"
                            5 => "P&#46; McNamara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0032-1310523"
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                        "paginaInicial" => "519"
                        "paginaFinal" => "526"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22495900"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of echocardiography on patient management in the intensive care unit&#58; an audit of district general hospital practice"
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                          "etal" => false
                          "autores" => array:3 [
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                            2 => "C&#46;E&#46; McKinstry"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aen378"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2009"
                        "volumen" => "102"
                        "paginaInicial" => "340"
                        "paginaFinal" => "344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19151420"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Duration of indomethacin treatment of the preterm patent ductus arteriosus as directed by echocardiography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "M&#46; Paradisis"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2009.06.013"
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                        "tituloSerie" => "J Pediatr"
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                        "paginaInicial" => "819"
                        "paginaFinal" => "822&#46;e1"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19643435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiography on the neonatal unit&#58; a job for the neonatologist or the cardiologist&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;R&#46; Skinner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "1998"
                        "volumen" => "78"
                        "paginaInicial" => "401"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9659081"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiography by a neonatologist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Whitehall"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "1999"
                        "volumen" => "80"
                        "paginaInicial" => "580"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10523254"
                            "web" => "Medline"
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                      ]
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                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Point-of-care ultrasound in the neonatal intensive care unit&#58; international perspectives"
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                        "paginaInicial" => "61"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20663724"
                            "web" => "Medline"
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Original Article
Functional echocardiography in neonatal intensive care: 1-Year experience in a unit in Spain
Ecocardiografía funcional en cuidados intensivos neonatales: experiencia en una unidad española a lo largo de un año
A. Corredera, M.J. Rodríguez, P. Arévalo, B. Llorente, M. Moro, L. Arruza
Corresponding author
luisarruza@yahoo.es

Corresponding author.
Servicio de Neonatología, Hospital Clínico San Carlos, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The newborn may have a variety of haemodynamic problems with a variable and complex pathophysiology&#44; that at times have limited clinical manifestations&#46; This cardiovascular vulnerability stems from particular features of the newborn&#44; such as incomplete myocardial development&#44; the presence of foetal shunts&#44; changes in systemic and pulmonary vascular resistance&#44; and more generally the complex haemodynamic changes that take place during transition to extrauterine life&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Despite progressive technological advances in neonatal intensive care&#44; in most cases haemodynamic monitoring in newborns is still based on assessment of continuous heart rate&#44; blood pressure &#40;BP&#41;&#44; acid&#8211;base status&#44; urine output&#44; or poorly validated clinical signs such as capillary refill time&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> While these measures provide important and useful information to the clinician&#44; they are just variables associated in varying degrees to tissue perfusion&#44; which is the key haemodynamic parameter&#44; and for which an adequate monitoring method has yet to be developed&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> One potentially interesting option would be measurement of regional oxygen saturation by means of near-infrared spectroscopy&#44; although further research is required to confirm this&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Many publications have demonstrated that the correlation between BP and cardiac output is weak&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6</span></a> It is not uncommon to find situations in which BP is normal and peripheral blood flow is below normal range&#46; This can have important implications&#44; as low peripheral blood flow in the first hours of life has been associated with the development of brain damage and neurodevelopmental abnormalities in premature infants&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> On the other hand&#44; there is no clear definition of what constitutes a normal BP in newborns&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> The use of clinical assessment and the classic parameters mentioned before to elucidate the underlying pathophysiology in haemodynamic disturbances can lead to incorrect assumptions and therapeutic decisions&#44; which may even cause harm&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In the neonate&#44; echocardiography is commonly performed by a cardiologist to assess structure and function of the heart&#46; Usually&#44; a single study is done to rule out congenital heart disease or global myocardial dysfunction&#44; and the time at which it is performed often depends on the availability of a cardiologist&#46; This can be an important factor in units that have limited access to a cardiologist&#44; or in situations in which serial assessment is needed to evaluate response to treatment or the haemodynamic changes that take place during transition from foetal to postnatal circulation&#46; It is important to consider that these changes can be very different from what might be assumed clinically based on conventional assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Functional echocardiography&#44; or neonatologist-performed cardiac ultrasound&#44; depending on the terminology suggested by different authors&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;12</span></a> is being introduced progressively in neonatal intensive care units &#40;NICU&#41; as a tool to help guide treatment choices&#46; Functional echocardiography &#40;FnECHO&#41; adds to the assessment of classic clinical parameters in an attempt to provide individualised treatment based on the specific pathophysiology at hand&#46; It must be used as an adjunct to clinical assessment and not as a substitute for assessment by a cardiologist&#44; as their purposes are different and complementary&#46; The neonatologist can use FnECHO to obtain information about haemodynamic function in real time and to make longitudinal assessments as needed&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The aims of FnECHO are assessment of myocardial function&#44; systemic and pulmonary blood flow&#44; intracardiac and extracardiac shunts&#44; and tissue perfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Functional echocardiography is commonly used to assess haemodynamic status during the transition from foetal to postnatal circulation in the extremely premature neonate&#44; to assess for the presence and significance of PDA&#44; to determine the underlying pathophysiology in patients with haemodynamic instability&#44; and in neonates with high oxygen requirements&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;13&#8211;15</span></a> It has shown a positive impact on the management of adult patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#8211;18</span></a> However&#44; there is no clear evidence associating the use of FnECHO with improved outcomes of neonates admitted to the NICU&#44; although some publications show a positive effect in this regard&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;19&#44;20</span></a> As far as we know&#44; there are no publications on the use of FnECHO in Spanish NICUs&#46; We present the results of a retrospective study on the use of FnECHO in a Spanish NICU during a 1-year period&#44; in which we analysed frequency of FnECHO use&#44; type of patient receiving it&#44; indications for FnECHO&#44; and effects on the management of patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">We performed a retrospective study of every FnECHO done in newborns admitted to the NICU of the Hospital Cl&#237;nico San Carlos of Madrid between January 2012 and January 2013&#46; This 11-bed unit provides treatment for all types of neonatal disease except for heart surgery and ECMO &#40;Level <span class="elsevierStyleSmallCaps">IIIB</span>&#41;&#46; All the studies were performed at the request of the physicians in charge by 2 NICU neonatologists &#40;AC and LA&#41; that have more than 5-year experience in FnECHO&#46; The ultrasound assessments and measurements were performed according to a standardised procedure that has been previously described and is presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;21</span></a> The indications for the ultrasound scans and their results were documented in the medical record of each patient&#46; When an ultrasound was done&#44; the results were discussed with the physicians in charge to decide on the therapeutic approach&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">We collected the following general data on patients&#58; gestational age &#40;GA&#41;&#44; birth weight&#44; and principal diagnosis&#46; The following clinical data were recorded from the ultrasound tests&#58; heart rate&#44; presence of a murmur&#44; presence of a gradient between preductal and postductal haemoglobin oxygen saturation &#62;10&#37;&#44; mean BP &#40;MBP&#59; mmHg&#41;&#44; lactate levels &#40;mmol&#47;L&#41; and presence of oliguria &#40;diuresis &#60;1<span class="elsevierStyleHsp" style=""></span>ml&#47;kg&#47;h&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The data about the echocardiographic examinations included&#58; days of life at the time of examination&#44; number of ultrasound studies per patient&#44; and indication for examination&#46; We documented whether the results of FnECHO led to treatment modification&#44; and if so&#44; what changes were made&#46; Our analysis excluded ultrasound examinations performed in newborns with a suspected or confirmed structural congenital cardiopathy &#40;CC&#41;&#46; Although neonatologist-performed FnECHO&#44; our unit is also used to localise catheters&#44; assess for the presence of pleural effusion and its evacuation&#44; the study of brain blood flow&#44; or screening for gross brain injury&#44; our study only took into account echocardiographic examinations&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Analysed ultrasound parameters&#58; all echocardiograms were done with a portable ultrasound machine with a neonatal probe &#40;Titan&#44; SonoSite Inc&#46;&#44; Bothell&#44; USA&#44; probe C11&#47;5&#8211;8<span class="elsevierStyleHsp" style=""></span>MHz&#41;&#58; &#40;1&#41; assessment of ductus presence&#47;consequences&#58; presence&#44; diameter in colour or 2D Doppler&#59; shunt direction&#44; ratio of left atrium to aorta&#44; ductal Doppler pattern&#59; &#40;2&#41; assessment of myocardial function and systemic blood flow&#58; ejection fraction &#40;EF&#41;&#44; shortening fraction &#40;SF&#41;&#44; left ventricle &#40;LV&#41; and right ventricle &#40;RV&#41; cardiac output&#44; superior vena cava blood flow and &#40;3&#41; assessment of pulmonary hypertension&#58; calculation of pulmonary artery pressure in the presence of tricuspid regurgitation&#44; interventricular septal shape&#44; shunt direction&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Qualitative variables are expressed as absolute and relative frequencies&#44; and quantitative variables as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation or median and interquartile range in case of asymmetrical distribution or high dispersion of the data&#46; We used the statistical package STATA 12 to do the analysis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">A total of 168 ultrasound examinations were performed in 50 patients during the period under study&#44; with a mean of 3&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;83 examinations per patient&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the general characteristics of the patients&#46; The mean GA of the patients was 31&#46;3 weeks&#44; with a range of 24&#46;1&#8211;40&#46;2 weeks&#44; and the mean birth weight was 1549<span class="elsevierStyleHsp" style=""></span>g &#40;590&#8211;4160<span class="elsevierStyleHsp" style=""></span>g&#41;&#46; Seventy percent of patients were born before 32 weeks of gestation&#46; The most frequent admission diagnosis was extreme prematurity and&#47;or extremely low weight at birth &#40;38&#37;&#41;&#46; Very low birth weight occurred in 34&#37; of the patients &#40;1000&#8211;1500<span class="elsevierStyleHsp" style=""></span>g&#41;&#46; Other principal diagnoses &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; at the time of admission were hypoxic ischaemic encephalopathy to be treated with hypothermia &#40;10&#37;&#41;&#44; respiratory distress syndrome &#40;8&#37;&#41;&#44; transient tachypnoea &#40;6&#37;&#41; and other &#40;4&#37;&#41;&#46; The median days of life at the time of ultrasound examination was 6 days &#40;2&#8211;19 days&#41;&#46; The most frequent indication for echocardiography was assessment of the presence and significance of PDA&#44; accounting for 58&#46;3&#37; of examinations &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; Other indications included haemodynamic instability &#40;22&#46;2&#37;&#41;&#44; presence of heart murmur &#40;8&#46;3&#37;&#41;&#44; assessment of transition from foetal to postnatal circulation in extremely preterm neonates &#40;5&#46;4&#37;&#41;&#44; pulmonary hypertension screening &#40;1&#46;2&#37;&#41;&#44; and other &#40;4&#46;8&#37;&#41;&#46; As for the impact of FnECHO on patient management&#44; the echocardiography results led to treatment modification in 62 patients &#40;36&#46;9&#37;&#41;&#46; The most common modifications involved the management of PDA&#46; Thus&#44; treatment with ibuprofen was initiated in 17&#46;4&#37; of patients following the ultrasound test&#44; while in 1&#46;2&#37; of patients treatment with this drug was discontinued early&#46; As for haemodynamic support&#44; ultrasound results led to changes in the management of 10&#46;8&#37; of the patients&#46; The changes involved volume expansion therapy &#40;0&#46;6&#37;&#41;&#44; initiation or modification of inotropic therapy &#40;9&#46;6&#37;&#41; or initiation of hydrocortisone therapy &#40;0&#46;6&#37;&#41;&#46; Out of all ultrasound scans&#44; 36&#46;3&#37; were done in patients who had no murmur&#44; arterial hypotension&#44; oliguria&#44; increased lactate levels&#44; tachycardia&#44; or presence of an oxygen saturation gradient&#46; Of all these examinations&#44; 21&#46;7&#37; corresponded to routine studies in the early days of life&#46; Another 78&#46;3&#37; were follow-up studies in patients who had been previously assessed&#46; In 14 of these ultrasounds &#40;22&#46;9&#37;&#41; the results led to a modification of treatment&#46; Twelve corresponded to PDA&#46; The analysis of echocardiography parameters included the assessment of the presence and significance of PDA in 100&#37; of the patients&#46; Myocardial function was assessed by means of the EF&#47;FA ratio in 23&#46;8&#37;&#44; LV output in 24&#46;4&#37; and RV output in 21&#46;4&#37; of patients&#46; Systemic blood flow in the superior vena cava was measured in 42&#37; of the examinations&#46; The presence of pulmonary hypertension was assessed in 7&#46;7&#37; of patients&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">This study is the first to describe the use of FnECHO in a Spanish NICU&#46; The results suggest that this technique is used frequently and that it leads to treatment modification in a significant percentage of cases&#46; A similar study published recently describes the performance of 512 FnECHOs in a Canadian unit over a period of 3&#46;5 years&#44; which works out at an average of 142 examinations a year&#44; a figure that is very close to the one described in this work of 168 examinations in 12 months&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> That study also observed an increasing use of this technique during the period under analysis&#44; which confirms the interest in FnECHO and its progressive implantation in neonatology units&#46; A survey-based study shows that as early as 10 years ago 41&#37; of the level 3 neonatology units in Australia and New Zealand had at least 1 neonatologist with FnECHO skills&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> This figure had increased by more than 90&#37; in 2010&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> The neonatologist in our unit started to use FnECHO 10 years ago and used it mostly as a diagnostic tool and to monitor response to treatment of PDA&#46; Since then&#44; the range of indications has increased to the point that it has nearly turned into an additional part of the clinical assessment of haemodynamic disturbances&#46; According to our study&#44; the most frequent indication for FnECHO is diagnosis or monitoring of PDA &#40;58&#46;3&#37; of patients&#41;&#44; followed by assessment of pathophysiology underlying haemodynamic instability &#40;22&#46;2&#37;&#41;&#46; This is consistent with the data of the study by El-Kuffash et al&#46;&#44; in which PDA assessment amounted for 51&#37; of FnECHO indications&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In our study&#44; the results of 36&#46;9&#37; of FnECHO examinations led to changes in the management of the patient&#44; a figure that is very close to the one reported by El-Kuffash&#44; with a 41&#37; rate of management changes following the ultrasound examination&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Studies in adults suggest that FnECHO results in treatment changes in up to 51&#46;4&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> This supports the definition of FnECHO as a tool that guides therapeutic decision making&#46; In the study presented here&#44; 36&#46;3&#37; of the ultrasounds were performed in patients with no other abnormal haemodynamic parameters or heart murmur&#44; despite which the management of 22&#46;9&#37; of them changed after the examination&#46; Almost all of these patients had PDA&#46; We already mentioned that FnECHO findings are not always predictable based on traditional clinical assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Thus&#44; El-Kuffash et al&#46; found 6&#37; of unexpected diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> In fact&#44; in FnECHO study performed in adult intensive care units&#44; previously undetected severe abnormalities were found in up to 7&#46;5&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> In our study&#44; an average of 3&#46;4 ultrasounds were made per patient&#44; with some patients receiving up to 16 ultrasounds&#46; This shows how FnECHO can be used for patient follow-up or to monitor response to treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">While it is clear that this technique is useful in practise&#44; strong evidence of the positive impact of the use of FnECHO in the NICU on patient outcomes is still lacking&#46; But several retrospective studies<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;19&#44;20</span></a> and a few clinical trials<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> suggest that FnECHO is beneficial in this way&#46; In any case&#44; randomised studies need to be performed to see whether the FnECHO has an effect on patient outcomes&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The main controversy surrounding performance of echocardiography by a neonatologist is based on the potential danger of missing a CC or making an incorrect diagnosis and starting the wrong treatment in a patient with CC&#46; However&#44; while this is a real danger&#44; in most cases an existing structural cardiopathy is detected by FnECHO&#44; even if a complete diagnostic assessment is not made&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#44;28</span></a> Either way&#44; cardiologists and neonatologists must work in close collaboration&#44; and a cardiology consult must be requested whenever there are doubts&#46; Adequate training in FnECHO is essential to minimise these risks&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Yet&#44; despite the increasingly widespread use of this technique worldwide&#44; many countries&#44; including Spain&#44; do not have a standardised training programme&#46; In this case&#44; training depends on personal interest&#44; is performed at the same time as the working routine and relies on the collaboration of the cardiologists and&#47;or the availability of specific materials like text books or CDs&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> This has been how training in FnECHO has been done in our unit&#44; and it would not have been possible without the collaboration of paediatric cardiologists who understood that this technique is used by the neonatologist as an adjunct in clinical assessment&#44; and not an intrusion in their field&#46; Other countries like Australia&#44; New Zealand&#44; the United States&#44; Canada&#44; and some European countries have accredited training programmes&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;29&#44;30</span></a> The American Society of Echocardiography&#44; in collaboration with the European Association of Echocardiography and the Association for European Pediatric Cardiologists&#44; has recently published specific recommendations for the training of neonatologists in FnECHO&#44; which explain in detail what the training and accrediting process should entail&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> recommendations that have been modified by other authors&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Given the growing interest in this technique and its widespread use&#44; training and accreditation programmes should be developed in Spain with the support of the Sociedad Espa&#241;ola de Neonatolog&#237;a &#40;Spanish Society of Neonatologists&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">There are several limitations to this study&#44; most of which derive from its retrospective nature&#46; For instance&#44; treatment modification following FnECHO ultimately depended on the decision of the physician in charge of the patient&#44; and not only on the data obtained from the ultrasound&#44; which may have affected the perceived influence of this technique on the management of neonates&#44; making it smaller or greater than it is&#46; On the other hand&#44; this study cannot determine whether therapeutic choices would have been different if FnECHO had not been available&#44; nor whether those choices were the correct ones&#46; Furthermore&#44; the very decision of performing the ultrasound test&#44; or not&#44; also rested with the physician in charge rather than being determined by a study protocol&#44; which could have a considerable effect on the observed frequency of use&#46; Also&#44; the echocardiographic view may constitute an important limitation in some patients&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Although this study did not collect information on this variable in a systematic manner&#44; technical limitations associated to the view and the use of a 5&#8211;8<span class="elsevierStyleHsp" style=""></span>MHz probe rather than a probe with a higher frequency &#40;8&#8211;12<span class="elsevierStyleHsp" style=""></span>MHz&#41;&#44; which would be ideal&#44; may have affected the quality of some of these ultrasound studies&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusions</span><p id="par0070" class="elsevierStylePara elsevierViewall">Functional echocardiography is a useful tool employed widely in the NICU&#46; It provides complementary information that aids in making therapeutic decisions&#46; Its use is spreading in neonatology units&#44; although clinical trials need to be done to assess its impact on patient outcomes&#46; Structured training and accreditation programmes based on existing recommendations need to be developed to ensure the correct and safe use of this technique&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46;</p></span></span>"
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            1 => "Newborn"
            2 => "Intensive care unit"
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          "palabras" => array:4 [
            0 => "Ecocardiograf&#237;a funcional"
            1 => "Reci&#233;n nacido"
            2 => "Cuidados intensivos neonatales"
            3 => "Ecograf&#237;a en el punto de la asistencia"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Several publications highlight the usefulness of functional echocardiography &#40;FnECHO&#41; in neonatal intensive care&#46; Data are lacking on its use in neonatal units in Spain&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To evaluate frequency of use&#44; patient characteristics&#44; indications&#44; measurements&#44; and impact on patient management of FnECHO in a neonatal intensive care unit &#40;NICU&#41; in Spain over a 1-year period&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A retrospective study conducted in NICU patients during 1 year&#46; Variables&#58; gestational age&#44; birthweight&#44; admission criteria&#44; days of life at examination&#44; indication for FnECHO&#44; parameters assessed&#44; and treatment modifications&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">168 echocardiographic studies were performed in 50 patients &#40;mean 3&#46;4&#59; SD 2&#46;83&#41;&#46; The most frequent indication was patent ductus &#40;PDA&#41; assessment &#40;58&#46;3&#37;&#41;&#44; followed by haemodynamic instability &#40;22&#46;2&#37;&#41;&#46; The results of FnECHO modified treatment in 62 cases &#40;36&#46;9&#37;&#41;&#46; In 17&#46;4&#37; of them treatment with ibuprofen was initiated&#44; and in 1&#46;2&#37; it was discontinued&#46; In 10&#46;8&#37; of the cases&#44; the results of FnECHO modified haemodynamic support&#46; Echocardiographic evaluation included&#58; assessment of presence&#47;haemodynamic significance of PDA &#40;100&#37;&#41;&#59; myocardiac function&#58; ejection fraction&#47;shortening fraction &#40;EF&#47;SF&#41; 23&#46;8&#37;&#44; left ventricular output 24&#46;4&#37;&#44; right ventricular output 21&#46;4&#37;&#44; systemic blood flow 42&#46;3&#37;&#59; and signs of pulmonary hypertension 7&#46;7&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">FnECHO is frequently used in the NICU&#44; and in many cases it guides treatment&#46; PDA assessment and haemodynamic instability are the most frequent indications&#46; It still needs to be elucidated if the use of FnECHO modifies patient outcomes&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numerosas publicaciones destacan la utilidad de la ecocardiograf&#237;a funcional &#40;EcoFn&#41; en neonatolog&#237;a&#46; No existen datos sobre su uso en unidades espa&#241;olas&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluar la frecuencia de uso&#44; pacientes&#44; indicaciones&#44; mediciones y repercusi&#243;n sobre el tratamiento de la EcoFn en un a&#241;o en una unidad de cuidados intensivos neonatales &#40;UCIN&#41; espa&#241;ola&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo retrospectivo en pacientes ingresados en UCIN en un a&#241;o&#46; Variables&#58; edad gestacional&#44; peso&#44; diagn&#243;stico principal&#44; d&#237;as de vida en el momento del estudio&#44; indicaci&#243;n&#44; par&#225;metros medidos y modificaciones del tratamiento&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se realizaron 168 ecograf&#237;as en 50 pacientes&#44; con una media &#177; desviaci&#243;n est&#225;ndar de 3&#44;4 &#177; 2&#44;83 por paciente&#46; Las indicaciones m&#225;s frecuentes fueron la valoraci&#243;n del ductus &#40;58&#44;3&#37;&#41; seguida de la inestabilidad hemodin&#225;mica &#40;22&#44;2&#37;&#41;&#46; El resultado de la ecograf&#237;a modific&#243; el tratamiento en 62 casos &#40;36&#44;9&#37;&#41;&#46; En un 17&#44;4&#37; se inici&#243; tratamiento con ibuprofeno y en un 1&#44;2&#37; de los casos se adelant&#243; el fin de este&#46; En un 10&#44;8&#37; de los casos&#44; la ecograf&#237;a modific&#243; el soporte hemodin&#225;mico&#46; Los par&#225;metros principales valorados fueron&#58; valoraci&#243;n de presencia&#47;repercusi&#243;n del ductus 100&#37;&#59; funci&#243;n mioc&#225;rdica&#58; fracci&#243;n de eyecci&#243;n&#47;acortamiento 23&#44;8&#37;&#44; gasto ventr&#237;culo del izquierdo 24&#44;4&#37;&#44; gasto del ventr&#237;culo derecho 21&#44;4&#37;&#59; flujo sist&#233;mico 42&#44;3&#37;&#59; signos de hipertensi&#243;n pulmonar 7&#44;7&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La EcoFn es utilizada frecuentemente en UCIN y en muchos casos gu&#237;a el tratamiento de los pacientes&#46; La valoraci&#243;n del ductus y de la inestabilidad hemodin&#225;mica son las indicaciones m&#225;s frecuentes&#46; Queda por determinar si el uso de la EcoFn modifica la evoluci&#243;n de los pacientes de UCIN&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Corredera A&#44; Rodr&#237;guez MJ&#44; Ar&#233;valo P&#44; Llorente B&#44; Moro M&#44; Arruza L&#46; Ecocardiograf&#237;a funcional en cuidados intensivos neonatales&#58; experiencia en una unidad espa&#241;ola a lo largo de un a&#241;o&#46; An Pediatr &#40;Barc&#41;&#46; 2014&#59;81&#58;167&#8211;173&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">CW&#58; continuous wave&#59; EF&#58; ejection fraction&#59; PW&#58; pulsed wave&#59; LV&#58; left ventricle&#59; MV&#58; mitral valve&#59; RV&#58; right ventricle&#59; SF&#58; shortening fraction&#59; SVC&#58; superior vena cava&#46;</p>"
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                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of overall myocardial function</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV Tei index</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Time interval between end and onset of transmitral flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical four-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>LV ejection time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical five-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV Tei index</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Time interval between end and onset of transtricuspid flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical four-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>RV ejection time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of pulmonary hypertension</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Peak tricuspid regurgitation velocity</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colour Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical four-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Interventricular septum morphology</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal short axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of atrial-level shunt</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Directionality</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colour&#47;PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subxiphoid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">LV cardiac index</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV outflow tract diameter</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2D&#47;M mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Velocity&#8211;time integral of PW in LV outflow tract</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical five-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">RV cardiac index</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV outflow tract diameter</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Velocity&#8211;time integral of PW in RV outflow tract</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parasternal long axis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">SVC flow</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SVC diameter &#40;mean of systolic and diastolic diameter&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">High parasternal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Velocity&#8211;time integral of SVC &#40;mean of 5 cycles&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PW Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subxiphoid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Assessment of RV function</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Tricuspid annular plane systolic excursion &#40;TAPSE&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apical four-chamber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Characteristic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gestational age</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;32 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;70&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>32&#8211;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;12&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;37&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">9 &#40;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;1500<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1500&#8211;2499<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;14&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805;2500<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;14&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Gestational age and weight of the patients&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Principal diagnosis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>50&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Extreme prematurity&#47;extreme low weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">19 &#40;38&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Respiratory distress syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">4 &#40;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Hypoxic ischaemic encephalopathy&#47;therapeutic hypothermia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5 &#40;10&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate prematurity&#47;very low weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;34&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">3 &#40;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2 &#40;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Results are expressed as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation&#44; percentage&#44; or median with interquartile range&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Ao&#58; aorta&#59; LA&#58; left atrium&#59; PDA&#58; patent ductus arteriosus&#46;</p>"
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                  \t\t\t\t">28&#46;2 &#40;2&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Weight&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1196&#46;5 &#40;410&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Median days of life at first ultrasound&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2 &#40;1&#8211;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Murmur&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">53&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Treatment modification&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">42&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Start of ibuprofen treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">42&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Ductus diameter&#44; mm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">LA&#58;Ao ratio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;8 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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    ]
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic and cerebral hemodynamics during the transitional period after premature birth"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Noori"
                            1 => "T&#46;A&#46; Stavroudis"
                            2 => "I&#46; Seri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clp.2009.07.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Perinatol"
                        "fecha" => "2009"
                        "volumen" => "36"
                        "paginaInicial" => "723"
                        "paginaFinal" => "736"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19944832"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional echocardiography&#58; an emerging clinical tool for the neonatologist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Kluckow"
                            1 => "I&#46; Seri"
                            2 => "N&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2006.10.056"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2007"
                        "volumen" => "150"
                        "paginaInicial" => "125"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17236886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical detection of low upper body blood flow in very premature infants using blood pressure&#44; capillary refill time&#44; and central-peripheral temperature difference"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;A&#46; Osborn"
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                            2 => "M&#46; Kluckow"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child Fetal Neonatal Ed"
                        "fecha" => "2004"
                        "volumen" => "89"
                        "paginaInicial" => "F168"
                        "paginaFinal" => "F173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14977905"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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                ]
              ]
            ]
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              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemodynamic monitoring in neonates&#58; advances and challenges"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Soleymani"
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                            2 => "I&#46; Seri"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jp.2010.101"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "2010"
                        "volumen" => "30"
                        "numero" => "Suppl&#46;"
                        "paginaInicial" => "S38"
                        "paginaFinal" => "S45"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20877406"
                            "web" => "Medline"
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              "identificador" => "bib0025"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Greisen"
                            1 => "T&#46; Leung"
                            2 => "M&#46; Wolf"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1098/rsta.2011.0261"
                      "Revista" => array:6 [
                        "tituloSerie" => "Philos Trans A Math Phys Eng Sci"
                        "fecha" => "2011"
                        "volumen" => "369"
                        "paginaInicial" => "4440"
                        "paginaFinal" => "4451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22006900"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between cardiac output&#44; cerebral electrical activity&#44; cerebral fractional oxygen extraction and peripheral blood flow in premature newborn infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Victor"
                            1 => "R&#46;E&#46; Appleton"
                            2 => "M&#46; Beirne"
                            3 => "A&#46;G&#46; Marson"
                            4 => "A&#46;M&#46; Weindling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1203/01.pdr.0000238379.67720.19"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Res"
                        "fecha" => "2006"
                        "volumen" => "60"
                        "paginaInicial" => "456"
                        "paginaFinal" => "460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16940235"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low superior vena cava flow and intraventricular haemorrhage in preterm infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Kluckow"
                            1 => "N&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child Fetal Neonatal Ed"
                        "fecha" => "2000"
                        "volumen" => "82"
                        "paginaInicial" => "F188"
                        "paginaFinal" => "F194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10794784"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low superior vena cava flow and effect of inotropes on neurodevelopment to 3 years in preterm infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;A&#46; Osborn"
                            1 => "N&#46; Evans"
                            2 => "M&#46; Kluckow"
                            3 => "J&#46;R&#46; Bowen"
                            4 => "I&#46; Rieger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2006-3398"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2007"
                        "volumen" => "120"
                        "paginaInicial" => "372"
                        "paginaFinal" => "380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17671064"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood pressure measurements in the newborn"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Nuntnarumit"
                            1 => "W&#46; Yang"
                            2 => "H&#46;S&#46; Bada-Ellzey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Perinatol"
                        "fecha" => "1999"
                        "volumen" => "26"
                        "paginaInicial" => "981"
                        "paginaFinal" => "996"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10572732"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mean arterial pressures during the first 24<span class="elsevierStyleHsp" style=""></span>hours of life in &#60; or &#61;600-gram birth weight infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Cordero"
                            1 => "C&#46;J&#46; Timan"
                            2 => "H&#46;H&#46; Waters"
                            3 => "L&#46;A&#46; Sachs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.jp.7210736"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "2002"
                        "volumen" => "22"
                        "paginaInicial" => "348"
                        "paginaFinal" => "353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12082467"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does point-of-care functional echocardiography enhance cardiovascular care in the NICU&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Sehgal"
                            1 => "P&#46;J&#46; McNamara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jp.2008.100"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "2008"
                        "volumen" => "28"
                        "paginaInicial" => "729"
                        "paginaFinal" => "735"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18633423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neonatology concerns about the TNE consensus statement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Evans"
                            1 => "M&#46; Kluckow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.echo.2011.11.006"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Soc Echocardiogr"
                        "fecha" => "2012"
                        "volumen" => "25"
                        "paginaInicial" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22169045"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeted neonatal echocardiography in the neonatal intensive care unit&#58; practice guidelines and recommendations for training"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Mertens"
                            1 => "I&#46; Seri"
                            2 => "J&#46; Marek"
                            3 => "R&#46; Arlettaz"
                            4 => "P&#46; Barker"
                            5 => "P&#46; McNamara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ejechocard/jer181"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Echocardiogr"
                        "fecha" => "2011"
                        "volumen" => "12"
                        "paginaInicial" => "715"
                        "paginaFinal" => "736"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21998460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional echocardiography in assessment of the cardiovascular system in asphyxiated neonates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Kluckow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2010.11.007"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2011"
                        "volumen" => "158"
                        "numero" => "2 Suppl&#46;"
                        "paginaInicial" => "e13"
                        "paginaFinal" => "e18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21238700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Range of echocardiographic findings in term neonates with high oxygen requirements"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46; Evans"
                            1 => "M&#46; Kluckow"
                            2 => "A&#46; Currie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child Fetal Neonatal Ed"
                        "fecha" => "1998"
                        "volumen" => "78"
                        "paginaInicial" => "F105"
                        "paginaFinal" => "F111"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9577279"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Routine transthoracic echocardiography in a general Intensive Care Unit&#58; an 18 month survey in 704 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;A&#46; Marcelino"
                            1 => "S&#46;M&#46; Marum"
                            2 => "A&#46;P&#46; Fernandes"
                            3 => "N&#46; Germano"
                            4 => "M&#46;G&#46; Lopes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejim.2008.09.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Intern Med"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "e37"
                        "paginaFinal" => "e42"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19393476"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Feasibility and potential clinical utility of goal-directed transthoracic echocardiography performed by noncardiologist intensivists using a small hand-carried device &#40;SonoHeart&#41; in critically ill patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;R&#46; Manasia"
                            1 => "H&#46;M&#46; Nagaraj"
                            2 => "R&#46;B&#46; Kodali"
                            3 => "L&#46;B&#46; Croft"
                            4 => "J&#46;M&#46; Oropello"
                            5 => "R&#46; Kohli-Seth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiothorac Vasc Anesth"
                        "fecha" => "2005"
                        "volumen" => "19"
                        "paginaInicial" => "155"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15868520"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic accuracy of left ventricular function for identifying sepsis among emergency department patients with nontraumatic symptomatic undifferentiated hypotension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;E&#46; Jones"
                            1 => "P&#46;A&#46; Craddock"
                            2 => "V&#46;S&#46; Tayal"
                            3 => "J&#46;A&#46; Kline"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Shock"
                        "fecha" => "2005"
                        "volumen" => "24"
                        "paginaInicial" => "513"
                        "paginaFinal" => "517"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16317380"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patent ductus arteriosus evaluation by serial echocardiography in preterm infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;J&#46; O&#8217;Rourke"
                            1 => "A&#46; El-Khuffash"
                            2 => "C&#46; Moody"
                            3 => "K&#46; Walsh"
                            4 => "E&#46;J&#46; Molloy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1651-2227.2008.00745.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Paediatr"
                        "fecha" => "2008"
                        "volumen" => "97"
                        "paginaInicial" => "574"
                        "paginaFinal" => "578"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18394102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Jain"
                            1 => "M&#46; Sahni"
                            2 => "A&#46; El-Khuffash"
                            3 => "E&#46; Khadawardi"
                            4 => "A&#46; Sehgal"
                            5 => "P&#46;J&#46; McNamara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2011.09.027"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2012"
                        "volumen" => "160"
                        "paginaInicial" => "584"
                        "paginaFinal" => "589&#46;e1"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22050874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neonatologist-performed functional echocardiography in the neonatal intensive care unit"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;F&#46; El-Khuffash"
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.siny.2010.05.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Fetal Neonatal Med"
                        "fecha" => "2011"
                        "volumen" => "16"
                        "paginaInicial" => "50"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20646976"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeted neonatal echocardiography &#40;TnECHO&#41; service in a Canadian neonatal intensive care unit&#58; a 4-year experience"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "A&#46; Jain"
                            3 => "A&#46; Lapointe"
                            4 => "P&#46;J&#46; McNamara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jp.2013.42"
                      "Revista" => array:3 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "2013"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23624969"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiography on neonatal intensive care units in Australia and New Zealand"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Paediatr Child Health"
                        "fecha" => "2000"
                        "volumen" => "36"
                        "paginaInicial" => "169"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10760017"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variation in the management of persistent pulmonary hypertension of the newborn&#58; a survey of physicians in Canada&#44; Australia&#44; and New Zealand"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            1 => "L&#46; Ahliwahlia"
                            2 => "M&#46; Kluckow"
                            3 => "J&#46; Luc"
                            4 => "R&#46; Jankov"
                            5 => "P&#46; McNamara"
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                        "tituloSerie" => "Am J Perinatol"
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                        "paginaInicial" => "519"
                        "paginaFinal" => "526"
                        "link" => array:1 [
                          0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Impact of echocardiography on patient management in the intensive care unit&#58; an audit of district general hospital practice"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;M&#46; Orme"
                            1 => "M&#46;P&#46; Oram"
                            2 => "C&#46;E&#46; McKinstry"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aen378"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2009"
                        "volumen" => "102"
                        "paginaInicial" => "340"
                        "paginaFinal" => "344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19151420"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "26"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Duration of indomethacin treatment of the preterm patent ductus arteriosus as directed by echocardiography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;B&#46; Carmo"
                            1 => "N&#46; Evans"
                            2 => "M&#46; Paradisis"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2009.06.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2009"
                        "volumen" => "155"
                        "paginaInicial" => "819"
                        "paginaFinal" => "822&#46;e1"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19643435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiography on the neonatal unit&#58; a job for the neonatologist or the cardiologist&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;R&#46; Skinner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "1998"
                        "volumen" => "78"
                        "paginaInicial" => "401"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9659081"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiography by a neonatologist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Whitehall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "1999"
                        "volumen" => "80"
                        "paginaInicial" => "580"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10523254"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Point-of-care ultrasound in the neonatal intensive care unit&#58; international perspectives"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Evans"
                            1 => "V&#46; Gournay"
                            2 => "F&#46; Cabanas"
                            3 => "M&#46; Kluckow"
                            4 => "T&#46; Leone"
                            5 => "A&#46; Groves"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.siny.2010.06.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Fetal Neonatal Med"
                        "fecha" => "2011"
                        "volumen" => "16"
                        "paginaInicial" => "61"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20663724"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                  "referenciaCompleta" => "Australasian Society for Ultrasound in Medicine&#46; CCPU in neonatal ultrasound&#46; Available from&#58; <a id="intr0010" class="elsevierStyleInterRef" href="http://www.asum.com.au/site/qualifications.php%3Fp=content-ccp-neonatalchart">http&#58;&#47;&#47;www&#46;asum&#46;com&#46;au&#47;site&#47;qualifications&#46;php&#63;p&#61;content-ccp-neonatalchart</a> &#91;accessed 22&#46;11&#46;11&#93;&#46;"
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Article information
ISSN: 23412879
Original language: English
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