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Asimismo&#44; se compararon las caracter&#237;sticas de los episodios de LA durante los periodos epid&#233;micos antes y despu&#233;s de la pandemia&#58; presentaci&#243;n cl&#237;nica&#44; tratamientos administrados y evoluci&#243;n&#46; Para la comparaci&#243;n se realiz&#243; un muestreo aleatorio simple estratificado&#46; El an&#225;lisis estad&#237;stico se hizo con STATA v&#46;17&#46; El protocolo de manejo de los pacientes con LA en el SUP no se modific&#243; durante el periodo estudiado&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">En los cinco a&#241;os analizados se identificaron tres periodos epid&#233;micos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Dos de ellos antes de la pandemia COVID-19 &#40;septiembre-octubre de 2018 y septiembre-octubre de 2019&#41; y uno tras la pandemia &#40;septiembre-octubre de 2022&#41;&#46; El n&#250;mero de episodios atendidos fue mayor en la epidemia del a&#241;o 2022 &#40;2018&#58; 404 episodios &#91;3&#44;8&#37; del total de episodios atendidos&#93;&#59; 2019&#58; 507 episodios &#91;4&#44;8&#37; del total&#93;&#59; 2022&#58; 669 episodios &#91;5&#44;1&#37; del total&#93;&#41;&#46; Se incluyeron para el an&#225;lisis 601 episodios &#40;37&#44;8&#37; del total de episodios de LA atendidos&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Los resultados de comparar las caracter&#237;sticas de los episodios de LA atendidos antes y despu&#233;s de la pandemia COVID-19 se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; La mediana de la puntuaci&#243;n num&#233;rica de la escala de Westley fue mayor en la primera epidemia de LA tras la pandemia COVID-19&#44; as&#237; como la tasa de ingreso&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Respecto a la microbiolog&#237;a de los doce pacientes ingresados con LA en septiembre y octubre de 2022&#44; ning&#250;n paciente fue positivo para SARS-CoV-2 por test r&#225;pido de ant&#237;geno o reacci&#243;n en cadena de la polimerasa&#46; En tres casos se realiz&#243; un panel de virus respiratorios&#44; detect&#225;ndose una coinfecci&#243;n de virus parainfluenza<span class="elsevierStyleHsp" style=""></span>1 &#47;<span class="elsevierStyleHsp" style=""></span>rinovirus&#44; una coinfecci&#243;n de virus parainfluenza<span class="elsevierStyleHsp" style=""></span>2 &#47;<span class="elsevierStyleHsp" style=""></span>rinovirus y un virus parainfluenza<span class="elsevierStyleHsp" style=""></span>2&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Las estrictas medidas higi&#233;nicas y sanitarias empleadas para contener la pandemia COVID-19 han modificado la forma de presentaci&#243;n de algunas enfermedades&#46; Se hipotetiza que&#44; fruto de una &#171;deuda inmunitaria&#187;&#44; podr&#237;an estar produci&#233;ndose cuadros infecciosos respiratorios&#44; tanto v&#237;ricos como bacterianos&#44; de mayor intensidad y gravedad<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#46; La epidemia anual de LA se produc&#237;a cl&#225;sicamente en los meses de oto&#241;o en relaci&#243;n con la infecci&#243;n por virus parainfluenza&#46; En nuestro centro&#44; en la primera epidemia de LA tras la pandemia COVID-19&#44; el n&#250;mero absoluto de episodios fue mayor al de las epidemias previas y&#44; por primera vez desde que se tienen estad&#237;sticas&#44; la LA fue uno de los 10 diagn&#243;sticos m&#225;s frecuentes en el SUP&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Durante los periodos epid&#233;micos estudiados no se identific&#243; ning&#250;n caso de LA grave&#44; probablemente porque&#44; seg&#250;n la estratificaci&#243;n utilizada a partir de la escala de Westley&#44; se necesita presentar cianosis o un nivel de conciencia alterado en la exploraci&#243;n para ser clasificada como grave<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#46; Sin embargo&#44; los pacientes atendidos durante la primera epidemia de LA tras la pandemia COVID-19 s&#237; presentaron una puntuaci&#243;n num&#233;rica en la escala de Westley m&#225;s alta&#46; Esto se tradujo en una mayor tasa de ingreso&#44; aunque su impacto en la planta de hospitalizaci&#243;n fue reducido porque la gran mayor&#237;a de cuadros se pudieron seguir manejando de forma ambulatoria&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Dado que en nuestro SUP el estudio microbiol&#243;gico &#250;nicamente se realiza en aquellos pacientes que precisan ingreso&#44; no se puede valorar el impacto del SARS-CoV-2 en el conjunto del periodo epid&#233;mico&#46; La variante &#243;micron se ha asociado a un aumento de los casos de LA por SARS-CoV-2 respecto a variantes anteriores<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a>&#46; Si las LA por SARS-CoV-2 son m&#225;s graves que las LA producidas por otros virus sigue siendo objeto de controversia<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">5&#44;6</span></a>&#46; En nuestro centro&#44; durante el periodo epid&#233;mico analizado ninguno de los cuadros que precisaron ingreso fue positivo a SARS-CoV-2&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A pesar de las limitaciones derivadas de ser un estudio retrospectivo y unic&#233;ntrico&#44; se concluye que la deuda inmunitaria adquirida fruto de las medidas aplicadas para contener la pandemia COVID-19 tambi&#233;n ha podido afectar a la presentaci&#243;n de los casos de LA&#44; al igual que ha ocurrido con otras infecciones respiratorias&#46; Sin embargo&#44; el impacto sobre la actividad asistencial es limitado&#44; dado que la gran mayor&#237;a de los cuadros se han podido seguir manejando ambulatoriamente&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financiaci&#243;n</span><p id="par0050" class="elsevierStylePara elsevierViewall">Este trabajo no ha recibido ning&#250;n tipo de financiaci&#243;n&#46;</p></span></span>"
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Moderada&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;17&#44;8&#37;&#41; &#91;12&#44;3-24&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;19&#44;0&#37;&#41; &#91;13&#44;8-25&#44;1&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59 &#40;25&#44;4&#37;&#41; &#91;20&#44;0-31&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grave&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana puntuaci&#243;n escala de Westley &#40;RIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;026</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tratamiento en urgencias</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dexametasona oral&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151 &#40;91&#44;7&#37;&#41; &#91;83&#44;7-93&#44;6&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185 &#40;92&#44;5&#37;&#41; &#91;87&#44;9-95&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">212 &#40;91&#44;4&#37;&#41; &#91;87&#44;0-94&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;874&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Budesonida nebulizada&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;2&#37;&#41; &#91;0&#44;1-4&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;5&#37;&#41; &#91;0&#44;3-4&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;4&#37;&#41; &#91;0-2&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;410&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adrenalina nebulizada&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;7&#44;1&#37;&#41; &#91;3&#44;7-12&#44;1&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;6&#44;0&#37;&#41; &#91;3&#44;1-10&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;9&#44;1&#37;&#41; &#91;5&#44;7-13&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;413&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Oxigenoterapia&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;2&#37;&#41; &#91;0&#44;1-4&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;4&#37;&#41; &#91;0-2&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;348&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Evoluci&#243;n</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingreso&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;6&#37;&#41; &#91;0-3&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#44;6&#37;&#41; &#91;1&#44;0-5&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;045</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingreso en UCIP&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;6&#37;&#41; &#91;0-3&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;9&#37;&#41; &#91;0&#44;1-3&#44;1&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;625&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Readmisi&#243;n en urgencias en 72 horas&#44; n&#47;total pacientes que no ingresan &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#47;168 &#40;9&#44;5&#37;&#41; &#91;5&#44;5-15&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#47;200 &#40;10&#44;0&#37;&#41; &#91;6&#44;2-15&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#47;226 &#40;9&#44;3&#37;&#41; &#91;5&#44;8-13&#44;9&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;922&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Comparaci&#243;n de datos demogr&#225;ficos&#44; cl&#237;nicos&#44; tratamiento y evoluci&#243;n de los episodios de laringitis aguda atendidos en el SUP en el periodo a estudio &#40;2018-2022&#41;</p>"
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                      "titulo" => "SARS-CoV-2 pandemic impact in asthmatic exacerbations emergency visits in Spain"
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                        0 => array:3 [
                          "colaboracion" => "en representaci&#243;n del Grupo de trabajo respiratorio de la Sociedad Espa&#241;ola de Urgencias Pedi&#225;tricas &#40;SEUP&#41;"
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Laringitis agudas en un servicio de urgencias pediátrico antes y después de la pandemia COVID-19. ¿Han cambiado sus características?
Acute laryngitis in a paediatric emergency department before and after the COVID-19 pandemic. Has anything changed?
Juan Añón-Hidalgoa,
Autor para correspondencia
Juanjesus.anon@salud.madrid.org

Autor para correspondencia.
, Rocío Trincado-Lamuñoa, Elena Esparza-Isasaa, José Antonio Alonso-Cadenasb,c, David Andina-Martínezb,c
a Servicio de Pediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España
b Servicio de Urgencias, Hospital Infantil Universitario Niño Jesús, Madrid, España
c Instituto de Investigación Sanitaria Hospital La Princesa, Madrid, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Estudios recientes publicados en <span class="elsevierStyleItalic">ANALES DE PEDIATR&#205;A</span> han descrito el impacto de la pandemia COVID-19 en la incidencia de exacerbaciones asm&#225;ticas y de bronquiolitis en los servicios de urgencias pedi&#225;tricos &#40;SUP&#41;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; Sin embargo&#44; no se ha estudiado su repercusi&#243;n sobre la incidencia de episodios de laringitis aguda &#40;LA&#41; y su gravedad&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Se plantea un estudio transversal&#44; retrospectivo&#44; de los episodios de LA atendidos en un SUP entre enero de 2018 y diciembre de 2022&#46; Se analizaron las visitas mensuales por LA&#44; definidas seg&#250;n el c&#243;digo J04&#46;0 del CIE-10&#44; y el n&#250;mero de ingresos hospitalarios&#46; Asimismo&#44; se compararon las caracter&#237;sticas de los episodios de LA durante los periodos epid&#233;micos antes y despu&#233;s de la pandemia&#58; presentaci&#243;n cl&#237;nica&#44; tratamientos administrados y evoluci&#243;n&#46; Para la comparaci&#243;n se realiz&#243; un muestreo aleatorio simple estratificado&#46; El an&#225;lisis estad&#237;stico se hizo con STATA v&#46;17&#46; El protocolo de manejo de los pacientes con LA en el SUP no se modific&#243; durante el periodo estudiado&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">En los cinco a&#241;os analizados se identificaron tres periodos epid&#233;micos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Dos de ellos antes de la pandemia COVID-19 &#40;septiembre-octubre de 2018 y septiembre-octubre de 2019&#41; y uno tras la pandemia &#40;septiembre-octubre de 2022&#41;&#46; El n&#250;mero de episodios atendidos fue mayor en la epidemia del a&#241;o 2022 &#40;2018&#58; 404 episodios &#91;3&#44;8&#37; del total de episodios atendidos&#93;&#59; 2019&#58; 507 episodios &#91;4&#44;8&#37; del total&#93;&#59; 2022&#58; 669 episodios &#91;5&#44;1&#37; del total&#93;&#41;&#46; Se incluyeron para el an&#225;lisis 601 episodios &#40;37&#44;8&#37; del total de episodios de LA atendidos&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Los resultados de comparar las caracter&#237;sticas de los episodios de LA atendidos antes y despu&#233;s de la pandemia COVID-19 se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; La mediana de la puntuaci&#243;n num&#233;rica de la escala de Westley fue mayor en la primera epidemia de LA tras la pandemia COVID-19&#44; as&#237; como la tasa de ingreso&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Respecto a la microbiolog&#237;a de los doce pacientes ingresados con LA en septiembre y octubre de 2022&#44; ning&#250;n paciente fue positivo para SARS-CoV-2 por test r&#225;pido de ant&#237;geno o reacci&#243;n en cadena de la polimerasa&#46; En tres casos se realiz&#243; un panel de virus respiratorios&#44; detect&#225;ndose una coinfecci&#243;n de virus parainfluenza<span class="elsevierStyleHsp" style=""></span>1 &#47;<span class="elsevierStyleHsp" style=""></span>rinovirus&#44; una coinfecci&#243;n de virus parainfluenza<span class="elsevierStyleHsp" style=""></span>2 &#47;<span class="elsevierStyleHsp" style=""></span>rinovirus y un virus parainfluenza<span class="elsevierStyleHsp" style=""></span>2&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Las estrictas medidas higi&#233;nicas y sanitarias empleadas para contener la pandemia COVID-19 han modificado la forma de presentaci&#243;n de algunas enfermedades&#46; Se hipotetiza que&#44; fruto de una &#171;deuda inmunitaria&#187;&#44; podr&#237;an estar produci&#233;ndose cuadros infecciosos respiratorios&#44; tanto v&#237;ricos como bacterianos&#44; de mayor intensidad y gravedad<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#46; La epidemia anual de LA se produc&#237;a cl&#225;sicamente en los meses de oto&#241;o en relaci&#243;n con la infecci&#243;n por virus parainfluenza&#46; En nuestro centro&#44; en la primera epidemia de LA tras la pandemia COVID-19&#44; el n&#250;mero absoluto de episodios fue mayor al de las epidemias previas y&#44; por primera vez desde que se tienen estad&#237;sticas&#44; la LA fue uno de los 10 diagn&#243;sticos m&#225;s frecuentes en el SUP&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Durante los periodos epid&#233;micos estudiados no se identific&#243; ning&#250;n caso de LA grave&#44; probablemente porque&#44; seg&#250;n la estratificaci&#243;n utilizada a partir de la escala de Westley&#44; se necesita presentar cianosis o un nivel de conciencia alterado en la exploraci&#243;n para ser clasificada como grave<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a>&#46; Sin embargo&#44; los pacientes atendidos durante la primera epidemia de LA tras la pandemia COVID-19 s&#237; presentaron una puntuaci&#243;n num&#233;rica en la escala de Westley m&#225;s alta&#46; Esto se tradujo en una mayor tasa de ingreso&#44; aunque su impacto en la planta de hospitalizaci&#243;n fue reducido porque la gran mayor&#237;a de cuadros se pudieron seguir manejando de forma ambulatoria&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Dado que en nuestro SUP el estudio microbiol&#243;gico &#250;nicamente se realiza en aquellos pacientes que precisan ingreso&#44; no se puede valorar el impacto del SARS-CoV-2 en el conjunto del periodo epid&#233;mico&#46; La variante &#243;micron se ha asociado a un aumento de los casos de LA por SARS-CoV-2 respecto a variantes anteriores<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a>&#46; Si las LA por SARS-CoV-2 son m&#225;s graves que las LA producidas por otros virus sigue siendo objeto de controversia<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">5&#44;6</span></a>&#46; En nuestro centro&#44; durante el periodo epid&#233;mico analizado ninguno de los cuadros que precisaron ingreso fue positivo a SARS-CoV-2&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A pesar de las limitaciones derivadas de ser un estudio retrospectivo y unic&#233;ntrico&#44; se concluye que la deuda inmunitaria adquirida fruto de las medidas aplicadas para contener la pandemia COVID-19 tambi&#233;n ha podido afectar a la presentaci&#243;n de los casos de LA&#44; al igual que ha ocurrido con otras infecciones respiratorias&#46; Sin embargo&#44; el impacto sobre la actividad asistencial es limitado&#44; dado que la gran mayor&#237;a de los cuadros se han podido seguir manejando ambulatoriamente&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financiaci&#243;n</span><p id="par0050" class="elsevierStylePara elsevierViewall">Este trabajo no ha recibido ning&#250;n tipo de financiaci&#243;n&#46;</p></span></span>"
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gravedad seg&#250;n escala de Westley</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;053&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Leve&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">139 &#40;82&#44;2&#37;&#41; &#91;75&#44;6-87&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">162 &#40;81&#44;0&#37;&#41; &#91;74&#44;9-86&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">173 &#40;74&#44;5&#37;&#41; &#91;68&#44;5-80&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Moderada&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;17&#44;8&#37;&#41; &#91;12&#44;3-24&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;19&#44;0&#37;&#41; &#91;13&#44;8-25&#44;1&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59 &#40;25&#44;4&#37;&#41; &#91;20&#44;0-31&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grave&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana puntuaci&#243;n escala de Westley &#40;RIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;026</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tratamiento en urgencias</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dexametasona oral&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151 &#40;91&#44;7&#37;&#41; &#91;83&#44;7-93&#44;6&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185 &#40;92&#44;5&#37;&#41; &#91;87&#44;9-95&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">212 &#40;91&#44;4&#37;&#41; &#91;87&#44;0-94&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;874&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Budesonida nebulizada&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;2&#37;&#41; &#91;0&#44;1-4&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#44;5&#37;&#41; &#91;0&#44;3-4&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;4&#37;&#41; &#91;0-2&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;410&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adrenalina nebulizada&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;7&#44;1&#37;&#41; &#91;3&#44;7-12&#44;1&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;6&#44;0&#37;&#41; &#91;3&#44;1-10&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;9&#44;1&#37;&#41; &#91;5&#44;7-13&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;413&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Oxigenoterapia&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;2&#37;&#41; &#91;0&#44;1-4&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;4&#37;&#41; &#91;0-2&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;348&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Evoluci&#243;n</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingreso&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;6&#37;&#41; &#91;0-3&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#44;6&#37;&#41; &#91;1&#44;0-5&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;045</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ingreso en UCIP&#44; n &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;6&#37;&#41; &#91;0-3&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;9&#37;&#41; &#91;0&#44;1-3&#44;1&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;625&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Readmisi&#243;n en urgencias en 72 horas&#44; n&#47;total pacientes que no ingresan &#40;&#37;&#41; &#91;IC 95&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#47;168 &#40;9&#44;5&#37;&#41; &#91;5&#44;5-15&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#47;200 &#40;10&#44;0&#37;&#41; &#91;6&#44;2-15&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#47;226 &#40;9&#44;3&#37;&#41; &#91;5&#44;8-13&#44;9&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;922&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3430558.png"
              ]
            ]
          ]
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ISSN: 16954033
Idioma original: Español
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