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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">&#91;vs2&#93; Regresi&#243;n binaria log&#237;stica de los factores de riesgo asociados a toxicolog&#237;a positiva de de los neonatos mayores a 34 SG ingresados en UCIN y UCMN&#46; <span class="elsevierStyleItalic">Forest plot</span> &#40;A&#41; y curva ROC &#40;B&#41; del modelo multivariante obtenido&#46; En la tabla se indican las&#160;<span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41;&#160;crudas&#160;y&#160;ajustadas con sus intervalos de confianza entre par&#233;ntesis&#46;&#160;Los valores de punto corte &#243;ptimos fueron determinados por el &#237;ndice m&#225;ximo de Youden &#40;J&#41;&#44; definido como &#40;sensibilidad &#43; especificidad -1&#41;&#46; La comparaci&#243;n de las frecuencias esperadas y observadas se realiz&#243; por la prueba de bondad de ajuste Hosmer-Lemeshow &#40;p&#160;&#61;&#160;0&#44;983&#41; y por su curva ROC y su &#225;rea bajo la curva &#40;ABC&#41;&#44; indicando un buen ajuste para el modelo&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Los neonatos expuestos a drogas de abuso durante el embarazo tienen un mayor riesgo de ingreso a una Unidad de Cuidados Intensivos Neonatales e Intermedios Neonatales &#40;UCIN y UCMN&#41;&#46; Su identificaci&#243;n temprana permite garantizar una evaluaci&#243;n cl&#237;nica precisa&#44; promover una intervenci&#243;n temprana y mitigar los signos de abstinencia en el neonato&#44; si estos aparecen<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a>&#46; Los biomarcadores de drogas y alcohol en matrices biol&#243;gicas neonatales son una herramienta &#250;til para detectar exposici&#243;n<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">2-5</span></a>&#46; Esto es especialmente relevante si se detectan durante el curso cl&#237;nico&#44; cuando se toman decisiones terap&#233;uticas y sociales&#46; Adem&#225;s&#44; proporciona la base para un seguimiento m&#233;dico y social adecuado en edades pedi&#225;tricas y adolescentes<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#44;7</span></a>&#46; A pesar de que la literatura cient&#237;fica respalda su uso&#44; su implementaci&#243;n es a&#250;n limitada&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Las manifestaciones cl&#237;nicas de la exposici&#243;n prenatal a drogas de abuso var&#237;an desde abortos&#44; muerte intrauterina&#44; malformaciones&#44; bajo peso&#44; prematuridad&#44; sufrimiento fetal&#44; rotura prematura de membranas&#44; asfixia e infarto cerebral hasta patrones anormales card&#237;acos y respiratorios&#46; Tambi&#233;n se asocia con el s&#237;ndrome de abstinencia neonatal y trastornos f&#237;sicos y neuroconductuales que se hacen evidentes en la primera infancia<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#44;7</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; la exposici&#243;n a alcohol durante el embarazo puede desencadenar un espectro de discapacidades f&#237;sicas&#44; cognitivas y conductuales conocidas como trastornos del espectro alcoh&#243;lico fetal &#40;FASD&#41;&#46; El s&#237;ndrome alcoh&#243;lico fetal &#40;FAS&#41; es la forma de presentaci&#243;n m&#225;s grave<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">8-10</span></a>&#46; Tanto el FASD como el FAS representan la causa m&#225;s recurrente y f&#225;cilmente prevenible de discapacidades del desarrollo adquiridas en los neonatos&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">La prevalencia estimada de la exposici&#243;n prenatal a drogas de abuso es dif&#237;cil de establecer&#44; debido a los diferentes resultados obtenidos dependiendo del dise&#241;o y la metodolog&#237;a de los estudios<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">6</span></a>&#46; Estudios con biomarcadores realizados en Espa&#241;a e Italia han documentado que la exposici&#243;n a drogas se sit&#250;a entre el 7&#44;9-15&#44;9&#37;&#44; y a alcohol entre 1&#44;7-45&#37;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">4&#44;11-14</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Los objetivos de este estudio fueron describir las caracter&#237;sticas cl&#237;nicas e identificar factores de riesgo asociados a la detecci&#243;n precoz de neonatos expuestos a drogas de abuso en una Unidad de Cuidados Intensivos e Intermedios Neonatales&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material y m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Dise&#241;o</span><p id="par0030" class="elsevierStylePara elsevierViewall">Estudio observacional prospectivo realizado en una UCIN y UCMN catalogada como centro de referencia IIIB entre marzo de 2018 y diciembre de 2019&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Criterios de inclusi&#243;n</span><p id="par0035" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Casos de sospecha cl&#237;nica de exposici&#243;n prenatal a drogas de abuso por presentar factores sociosanitarios y epidemiol&#243;gicos de riesgo&#160;&#40;madres con antecedentes o sospecha de consumo activo de drogas de abuso&#44; embarazo no controlado o con control insuficiente&#44; y&#47;o adolescentes&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Casos de sospecha por la cl&#237;nica &#40;hiperton&#237;a&#44; irritabilidad&#44; llanto exagerado&#44; temblores&#44; reflejos tendinosos o crecimiento intrauterino restringido &#91;CIR&#93; injustificado&#41; y por el entorno&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Casos sin criterios de sospecha cl&#237;nica ni por su entorno de exposici&#243;n prenatal a drogas de abuso&#44; y cuyas madres aceptaron participar en el estudio mediante un consentimiento informado&#46;</p></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Criterios de exclusi&#243;n</span><p id="par0055" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Neonatos que presentaron s&#237;ndrome de aspiraci&#243;n meconial&#44; perforaci&#243;n intestinal intra&#250;tero&#44; retraso de evacuaci&#243;n de meconio&#44; deposiciones mel&#233;nicas&#44; asfixia grave o &#233;xitus&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Neonatos sin sospecha de exposici&#243;n prenatal a drogas de abuso que ingresaron en d&#237;as no laborables o en per&#237;odos vacacionales o a los que no se les pudo recoger meconio&#46;</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">M&#233;todos anal&#237;ticos</span><p id="par0070" class="elsevierStylePara elsevierViewall">Se registraron las caracter&#237;sticas cl&#237;nicas de los neonatos al nacimiento y al alta&#44; y la informaci&#243;n de los diagn&#243;sticos&#44; manejo y evoluci&#243;n durante su ingreso&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">El consumo de drogas de abuso se determin&#243; mediante el an&#225;lisis de meconio recogido dentro de las primeras 24&#160;h de vida&#46; La detecci&#243;n de drogas se realiz&#243; inmediatamente y se almacen&#243; una al&#237;cuota a -20<span class="elsevierStyleHsp" style=""></span>&#176;C para la detecci&#243;n posterior de etanol&#46; En el grupo de pacientes con sospecha se realiz&#243; el an&#225;lisis de drogas de abuso en orina y en cabello neonatal cuando no hab&#237;a muestra de meconio disponible&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">El meconio se analiz&#243; mediante la estrategia de cribado m&#225;s confirmaci&#243;n&#46; El inmunoan&#225;lisis DRI&#174; &#40;Abbott Laboratories Inc&#46;&#44; IL&#44; EE&#46; UU&#46;&#41; se utiliz&#243; para el cribado de cannabinoides&#44; coca&#237;na&#44; opi&#225;ceos&#44; metadona&#44; anfetaminas y &#233;xtasis<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">15&#44;16</span></a>&#46; Las muestras positivas se confirmaron por cromatograf&#237;a de gases-espectrometr&#237;a de masas &#40;GC-MS&#41;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">15&#44;17&#44;18</span></a>&#46; El an&#225;lisis de drogas de abuso en orina se realiz&#243; siguiendo la misma estrategia<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">19-21</span></a>&#46; El an&#225;lisis de drogas de abuso en pelo se realiz&#243; directamente por GC-MS<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">19&#44;22&#44;23</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">El etilglucur&#243;nido &#40;ETG&#41; se utiliz&#243; como biomarcador de la exposici&#243;n prenatal a alcohol&#46; Se analiz&#243; en muestras de meconio mediante cromatograf&#237;a l&#237;quida de ultra-alta resoluci&#243;n acoplada a espectrometr&#237;a de masas en t&#225;ndem &#40;UPLC-MS&#47;MS&#41;&#44; con l&#237;mites de detecci&#243;n y cuantificaci&#243;n de 0&#44;5 ng&#47;g y 5 ng&#47;g&#44; respectivamente<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">24</span></a>&#46; El punto de corte para considerar ETG positivo fue de 30 ng&#47;g de meconio<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">25</span></a>&#46; En muestras de pelo el an&#225;lisis de ETG se realiz&#243; utilizando un m&#233;todo previamente validado con un l&#237;mite de cuantificaci&#243;n de 3 pg&#47;mg y un punto de corte de &#62;&#160;7 pg&#47;mg<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">26</span></a>&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">An&#225;lisis estad&#237;stico</span><p id="par0090" class="elsevierStylePara elsevierViewall">Los datos obtenidos de cada neonato y los resultados toxicol&#243;gicos se registraron en una hoja de c&#225;lculo Excel 10 de Microsoft Office&#174;&#46; Las caracter&#237;sticas cl&#237;nicas&#44; de manejo y evoluci&#243;n de neonatos con resultados toxicol&#243;gicos negativos se compararon con&#58; a&#41; el grupo toxicol&#243;gico positivo para alguna droga de abuso&#44; b&#41; con los grupos positivos para un &#250;nico t&#243;xico y c&#41; con el grupo positivo para m&#225;s de una droga&#46; Adem&#225;s&#44; se compararon entre s&#237; los perfiles asociados a la exposici&#243;n neonatal a cannabis&#44; alcohol o coca&#237;na&#46; Esta misma comparaci&#243;n se realiz&#243; con el grupo de neonatos con edad gestacional superior a 34 semanas&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Los valores se expresaron como media &#40;&#177;&#41;&#44; desviaci&#243;n est&#225;ndar&#44; mediana &#40;rango intercuart&#237;lico&#41; o frecuencia &#40;porcentaje&#41;&#46; Las comparaciones se realizaron mediante an&#225;lisis ANOVA unidireccional y la prueba t de muestras independientes o la prueba U de Kruskal-Wallis y Mann-Whitney para variables continuas&#44; y &#967;<span class="elsevierStyleSup">2</span> o Fisher prueba exacta para variables categ&#243;ricas&#46; Un valor p de dos colas &#60;&#160;0&#44;05 se consider&#243; estad&#237;sticamente significativo&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">La regresi&#243;n log&#237;stica binaria &#40;RLB&#41; univariante y multivariante se utiliz&#243; para identificar los factores de riesgo independientes de los neonatos asociados a tener una toxicolog&#237;a positiva utilizando como referencia aquellos con toxicolog&#237;a negativa &#40;<span class="elsevierStyleItalic">odds ratio</span>&#160;&#61;&#160;1&#41;&#46; Inicialmente se introdujeron en el modelo las caracter&#237;sticas del neonato al nacimiento y los motivos de ingreso en UCIN con una p&#160;&#60;&#160;0&#44;1 &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1-4</a>&#41;&#44; excepto el motivo de ingreso &#171;consumo de t&#243;xicos&#187;&#46; El modelo multivariante se construy&#243; incluyendo de forma manual&#44; paso a paso&#44; hasta obtener el modelo final&#46; Los valores de corte &#243;ptimos de las variables cuantitativas asociadas a toxicolog&#237;a positiva fueron determinados por curvas ROC y el &#237;ndice m&#225;ximo de Youden &#40;J&#41;&#44; definido como&#58; sensibilidad &#43; especificidad -1&#46; A partir del modelo final por RLB de las variables independientes asociadas a toxicolog&#237;a positiva&#44; se calcul&#243; la probabilidad para cada paciente y&#44; a partir de estos valores de probabilidades&#44; se determin&#243; el &#225;rea bajo la curva &#40;ABC&#41; de la curva ROC para evaluar el modelo final&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Los an&#225;lisis estad&#237;sticos se realizaron con SPSS 23&#46;0&#174; &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#44; EE&#46; UU&#46;&#41;&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Resultados</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Participantes</span><p id="par0110" class="elsevierStylePara elsevierViewall">Se incluyeron 372 &#40;41&#44;6&#37;&#41; de los 895 neonatos ingresados en la UCIN y UCMN durante el periodo de estudio&#46; En funci&#243;n de la edad gestacional al ingreso&#44; se incluyeron&#58; 225 &#40;60&#44;5&#37;&#41; mayores de 34 semanas de gestaci&#243;n &#40;SG&#41;&#44; 136 &#40;36&#44;4&#37;&#41; entre 28-34 SG y 11 &#40;3&#44;0&#37;&#41; menores de 28 SG&#46; En 49 &#40;13&#44;2&#37;&#41; casos se detect&#243; exposici&#243;n a drogas de abuso&#44; de los cuales 39 &#40;79&#44;6&#37;&#41; fueron mayores de 34 SG&#46; Por este motivo tambi&#233;n se realiz&#243; el an&#225;lisis estad&#237;stico en este subgrupo de neonatos&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">En 41 &#40;83&#44;7&#37;&#41; casos se detect&#243; una sola droga&#58; 24 &#40;58&#44;5&#37;&#41; cannabis&#44; 11 &#40;26&#44;8&#37;&#41; ETG y en seis &#40;14&#44;6&#37;&#41; coca&#237;na&#46; En ocho &#40;16&#44;3&#37;&#41; casos se detect&#243; m&#225;s de una droga&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">De los 64 &#40;17&#44;2&#37;&#41; casos con sospecha cl&#237;nica&#44; 36 &#40;56&#44;6&#37;&#41; fueron positivos&#44; mientras que de los 308 &#40;82&#44;8&#37;&#41; casos sin sospecha cl&#237;nica&#44; 13 &#40;4&#44;2&#37;&#41; fueron positivos&#46; En los casos con sospecha de exposici&#243;n se obtuvo muestra de orina en 55 &#40;85&#44;9&#37;&#41;&#46; En 22 &#40;40&#37;&#41; de estas muestras se detectaron drogas&#46; Se recogi&#243; muestra de pelo en 12 casos con sospecha&#44; de los cuales 11 &#40;91&#44;7&#37;&#41; fueron positivos a t&#243;xicos&#46;</p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Caracter&#237;sticas cl&#237;nicas &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1 y 2</a>&#41;</span><p id="par0125" class="elsevierStylePara elsevierViewall">El estado de exposici&#243;n se asoci&#243; a una mayor puntuaci&#243;n del test de Apgar al minuto y a los cinco minutos en los neonatos expuestos a alguna droga de abuso y a cannabis&#44; en comparaci&#243;n con los no expuestos&#46; Estos resultados se dieron tambi&#233;n en el grupo de m&#225;s de 34 SG &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1 y 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">El percentil de longitud al nacimiento de los neonatos expuestos a alguna droga &#40;29&#44;0 &#91;9&#44;0-52&#44;5&#93;&#41;&#44; a m&#225;s de una &#40;10&#44;0 &#91;3&#44;0-43&#44;8&#93;&#41; y a cannabis&#44; en concreto &#40;25&#44;0 &#91;8&#44;0-49&#44;5&#93;&#41;&#44; fue menor respecto a los no expuestos &#40;44&#44;0 &#91;21&#44;0-72&#44;0&#93;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; El percentil de longitud fue tambi&#233;n inferior en los expuestos a cannabis con respecto a los expuestos a coca&#237;na &#40;25&#44;0 &#91;8&#44;0-49&#44;5&#93; vs&#46; 63&#44;0 &#91;33&#44;3-85&#44;3&#93;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; El percentil de peso de los expuestos a cannabis &#40;18&#44;5 &#91;8&#44;5-52&#44;3&#93;&#41; fue menor que el de los no expuestos &#40;38&#44;0 &#91;15&#44;0-63&#44;0&#93;&#44; p&#160;&#60;&#160;0&#44;05&#41; y los expuestos a alcohol &#40;42&#44;0 &#91;17&#44;0-83&#44;0&#93;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">En los neonatos mayores a 34 SG&#44; el percentil de longitud de los expuestos a alguna droga de abuso &#40;17&#44;0 &#91;8&#44;0-46&#44;0&#93;&#41; y a m&#225;s de una &#40;3&#44;0 &#91;3&#44;0-37&#44;0&#93;&#41; fue inferior al de los no expuestos &#40;40&#44;0 &#91;15&#44;0-63&#44;5&#93;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; El percentil de peso de los expuestos a m&#225;s de una droga &#40;15&#44;0 &#91;1&#44;0-30&#44;0&#93;&#41; tambi&#233;n fue inferior al de los no expuestos &#40;30&#44;0 &#91;10&#44;0-57&#44;0&#93;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#44;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Al alta&#44; el per&#237;metro craneal de los neonatos expuestos a alguna droga de abuso &#40;22&#44;0 &#91;10&#44;0-45&#44;0&#93;&#41; y a m&#225;s de una &#40;3&#44;0 &#91;1&#44;0-50&#44;0&#93;&#41; fue menor que el de los no expuestos &#40;40&#44;0 &#91;19&#44;0-62&#44;0&#93;&#41;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; Estas diferencias tambi&#233;n se observaron en el grupo de mayores a 34 SG&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">La edad gestacional de los neonatos expuestos a alguna droga de abuso &#40;37&#46;0&#160;&#177;&#160;3&#44;4 semanas&#41;&#44; a m&#225;s de una &#40;37&#44;3&#160;&#177;&#160;4&#44;2 semanas&#41;&#44; a cannabis &#40;36&#44;9&#160;&#177;&#160;3&#44;4 semanas&#41; y a coca&#237;na &#40;38&#44;3&#160;&#177;&#160;2&#44;4&#41; fue superior a la de los no expuestos &#40;34&#44;8&#160;&#177;&#160;3&#44;7 semanas&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; En los mayores a 34 SG&#44; la edad gestacional fue mayor en el grupo de expuestos a cualquier droga de abuso &#40;38&#44;5&#160;&#177;&#160;1&#44;7 semanas&#41; y a cannabis &#40;38&#44;7&#160;&#177;&#160;1&#44;5 semanas&#41;&#44; respecto a los no expuestos &#40;37&#44;3&#160;&#177;&#160;2&#44;2 semanas&#44; p&#160;&#60;&#160;0&#44;005&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">No se encontraron diferencias en el resto de las variables estudiadas&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Diagn&#243;stico y manejo cl&#237;nico</span><p id="par0155" class="elsevierStylePara elsevierViewall">La prematuridad fue m&#225;s frecuente como motivo de ingreso en los neonatos no expuestos que en los expuestos &#40;59&#44;4&#37; vs&#46; 18&#44;4&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41; &#40;<a class="elsevierStyleCrossRefs" href="#tbl0015">tablas 3 y 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0160" class="elsevierStylePara elsevierViewall">Los motivos de ingreso m&#225;s frecuentes en neonatos expuestos fue el consumo materno de drogas de abuso &#40;36&#44;7&#37;&#41;&#44; espec&#237;ficamente cannabis &#40;50&#37;&#41;&#44; coca&#237;na &#40;66&#44;7&#37;&#41; y m&#225;s de una droga &#40;25&#44;0&#37;&#41;&#44; siendo los porcentajes superiores a los no expuestos &#40;0&#44;6&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; Estas diferencias tambi&#233;n se observan en mayores de 34 SG&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Los ingresos por distocia social&#44; embarazo no controlado o adopci&#243;n fueron m&#225;s frecuentes en casos de consumo de m&#225;s de una droga de abuso &#40;25&#37;&#41; que en negativos &#40;1&#44;5&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">La sospecha cl&#237;nica de consumo fue m&#225;s frecuente en casos positivos a alguna droga de abuso &#40;73&#44;5&#37;&#41;&#44; cannabis &#40;83&#44;3&#37;&#41;&#44; coca&#237;na &#40;100&#37;&#41; o m&#225;s de una &#40;87&#44;5&#37;&#41;&#44; que en casos negativos &#40;17&#44;2&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; Estos resultados tambi&#233;n se observaron en mayores de 34 SG&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">En relaci&#243;n con los diagn&#243;sticos&#44; el s&#237;ndrome de abstinencia se dio en casos positivos con mayor frecuencia que en negativos &#40;6&#44;1&#37; vs&#46; 0&#44;3&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; Fue m&#225;s frecuente en los casos positivos a m&#225;s de una droga que en negativos&#44; tanto en neonatos de cualquier edad gestacional &#40;25&#44;0&#37; vs&#46; 0&#44;3&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#44; como en mayores de 34 SG &#40;28&#44;6&#37; vs&#46; 0&#44;5&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#44; El s&#237;ndrome de abstinencia en el caso con resultado negativo se detect&#243; en el hijo de una madre en tratamiento con metadona&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Con respecto al manejo cl&#237;nico&#44; el estado de exposici&#243;n se asoci&#243; a una menor necesidad de surfactante &#40;10&#44;8&#37; vs&#46; 0&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41; y de ventilaci&#243;n mec&#225;nica no invasiva &#40;VMNI&#41; &#40;40&#44;2&#37; vs&#46; 18&#44;4&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41; con respecto a los neonatos no expuestos ingresados en la UCIN y UCMN&#46; En mayores de 34 SG&#44; se observ&#243; una menor necesidad de VMNI &#40;21&#37; vs&#46; 2&#44;6&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41; y de sonda nasog&#225;strica &#40;SNG&#41; &#40;33&#44;9&#37; vs&#46; 10&#44;3&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41; de los expuestos respecto a los no expuestos&#44; siendo el uso de SNG menos frecuente en expuestos a cannabis&#46; La nutrici&#243;n parenteral &#40;NP&#41; fue menos frecuente en expuestos a cualquier droga &#40;16&#44;3&#37;&#41; y a cannabis &#40;16&#44;7&#37;&#41; respecto a los no expuestos &#40;37&#44;2&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#44;</p><p id="par0185" class="elsevierStylePara elsevierViewall">La lactancia materna &#40;LM&#41; fue menor &#40;32&#44;7&#37; vs&#46; 88&#44;2&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41; y la artificial &#40;LA&#41; mayor &#40;95&#44;9&#37; vs&#46; 71&#44;5&#37;&#44; p&#160;&#60;&#160;0&#44;05&#41; en los neonatos expuestos&#44; excepto en el caso de consumo de alcohol &#40;LM&#58; 81&#44;8&#37;&#59; LA&#58; 90&#44;9&#37;&#41;&#44; cuya detecci&#243;n no se realiz&#243; durante el proceso asistencial&#46; Estas diferencias tambi&#233;n se observaron en mayores a 34 SG&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Finalmente&#44; se&#241;alar que el consumo de alguna droga de abuso &#40;8&#44;0 &#91;6&#44;0-15&#44;5&#93;&#41;&#44; cannabis &#40;8&#44;5 &#91;5&#44;0-18&#44;5&#93;&#41;&#44; y coca&#237;na &#40;7&#44;0 &#91;6&#44;5-8&#44;0&#93;&#41;&#44; se asoci&#243; a una menor duraci&#243;n del ingreso respecto a neonatos no expuestos &#40;9&#44;5 &#91;8&#44;0-23&#44;3&#93;&#44; p&#160;&#60;&#160;0&#44;05&#41;&#46; Estas diferencias no se observaron en mayores a 34 SG&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Destacamos que&#44; aunque sin alcanzar significaci&#243;n estad&#237;stica &#40;0&#44;05&#160;&#60;&#160;p&#160;&#60;&#160;0&#44;1&#41;&#44; las malformaciones genitourinarias se asociaron a neonatos expuestos a m&#225;s de una droga respecto a los no expuestos &#40;25&#37; vs&#46; 5&#44;9&#37;&#44; p&#160;&#61;&#160;0&#44;085&#41;&#44; incluidos los mayores de 34 SG &#40;28&#44;6 vs&#46; 7&#44;0&#37;&#44; p&#160;&#61;&#160;0&#44;094&#41;&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">No se encontraron diferencias en el resto de las variables estudiadas&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Factores de riesgo independientes asociados a presentar un an&#225;lisis toxicol&#243;gico positivo</span><p id="par0205" class="elsevierStylePara elsevierViewall">El modelo final indic&#243; que&#44; de todos los neonatos ingresados&#44; los factores de riesgo independientes asociados a presentar un an&#225;lisis toxicol&#243;gico positivo fueron &#40;<span class="elsevierStyleItalic">odds ratio</span> &#91;IC 95&#37;&#93;&#41;&#58; motivo de ingreso distinto a prematuridad &#40;5&#44;52 &#91;2&#44;55-1&#44;93&#93;&#41;&#44; Apgar al minuto 1 mayor a 7&#44;5 &#40;3&#44;28 &#91;1&#44;50-7&#44;21&#93;&#41; y percentil de longitud menor a 33 &#40;1&#44;95 &#91;1&#44;05-3&#44;60&#93;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; En los neonatos mayores a 34 SG&#44; los factores de riesgo fueron&#58; motivo de ingreso debido a distocia social&#47;embarazo no controlado &#40;4&#44;47 &#91;1&#44;03-19&#44;29&#93;&#41;&#44; un test de Apgar al minuto 1 mayor a 7&#44;5 &#40;3&#44;38 &#91;1&#44;33-8&#44;54&#93;&#41; y un percentil de longitud al nacimiento menor a 33 &#40;2&#44;14 &#91;1&#44;04-3&#44;40&#93;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discusi&#243;n</span><p id="par0210" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas y factores de riesgo identificados pueden servir de gu&#237;a para la detecci&#243;n precoz de neonatos expuestos&#46; Esto es especialmente relevante en aquellos hospitales que no pueden detectar estas drogas y de utilidad para solicitar biomarcadores de exposici&#243;n en matrices biol&#243;gicas en aquellos donde sea posible su detecci&#243;n&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Este es&#44; a nuestro conocimiento&#44; el primer estudio con estas caracter&#237;sticas realizado en nuestro pa&#237;s&#46; La comparaci&#243;n entre s&#237; de los efectos asociados a la exposici&#243;n a diferentes drogas de abuso es un aspecto innovador y permite minimizar los sesgos que se producen al comparar resultados de diferentes poblaciones&#46;</p><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Caracter&#237;sticas cl&#237;nicas</span><p id="par0220" class="elsevierStylePara elsevierViewall">Las consecuencias en el neonato de la exposici&#243;n a drogas de abuso durante el embarazo son multifactoriales &#40;tipo de droga&#44; momento del consumo&#44; duraci&#243;n&#44; dosis&#44; v&#237;a de administraci&#243;n&#44; estado nutricional&#44; psicopatolog&#237;a materna y falta de atenci&#243;n prenatal&#41;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#44;7</span></a>&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">El an&#225;lisis de los par&#225;metros somatom&#233;tricos revel&#243; que los neonatos expuestos a drogas de abuso presentaron percentiles inferiores en diferentes par&#225;metros&#44; con diferencias muy marcadas en los expuestos a cannabis&#46; Aunque el cannabis se ha asociado a unas peores caracter&#237;sticas somatom&#233;tricas<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">27&#44;28</span></a>&#44; en otros estudios no se pudo demostrar esta relaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">4&#44;13&#44;29</span></a>&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Est&#225; demostrado que los fetos con CIR presentan un mayor riesgo de complicaciones perinatales y complicaciones neonatales inmediatas&#46; El desarrollo neurol&#243;gico tambi&#233;n debe ser monitorizado&#44; principalmente en los primeros a&#241;os de vida&#44; para diagnosticar precozmente retrasos de desarrollo y para el tratamiento precoz de los mismos&#46; Se conoce que la exposici&#243;n a condiciones ambientales desfavorables&#44; en un periodo relativo pero cr&#237;tico&#44; perjudica la interrelaci&#243;n entre los sistemas endocrinos&#44; metab&#243;licos y mecanismos de homeostasis cardiovascular&#46; La problem&#225;tica que presenta la restricci&#243;n del crecimiento fetal es la dificultad de disponer de un diagn&#243;stico cierto<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">30</span></a>&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Los resultados de este estudio podr&#237;an servir para ampliar el diagn&#243;stico diferencial y las posibles causas de las alteraciones somatom&#233;tricas en neonatos&#44; incluyendo entre ellas la exposici&#243;n a drogas de abuso&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; nuestros resultados podr&#237;an usarse con el prop&#243;sito de dise&#241;ar estrategias preventivas y pol&#237;ticas destinadas a evitar y detectar la exposici&#243;n prenatal a drogas de abuso<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">31&#44;32</span></a>&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Diagn&#243;stico y manejo cl&#237;nico</span><p id="par0245" class="elsevierStylePara elsevierViewall">Los motivos de ingreso asociados a sospecha de exposici&#243;n a drogas de abuso fueron&#44; como se esperaba&#44; m&#225;s frecuentes en los neonatos expuestos&#44; a excepci&#243;n del grupo de neonatos expuestos a alcohol&#44; en concordancia con el hecho de que el alcohol es la droga m&#225;s detectada en casos sin sospecha&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">En tres de cada cuatro neonatos en los que se detect&#243; alguna droga hubo sospecha cl&#237;nica previa&#44; mientras que en uno de cada cuatro casos positivos no hubo sospecha&#46; Por tanto&#44; la sospecha cl&#237;nica tiene un rendimiento diagn&#243;stico elevado&#46; Sin embargo&#44; se precisan futuros estudios para confirmar estos datos&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Otros estudios s&#237; han comparado el grado de concordancia entre la autodeclaraci&#243;n materna y la confirmaci&#243;n toxicol&#243;gica<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">4&#44;11&#44;13&#44;31</span></a>&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">En paralelo al aumento de los casos de dependencia a opioides que se ha producido en el mundo en la &#250;ltima d&#233;cada&#44; tambi&#233;n han aumentado los casos de s&#237;ndrome de abstinencia neonatal &#40;NAS&#41;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">1&#44;3</span></a>&#46; Aunque en Espa&#241;a el problema no ha alcanzado las dimensiones de los EEUU&#44; en donde los casos de NAS se multiplicaron por cinco en una d&#233;cada<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a>&#44; en nuestro estudio este s&#237;ndrome se diagnostic&#243; en los dos casos en los que se detectaron opi&#225;ceos&#46; Se han observado s&#237;ntomas similares al NAS en neonatos expuestos a marihuana y a coca&#237;na<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#44;27&#44;33</span></a>&#46; La exposici&#243;n a etanol no se ha asociado a s&#237;ndrome de abstinencia&#44; en concordancia con nuestros resultados<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">No existen datos concluyentes sobre la teratogenicidad del cannabis&#44; la coca&#237;na o los opi&#225;ceos<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#44;27</span></a>&#46; Hemos documentado una posible asociaci&#243;n entre la exposici&#243;n a m&#225;s de una droga de abuso y malformaciones genitourinarias&#44; de la que no hemos encontrado evidencias previas&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall">El FAS y el FDAS pueden manifestarse con malformaciones faciales y del sistema nervioso central &#40;SNC&#41;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">8</span></a>&#46; Hallamos malformaciones en el SNS en dos neonatos expuestos a alcohol&#44; uno de ellos adem&#225;s con malformaciones faciales&#46; En ning&#250;n caso existi&#243; sospecha de exposici&#243;n y en uno la detecci&#243;n de ETG permiti&#243; el diagn&#243;stico de FAS&#46; En nuestra UCIN ya se hab&#237;a confirmado un caso de FAS<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">En t&#233;rminos de manejo cl&#237;nico&#44; debido al riesgo asociado a la exposici&#243;n prenatal a drogas de abuso&#44; los neonatos con sospecha fueron ingresados para una mayor vigilancia&#46; Por este motivo necesitaron menos intervenciones &#40;surfactante&#44; VMNI&#44; nutrici&#243;n parenteral&#44; SNG&#41; en comparaci&#243;n con los prematuros no expuestos de una unidad de tercer nivel y probablemente tambi&#233;n debido a su mayor edad gestacional&#46; Adem&#225;s&#44; generalmente no presentaron las complicaciones m&#233;dicas asociadas a los ingresados en la UCIN y UCMN por otras razones&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">La LM est&#225; contraindicada en caso de consumo de drogas de abuso<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#44;27</span></a>&#44; como m&#237;nimo hasta que los resultados toxicol&#243;gicos maternos sean negativos&#46; Por esta raz&#243;n&#44; los neonatos expuestos presentaron una baja frecuencia de LM&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Factores de riesgo independientes asociados a presentar un an&#225;lisis toxicol&#243;gico positivo</span><p id="par0285" class="elsevierStylePara elsevierViewall">Desde un punto de vista cl&#237;nico&#44; un motivo de ingreso distinto a la prematuridad&#44; un percentil de longitud al nacimiento menor a 33&#44; o la distocia social&#47;embarazo no controlado en el caso de neonatos mayores a 34 SG son factores de riesgo &#250;tiles para detectar casos de exposici&#243;n prenatal a drogas de abuso y reforzar la sospecha cl&#237;nica en el caso de que exista&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Un test de Apgar al minuto 1 mayor a 7&#44;5 como un factor de riesgo independiente podr&#237;a justificarse debido a que los neonatos no expuestos a drogas de abuso que ingresaron en las UCIN y UCMN presentaron patolog&#237;as m&#225;s severas y un mayor grado de prematuridad que los expuestos&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Resultados toxicol&#243;gicos</span><p id="par0295" class="elsevierStylePara elsevierViewall">En nuestro estudio el uso de matrices biol&#243;gicas neonatales alternativas ha sido esencial para confirmar el consumo de drogas de abuso en los casos con sospecha&#46; Tradicionalmente&#44; la orina ha sido la muestra utilizada para detectar el consumo de drogas durante el embarazo<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">3</span></a>&#46; Sin embargo&#44; en los neonatos con sospecha incluidos en nuestro estudio&#44; en nueve &#40;14&#44;1&#37;&#41; casos no se pudo obtener muestra de orina y en 11 &#40;33&#44;3&#37;&#41; de los casos positivos en los que pudo obtenerse fue negativa&#46; Se analiz&#243; cabello en cuatro &#40;6&#44;3&#37;&#41; neonatos con muestra de meconio no disponible o insuficiente para el an&#225;lisis y en ocho &#40;12&#44;5&#37;&#41; neonatos para confirmar los resultados&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">Nuestro trabajo presenta algunas limitaciones&#46; 1&#41; Los resultados de exposici&#243;n a alcohol no estuvieron disponibles durante el ingreso&#44; lo que imposibilit&#243; la toma de decisiones cl&#237;nicas inmediatas&#46; 2&#41; No se ha incluido un grupo control de neonatos sanos lo que podr&#237;a suponer un sesgo a la hora de evaluar variables como el test de Apgar&#44; tiempo de hospitalizaci&#243;n o requerimientos como VMNI&#44; entre otros&#46; Sin embargo&#44; es conocida la limitaci&#243;n de conseguir una muestra suficiente con este tipo de participantes&#46; 3&#41; No se incluyeron biomarcadores de exposici&#243;n al tabaco&#46; 4&#41; El an&#225;lisis en meconio puede detectar solo el consumo durante el segundo y tercer trimestre del embarazo&#46;</p><p id="par0305" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; existen alteraciones somatom&#233;tricas y factores de riesgo asociados a la exposici&#243;n a drogas de abuso que pueden ayudar a detectar precozmente a los neonatos expuestos y a reforzar la sospecha cl&#237;nica en el caso de que &#233;sta ya exista&#46; Adem&#225;s&#44; las alteraciones somatom&#233;tricas pueden servir para ampliar el diagn&#243;stico diferencial de estas alteraciones y el estudio de sus causas&#46; La detecci&#243;n de drogas de abuso durante el proceso asistencial permiti&#243; realizar un manejo cl&#237;nico m&#225;s preciso&#44; retirar la LM si el consumo de la madre continuaba e iniciar intervenciones sociales y seguimiento familiar&#46;</p></span></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Financiaci&#243;n</span><p id="par0310" class="elsevierStylePara elsevierViewall">Este estudio fue financiado por el proyecto <span class="elsevierStyleItalic">2017I033 Estudio de la incidencia de la exposici&#243;n prenatal a alcohol y otras sustancias de abuso en reci&#233;n nacidos ingresados en una secci&#243;n de neonatolog&#237;a mediante la determinaci&#243;n de biomarcadores en matrices biol&#243;gicas</span>&#44; del Plan Nacional sobre Drogas &#40;Ministerio de Sanidad&#44; Servicios Sociales e Igualdad&#44; Espa&#241;a&#41;&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Conflicto de intereses</span><p id="par0315" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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              "titulo" => "Participantes"
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    "fechaRecibido" => "2020-06-23"
    "fechaAceptado" => "2020-08-03"
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            0 => "Exposici&#243;n prenatal"
            1 => "Unidad de Cuidados Intensivos Neonatales"
            2 => "Biomarcadores"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La identificaci&#243;n temprana de los neonatos expuestos a drogas de abuso permite realizar un manejo cl&#237;nico m&#225;s preciso&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas cl&#237;nicas e identificar factores de riesgo asociados a la detecci&#243;n precoz de neonatos expuestos a drogas de abuso en una Unidad de Cuidados Intensivos e Intermedios Neonatales&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional prospectivo de neonatos con y sin sospecha cl&#237;nica de exposici&#243;n prenatal a drogas de abuso&#46; Se analiz&#243; meconio empleando t&#233;cnicas cromatogr&#225;ficas estandarizadas&#46; Se realizaron an&#225;lisis estad&#237;sticos univariante y multivariante&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 372 neonatos&#46; En 49 &#40;13&#44;2&#37;&#41; casos se detect&#243; exposici&#243;n a alguna droga de abuso&#59; en 41 &#40;83&#44;7&#37;&#41; a una&#44; y en ocho &#40;16&#44;3&#37;&#41; a m&#225;s de una&#46; La somatometr&#237;a al nacimiento objetiv&#243;&#58; a&#41; menor percentil de longitud en expuestos a alguna droga&#44; a m&#225;s de una y a cannabis&#59; b&#41; menor percentil de peso en expuestos a cannabis&#44; y de &#233;stos en comparaci&#243;n con los expuestos a alcohol&#46; En mayores de 34 semanas de gestaci&#243;n &#40;SG&#41;&#58; a&#41; menor percentil de longitud en expuestos a alguna droga&#59; b&#41; menor percentil de longitud y peso en expuestos a m&#225;s de una&#46; Los factores de riesgo independientes cl&#237;nicamente &#250;tiles para detectar casos de exposici&#243;n prenatal a drogas de abuso fueron &#40;<span class="elsevierStyleItalic">odds ratio</span> &#91;IC 95&#37;&#93;&#41;&#58; motivo de ingreso distinto a prematuridad &#40;5&#44;52 &#91;2&#44;55-1&#44;93&#93;&#41;&#44; percentil de longitud menor a 33 &#40;1&#44;95 &#91;1&#44;05-3&#44;60&#93;&#41; y &#40;2&#44;14 &#91;1&#44;04-3&#44;40&#93;&#41; en mayores de 34 SG y distocia social&#47;embarazo no controlado en mayores a 34SG &#40;4&#44;47 &#91;1&#44;03-19&#44;29&#93;&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Existen alteraciones somatom&#233;tricas y factores de riesgo que pueden ayudar a detectar precozmente a los neonatos expuestos a drogas de abuso&#46; Las alteraciones somatom&#233;tricas identificadas pueden servir para ampliar su diagn&#243;stico diferencial y el estudio de sus causas&#46;</p></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Early identification of neonates exposed to drugs of abuse during pregnancy allows a more precise clinical management&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objectives</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical characteristics and to identify risk factors associated with the early detection of neonates exposed to drugs of abuse in a Neonatal Intermediate and Intensive Care Unit&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Methods</span><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Prospective observational study of neonates with and without clinical suspicion of prenatal exposure to drugs of abuse&#46; Meconium was analyzed using standard chromatographic techniques&#46; Univariate and multivariate statistical analyzes were performed&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">372 neonates were included&#46; Exposure to drugs of abuse was detected in 49 &#40;13&#46;2&#37;&#41; cases&#58; in 41 &#40;83&#46;7&#37;&#41; one drug and in 8 &#40;16&#46;3&#37;&#41; more than one&#46; Somatometry at birth revealed&#58; a&#41; lower length percentile in those exposed to some drug&#44; more than one and cannabis&#59; b&#41; lower weight percentile in those exposed to cannabis and of these compared to those exposed to alcohol&#46; In neonates older than 34 pregnancy weeks &#40;PW&#41;&#58; a&#41; lower length percentile in those exposed to any substance&#59; b&#41; lower percentile of length and weight in exposed to more than one&#46; The most clinically relevant independent risk factors useful to detect cases of prenatal exposure to drugs of abuse were &#40;Odds ratio &#40;95&#37; CI&#41;&#41;&#58; reason for admission other than prematurity &#40;5&#46;52 &#40;2&#46;55-1&#46;93&#41;&#41;&#44; length percentile less than 33 &#40;1&#46;95 &#40;1&#46;05-3&#46;60&#41; and 2&#46;14 &#40;1&#46;04-3&#46;40&#41; in older than 34 PW&#41; and social dystocia&#47;uncontrolled pregnancy in older than 34 PW &#40;4&#46;47 &#40;1&#46;03-19&#46;29&#41;&#41;&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">There are somatometric alterations and risk factors that can help in the early detection of neonates exposed to drugs of abuse&#46; The somatometric alterations identified can be useful to extend the differential diagnosis of these alterations and to study their causes&#46;</p></span>"
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                  \t\t\t\t">7&#44;0&#160;&#177;&#160;3&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;3&#160;&#177;&#160;2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Apgar 5 minutos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;4&#160;&#177;&#160;1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;3&#160;&#177;&#160;1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;1&#160;&#177;&#160;1&#44;3<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;5&#160;&#177;&#160;0&#44;6<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;5&#160;&#177;&#160;1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;4&#160;&#177;&#160;0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;5&#160;&#177;&#160;2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>pH cord&#243;n umbilical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;28&#160;&#177;&#160;0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;28&#160;&#177;&#160;0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;27&#160;&#177;&#160;0&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;28&#160;&#177;&#160;0&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;26&#160;&#177;&#160;0&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;26&#160;&#177;&#160;0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;28&#160;&#177;&#160;0&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peso &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;266&#44;0&#160;&#177;&#160;784&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;223&#44;7&#160;&#177;&#160;789&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;544&#44;6&#160;&#177;&#160;699&#44;8<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;454&#44;2&#160;&#177;&#160;734&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;633&#44;6&#160;&#177;&#160;656&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;931&#44;7&#160;&#177;&#160;677&#44;1<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;403&#44;1&#160;&#177;&#160;371&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Longitud &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;7&#160;&#177;&#160;4&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;5&#160;&#177;&#160;4&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#44;2&#160;&#177;&#160;3&#44;8<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#44;0&#160;&#177;&#160;4&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;9&#160;&#177;&#160;2&#44;7<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#44;3&#160;&#177;&#160;2&#44;8<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;9&#160;&#177;&#160;3&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PC &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;3&#160;&#177;&#160;3&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;1 &#177;&#160;3&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;6&#160;&#177;&#160;3&#44;5<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;0&#160;&#177;&#160;2&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;5&#160;&#177;&#160;2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;2&#160;&#177;&#160;1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;9&#160;&#177;&#160;7&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil peso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;5 &#91;15&#44;0-63&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;0 &#91;15&#44;0-63&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;0 &#91;10&#44;0-60&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;5 &#91;8&#44;5-52&#44;3&#93;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#44;0 &#91;17&#44;0-83&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;0 &#91;12&#44;8-79&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#44;5 &#91;1&#44;5-32&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil longitud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#44;0 &#91;17&#44;0-67&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;0 &#91;21&#44;0-72&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;0 &#91;9&#44;0-52&#44;5&#93;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;0 &#91;8&#44;0-49&#44;5&#93;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;0 &#91;12&#44;0-43&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;0 &#91;33&#44;3-85&#44;3&#93;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0 &#91;3&#44;0-43&#44;8&#93;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil PC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;0 &#91;17&#44;0-70&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;0 &#91;19&#44;0-70&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;0 &#91;10&#44;5-63&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;0 &#91;10&#44;3-51&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;0 &#91;26&#44;0-73&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;5 &#91;18&#44;8-74&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;0 &#91;4&#44;5-64&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>EG &#40;semanas&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#44;1&#160;&#177;&#160;3&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#44;8&#160;&#177;&#160;3&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;0&#160;&#177;&#160;3&#44;4<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;9&#160;&#177;&#160;3&#44;4<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;5&#160;&#177;&#160;3&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;3&#160;&#177;&#160;2&#44;4<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;3&#160;&#177;&#160;4&#44;2<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Grado de prematuridad &#40;semanas&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;&#160;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;3&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;3&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;4&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>28-34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136 &#40;36&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127 &#40;39&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;18&#44;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;20&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;18&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;16&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;12&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;&#160;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">225 &#40;60&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">186 &#40;57&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;79&#44;6&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;75&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;81&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;83&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;87&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Caracter&#237;sticas al alta</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil peso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;0 &#91;6&#44;0-40&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;5 &#91;6&#44;0-40&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#44;0 &#91;4&#44;0-31&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;5 &#91;4&#44;0-30&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0 &#91;8&#44;0-58&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;0 &#91;6&#44;0-78&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;5 &#91;1&#44;5-22&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil longitud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;0 &#91;10&#44;0-55&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;0 &#91;10&#44;0-56&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#44;0 &#91;10&#44;0-53&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;5 &#91;11&#44;5-51&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#44;0 &#91;10&#44;0-55&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#44;0 &#91;39&#44;3-70&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;0 &#91;1&#44;5-34&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil PC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;0 &#91;19&#44;0-60&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;0 &#91;20&#44;0-62&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;0 &#91;10&#44;0-50&#44;0&#93;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;0 &#91;10&#44;0-55&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;0 &#91;17&#44;0-50&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;5 &#91;10&#44;5-53&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;0 &#91;1&#44;5-46&#44;3&#93;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  \t\t\t\t">1 &#40;20&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Apgar 5 minutos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#44;7&#160;&#177;&#160;1&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&#44;9&#160;&#177;&#160;1&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&#44;5&#160;&#177;&#160;0&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&#44;6&#160;&#177;&#160;2&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>pH de cord&#243;n umbilical&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&#44;27&#160;&#177;&#160;0&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&#44;27&#160;&#177;&#160;0&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&#44;26&#160;&#177;&#160;0&#44;12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&#44;28&#160;&#177; 0&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peso &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">2&#46;696&#160;&#177;&#160;650&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">47&#44;2&#160;&#177;&#160;3&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47&#44;2&#160;&#177;&#160;3&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47&#44;4&#160;&#177;&#160;2&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">47&#44;6&#160;&#177;&#160;3&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">50&#44;1&#160;&#177;&#160;2&#44;4<a class="elsevierStyleCrossRefs" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#44;b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;0&#160;&#177;&#160;2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;9&#160;&#177;&#160;2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;5&#160;&#177;&#160;3&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;2&#160;&#177;&#160;1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;1&#160;&#177;&#160;1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#44;4&#160;&#177;&#160;1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#44;1&#160;&#177;&#160;6&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil peso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;0 &#91;10&#44;0-56&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;0 &#91;10&#44;0-57&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;0 &#91;8&#44;0-42&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;5 &#91;6&#44;8-36&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;0 &#91;16&#44;5-72&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#44;0 &#91;9&#44;5-80&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;0 &#91;1&#44;0-30&#44;0&#93;<a class="elsevierStyleCrossRef" href="#tblfn0025">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil longitud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;0 &#91;13&#44;5-62&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;0 &#91;15&#44;0-63&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;0 &#91;8&#44;0-46&#44;0&#93;<a class="elsevierStyleCrossRef" href="#tblfn0025">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#44;0 &#91;7&#44;5-48&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;0 &#91;11&#44;5-42&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#44;0 &#91;25&#44;5-79&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;0 &#91;3&#44;0-37&#44;0&#93;<a class="elsevierStyleCrossRef" href="#tblfn0025">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil PC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;0 &#91;14&#44;0-65&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#44;5 &#91;15&#44;0-67&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;0 &#91;10&#44;0-50&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#44;0 &#91;10&#44;0-52&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;0 &#91;25&#44;5-61&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;0 &#91;13&#44;5-53&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0 &#91;3&#44;0-61&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>EG &#40;semanas&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;5&#160;&#177;&#160;2&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;3&#160;&#177;&#160;2&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;5&#160;&#177;&#160;1&#44;7<a class="elsevierStyleCrossRef" href="#tblfn0025">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;7&#160;&#177;&#160;1&#44;5<a class="elsevierStyleCrossRef" href="#tblfn0025">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;7&#160;&#177;&#160;2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;2&#160;&#177;&#160;1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;6&#160;&#177;&#160;2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Caracter&#237;sticas al alta</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil peso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;5 &#91;4&#44;3-47&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;0 &#91;5&#44;0-49&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0 &#91;3&#44;0-24&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;5 &#91;3&#44;0-36&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0 &#91;5&#44;0-34&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#44;0 &#91;5&#44;0-78&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0 &#91;1&#44;0-17&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil longitud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;5 &#91;10&#44;0-61&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;0 &#91;10&#44;0-63&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;0 &#91;10&#44;0-54&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;5 &#91;12&#44;3-52&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;0 &#91;10&#44;0-44&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#44;0 &#91;29&#44;5-78&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0 &#91;1&#44;0-36&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Percentil PC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;0 &#91;16&#44;0-60&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;0 &#91;19&#44;0-62&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;0 &#91;10&#44;0-45&#44;0&#93;<a class="elsevierStyleCrossRef" href="#tblfn0025">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;0 &#91;10&#44;0-43&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;0 &#91;15&#44;5-47&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#44;0 &#91;8&#44;0-48&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipoglucemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Convulsiones&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Distocia social&#47;embarazo no controlado&#47;adopci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;10&#44;2&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;25&#44;0&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atresia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Malformaci&#243;n&#44; ventriculomegalia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hiperbilirrubinemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sospecha de infecci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Distensi&#243;n abdominal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Otras causas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;16&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sospecha cl&#237;nica de exposici&#243;n prenatal a drogas de abuso</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">64 &#40;17&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">28 &#40;8&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36 &#40;73&#44;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">20 &#40;83&#44;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045">&#42;</a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0050"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;100&#44;0&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;87&#44;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0045">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Embarazo m&#250;ltiple</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="8" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Diagn&#243;sticos durante el ingreso en UCIN</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">HIV</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HIV grado <span class="elsevierStyleSmallCaps">i</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">44 &#40;11&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HIV grado <span class="elsevierStyleSmallCaps">ii</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;2&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;3&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HIV grado <span class="elsevierStyleSmallCaps">iii</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;0&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CIR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Asfixia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bajo peso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Consumo materno de drogas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Distr&#233;s&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipoglucemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Convulsiones&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Distocia social&#47;embarazo no controlado&#47;adopci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;12&#44;8&#41;<a class="elsevierStyleCrossRef" href="#tblfn0065">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;28&#44;6&#41;<a class="elsevierStyleCrossRef" href="#tblfn0065">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;2&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atresia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Malformaci&#243;n&#44; ventriculomegalia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hiperbilirrubinemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sospecha de infecci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Distensi&#243;n abdominal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Otras causas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19 &#40;8&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">15 &#40;8&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;10&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;22&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sospecha cl&#237;nica de exposici&#243;n prenatal a drogas de abuso</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">54 &#40;24&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#40;11&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32 &#40;82&#44;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0065">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;100&#41;<a class="elsevierStyleCrossRef" href="#tblfn0065">&#42;</a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0070"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;33&#44;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0075"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;100&#41;<a class="elsevierStyleCrossRef" href="#tblfn0065">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;85&#44;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0065">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Embarazo m&#250;ltiple</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HIV grado <span class="elsevierStyleSmallCaps">i</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HIV grado <span class="elsevierStyleSmallCaps">ii</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Neumot&#243;rax</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Surfactante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Terapia de ox&#237;geno domiciliaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Inotr&#243;picos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad cronol&#243;gica a la retirada de la SNG &#40;semanas&#41;&nbsp;\t\t\t\t\t\t\n
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