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siendo el principal indicador del diagn&#243;stico&#46; Un ni&#241;o con angioma facial en esta localizaci&#243;n tiene un riesgo del 10-25&#37; de tener lesiones cerebrales y&#47;o oculares concomitantes&#44; lo que parece tener relaci&#243;n con la extensi&#243;n de los angiomas faciales&#44; especialmente si son bilaterales<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a>&#46; No obstante&#44; se observ&#243; que un paciente con angioma facial bilateral presentaba solo dilataci&#243;n venosa profunda en la RM&#44; sin s&#237;ntomas neurol&#243;gicos &#40;caso 7&#41;&#46; Adem&#225;s&#44; el caso m&#225;s grave desde el punto de vista neurol&#243;gico no presentaba angioma facial &#40;caso 11&#41;&#46; Esta paciente ten&#237;a una forma de presentaci&#243;n cut&#225;nea rara&#58; atriquia en la zona de afectaci&#243;n cerebral&#46; Est&#225; descrito por lo menos un caso similar<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; Los autores consideraron que se trata de una variante de SSW&#44; ya que cerca del 13&#37; de los casos no tienen el angioma facial<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5&#44;9-14</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Cuatro pacientes presentaban angiomas en los miembros&#44; una localizaci&#243;n caracter&#237;stica del s&#237;ndrome de Klippel-Trenaunay&#44; estando ya descrita la ocurrencia de fenotipos sobrepuestos entre los dos s&#237;ndromes<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Manifestaciones oculares</span><p id="par0055" class="elsevierStylePara elsevierViewall">Los angiomas oculares conducen a la aparici&#243;n de glaucoma&#44; la complicaci&#243;n ocular m&#225;s frecuente que aparece en el 30-40&#37; de los casos<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> y que se observ&#243; en el 31&#37; de la muestra&#46; Si no se trata&#44; puede causar p&#233;rdida de visi&#243;n<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#44; lo que no sucedi&#243; en ning&#250;n caso&#46; A pesar de que su aparici&#243;n es m&#225;s frecuente durante el primer a&#241;o de vida&#44; puede aparecer a cualquier edad<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; Por eso&#44; todos los ni&#241;os con SSW deben ser vigilados regularmente por un oftalm&#243;logo&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Manifestaciones neurol&#243;gicas</span><p id="par0060" class="elsevierStylePara elsevierViewall">Los vasos cerebrales an&#243;malos condicionan alteraciones en el tejido cerebral circundante<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; La isquemia cortical cr&#243;nica evoluciona hacia &#225;reas de calcificaci&#243;n&#44; gliosis o atrofia cerebral&#44; pudiendo provocar la aparici&#243;n de s&#237;ntomas neurol&#243;gicos<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Las crisis epil&#233;pticas se presentan en el 80&#37; de los pacientes y ocurren habitualmente antes de los 2 a&#241;os de edad<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5&#44;16</span></a>&#46; Las primeras crisis suelen ser parciales&#44; pero a lo largo del tiempo evolucionan a crisis generalizadas<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;17</span></a>&#46; M&#225;s raramente pueden manifestarse como espasmos en flexi&#243;n&#44; mioclon&#237;as o crisis at&#243;nicas<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5&#44;17&#44;18</span></a>&#46; De los 13 pacientes estudiados&#44; solo 6 &#40;46&#37;&#41; presentaban epilepsia&#44; que se manifest&#243; en todos como crisis parciales complejas antes de los 2 a&#241;os de edad&#46; En cerca del 40&#37; de los casos hay buena respuesta al tratamiento con antiepil&#233;pticos<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#44; tal y como se observ&#243; en 5 de los 6 ni&#241;os con epilepsia&#46; Crisis frecuentes y prolongadas provocan un agravamiento de las lesiones cerebrales&#46; La aparici&#243;n de epilepsia antes del a&#241;o de edad&#44; as&#237; como la mala respuesta al tratamiento antiepil&#233;ptico son&#44; por tanto&#44; factores de mal pron&#243;stico<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5&#44;19</span></a>&#46; Se debe considerar la lobectom&#237;a&#47;hemisferectom&#237;a en los casos de epilepsia farmacorresistente&#44; como en el caso 11<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Cerca del 33&#37; de los pacientes presentan hemiplej&#237;a&#44; tal como se observ&#243; en 4 ni&#241;os de la muestra &#40;31&#37;&#41;&#44; debido a la oclusi&#243;n venosa o anoxia de los tejidos locales&#46; Habitualmente es transitoria&#44; pero la recurrencia de los episodios evoluciona a una hemiplej&#237;a persistente<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;5</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">La hemianopsia se detecta en cerca del 40&#37; de los pacientes y aparece cuando hay compromiso del l&#243;bulo occipital&#44; lo que sucedi&#243; en el caso 11<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Cerca del 60&#37; de los pacientes tienen retraso del desarrollo psicomotor&#44; que parece tener relaci&#243;n con la extensi&#243;n de las lesiones cerebrales y con la gravedad y la edad de inicio de la epilepsia<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;5&#44;19</span></a>&#46; En el grupo analizado&#44; 7 pacientes &#40;54&#37;&#41; presentan retraso del desarrollo&#44; aunque 2 sin epilepsia y 2 sin lesiones cerebrales en la RM &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Imagen cerebral</span><p id="par0085" class="elsevierStylePara elsevierViewall">La RM cerebral es el examen de elecci&#243;n para evaluar el grado de afectaci&#243;n cerebral&#46; La imagen m&#225;s t&#237;pica es el angioma leptomen&#237;ngeo&#44; que se traduce por captaci&#243;n de contraste en la duramadre en las secuencias T1&#44; y que se observ&#243; en casi la mitad de los casos<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; Otras im&#225;genes t&#237;picas son la dilataci&#243;n del plexo coroideo&#44; &#225;reas de calcificaci&#243;n y atrofia corticales&#44; presentes en casi la mitad de la muestra&#44; y dilataci&#243;n del sistema venoso profundo&#44; presente en 2 casos<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;17</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Las lesiones cerebrales son ipsolaterales al angioma facial y en la mayor&#237;a&#44; unilaterales&#46; El compromiso bilateral ocurre en el 7-26&#37; y se asocia a un mayor riesgo de presentar epilepsia refractaria y retraso psicomotor<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;15</span></a>&#46; Tres pacientes de la muestra ten&#237;an lesiones cerebrales bilaterales&#44; todos con epilepsia&#44; y 2 de ellos con retraso del desarrollo&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">En la RM cerebral de una paciente se observ&#243; una anomal&#237;a venosa de localizaci&#243;n at&#237;pica en el cerebelo &#40;caso 1&#41;&#46; Ya que no hab&#237;a afectaci&#243;n arterial o anomal&#237;a estructural cerebelosa o de otro tipo concomitante&#44; se descart&#243; el diagn&#243;stico de s&#237;ndrome PHACE y se consider&#243; el diagn&#243;stico de SSW&#46; Est&#225;n descritos muy pocos casos de SSW con anomal&#237;as cerebelosas&#44; todos ellos tambi&#233;n con afectaci&#243;n supratentorial<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6&#44;15&#44;17</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Frente a un ni&#241;o con angioma facial en el territorio inervado por la primera rama trigeminal&#44; se debe realizar RM cerebral siempre que surjan s&#237;ntomas neurol&#243;gicos o a los 2 a&#241;os de edad en los pacientes asintom&#225;ticos<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a>&#46; En edades precoces puede no haber anomal&#237;as de neuroimagen&#59; as&#237;&#44; si la RM es normal en los lactantes sintom&#225;ticos&#44; es necesario repetirla con 1-2 a&#241;os de edad<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a>&#46; Por otro lado&#44; puede haber alteraciones de neuroimagen sin s&#237;ntomas neurol&#243;gicos&#44; como en 2 ni&#241;os de esta muestra&#44; por lo que se debe realizar RM incluso en los ni&#241;os asintom&#225;ticos&#46; Si la RM es normal a los 2 a&#241;os de edad&#44; no es necesario repetirla&#44; a menos que aparezcan s&#237;ntomas<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">La tomograf&#237;a computarizada permite la visualizaci&#243;n de &#225;reas de calcificaci&#243;n cortical &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; pudiendo tener alguna utilidad s&#243;lo cuando la RM no est&#225; disponible<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">En resumen&#44; la cl&#237;nica presentada es variable y no siempre hay relaci&#243;n entre la gravedad de las manifestaciones cut&#225;neas&#44; neurol&#243;gicas y oculares entre s&#237;&#44; y con las alteraciones cerebrales&#44; que pueden ocurrir hasta en ausencia de s&#237;ntomas neurol&#243;gicos&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p id="par0130" class="elsevierStylePara elsevierViewall">Los autores declaran que no existe ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "titulo" => "Pacientes y m&#233;todos"
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          "titulo" => "Discusi&#243;n"
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            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Manifestaciones cut&#225;neas"
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            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Manifestaciones oculares"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Manifestaciones neurol&#243;gicas"
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            3 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Imagen cerebral"
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          "titulo" => "Conflicto de intereses"
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    "fechaRecibido" => "2011-07-27"
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            2 => "Glaucoma"
            3 => "S&#237;ndrome"
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            0 => "Angioma"
            1 => "Epilepsy"
            2 => "Glaucoma"
            3 => "Syndrome"
            4 => "Sturge-Weber"
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    "resumen" => array:2 [
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        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de Sturge-Weber es un s&#237;ndrome neurocut&#225;neo raro cuya gravedad est&#225; determinada por el grado de afectaci&#243;n cerebral y el control de la epilepsia&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los autores describen y analizan las caracter&#237;sticas cl&#237;nicas y de neuroimagen de este s&#237;ndrome&#44; a trav&#233;s de un estudio retrospectivo de 13 pacientes &#40;8 ni&#241;as&#59; con edad en la primera consulta entre los 15 d&#237;as y los 9 a&#241;os&#41;&#46; Doce presentaban angioma facial y una atriquia en la zona de afectaci&#243;n cerebral&#46; Se diagnostic&#243; epilepsia en 6 casos&#44; hemiplej&#237;a en 4&#44; retraso psicomotor en 7 y glaucoma en 4 casos&#46; Se encontraron alteraciones cerebrales en 10 ni&#241;os&#44; 3 sin sintomatolog&#237;a neurol&#243;gica&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La cl&#237;nica presentada es variable y no siempre hay relaci&#243;n entre la gravedad cl&#237;nica y las anomal&#237;as de neuroimagen&#44; que pueden aparecer hasta en ausencia de s&#237;ntomas neurol&#243;gicos&#46;</p>"
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      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Sturge Weber Syndrome is a rare neurocutaneous syndrome in which the severity is determined by degree of brain involvement and control of epilepsy&#46; The authors describe and analyse clinical and imaging features of this syndrome&#44; through a retrospective study of 13 patients &#40;8 girls&#59; aged between 15 days and 9 years at first visit&#41;&#46; Twelve had facial angioma and one had atrichia corresponding to the area of brain involvement&#46; Epilepsy was diagnosed in 6 cases&#44; hemiplegia in 4&#44; psychomotor delay in 7&#44; and glaucoma in 4&#46; Cerebral abnormalities were found in 10 children&#44; 3 without neurological symptoms&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The clinical signs and symptoms vary and there is not always a relationship between the severity of the clinical and neuroimaging abnormalities&#44; which may occur even in the absence of neurological symptoms&#46;</p>"
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          "es" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Ejemplos de manifestaciones cut&#225;neas&#58; caso 4&#44; angioma facial a la izquierda&#59; caso 5&#44; angiomas en la cara&#44; el tronco y los miembros&#44; de tonalidad m&#225;s clara 8 a&#241;os despu&#233;s&#59; caso 10&#44; angioma a la izquierda&#44; m&#225;s discreto 10 a&#241;os despu&#233;s&#59; caso 11&#44; zona de atriquia ipsolateral a las lesiones cerebrales&#59; caso 12&#44; angiomas bilaterales en la cara&#44; el tronco y los miembros&#46;</p>"
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          "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ejemplos de anomal&#237;as de neuroimagen&#46; A&#41; Caso 1&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angioma de la coroides a la izquierda &#40;flecha&#41;&#46; B&#41; Caso 4&#44; RM&#44; corte coronal&#44; secuencia en T2&#58; calcificaciones corticales y atrofia parietooccipital a la izquierda &#40;flecha&#41;&#46; C&#41; Caso 4&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angiomatosis pial &#40;flecha&#41; y atrofia cortical a la izquierda&#44; con asimetr&#237;a hemisf&#233;rica y de la calota craneal&#46; D&#41; Caso 4&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angiomatosis pial&#44; angioma del plexo coroideo &#40;flecha&#41; y atrofia cortical a la izquierda&#46; E&#41; Caso 10&#44; RM&#44; corte axial&#44; secuencia T2&#58; calcificaciones y atrofia del hemisferio izquierdo&#44; gliosis del par&#233;nquima adyacente &#40;flecha&#41;&#59; dilataci&#243;n de vena prepontina&#46; F&#41; Caso 10&#44; RM&#44; corte axial&#44; secuencia en T2&#58; calcificaciones y atrofia parietal a la izquierda&#59; plexo coroideo mayor a la izquierda &#40;flecha&#41;&#46; G&#41; Caso 11&#44; RM&#44; corte axial&#44; secuencia en T1&#44; con contraste&#58; &#225;rea encefalocl&#225;stica cortico-subcortical parieto-occipital&#44; angiomatosis pial y plexo venoso m&#225;s prominente a la derecha &#40;flecha&#41;&#46; H&#41; Caso 11&#44; TC&#44; corte axial&#44; sin contraste&#58; calcificaciones corticales parieto-occipitales a la derecha &#40;flecha&#41;&#46;</p>"
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          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Bi&#58; bilateral&#59; CBZ&#58; carbamazepina&#59; D&#58; a la derecha&#59; FNB&#58; fenobarbital&#59; I&#58; a la izquierda&#59; M&#58; meses&#59; PC&#58; parciales complejas&#59; VPA&#58; valproato&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">Caso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Edad en la 1&#46;&#170; consulta &#40;meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Edad actual &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Angioma facial&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Angioma&#44; otras localizaciones&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Otras anomal&#237;as cut&#225;neas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Epilepsia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Hemiplej&#237;a&#47; hemianopsia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Retraso psicomotor&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Glaucoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Alteraciones de neuroimagen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&#44; cerebelo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">113&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&#44; cuello y paladar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">T&#243;rax y miembros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Crisis PC a los 18<span class="elsevierStyleHsp" style=""></span>M&#59; controlada con CBZ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&#44; cuello y miembros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t" style="border-bottom: 2px solid black">Caso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Localizaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Angioma leptomen&#237;ngeo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Calcificaciones corticales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Atrofia cerebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Dilataci&#243;n del plexo coroideo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Aceleraci&#243;n de la mielinizaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Alteraciones venosas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICerebelo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ITemporal&#44; parietal y occipital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BiParietal D y occipital Bi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ITemporal&#44; parietal y occipital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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Original breve
Síndrome de Sturge-Weber: variabilidad clínica y de neuroimagen
Sturge-Weber syndrome –clinical and neuroimaging variability
M. Riosa,
Autor para correspondencia
martariospinho@gmail.com

Autor para correspondencia.
, C. Barbota, P.S. Pintob, L. Salícioa, M. Santosa, I. Carrilhoa, T. Temudoa
a Servicio de Neuropediatría, Centro Hospitalar do Porto, Oporto, Portugal
b Servicio de Neuroradiología, Centro Hospitalar do Porto, Oporto, Portugal
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          "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ejemplos de anomal&#237;as de neuroimagen&#46; A&#41; Caso 1&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angioma de la coroides a la izquierda &#40;flecha&#41;&#46; B&#41; Caso 4&#44; RM&#44; corte coronal&#44; secuencia en T2&#58; calcificaciones corticales y atrofia parietooccipital a la izquierda &#40;flecha&#41;&#46; C&#41; Caso 4&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angiomatosis pial &#40;flecha&#41; y atrofia cortical a la izquierda&#44; con asimetr&#237;a hemisf&#233;rica y de la calota craneal&#46; D&#41; Caso 4&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angiomatosis pial&#44; angioma del plexo coroideo &#40;flecha&#41; y atrofia cortical a la izquierda&#46; E&#41; Caso 10&#44; RM&#44; corte axial&#44; secuencia T2&#58; calcificaciones y atrofia del hemisferio izquierdo&#44; gliosis del par&#233;nquima adyacente &#40;flecha&#41;&#59; dilataci&#243;n de vena prepontina&#46; F&#41; Caso 10&#44; RM&#44; corte axial&#44; secuencia en T2&#58; calcificaciones y atrofia parietal a la izquierda&#59; plexo coroideo mayor a la izquierda &#40;flecha&#41;&#46; G&#41; Caso 11&#44; RM&#44; corte axial&#44; secuencia en T1&#44; con contraste&#58; &#225;rea encefalocl&#225;stica cortico-subcortical parieto-occipital&#44; angiomatosis pial y plexo venoso m&#225;s prominente a la derecha &#40;flecha&#41;&#46; H&#41; Caso 11&#44; TC&#44; corte axial&#44; sin contraste&#58; calcificaciones corticales parieto-occipitales a la derecha &#40;flecha&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El s&#237;ndrome de Sturge-Weber &#40;SSW&#41; es un s&#237;ndrome neurocut&#225;neo raro &#40;incidencia de 1&#47;20-50&#46;000&#41; que se caracteriza por angiomas en el territorio inervado por la primera rama trigeminal&#44; leptomeninges y&#47;o coroides ocular<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-4</span></a>&#46; La gravedad est&#225; determinada por el grado de afectaci&#243;n cerebral y el control de la epilepsia<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-4</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El objetivo de este trabajo es describir y analizar las caracter&#237;sticas cl&#237;nicas y de neuroimagen de este s&#237;ndrome&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="par0015" class="elsevierStylePara elsevierViewall">Estudio retrospectivo y descriptivo&#44; basado en la consulta de los expedientes cl&#237;nicos de una muestra consecutiva de 13 pacientes con diagn&#243;stico de SSW seguidos en una consulta de neuropediatr&#237;a&#46; Se incluy&#243; a pacientes con los 3 tipos de SSW reconocidos&#58; angioma facial y leptomen&#237;ngeo con o sin glaucoma &#40;tipo I&#41;&#44; angioma facial y glaucoma &#40;tipo II&#41; y angioma leptomen&#237;ngeo sin angioma facial &#40;tipo III&#41;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a>&#46; Tambi&#233;n se han incluido casos de angioma facial asociado a otro tipo de anomal&#237;as cerebrales t&#237;picas del SSW &#40;tales como dilataci&#243;n venosa profunda&#41;&#44; anomal&#237;a venosa del cerebelo y retraso psicomotor&#46; Se analizaron los siguientes par&#225;metros&#58; sexo&#44; edad&#44; manifestaciones cl&#237;nicas y anomal&#237;as de neuroimagen&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p id="par0020" class="elsevierStylePara elsevierViewall">Se observ&#243; a 13 pacientes &#40;8 ni&#241;as&#41;&#44; con mediana de edad en la primera consulta de 4 meses &#40;m&#237;nimo 15 d&#237;as&#44; m&#225;ximo 9 a&#241;os&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Doce ni&#241;os presentaban el t&#237;pico angioma facial&#44; bilateral en 5 casos &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a> y <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; En 8 se observaron angiomas en otras localizaciones&#44; como en los miembros en 4 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a> y <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La &#250;nica paciente sin angioma facial presentaba una zona de atriquia en la regi&#243;n parieto-temporal derecha&#44; correspondiente a la zona de afectaci&#243;n cerebral &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#44; caso 11&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Seis ni&#241;os presentaron crisis epil&#233;pticas parciales complejas &#40;edad de inicio&#58; promedio de 9 meses&#44; m&#225;ximo 22 meses&#44; m&#237;nimo 3 semanas&#41;&#46; Cinco casos est&#225;n controlados con medicaci&#243;n anticomicial &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La &#250;nica paciente con epilepsia farmacorresistente no tiene angioma facial y aguarda tratamiento quir&#250;rgico &#40;caso 11&#41;&#46; Cuatro ni&#241;os tienen hemiplej&#237;a&#44; 1 hemianopsia y 7 retraso psicomotor&#44; 2 de ellos sin epilepsia &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">En 4 casos se asoci&#243; glaucoma&#44; ninguno con p&#233;rdida total de la visi&#243;n&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En 10 ni&#241;os se encontraron alteraciones en la resonancia magn&#233;tica &#40;RM&#41; cerebral&#58; angioma leptomen&#237;ngeo &#40;7&#41;&#44; calcificaciones corticales &#40;4&#41;&#44; atrofia cerebral &#40;5&#41;&#44; dilataci&#243;n del plexo coroideo &#40;5&#41; y&#47;o alteraciones venosas&#58; 2 dilataci&#243;n venosa profunda&#44; 1 malformaci&#243;n venosa en el cerebelo &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a> y <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Dos de ellos no presentaban s&#237;ntomas neurol&#243;gicos &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Manifestaciones cut&#225;neas</span><p id="par0045" class="elsevierStylePara elsevierViewall">La cl&#237;nica fue variable&#59; sin embargo&#44; el t&#237;pico angioma facial con afectaci&#243;n de la regi&#243;n frontal y&#47;o el p&#225;rpado superior fue un signo pr&#225;cticamente constante&#44; siendo el principal indicador del diagn&#243;stico&#46; Un ni&#241;o con angioma facial en esta localizaci&#243;n tiene un riesgo del 10-25&#37; de tener lesiones cerebrales y&#47;o oculares concomitantes&#44; lo que parece tener relaci&#243;n con la extensi&#243;n de los angiomas faciales&#44; especialmente si son bilaterales<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a>&#46; No obstante&#44; se observ&#243; que un paciente con angioma facial bilateral presentaba solo dilataci&#243;n venosa profunda en la RM&#44; sin s&#237;ntomas neurol&#243;gicos &#40;caso 7&#41;&#46; Adem&#225;s&#44; el caso m&#225;s grave desde el punto de vista neurol&#243;gico no presentaba angioma facial &#40;caso 11&#41;&#46; Esta paciente ten&#237;a una forma de presentaci&#243;n cut&#225;nea rara&#58; atriquia en la zona de afectaci&#243;n cerebral&#46; Est&#225; descrito por lo menos un caso similar<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; Los autores consideraron que se trata de una variante de SSW&#44; ya que cerca del 13&#37; de los casos no tienen el angioma facial<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5&#44;9-14</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Cuatro pacientes presentaban angiomas en los miembros&#44; una localizaci&#243;n caracter&#237;stica del s&#237;ndrome de Klippel-Trenaunay&#44; estando ya descrita la ocurrencia de fenotipos sobrepuestos entre los dos s&#237;ndromes<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Manifestaciones oculares</span><p id="par0055" class="elsevierStylePara elsevierViewall">Los angiomas oculares conducen a la aparici&#243;n de glaucoma&#44; la complicaci&#243;n ocular m&#225;s frecuente que aparece en el 30-40&#37; de los casos<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> y que se observ&#243; en el 31&#37; de la muestra&#46; Si no se trata&#44; puede causar p&#233;rdida de visi&#243;n<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#44; lo que no sucedi&#243; en ning&#250;n caso&#46; A pesar de que su aparici&#243;n es m&#225;s frecuente durante el primer a&#241;o de vida&#44; puede aparecer a cualquier edad<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; Por eso&#44; todos los ni&#241;os con SSW deben ser vigilados regularmente por un oftalm&#243;logo&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Manifestaciones neurol&#243;gicas</span><p id="par0060" class="elsevierStylePara elsevierViewall">Los vasos cerebrales an&#243;malos condicionan alteraciones en el tejido cerebral circundante<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; La isquemia cortical cr&#243;nica evoluciona hacia &#225;reas de calcificaci&#243;n&#44; gliosis o atrofia cerebral&#44; pudiendo provocar la aparici&#243;n de s&#237;ntomas neurol&#243;gicos<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Las crisis epil&#233;pticas se presentan en el 80&#37; de los pacientes y ocurren habitualmente antes de los 2 a&#241;os de edad<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5&#44;16</span></a>&#46; Las primeras crisis suelen ser parciales&#44; pero a lo largo del tiempo evolucionan a crisis generalizadas<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;17</span></a>&#46; M&#225;s raramente pueden manifestarse como espasmos en flexi&#243;n&#44; mioclon&#237;as o crisis at&#243;nicas<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5&#44;17&#44;18</span></a>&#46; De los 13 pacientes estudiados&#44; solo 6 &#40;46&#37;&#41; presentaban epilepsia&#44; que se manifest&#243; en todos como crisis parciales complejas antes de los 2 a&#241;os de edad&#46; En cerca del 40&#37; de los casos hay buena respuesta al tratamiento con antiepil&#233;pticos<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#44; tal y como se observ&#243; en 5 de los 6 ni&#241;os con epilepsia&#46; Crisis frecuentes y prolongadas provocan un agravamiento de las lesiones cerebrales&#46; La aparici&#243;n de epilepsia antes del a&#241;o de edad&#44; as&#237; como la mala respuesta al tratamiento antiepil&#233;ptico son&#44; por tanto&#44; factores de mal pron&#243;stico<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5&#44;19</span></a>&#46; Se debe considerar la lobectom&#237;a&#47;hemisferectom&#237;a en los casos de epilepsia farmacorresistente&#44; como en el caso 11<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Cerca del 33&#37; de los pacientes presentan hemiplej&#237;a&#44; tal como se observ&#243; en 4 ni&#241;os de la muestra &#40;31&#37;&#41;&#44; debido a la oclusi&#243;n venosa o anoxia de los tejidos locales&#46; Habitualmente es transitoria&#44; pero la recurrencia de los episodios evoluciona a una hemiplej&#237;a persistente<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;5</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">La hemianopsia se detecta en cerca del 40&#37; de los pacientes y aparece cuando hay compromiso del l&#243;bulo occipital&#44; lo que sucedi&#243; en el caso 11<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Cerca del 60&#37; de los pacientes tienen retraso del desarrollo psicomotor&#44; que parece tener relaci&#243;n con la extensi&#243;n de las lesiones cerebrales y con la gravedad y la edad de inicio de la epilepsia<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;5&#44;19</span></a>&#46; En el grupo analizado&#44; 7 pacientes &#40;54&#37;&#41; presentan retraso del desarrollo&#44; aunque 2 sin epilepsia y 2 sin lesiones cerebrales en la RM &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Imagen cerebral</span><p id="par0085" class="elsevierStylePara elsevierViewall">La RM cerebral es el examen de elecci&#243;n para evaluar el grado de afectaci&#243;n cerebral&#46; La imagen m&#225;s t&#237;pica es el angioma leptomen&#237;ngeo&#44; que se traduce por captaci&#243;n de contraste en la duramadre en las secuencias T1&#44; y que se observ&#243; en casi la mitad de los casos<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; Otras im&#225;genes t&#237;picas son la dilataci&#243;n del plexo coroideo&#44; &#225;reas de calcificaci&#243;n y atrofia corticales&#44; presentes en casi la mitad de la muestra&#44; y dilataci&#243;n del sistema venoso profundo&#44; presente en 2 casos<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;17</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Las lesiones cerebrales son ipsolaterales al angioma facial y en la mayor&#237;a&#44; unilaterales&#46; El compromiso bilateral ocurre en el 7-26&#37; y se asocia a un mayor riesgo de presentar epilepsia refractaria y retraso psicomotor<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;15</span></a>&#46; Tres pacientes de la muestra ten&#237;an lesiones cerebrales bilaterales&#44; todos con epilepsia&#44; y 2 de ellos con retraso del desarrollo&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">En la RM cerebral de una paciente se observ&#243; una anomal&#237;a venosa de localizaci&#243;n at&#237;pica en el cerebelo &#40;caso 1&#41;&#46; Ya que no hab&#237;a afectaci&#243;n arterial o anomal&#237;a estructural cerebelosa o de otro tipo concomitante&#44; se descart&#243; el diagn&#243;stico de s&#237;ndrome PHACE y se consider&#243; el diagn&#243;stico de SSW&#46; Est&#225;n descritos muy pocos casos de SSW con anomal&#237;as cerebelosas&#44; todos ellos tambi&#233;n con afectaci&#243;n supratentorial<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6&#44;15&#44;17</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Frente a un ni&#241;o con angioma facial en el territorio inervado por la primera rama trigeminal&#44; se debe realizar RM cerebral siempre que surjan s&#237;ntomas neurol&#243;gicos o a los 2 a&#241;os de edad en los pacientes asintom&#225;ticos<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a>&#46; En edades precoces puede no haber anomal&#237;as de neuroimagen&#59; as&#237;&#44; si la RM es normal en los lactantes sintom&#225;ticos&#44; es necesario repetirla con 1-2 a&#241;os de edad<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a>&#46; Por otro lado&#44; puede haber alteraciones de neuroimagen sin s&#237;ntomas neurol&#243;gicos&#44; como en 2 ni&#241;os de esta muestra&#44; por lo que se debe realizar RM incluso en los ni&#241;os asintom&#225;ticos&#46; Si la RM es normal a los 2 a&#241;os de edad&#44; no es necesario repetirla&#44; a menos que aparezcan s&#237;ntomas<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">La tomograf&#237;a computarizada permite la visualizaci&#243;n de &#225;reas de calcificaci&#243;n cortical &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; pudiendo tener alguna utilidad s&#243;lo cuando la RM no est&#225; disponible<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">En resumen&#44; la cl&#237;nica presentada es variable y no siempre hay relaci&#243;n entre la gravedad de las manifestaciones cut&#225;neas&#44; neurol&#243;gicas y oculares entre s&#237;&#44; y con las alteraciones cerebrales&#44; que pueden ocurrir hasta en ausencia de s&#237;ntomas neurol&#243;gicos&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p id="par0130" class="elsevierStylePara elsevierViewall">Los autores declaran que no existe ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec94565"
          "palabras" => array:5 [
            0 => "Angioma"
            1 => "Epilepsy"
            2 => "Glaucoma"
            3 => "Syndrome"
            4 => "Sturge-Weber"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de Sturge-Weber es un s&#237;ndrome neurocut&#225;neo raro cuya gravedad est&#225; determinada por el grado de afectaci&#243;n cerebral y el control de la epilepsia&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los autores describen y analizan las caracter&#237;sticas cl&#237;nicas y de neuroimagen de este s&#237;ndrome&#44; a trav&#233;s de un estudio retrospectivo de 13 pacientes &#40;8 ni&#241;as&#59; con edad en la primera consulta entre los 15 d&#237;as y los 9 a&#241;os&#41;&#46; Doce presentaban angioma facial y una atriquia en la zona de afectaci&#243;n cerebral&#46; Se diagnostic&#243; epilepsia en 6 casos&#44; hemiplej&#237;a en 4&#44; retraso psicomotor en 7 y glaucoma en 4 casos&#46; Se encontraron alteraciones cerebrales en 10 ni&#241;os&#44; 3 sin sintomatolog&#237;a neurol&#243;gica&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La cl&#237;nica presentada es variable y no siempre hay relaci&#243;n entre la gravedad cl&#237;nica y las anomal&#237;as de neuroimagen&#44; que pueden aparecer hasta en ausencia de s&#237;ntomas neurol&#243;gicos&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Sturge Weber Syndrome is a rare neurocutaneous syndrome in which the severity is determined by degree of brain involvement and control of epilepsy&#46; The authors describe and analyse clinical and imaging features of this syndrome&#44; through a retrospective study of 13 patients &#40;8 girls&#59; aged between 15 days and 9 years at first visit&#41;&#46; Twelve had facial angioma and one had atrichia corresponding to the area of brain involvement&#46; Epilepsy was diagnosed in 6 cases&#44; hemiplegia in 4&#44; psychomotor delay in 7&#44; and glaucoma in 4&#46; Cerebral abnormalities were found in 10 children&#44; 3 without neurological symptoms&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The clinical signs and symptoms vary and there is not always a relationship between the severity of the clinical and neuroimaging abnormalities&#44; which may occur even in the absence of neurological symptoms&#46;</p>"
      ]
    ]
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      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1009
            "Ancho" => 1900
            "Tamanyo" => 305180
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Ejemplos de manifestaciones cut&#225;neas&#58; caso 4&#44; angioma facial a la izquierda&#59; caso 5&#44; angiomas en la cara&#44; el tronco y los miembros&#44; de tonalidad m&#225;s clara 8 a&#241;os despu&#233;s&#59; caso 10&#44; angioma a la izquierda&#44; m&#225;s discreto 10 a&#241;os despu&#233;s&#59; caso 11&#44; zona de atriquia ipsolateral a las lesiones cerebrales&#59; caso 12&#44; angiomas bilaterales en la cara&#44; el tronco y los miembros&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1687
            "Ancho" => 3167
            "Tamanyo" => 403406
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ejemplos de anomal&#237;as de neuroimagen&#46; A&#41; Caso 1&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angioma de la coroides a la izquierda &#40;flecha&#41;&#46; B&#41; Caso 4&#44; RM&#44; corte coronal&#44; secuencia en T2&#58; calcificaciones corticales y atrofia parietooccipital a la izquierda &#40;flecha&#41;&#46; C&#41; Caso 4&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angiomatosis pial &#40;flecha&#41; y atrofia cortical a la izquierda&#44; con asimetr&#237;a hemisf&#233;rica y de la calota craneal&#46; D&#41; Caso 4&#44; RM&#44; corte axial&#44; secuencia en T1 con contraste&#58; angiomatosis pial&#44; angioma del plexo coroideo &#40;flecha&#41; y atrofia cortical a la izquierda&#46; E&#41; Caso 10&#44; RM&#44; corte axial&#44; secuencia T2&#58; calcificaciones y atrofia del hemisferio izquierdo&#44; gliosis del par&#233;nquima adyacente &#40;flecha&#41;&#59; dilataci&#243;n de vena prepontina&#46; F&#41; Caso 10&#44; RM&#44; corte axial&#44; secuencia en T2&#58; calcificaciones y atrofia parietal a la izquierda&#59; plexo coroideo mayor a la izquierda &#40;flecha&#41;&#46; G&#41; Caso 11&#44; RM&#44; corte axial&#44; secuencia en T1&#44; con contraste&#58; &#225;rea encefalocl&#225;stica cortico-subcortical parieto-occipital&#44; angiomatosis pial y plexo venoso m&#225;s prominente a la derecha &#40;flecha&#41;&#46; H&#41; Caso 11&#44; TC&#44; corte axial&#44; sin contraste&#58; calcificaciones corticales parieto-occipitales a la derecha &#40;flecha&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Bi&#58; bilateral&#59; CBZ&#58; carbamazepina&#59; D&#58; a la derecha&#59; FNB&#58; fenobarbital&#59; I&#58; a la izquierda&#59; M&#58; meses&#59; PC&#58; parciales complejas&#59; VPA&#58; valproato&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Caso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Edad en la 1&#46;&#170; consulta &#40;meses&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Edad actual &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Angioma facial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Angioma&#44; otras localizaciones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Otras anomal&#237;as cut&#225;neas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Epilepsia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Hemiplej&#237;a&#47; hemianopsia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Retraso psicomotor&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Glaucoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Alteraciones de neuroimagen&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&#44; cerebelo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">113&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&#44; cuello y paladar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">T&#243;rax y miembros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Crisis PC a los 18<span class="elsevierStyleHsp" style=""></span>M&#59; controlada con CBZ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuero cabelludo&#44; cuello y miembros&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Crisis PC a los 3<span class="elsevierStyleHsp" style=""></span>M&#59; controlada con CBZ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Crisis PC a los 5<span class="elsevierStyleHsp" style=""></span>M&#59; controlada con 2 f&#225;rmacos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderado - grave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atriquia parieto-temporal D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Crisis PC a los 22<span class="elsevierStyleHsp" style=""></span>M&#59; farmacorresistente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&#47;&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderado - grave&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">D&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60; 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">T&#243;rax y miembros&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Crisis PC a los 4&#44;5<span class="elsevierStyleHsp" style=""></span>M&#59; controlada con VPA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60; 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">T&#243;rax&#44; miembros y paladar&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Crisis PC a los 0&#44;7<span class="elsevierStyleHsp" style=""></span>M&#59; controlada con VPA y FNB&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8211;&#47;&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Bi&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Localizaci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Dilataci&#243;n del plexo coroideo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ITemporal&#44; parietal y occipital&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BiParietal D y occipital Bi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">ITemporal&#44; parietal y occipital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">ITemporal&#44; parietal y occipital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DParietal y occipital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BiFrontal y parietal I&#44; temporal y occipital D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BiFrontal y parietal I&#44; temporal y occipital D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab193296.png"
              ]
            ]
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Alteraciones de neuroimagen</p>"
        ]
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    ]
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      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
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            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Uptodate on Sturge-Weber Syndrome&#58; diagnosis&#44; treatment&#44; quantitative measures&#44; and controversies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;M&#46; Comi"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/lrb.2007.1016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lymphat Res Biol"
                        "fecha" => "2007"
                        "volumen" => "5"
                        "paginaInicial" => "257"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18370916"
                            "web" => "Medline"
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2021 Febrero 553 61 614
2021 Enero 471 30 501
2020 Diciembre 463 39 502
2020 Noviembre 532 51 583
2020 Octubre 416 30 446
2020 Septiembre 510 37 547
2020 Agosto 448 51 499
2020 Julio 486 41 527
2020 Junio 567 62 629
2020 Mayo 544 60 604
2020 Abril 426 67 493
2020 Marzo 446 41 487
2020 Febrero 599 37 636
2020 Enero 460 58 518
2019 Diciembre 412 56 468
2019 Noviembre 342 40 382
2019 Octubre 544 52 596
2019 Septiembre 575 45 620
2019 Agosto 338 45 383
2019 Julio 449 64 513
2019 Junio 489 58 547
2019 Mayo 703 97 800
2019 Abril 716 87 803
2019 Marzo 486 50 536
2019 Febrero 500 51 551
2019 Enero 380 56 436
2018 Diciembre 321 58 379
2018 Noviembre 453 77 530
2018 Octubre 319 45 364
2018 Septiembre 167 54 221
2018 Agosto 2 0 2
2018 Julio 7 0 7
2018 Junio 6 0 6
2018 Mayo 41 0 41
2018 Abril 167 0 167
2018 Marzo 131 0 131
2018 Febrero 84 0 84
2018 Enero 83 1 84
2017 Diciembre 64 0 64
2017 Noviembre 72 0 72
2017 Octubre 60 0 60
2017 Septiembre 76 0 76
2017 Agosto 59 0 59
2017 Julio 76 0 76
2017 Junio 98 20 118
2017 Mayo 112 21 133
2017 Abril 64 33 97
2017 Marzo 69 7 76
2017 Febrero 165 12 177
2017 Enero 45 16 61
2016 Diciembre 79 7 86
2016 Noviembre 169 10 179
2016 Octubre 147 20 167
2016 Septiembre 217 27 244
2016 Agosto 189 30 219
2016 Julio 56 35 91
2016 Junio 1 0 1
2016 Mayo 1 0 1
2016 Abril 1 0 1
2016 Febrero 5 0 5
2016 Enero 4 0 4
2015 Diciembre 3 0 3
2015 Noviembre 2 0 2
2015 Octubre 2 31 33
2015 Septiembre 3 0 3
2015 Agosto 2 20 22
2015 Julio 21 14 35
2015 Junio 17 9 26
2015 Mayo 14 15 29
2015 Abril 23 11 34
2015 Marzo 16 2 18
2015 Febrero 9 0 9
2015 Enero 12 2 14
2014 Diciembre 19 3 22
2014 Noviembre 22 2 24
2014 Octubre 18 2 20
2014 Septiembre 14 3 17
2014 Agosto 29 3 32
2014 Julio 30 3 33
2014 Junio 64 5 69
2014 Mayo 124 9 133
2014 Abril 83 13 96
2014 Marzo 126 8 134
2014 Febrero 179 7 186
2014 Enero 126 4 130
2013 Diciembre 96 12 108
2013 Noviembre 95 9 104
2013 Octubre 110 12 122
2013 Septiembre 113 14 127
2013 Agosto 114 19 133
2013 Julio 113 10 123
2013 Junio 28 0 28
2013 Mayo 1 0 1
2013 Abril 3 0 3
2013 Marzo 4 0 4
2013 Febrero 4 0 4
2013 Enero 1 0 1
2012 Diciembre 769 0 769
2012 Noviembre 1 0 1
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