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Vol. 55. Núm. 3.
Páginas 251-255 (septiembre 2001)
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Vol. 55. Núm. 3.
Páginas 251-255 (septiembre 2001)
Acceso a texto completo
Recomendaciones para la utilización del óxido nítrico inhalado en patología neonatal
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J. Figueras Aloy, Grupo Respiratorio Neonatal de la Sociedad Española de Neonatología
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Las recomendaciones incluidas en este documento señalan las actuales indicaciones del tratamiento con óxido nítrico inhalado en el recién nacido, diferenciando claramente las apoyadas en evidencia científica de las que todavía no lo están, como su uso en prematuros o cardiopatías congénitas. Tras comentar la metodología, dosificación y efectos secundarios, se insiste en las causas de inefectividad del ON inhalado.

Palabras clave:
Recién nacido
Óxido nítrico inhalado
Hipertensión pulmonar neonatal

The recommendations in this document highlight current indications for inhaled nitric oxide (iNO) treatment in the newborn by clearly differentiating between those that are supported by scientific evidence and those for which evidence is still lacking. However, the use of this treatment in preterm infants and in those with congenital heart disease has not yet been scientifically approved. We discuss the methodology, dosage and adverse effects of iNO administration, as well as the reasons for its ineffectiveness.

Key words:
Newborn
Inhaled nitric oxide
Pulmonary hypertension
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Bibliografía
[1.]
Neonatal Inhaled Nitric Oxide Study Group.
Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure, 336 (1997), pp. 597-604
[2.]
L. Storme, M. Françoise, C. Tahiri, U. Zupan, J.C. Rozé, D. Oriot, et al.
and the French NO Study Group. Inhaled nitric oxide (NO) in persistent pulmonary hypertension of the newborn (PPHN).
Pediatr Res, 35 (1994), pp. 346A
[3.]
H.L. Karamanoukian, P.L. Glick, M. Zayek, R.H. Steinhorn, M. Zwass.
Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia (CDH) or oligohydramnios.
Pediatr Res, 35 (1994), pp. 1380A
[4.]
Neonatal Inhaled Nitric Oxide Study Group (NINOS).
Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia.
Pediatrics, 99 (1997), pp. 838-845
[5.]
J. Figueras, A. Sorni, F. Botet, J.M. Rodríguez, R. Jiménez.
Respuesta inmediata a la administración de óxido nítrico inhalado en un neonato con hernia diafragmática congénita e hipertensión pulmonar.
An Esp Pediatr, 44 (1996), pp. 70-72
[6.]
J.W. Skimming, K.A. Bender, A.A. Hutchinson, W.H. Drummond.
Nitric oxide inhalation in infants with respiratory distress syndrome.
J Pediatr, 130 (1997), pp. 225-230
[7.]
K.P. Van Meurs, W.D. Rhine, J.M. Asselin, D.J. Durand.
and the Preemie NO Collaborative Group. Response of premature infants with severe respiratory failure to inhaled nitric oxide.
Pediatr Pulmonol, 24 (1997), pp. 319-323
[8.]
J.P. Kinsella, W.F. Walsh, C.L. Bose, D.R. Gertsmann, J.J. Labella, S. Sardesai, et al.
Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial.
Lancet, 354 (1999), pp. 1061-1065
[9.]
T. Hoehn, M.F. Krause, C. Bührer.
Inhaled nitric oxide in premature infants: a meta analysis.
J Perinat Med, 28 (2000), pp. 7-13
[10.]
D. Journois, P. Pouard, P. Mauriat, T. Malhere, P. Vouhe, D. Safran.
Inhaled nitric oxide as a therapy for pulmonary hypertension after operations for congenital heart defects.
J Thorac Cardiovasc Surg, 107 (1994), pp. 1129-1135
[11.]
G. Zobel, A. Gamillscheg, W. Schhwinger, J. Berger, B. Urlesberger, D. Dacar, et al.
Inhaled nitric oxide in infants and children after open heart surgery.
J Cardiovasc Surg, 39 (1998), pp. 79-86
[12.]
I.A. Russell, M.S. Zwass, J.R. Fineman, M. Balea, K. Rouine-Rapp, M. Brook, et al.
The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease.
Anesth Analg, 87 (1998), pp. 46-51
[13.]
K. Morita, K. Ihnken, G.D. Buckberg, M.P. Sherman, L.J. Ignarro.
Pulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass.
Ann Thorac Surg, 61 (1996), pp. 1775-1780
[14.]
M. Berger, M. Beghetti, B. Ricou, J.C. Rouge, R. Pretre, B. Friedli.
Relief of severe pulmonary hypertension after closure of a large ventricular septal defect using low dose inhaled nitric oxide.
Intens Care Med, 19 (1993), pp. 75-77
[15.]
E. Bruckheimer, Z. Bulbul, E. Pinter, M. Gailani, C.S. Kleinman, J.T. Fahey.
Inhaled nitric oxide therapy in a critically ill neonate with Ebstein's anomaly.
Pediatr Cardiol, 19 (1998), pp. 477-479
[16.]
D. Albert, J. Girona, J. Casaldáliga, J. Roqueta, J. Perapoch, M. Murtra.
Transposición de grandes arterias e hipertensión pulmonar: Tratamiento con óxido nítrico inhalado y corrección anatómica precoz.
An Esp Pediatr, 47 (1997), pp. 633-635
[17.]
F. Leclerc, Y. Riou, A. Martinot, L. Storme, V. Hue, V. Flurin, et al.
Inhaled nitric oxide for a severe respiratory syncytial virus infection in an infant with bronchopulmonary dysplasia.
Intens Care Med, 20 (1994), pp. 511-512
[18.]
B.A. Banks, I. Seri, H. Ischiropoulos, J. Merrill, J. Rychik, R.A. Ballard.
Changes in oxygenation with inhaled nitric oxide in severe bronchopulmonary dysplasia.
Pediatrics, 103 (1999), pp. 667-670
[19.]
N.R. Patel, J. Hammer, S. Nichani, A. Numa, C.J. Newth.
Effect of inhaled nitric oxide on respiratory mechanics in ventilated infants with RSV bronchiolitis.
Intensive Care Med, 25 (1999), pp. 81-87
[20.]
American Academy of Pediatrics.
Committee on Fetus and Newborn. Use of inhaled Nitric Oxide.
Pediatrics, 106 (2000), pp. 344-345
[21.]
J. Figueras, X. Carbonell, X. Demestre, A. Diaz, A. Fina, G. Ginovart, et al.
Response to the administration of inhaled nitric oxide in the newborn infant.
RELAN, 1 (1998), pp. 47-55
[22.]
Franco-belgium Collaborative NO Trial Group.
Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neoantes with respiratory failure: a randomised controlled trial.
Lancet, 354 (1999), pp. 1066-1071
[23.]
A.P. Goldman, R.C. Tasker, P. Cook.
Transfer of critically ill patients with inhaled nitric oxide.
Arch Dis Child, 73F (1995), pp. 480
[24.]
J.P. Kinsella, J.M. Schmidt, J. Griebel, S.H. Abman.
Inhaled nitric oxide treatment for stabilization and emergency medical transport of critically ill newborns and infants.
Pediatrics, 95 (1995), pp. 773-776
[25.]
Unidades Españolas de Neonatología.
Utilización del óxido nítrico inhalado en el recién nacido.
Arch Pediatr, 47 (1996), pp. 233-235
[26.]
D. Davidson, E.S. Barefield, J. Kattwinkel, G. Dudell, M. Damask, R. Straube, et al.
Safety of withdrawing inhaled nitric oxide therapy in persistent pulmonary hypertension of the newborn.
Pediatrics, 104 (1999), pp. 231-236
[27.]
R.H. Clark, T.J. Kueser, M.W. Walker, W.M. Southgate, J.L. Huckaby, J.A. Perez, et al.
Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group.
N Engl J Med, 342 (2000), pp. 469-474
[28.]
J.P. Kinsella, S.H. Abman.
Clinical approach to inhaled Nitric Oxide therapy in the newborn with hypoxemia.
J Pediatr, 136 (2000), pp. 717-726
[29.]
J.P. Kinsella, S.H. Abman.
High-frequency oscillatory ventilation augments the response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn: Nitric Oxide Study Group.
Chest, 114 (1998), pp. 100S
Copyright © 2001. Asociación Española de Pediatría
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