Journal Information
Vol. 55. Issue 4.
Pages 355-364 (1 October 2001)
Share
Share
Download PDF
More article options
Vol. 55. Issue 4.
Pages 355-364 (1 October 2001)
Full text access
Bronquiolitis aguda: bases para un protocolo racional
Acute bronchiolitis. Fundamentals of a rational protocol
Visits
16388
D. González Caballeroa,
Corresponding author
lgcaballero@saludalia.com

Correspondencia: Unidad de Neumología Infantil. Servicio de Pediatría. Hospital San Rafael. Serrano, 199. 28016 Madrid
, E. González Pérez-Yarzab
a Unidad de Neumología Infantil Servicio de Pediatría. Hospital San Rafael. Madrid
b Unidad de Neumología Infantil Hospital Donostia. San Sebastián
This item has received
Article information

La bronquiolitis es la enfermedad del tracto respiratorio más frecuente durante los dos primeros años de vida, que ocurre de forma epidémica durante el invierno y principio de la primavera. Su etiología es viral y el agente que con más frecuencia lo causa es el virus respiratorio sincitial (VRS). En la mayoría de los casos es una enfermedad benigna, de curso autolimitado, y sólo en ocasiones se requiere hospitalización.

En la práctica diaria, uno de los problemas a los que se enfrenta el pediatra es la falta de acuerdo acerca del correcto tratamiento farmacológico de la bronquiolitis, así como la ausencia de escalas clínicas sencillas y bien estandarizadas que faciliten el diagnóstico de gravedad. En este trabajo se pretende hacer una revisión de la bibliografía médica en lo referente a las escalas clínicas más utilizadas, así como en la eficacia terapéutica de los diferentes fármacos. A la luz de ellos se incluye un protocolo de tratamiento práctico de bronquiolitis en el que se recomienda la utilización de adrenalina inhalada para el tratamiento de la bronquiolitis moderada-grave del lactante hospitalizado, además de las medidas de soporte de oxigenoterapia y fluidoterapia.

Palabras clave:
Bronquiolitis
Virus respiratorio sincitial
Adrenalina
Protocolo
Lactantes

Bronchiolitis is the most frequent respiratory tract disease in the first 2 years of life. It occurs in epidemics in winter and spring. Etiology is viral and the most frequent causative agent is respiratory syncytial virus. In most patients the disease is benign and self-limiting and only occasionally requires hospitalization.

In daily clinical practice, one of the problems most frequently faced by the pediatrician is the lack of agreement on the correct pharmacological treatment of bronchiolitis, as well as the absence of simple, or standardized, clinical scores with which to diagnose severity. The present study provides a review of the medical literature on the most commonly used clinical scores and the therapeutic efficacy of the different drugs employed. A protocol for the practical management of bronchiolitis is provided. The use of inhaled adrenaline in the treatment of moderate- to-severe bronchiolitis in hospitalized infants, as well as oxygen and fluid therapy as support measures, are recommended.

Key words:
Bronchiolitis
Respiratory syncytial virus
Adrenaline
Protocol
Infants
Full text is only aviable in PDF
Bibliografía
[1.]
T.P. Klassen.
Recent advances in the treatment of bronchiolitis and laryngitis.
Pediatr Clin North Am, 44 (1997), pp. 249-261
[2.]
M.E.B. Wohl.
Bronchiolitis.
Disorders of the respiratory tract in children, pp. 360-371
[3.]
S.E. Vieira, J.P. Lotufo, B. Ejzenberg, Y. Okay.
Efficacy of iv aminophylline as a suplemental therapy in moderate bronchoobstructive crisis in infants and preschool children.
Pulm Pharmacol Ther, 13 (2000), pp. 189-194
[4.]
P. Bertrand, H. Aranibar, E. Castro, I. Sanchez.
Efficacy of nebulized epinephrine versus salbutamol in hopitalized infants with bronchiolitis.
Pediatr Pulmonol, 31 (2001), pp. 284-288
[5.]
S. Schuh, A. Coates, R. Binnie, T. Allin, C. Goia, M. Corey.
Efficacy of oral dexamethasone in outpatients with acute bronchiolitis (abstract).
Acad Emerg Med, 8 (2001), pp. 417
[6.]
I. Berger, Z. Argaman, S.B. Schwartz, E. Segal, A. Kiderman, D. Branski.
Efficacy of corticoids in acute bronquiolitis: short-term and long-term follw-up.
Pediatr Pulmonol, 26 (1998), pp. 162-166
[7.]
S.M. Van Schaik, R.C. Welliver, J.L. Kimpen.
Novel pathways in the pathogenesis of respiratory syncytial virus disease.
Pediartr Pulmonol, 30 (2000), pp. 131-138
[8.]
R.A. Lugo, J.W. Salyer, J.M. Dean.
Albuterol in acute bronchiolitis continued therapy despite poor responseα.
Pharmacotherapy, 18 (1998), pp. 198-202
[9.]
J.V. Dovson, S.M. Stephens-Groff, S.R. Mc Mahon, M.M. Stembemler, S.L. Brallier, C. Bay.
The use of albuterol in hospitalized infants with bronchiolitis.
Pediatrics, 101 (1998), pp. 361-368
[10.]
G. Flores, R.I. Horwitz.
Efficacy of beta-2-agonists in bronchiolitis: areappraisal and meta-analysis.
Pediatrics, 100 (1997), pp. 233-239
[11.]
F.E. Barr, N.R. Patel, C.J. Newth.
The pharmacologic mechanism by which inhaled epinephrine reduces airway obstruction in respiratory syncytial virus-associated bronchiolitis.
J Pediatr, 16 (2000), pp. 699-700
[12.]
K.C. Lodrup-Carlsen, K.H. Carlsen.
Inhaled nebulized adrenaline improves lug function in infants with acute bronchiolitis.
Respir Med, 94 (2000), pp. 709-714
[13.]
M.M. Garrison, D.A. Christakis, E. Harvey, P. Cummings, R.L. Davis.
Systemic corticosterids in infants bronchiolitis: A meta-analysis.
Pediatrics, 105 (2000), pp. 44
[14.]
M. Modl, E. Eber, E. Weindhandl, W. Gruber, M.S. Zach.
Assessment of bronchodilator responsiveness in infants with bronchiolitis.A comparison of the tidal volume rapid thoracoabdominal compression technique.
Am J Respir Crit Care Med, 161 (2000), pp. 763-768
[15.]
A. Deschildre, C. Thumerelle, C. Bruno, E. Dubos, C. Santos, A. Dumonceaux.
Acute bronchiolitis in infants.
Arch Pediatr, 7 (2000), pp. 21-26
[16.]
M.C.J. Kneyber, E.W. Steyrberg, R. De Groot, H.A. Moll.
Long-term of respiratory syncytial virus (RSV) bronchiolitis in infants and toung children: a quiantitative review.
Acta Paediatr, 89 (2000), pp. 654-660
[17.]
J.B. Van Woensel, J.L. Kimpel, A.B. Sprikkelman, A. Ouwehand, W.M. Van Aelderen.
Long-term effects of prednisolone in the acute phase of bronchiolitis caused by respiratory syncytial virus.
Pediatr Pulmonol, 30 (2000), pp. 92-96
[18.]
J.F. Price.
Acute and long-term effects of viral bronchiolitis in infancy.
Lung, 168 (1990), pp. 414-421
[19.]
C.B. Hall.
Respiratory syncytial virus and parainfluenza virus.
N Engl J Med, 344 (2001), pp. 1917-1928
[20.]
F.D. Martínez, A.L. Wright, L.M. Taussig, C.J. Holberg, M. Halonen, W.J. Morgan.
Asthma and wheezing in the first six years of life.
N Engl J Med, 332 (1995), pp. 181-182
[21.]
R.S. Tepper, D. Rosenberg, H. Eigen.
Airway responsiveness in infants following bronchiolitis.
Pediatr Pulmonol, 13 (1992), pp. 6-10
[22.]
P.M. Renzi, J.P. Turgeon, J.E. Marcotte, S.P. Drblick, D. Berube, M.F. Gagnon.
Reduced interferon-gamma production in infants with bronchiolitis and asthma.
Am J Crit Care Med, 159 (1999), pp. 1417-1422
[23.]
G.F. Fox, M.L. Everard, M.J. Marsh, A.D. Milner.
Randomized controlled trial of budesonide for the prevention post-bronchiolitis wheezing.
Arch Dis Child, 80 (1999), pp. 343-347
[24.]
M. Kajosaari, P. Syvanen, M. Forars, K. Juntenen-Backman.
Inhaled corticosteriods during and after respiratory syncytial virus bronchiolitis may decrese subsecuent asthma.
Pediatr Allergy Immunol, 1 (2000), pp. 198-202
[25.]
W.J. Rodriguez, J. Arrobio, R. Fink, H.W. Kim, C. Milburn.
Prospective follow-up and pulmonary function from a placebo-controlled randomized trial of rivavirin therapy in respiratory syncytial virus bronchiolitis. Rivavirin Study Group.
Arch Pediatr Adolesc Med, 153 (1999), pp. 469-474
[26.]
L.V. Krilov.
Respiratory Syncytial Virus: Update on Infection, Treatment, and Prevention.
Curr Infect Dis Rep, 3 (2001), pp. 242-246
[27.]
A. Cade, K.G. Brownlee, S.P. Conway, D. Haigh, A. Short, J. Brown.
Randomized placebo controlled trial of nebulised corticosteroids in acute respiratory syncytial viral bronchiolitis.
Arch Dis Child, 82 (2000), pp. 126-130
[28.]
R. Aggarwal.
Lower airway disease caused by respiratory syncytial virus.
Indian J Pediatr, 65 (1998), pp. 355-362
[29.]
F. Freymuth, A. Vabret, S. Gouarin, J. Petitjean, M. Campet.
Epidemiology of respiratory virus infections.
Allerg Immunol (Paris), 33 (2001), pp. 66-69
[30.]
G.D. Hussey, P. Apolles, Z. Arendse, J. Yeates, A. Robertson, G. Swinglker.
Respiratory syncytial virus infection in children hospitalised with acute lower respiratory tract infection.
S Afr Med J, 90 (2000), pp. 509-512
[31.]
G. Dutau, P. Micheau, J.L. Rittie, A. Juchet, F. Rance, F. Bremont.
Relationship between respiratory syncytial virus bronchiolitis and asthma.
Arch Pediatr, 7 (2000), pp. 536-543
[32.]
J.B. Van Woensel, T.F. Wols, W.M. Van Aalderen, P.L. Brand, J.L. Kimpen.
Randomized double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis.
Thorax, 52 (1997), pp. 634-637
[33.]
N.J.C. Snell.
Economic and long-term benefits of ribavirin therapy on respiratory syncytial virus infection.
Lung, 168 (1990), pp. 422-429
[34.]
Ergón, (1996),
[35.]
D. Nadal, P.L. Ogra.
Development of local immunity: role in mechanisms of protection against or pathogenesis of respiratory syncytial viral infections.
Lung, 168 (1990), pp. 379-387
[36.]
C. O’Callaghan, A.D. Milner, A. Swarbrick.
Paradoxical deterioration in lung function after nebulized salbutamol in wheezy infants.
Lancet, 2 (1986), pp. 1442-1445
[37.]
J.J. Downes, D. Vidyasagar, T.R. Boggs, G.M. Morrow.
Respiratory distress syndrome of newborn infants. I. New clinical scoring system (RDS score) with acid-base and blood gas correlations.
Clin Pediatr (Phila), 9 (1970), pp. 625-631
[38.]
J.J. Downes, D.W. Wood, I. Harwood, H.N. Sheinkopf, R.C. Raphaely.
Intravenous isoproterenol infusion in children with severe hypercapnia in asthmaticus. Effects on ventilation, circulation and critical score.
Crit Care Med, 1 (1973), pp. 63-68
[39.]
D.W. Wood, J.J. Downes.
Intravenous isoproterenol in the treatment of respiratory failure in childhood status asthmaticus.
Ann Allergy, 31 (1973), pp. 607-610
[40.]
J. Ferres Mataro, M.A. Mangues Bafalluy, R. Farre Riba, A. Julia, J. Bonal de Falgas.
Adrenalina subcutánea versus salbutamol inhalado en el tratamiento de la crisis asmática infantil.
An Esp Pediatr, 27 (1987), pp. 37-40
[41.]
D.I. Lowell, G. Lister, H. Von Koss, P. McCarthy.
Wheezing in infants: The response to epinephrine.
Pediatr, 79 (1987), pp. 939-945
[42.]
R.J. Scarfone, S.M. Fuchs, A.L. Nager, S.A. Shane.
Controlled trial of oral prednisolone in the emergency department: treatment of children with acute asthma.
Pediatrics, 93 (1994), pp. 695-696
[43.]
L.M. Taussig, P.J. Helmes.
Introduction.
Infant Respiratory Function Testing, pp. 1-44
[44.]
P.N. Lesouëf, R. Castile, D.J. Turner, E. Motoyama, W.J. Morgan.
Forced expiratory maneuvers.
Infant Respiratory Function Testing, pp. 379-409
[45.]
S. Stick.
Measurement during tidal breathing.
Infant Respiratory Function Testing, pp. 117-138
[46.]
S. Stick, G. García Hernandez, M. Marín Ferrer, J.R. Villa Asensi, A. López Silvarrey, A. Nogales Espert.
Valoración de la función pulmonar del lactante mediante curvas de flujo espiratorio parcial forzado con chaquetilla neumática: patrones normales y patólogicos.
An Esp Pediatr, 40 (1994), pp. 279-310
[47.]
ATS-ERS Statement.
Respiratory Mechanics in Infants: Phisiologic Evaluation in health and Disease.
Eur Respir J, 6 (1993), pp. 279-310
[48.]
I. Sanchez, J.D. Koster, R.E. Powell, R. Wolstein, V. Chernic.
Effect of racemic epinephrine and salbutamol on clinical score and pulmonary mechanics in infants with bronchiolitis.
J Pediatr, 122 (1993), pp. 145-151
[49.]
A. Prendiville, S. Green, M. Silverman.
Paradoxical response to nebulized salbutamol in wheezy infants, assesed by partial expiratory flow-volume curves.
Thorax, 42 (1987), pp. 86-91
[50.]
S.M. Bülow, M. Nir, E. Levin, B. Friis, L.L. Thomsen, J.E. Nielsen.
Prednisolone treatment of respiratory syncytial virus infection: A randomized controlled trial of 147 Infants.
Pediatrics, 104 (1999), pp. 77
[51.]
C.C. Luaces, J.J. García, P. Torrico, M.L. Sánchez, D.E. Camacho.
Utilidad de un sistema de puntuación clínico y la pulsioximetría (SaO2) en la valoración de las crisis de asma.
An Esp Pediatr, 44 (1996), pp. 429-432
[52.]
M.J. Butte, B.X. Ngguyen, T.J. Hutchison, J.W. Wiggims, J.W. Ziegler.
Pediatric myocardial infarction after racemic epinephrine administration.
Pediatrics, 104 (1999), pp. 9
[53.]
E.E.L. Wang, R. Milner, U. Allen, H. Maj.
Bronchodilators for treatment of mild bronchiolitis: a factorial randomized trial.
Arch Dis Child, 67 (1992), pp. 289-293
[54.]
A. Goh, O.M. Chay, A.L. Foo, E.K. Ong.
Efficacy of bronchodilators in the treatment of bronchiolitis.
Singapore Med J, 38 (1997), pp. 326-328
[55.]
J. Mallol, L. Barrueto, G. Girardi.
Use of nebulized bronchodilators in infants under 1 year of age: analysis of four forms of theraphy.
Pediatr Pulmonol, 3 (1987), pp. 298-303
[56.]
A. Labbe.
Treatment of acute bronchiolitis in infants. Role of bronchodilators and steroids.
Arch Pediatr, 3 (1996), pp. 383-389
[57.]
K. Menon, T. Sutcliffe, T.P. Klassen.
A randomized trial comparing the efficacy of epinephrine with salbutamol in the treatment of acute bronchiolitis.
J Pediatr, 126 (1995), pp. 1004-1007
[58.]
A.M. Gadomsky, R. Lichenstein, L. Horton, J. King, V. Keane, T. Permutt.
Efficacy of albuterol in the management of bronchiolitis.
Pediatrics, 93 (1994), pp. 907-912
[59.]
S. Schuh, D. Johnson, G. Canny, J. Reisman, M. Shields, T. Kovesi.
Efficacy of adding nebulized ipratropium bromide to nebulized albuterol therapy in acute bronchiolitis.
Pediatrics, 90 (1992), pp. 920-923
[60.]
T. Reijonen, M. Korppi, S. Pitkakangas, S. Tenhola, K. Remes.
The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis.
Arch Pediatr Adolesc Med, 149 (1995), pp. 686-692
[61.]
A.J. Alario, W.J. Lewander, P. Dennehy, R. Seifer, a.l. Mansell.
The efficacy of nebulized mataproterenol in wheezing infants and young children.
Am J Dis Child, 146 (1992), pp. 412-418
[62.]
T.P. Klassen, P.C. Rowe, T. Sutcliffe, L.J. Ropp, I.W. McDowell, M.M. Li.
Randomized trial of salbutamol in acute bronchiolitis.
J Pediatr, 118 (1991), pp. 807-811
[63.]
D.M. Hughes, P.N. Lesouef, L.I. Landau.
Effect of salbutamol on respiratory mechanics in bronchiolitis.
[64.]
P.D. Sly, C.J. Lanteri, L.M. Raven.
Do wheezy infants recovering from bronchiolitis respond to inhaled salbutamolα.
Pediatr Pulmonol, 10 (1991), pp. 36-39
[65.]
J. Hammer, A. Numa, C. Newth.
Albuterol responsiveness in infants with respiratory failure caused by respiratory syncytial virus infection.
J Pediatr, 127 (1995), pp. 485-490
[66.]
D. Can, G. Inan, G. Yendur, R. Oral, I. Gunay.
Salbutamol or mist in acute bronchiolitis.
Acta Paediatr Jpn, 40 (1998), pp. 252-255
[67.]
R. Cengizlire, Y. Saraclar, G. Adalioglu, A. Tuncer.
Effect of oral and inhaled salbutamol in infants with bronchiolitis.
Acta Paediatr Jpn, 39 (1997), pp. 61-63
[68.]
S. Schuh, G. Canny, J.J. Reisman, E. Jerem, L. Bentur, M. Petric.
Nebulized albuterol in acute bronchiolitis.
J Pediatr, 117 (1990), pp. 633-637
[69.]
M. Soto, P.D. Sly, E. Uren, L.M. Taussig, L.I. Landay.
Bronchodilator response in acute viral bronchiolitis.
Pediatr Pulmonol, 1 (1985), pp. 85-90
[70.]
R. Kraemer, U. Frey, C.W. Sommer, E. Russi.
Short term effect of albuterol, delivered via a new auxilary device, in wheezy infants.
Am Rev Respir Dis, 144 (1991), pp. 347-351
[71.]
J. Goebel, B. Estrada, J. Quinonez, N. Nagii, D. Sanford, R.C. Boerth.
Prednisolone plus albuterol alone in mild to moderate bronchiolitis.
Clin Pediatr (Phila), 39 (2000), pp. 213-220
[72.]
E.G. Pérez-Yarza, C. De Frutos, J. Mintegui.
Bronquiolitis.
pp. 37-60
[73.]
T. Nicolai, A. Pohl.
Acute Viral Bronchiolitis in Infancy: Epidemiology and Management.
Lung, 168 (1990), pp. 396-405
[74.]
A. Prendiville, A. Rose, D.L. Maxwell, M. Silverman.
Hipoxaemia in wheezy infants after bronchodilator.
Arch Dis Child, 62 (1987), pp. 997-1000
[75.]
F. Khaldi, N. Salem.
Comparison of the effect of subcutaneuous injection of adrenaline and terbutaline in asthma crisis in infants.
Arch Pediatr, 5 (1998), pp. 745-748
[76.]
L. Ho, G.T. Collis, I. Landau, P.N. Le Souef.
Effect of salbutamol on oxygen saturation in bronchiolitis.
Arch Dis Child, 66 (1991), pp. 1061-1064
[77.]
B.T. Goodman, T.L. Chambers.
Bronchodilators for bronchiolitisα [carta].
Lancet, 341 (1993), pp. 1380
[78.]
A.M. Gadomski, G.H. Aref, O.B. El Din, I.H. El Sawy, N. Khallaf, R.E. Black.
Oral versus nebulized albuterol in the management of bronchiolitis in Egypt.
J Pediatr, 124 (1994), pp. 131-138
[79.]
D. Chowdhury, M. Al-Howasi, M. Khalil, A.S. Al-Frayh, S. Chowdhury, S. Ramia.
The role of bronchiodilators in the management of bronchiolitis: a clinical trial.
Ann Trop Pediatr, 15 (1995), pp. 77-84
[80.]
M.L. Everard, A. Swarbrick, A.S. Rigby, A.D. Milner.
The effect of rivavirin to treat previously healthy infants asmitted with acute bronchiolitis on acute and chronic respiratory morbilidity.
Respir Med, 95 (2000), pp. 275-280
[81.]
N.R. Patel, J. Hammer, S. Nichani, A. Numa, C.J. Newth.
Effect of inhaled nitric oxide on respiratory mechanics in ventilated infants with RSV bronchiolitis.
Intensive Care Med, 25 (1999), pp. 81-87
[82.]
R.O. Go, T.R. Martin, M.R. Lester.
A weezy infant unresponsive to bronchodilators.
Ann Allergy Asthma Immunol, 78 (1997), pp. 449-456
[83.]
T.M. Reijonen, M. Korppi, L. Kuikka, K. Savolainen, M. Kleemola, I. Mononen.
Serum eosinophil cationic protein as predictor of wheezing after bronchiolitis.
Pediatr Pulmonol, 23 (1997), pp. 397-403
[84.]
R.S. Tepper, D. Rossenberg, H. Eigen, T. Reister.
Bronchodilator responsiveness in infants with bronchiolitis.
Pediatr Pulmonol, 17 (1994), pp. 81-85
[85.]
G.M. Stokes, A.D. Milner, I.G.C. Hodges, R.L. Henry, M.C. Elphick.
Nebulised therapy in acute severe bronchiolitis in infancy.
Arch Dis Child, 58 (1993), pp. 279-283
[86.]
K. Dawson.
Rational prescribing for acute bronchiolitis.
Pharmacoeconomics, 8 (1995), pp. 9-13
[87.]
G. Roosevelt, K. Sheehan, J. Gruup-Phelan, R.R. Tanz, R. Liasternick.
Dexamethasone in bronchiolitis a randomized controlled trial.
Lancet, 348 (1996), pp. 292-295
[88.]
H. Richter, P. Seddon.
Early nebulized budesonide in treatment of bronchiolitis and the prevention of postbronchiolitic wheezing.
J Pediatr, 132 (1998), pp. 849-853
[89.]
González Caballero D, Romero Andújar F. Bronquiolitis. En: Curso de patología urgente en pediatría. Desde la atención primaria a la hospitalaria. Madrid: Fundación de Estudios y Formación Sanitaria, 2001. En prensa
[90.]
A.H. Numa, G.D. Williams, C.J. Dakin.
The effect of nebulized epinephrine on respiratory mechanic and gas exchange in bronchiolitis.
Am J Respir Crit Care Med, 164 (2001), pp. 86-91
[91.]
N.A. Hashmi, J.F. Cosgrove, P. Mac Mahon.
Prophilaxis in RSV infection (Palivizumab) is it worthwhileα [carta].
Ir Med J, 93 (2000), pp. 284
[92.]
M.J. Jeng, R.J. Lemen.
Respiratory syncytial virus bronchiolitis.
Am Fam Physician, 55 (1997), pp. 1139-1146
[93.]
G.L. Toms.
Respiratory Syncytial Virus: virology, diagnosis, and vaccination.
Lung, 168 (1990), pp. 388-395
[94.]
X. Carbonell, J. Quero.
y Comité de Estándares de la Sociedad Española de Neonatología. Recomendaciones para la prevención de la infección por virus respiratorio sincitial.
An Esp Pediatr, 52 (2000), pp. 372-374
[95.]
J.U. Barben, C.F. Robertson, P.J. Robinson.
Implementation of evidence-based management of acute bronchiolitis.
J Paediatr Child Health, 36 (2000), pp. 491-497
Copyright © 2001. Asociación Española de Pediatría
Download PDF
Idiomas
Anales de Pediatría (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?