Hipercrecimiento y déficit de hormona del crecimiento tras tratamiento para el craneofaringioma

López Siguero, J.P.; García García, E.; Martínez-Aedo y, M.J.; Martínez Valverde, A.

doi:10.1016/S1695-4033(00)77418-2

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Anales de Pediatría

ISSN: 1695-4033

La Asociación Española de Pediatría tiene como uno de sus objetivos principales la difusión de información científica rigurosa y actualizada sobre las distintas áreas de la pediatría. Anales de Pediatría es una revista de acceso abierto que actúa como el Órgano de Expresión Científica de la Asociación y constituye el vehículo a través del cual se comunican los asociados. Anales de Pediatría publica, en inglés y en español, trabajos originales sobre investigación en pediatría, así como artículos de revisión elaborados por los profesionales expertos de cada especialidad, y guías o documentos de posicionamiento elaborados por las diferentes Sociedades/Secciones Especializadas integradas en la Asociación Española de Pediatría. La revista, referente de la pediatría de habla española, está indexada en las más importantes bases de datos internacionales: Index Medicus/Medline IBECS, IME, SCOPUS, Science Citation Index Expanded, Journal Citations Report, Embase/Excerpta Medica, Directory of Open Access Journals (DOAJ).

In Memoriam: Alfredo García-Alix (1956-2024)

Indexada en:

Index Medicus/Medline IBECS, IME, SCOPUS, Science Citation Index Expanded, Journal Citations Report, Embase/Excerpta Medica, Directory of Open Access Journals (DOAJ)

Algunos niños continúan creciendo bien o experimentancrecimiento excesivo tras la extirpación de un craneo-faringioma, a pesar de tener deficiencias de hormona delcrecimiento. Presentamos el caso de una niña diagnosticada a los 4 años de craneofaringioma con extensión supraselar. Tras la intervención presentó hipopituitarismo múltiple. En los 5 años siguientes creció entre 8,4 y 10,6 cm/año. Después la velocidad de crecimiento disminuyó progresivamente hasta 1,2 cm/año, incrementándose de nuevo a 9,3 cm/año tras instaurar tratamiento con hormona del crecimiento.

Palabras clave:

Craneofaringioma

Crecimiento

Déficit de hormona del crecimiento

Some children grow normally or excessively after extirpation of a craniopharyngioma, despite growth hormone deficiency. We report a 4-year-old girl with suprasellar craniopharyngioma. Removal of the tumor resulted in panhypopituitarism. For the next 5 years growth continued at a rate of 8.4-10.6 cm/year and then decreased progressively to 1.2 cm/year. Administration of growth hormone increased growth rate to 9.3 cm/year.

Key words:

Craniopharyngioma

Growth

Growth hormone deficiency

El Texto completo está disponible en PDF

Bibliografía

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M.A. Rivarola, H. Mendilaharzu, M. Warman, A. Belgorosky, S. Lorcansky, M. Castellano, et al.

Endocrine disorders in 66 suprasellar and pineal tumors of patients with prepubertal and pubertal ages.

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Medline

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Replacement of growth hormone (GH) in normally growing GH-deficient patients operated for craniopharyngioma.

J Clin Endocrinol Metab, 80 (1995), pp. 374-378

http://dx.doi.org/10.1210/jcem.80.2.7852493 | Medline

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Growth in children with craniopharyngioma following surgery.

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Outcome in children with normal growth following removal of a craniopharyngioma.

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Medline

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H. Bucher, J. Zapf, T. Torresani, A. Prader, E.R. Froesch, R. Illig.

Insulin-like growth factors 1 and 2, prolactin, and insulin in 19 growth hormone-deficient children with excessive, normal, or decreased longitudinal growth after operation for craniopharyngioma.

N Engl J Med, 309 (1983), pp. 1142-1146

http://dx.doi.org/10.1056/NEJM198311103091902 | Medline

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