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tratamiento y control de los efectos tard&#237;os&#44; precisa de unidades hospitalarias interdisciplinarias coordinadas que participen en proyectos de investigaci&#243;n multic&#233;ntricos de donde emanan protocolos de tratamientos cl&#237;nicos estandarizados<a class="elsevierStyleCrossRef" href="#bib17"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="p0015" class="elsevierStylePara elsevierViewall">En Espa&#241;a desde 1980 se registran los tumores infantiles en el Registro Nacional de Tumores Infantiles &#40;RNTI&#41;<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a>&#46; Este es un registro central de base hospitalaria en el que participan 42 unidades hospitalarias de oncolog&#237;a pedi&#225;tricas ligadas a la Sociedad Espa&#241;ola de Hemato-Oncolog&#237;a Pedi&#225;tricas &#40;SEHOP&#41;&#46; Adem&#225;s desde 1990 el RNTI se beneficia de la colaboraci&#243;n de los registros de base poblacional en cinco comunidades aut&#243;nomas &#40;Arag&#243;n&#44; Baleares&#44; Catalu&#241;a&#44; Navarra y Pa&#237;s Vasco&#41;&#46; El RNTI es la principal fuente de informaci&#243;n de incidencia y supervivencia de neoplasias infantiles en Espa&#241;a y colabora con proyectos internacionales de investigaci&#243;n sobre el c&#225;ncer infantil&#58; causas de los tumores del sistema nervioso central&#44; variaciones internacionales de la incidencia &#40;ACCIS&#41; y variaciones internacionales de la supervivencia &#40;ACCIS y EUROCARE&#41;<a class="elsevierStyleCrossRefs" href="#bib4"><span class="elsevierStyleSup">4&#8211;9</span></a>&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">Para poder valorar la trascendencia de estas enfermedades en nuestra comunidad se pretende poner en marcha un <span class="elsevierStyleItalic">Registro Auton&#243;mico de Tumores Infantiles</span> en la Comunidad de Castilla y Le&#243;n de base poblacional &#40;RETINCYL&#41;&#44; mediante b&#250;squeda activa de los casos en las principales fuentes de informaci&#243;n&#44; que son los servicios sanitarios donde se diagnostica y se trata a los ni&#241;os oncol&#243;gicos&#46; Como paso previo a la implantaci&#243;n del registro se ha realizado el presente estudio retrospectivo de los tumores infantiles en pacientes menores de 15 a&#241;os diagnosticados entre los a&#241;os 2003 y 2007&#44; residentes en Castilla y Le&#243;n&#46;</p><p id="p0025" class="elsevierStylePara elsevierViewall">Los objetivos del presente trabajo son&#58; conocer el impacto del c&#225;ncer en la poblaci&#243;n menor de 15 a&#241;os de la Comunidad de Castilla y Le&#243;n&#44; estudiando la incidencia de estos procesos&#59; investigar la utilidad de los diagn&#243;sticos del alta hospitalaria &#40;CMBD&#41; como fuente de datos de un potencial registro de tumores infantiles&#59; ayudar en la planificaci&#243;n de los servicios de salud y estimular la investigaci&#243;n sobre el c&#225;ncer infantil&#46;</p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="p0030" class="elsevierStylePara elsevierViewall">A trav&#233;s del sistema de informaci&#243;n del Conjunto M&#237;nimo B&#225;sico de Datos &#40;CMBD&#41; al alta hospitalaria de los hospitales p&#250;blicos de la Comunidad Aut&#243;noma de Castilla y Le&#243;n&#44; se obtuvo informaci&#243;n de los pacientes que&#44; residiendo en dicha comunidad aut&#243;noma y teniendo una edad inferior a 15 a&#241;os&#44; fueron dados de alta por primera vez con diagn&#243;stico de tumor durante los a&#241;os 2003&#44; 2004&#44; 2005&#44; 2006 y 2007&#46; Se han incluido los tumores con comportamiento mayor o igual a 2 seg&#250;n la Clasificaci&#243;n Internacional de Enfermedades para Oncolog&#237;a &#40;CIE-O3&#41;<a class="elsevierStyleCrossRef" href="#bib21"><span class="elsevierStyleSup">21</span></a> o diagn&#243;stico cl&#237;nico equivalente&#44; excluyendo los tumores de piel&#44; a excepci&#243;n del melanoma&#46; Tambi&#233;n se incluyeron en la b&#250;squeda los papilomas de vejiga y todos los tumores del sistema nervioso central&#44; hip&#243;fisis y gl&#225;ndula pineal&#44; as&#237; como todas las met&#225;stasis de localizaci&#243;n primaria desconocida&#46;</p><p id="p0035" class="elsevierStylePara elsevierViewall">La informaci&#243;n sobre el diagn&#243;stico de c&#225;ncer de cada caso&#44; obtenida del CMBD al alta hospitalaria en forma de c&#243;digos de la Clasificaci&#243;n Internacional de Enfermedades&#44; 9&#46;<span class="elsevierStyleSup">a</span> revisi&#243;n&#44; Modificaci&#243;n Cl&#237;nica &#40;CIE-9-MC&#41;&#44; fue recodificada&#44; siguiendo las normas consensuadas internacionalmente &#40;IARC &#8212;International Agency for Research on Cancer&#8212; junto con la ENCR &#8212;European Network of Cancer Registries&#8212;&#41;<a class="elsevierStyleCrossRef" href="#bib22"><span class="elsevierStyleSup">22</span></a>&#46; Inicialmente se recodific&#243; a la Clasificaci&#243;n Internacional de Enfermedades para Oncolog&#237;a&#44; 3&#46;<span class="elsevierStyleSup">a</span> edici&#243;n &#40;CIE-O-3&#41;<a class="elsevierStyleCrossRef" href="#bib21"><span class="elsevierStyleSup">21</span></a> y posteriormente los diagn&#243;sticos fueron clasificados en 12 grandes grupos&#44; siguiendo la Internacional Classification of Childhood Cancer&#44; 2005 &#40;ICCC-3&#41;<a class="elsevierStyleCrossRef" href="#bib23"><span class="elsevierStyleSup">23</span></a>&#46; Debido a que la ICCC-3 no contempla la histiocitosis de c&#233;lulas de Langerhans&#44; en nuestro trabajo se ha ampliado la clasificaci&#243;n creando un nuevo grupo &#40;<span class="elsevierStyleSmallCaps">xiii</span>&#41; que incluye esta enfermedad&#46; En el caso de que con la informaci&#243;n aportada en las altas del CMBD&#44; un determinado caso pudiera clasificarse en unos de los 13 grupos de la ICCC-3 pero no se dispusiera de informaci&#243;n suficiente para determinar el tipo histol&#243;gico espec&#237;fico&#44; para este trabajo se cre&#243;&#44; en cada uno de los 13 grupos de tumores infantiles&#44; un nuevo subgrupo al que se ha denominado <span class="elsevierStyleItalic">&#171;imposible de clasificar&#187;</span> o <span class="elsevierStyleItalic">&#171;imposible de confirmar&#187;</span> con el m&#233;todo empleado&#46;</p><p id="p0040" class="elsevierStylePara elsevierViewall">Para cada caso registrado adem&#225;s del diagn&#243;stico se recogieron las siguientes variables&#58; fecha de nacimiento&#44; edad&#44; sexo&#44; a&#241;o de la primera alta hospitalaria con diagn&#243;stico de tumor&#44; c&#243;digo del hospital de referencia y provincia de la que procede&#46; La duplicidad de registro de casos se evit&#243; verificando que no existieran registros con el mismo diagn&#243;stico&#44; fecha de nacimiento&#44; sexo y provincia de procedencia&#46; Para intentar evitar la posible inclusi&#243;n de casos diagnosticados antes del periodo de estudio se excluyeron los casos en los que el diagn&#243;stico de tumor no fue el c&#243;digo principal&#46;</p><p id="p0045" class="elsevierStylePara elsevierViewall">De la variable cuantitativa edad se expres&#243; la mediana con los cuartiles primero y tercero como medida de dispersi&#243;n y de las variables cualitativas la frecuencia absoluta &#40;n&#41;&#44; que refleja el n&#250;mero de casos en la poblaci&#243;n establecida durante el periodo de estudio&#44; y la frecuencia relativa &#40;&#37;&#41;&#44; que indica el peso que un determinado tipo de c&#225;ncer infantil tiene dentro del conjunto&#46; Para el c&#225;ncer infantil la tasa bruta de incidencia determina el n&#250;mero de casos nuevos durante un a&#241;o por cada mill&#243;n de ni&#241;os menores de 15 a&#241;os&#46; Adem&#225;s se han calculado tasas espec&#237;ficas por grupos de edad &#40;0&#8211;4 a&#241;os&#44; 5&#8211;9 a&#241;os y 10&#8211;14 a&#241;os&#41;&#46; Los denominadores utilizados como poblaci&#243;n a riesgo en el c&#225;lculo de las tasas de incidencia se han obtenido a partir de los datos de poblaci&#243;n infantil &#40;menores de 15 a&#241;os y por grupos de edad&#41; del padr&#243;n municipal de las provincias de la Comunidad de Castilla y Le&#243;n&#44; obtenidos del Sistema de Informaci&#243;n Estad&#237;stica &#40;SIE&#41; de la Direcci&#243;n General de Estad&#237;stica de la Junta de Castilla y Le&#243;n &#40;<a href="http://www.jcyl.es/sie/">http&#58;&#47;&#47;www&#46;jcyl&#46;es&#47;sie&#47;</a>&#41;<a class="elsevierStyleCrossRef" href="#bib24"><span class="elsevierStyleSup">24</span></a>&#46; El ajuste de tasas se realiz&#243; mediante el m&#233;todo directo&#44; utilizando como referencia la poblaci&#243;n mundial de 0 a 14 a&#241;os desglosada en tres grupos&#58; 0&#8211;4 a&#241;os&#44; 5&#8211;9 a&#241;os y 10&#8211;14 a&#241;os&#59; cuyas cifras son 13&#46;000&#44; 9&#46;600 y 10&#46;000 ni&#241;os de cada grupo de edad&#44; respectivamente y ambos sexos&#44; calcul&#225;ndose la tasa de incidencia estandarizada a la poblaci&#243;n mundial por mill&#243;n de ni&#241;os &#40;TEPm&#41; y su intervalo de confianza al 95&#37;&#46; El programa estad&#237;stico utilizado en el an&#225;lisis de los datos fue el SPSS<span class="elsevierStyleSup">&#174;</span> v&#46;17&#46; Para el ajuste de tasas y el c&#225;lculo de incidencias se utiliz&#243; el programa Epidat 3&#46;1&#46;</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><p id="p0050" class="elsevierStylePara elsevierViewall">Se detectaron 220 casos nuevos de c&#225;ncer infantil en ni&#241;os menores de 15 a&#241;os residentes en la Comunidad de Castilla y Le&#243;n durante los cinco a&#241;os del estudio&#46; La mediana de edad global fue de 7 a&#241;os &#40;cuartiles&#58; 3&#8211;12&#41;&#46; En cuanto al sexo&#44; en la serie total&#44; 122 fueron varones &#40;55&#44;5&#37;&#41; y 98 mujeres &#40;44&#44;5&#37;&#41;&#44; con una relaci&#243;n global entre casos de sexo masculino y femenino &#40;raz&#243;n de masculinidad&#41; de 1&#44;24&#46;</p><p id="p0055" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#t0005">tabla 1</a> se muestra la distribuci&#243;n de los casos seg&#250;n los diferentes tipos tumorales y su variedad por grupos tumorales &#40;clasificaci&#243;n ICCC-3&#41;<a class="elsevierStyleCrossRef" href="#bib23"><span class="elsevierStyleSup">23</span></a>&#44; as&#237; como la distribuci&#243;n por grupos de edad y sus correspondientes porcentajes&#46; Las causas m&#225;s frecuentes de c&#225;ncer infantil fueron las leucemias&#44; que representan casi un tercio de los casos &#40;28&#44;6&#37;&#41;&#44; con claro predominio de la leucemia aguda linfoc&#237;tica &#40;79&#44;3&#37; del total de leucemias&#41;&#44; seguida de los tumores del SNC &#40;19&#44;5&#37;&#41; y los linfomas &#40;15&#44;9&#37;&#41;&#46;</p><elsevierMultimedia ident="t0005"></elsevierMultimedia><p id="p0060" class="elsevierStylePara elsevierViewall">Con el m&#233;todo empleado &#40;codificaci&#243;n de las altas del CMBD&#41; el n&#250;mero de casos en los que no se pudo clasificar seg&#250;n la variedad histol&#243;gica espec&#237;fica dentro de cada uno de los 13 grupos tumorales fue de 74 casos &#40;33&#44;6&#37;&#41;&#46; Por grupos tumorales &#40;<a class="elsevierStyleCrossRef" href="#t0005">tabla 1</a>&#41; no se pudo establecer la variedad histol&#243;gica espec&#237;fica en el 100&#44;0&#37; &#40;n&#61;3&#41; de los tumores hep&#225;ticos&#44; en el 79&#44;1&#37; &#40;n&#61;34&#41; de los tumores del SNC y m&#233;dula&#44; en el 66&#44;7&#37; &#40;n&#61;2&#41; de los tumores gonadales&#44; en el 50&#44;0&#37; &#40;n&#61;4&#41; de los sarcomas de tejidos blandos&#44; en el 42&#44;9&#37; &#40;n&#61;6&#41; de los tumores del SN simp&#225;tico&#44; en el 41&#44;2&#37; &#40;n&#61;7&#41; de los tumores &#243;seos&#44; en el 40&#44;0&#37; &#40;n&#61;6&#41; de los tumores epiteliales y en el 33&#44;3&#37; &#40;n&#61;3&#41; de los tumores renales&#46; Los grupos tumorales en los que con menor porcentaje no se pudo establecer la variedad espec&#237;fica fueron los linfomas &#40;17&#44;1&#37;&#44; n&#61;6&#41; y las leucemias &#40;4&#44;7&#37;&#44; n&#61;3&#41;&#46; En el 100&#37; de los casos se estableci&#243; la variedad histol&#243;gica en los grupos tumorales de histiocitosis&#44; retinoblastomas y &#171;otros tumores&#187;&#46;</p><p id="p0065" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#t0010">tabla 2</a> se muestran los tumores infantiles por grupos tumorales en nuestro estudio junto con los datos del Registro Nacional de Tumores Infantiles de Espa&#241;a &#40;RNTI-SEHOP&#41;<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a>&#46;</p><elsevierMultimedia ident="t0010"></elsevierMultimedia><p id="p0070" class="elsevierStylePara elsevierViewall">La tasa bruta de incidencia &#40;tasa anual media por mill&#243;n de ni&#241;os menores de 15 a&#241;os&#41; para el total de neoplasias fue de 152&#44;8 y la tasa ajuntada por la poblaci&#243;n mundial &#40;TEPm&#41; fue de 154&#44;8 &#40;IC 95&#37;&#58; 133&#44;9&#8211;175&#44;6&#41;&#46; En la <a class="elsevierStyleCrossRef" href="#t0015">tabla 3</a> se muestran las tasas brutas de incidencia y las tasas ajustadas para cada uno de los grupos tumorales en nuestro estudio y en las comunidades aut&#243;nomas espa&#241;olas con registro de tumores infantiles de base poblacional<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a>&#46; En la <a class="elsevierStyleCrossRef" href="#t0020">tabla 4</a> se refleja la incidencia de tumores infantiles total y por grupos tumorales en menores de 15 a&#241;os y ajustada por edad en EE&#46;UU&#46;<a class="elsevierStyleCrossRef" href="#bib3"><span class="elsevierStyleSup">3</span></a> y en nuestro estudio&#46; En este &#250;ltimo&#44; en el grupo de edad de 0&#8211;4 a&#241;os la incidencia fue de 170 casos anuales por mill&#243;n de ni&#241;os&#44; en el grupo de 5&#8211;9 a&#241;os de 145&#44;1 casos por mill&#243;n de ni&#241;os y en el grupo de 10&#8211;14 a&#241;os de 145&#44;2 casos por mill&#243;n de ni&#241;os&#44; sin diferencias estad&#237;sticamente significativas&#46;</p><elsevierMultimedia ident="t0015"></elsevierMultimedia><elsevierMultimedia ident="t0020"></elsevierMultimedia><p id="p0075" class="elsevierStylePara elsevierViewall">Al analizar el sexo con relaci&#243;n a los diferentes tipos de tumores infantiles &#40;<a class="elsevierStyleCrossRefs" href="#t0015">tablas 3 y 5</a>&#41;&#44; en nuestra serie no se encontraron diferencias estad&#237;sticamente significativas&#44; aunque se apreci&#243; predominio del sexo masculino en los linfomas&#44; tumores del SNC&#44; tumores del S&#46;N&#46; simp&#225;tico&#44; renales y sarcomas de tejidos blandos y predominio del sexo femenino en las leucemias y tumores &#243;seos&#46; En el resto de grupos tumorales o bien las diferencias no fueron importantes &#40;epiteliales&#41; o el n&#250;mero de casos de nuestra serie fue muy limitado para establecer alguna diferencia por sexo &#40;retinoblastomas&#44; hep&#225;ticos&#44; gonadales&#44; otros tumores e histiocitosis&#41;&#46;</p><elsevierMultimedia ident="t0025"></elsevierMultimedia><p id="p0080" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#t0030">tabla 6</a> muestra la evoluci&#243;n de la incidencia de tumores infantiles en los 5 a&#241;os del estudio&#46; Para el total de tumores infantiles las tasas anuales medias por mill&#243;n de ni&#241;os menores de 15 a&#241;os han sufrido un descenso progresivo desde el a&#241;o 2003 &#40;171&#44;6<span class="elsevierStyleHsp" style=""></span>casos&#47;a&#241;o&#47;10<span class="elsevierStyleSup">6</span> ni&#241;os menores de 15 a&#241;os&#41; hasta el a&#241;o 2007 &#40;137&#44;2<span class="elsevierStyleHsp" style=""></span>casos&#47;a&#241;o&#47;10<span class="elsevierStyleSup">6</span> ni&#241;os menores de 15 a&#241;os&#41; sin diferencias estad&#237;sticamente significativas&#46; Al analizar la incidencia evolutiva durante el periodo de estudio por grupos de edad &#40;<a class="elsevierStyleCrossRef" href="#t0030">tabla 6</a>&#41; se aprecia como es en el grupo de ni&#241;os menores de cuatro a&#241;os donde se ha producido&#44; en nuestro estudio&#44; un mayor descenso de la incidencia&#44; sin significaci&#243;n estad&#237;stica&#46;</p><elsevierMultimedia ident="t0030"></elsevierMultimedia><p id="p0085" class="elsevierStylePara elsevierViewall">La incidencia tumores infantiles present&#243; variaciones por provincias de la Comunidad de Castilla y Le&#243;n&#44; aunque sin diferencias estad&#237;sticamente significativas &#40;<a class="elsevierStyleCrossRef" href="#t0035">tabla 7</a>&#41;&#46; Las provincias con tasas m&#225;s elevadas con respecto a la media de toda la comunidad aut&#243;noma &#40;152&#44;8<span class="elsevierStyleHsp" style=""></span>casos&#47;a&#241;o&#47;10<span class="elsevierStyleSup">6</span> ni&#241;os menores de 15 a&#241;os&#41; fueron Valladolid &#40;193&#44;4<span class="elsevierStyleHsp" style=""></span>casos&#47;a&#241;o&#47;10<span class="elsevierStyleSup">6</span> ni&#241;os menores de 15 a&#241;os&#41;&#44; Burgos &#40;178&#44;6<span class="elsevierStyleHsp" style=""></span>casos&#47;a&#241;o&#47;10<span class="elsevierStyleSup">6</span> ni&#241;os menores de 15 a&#241;os&#41; y Palencia &#40;174&#44;6<span class="elsevierStyleHsp" style=""></span>casos&#47;a&#241;o&#47;10<span class="elsevierStyleSup">6</span> ni&#241;os menores de 15 a&#241;os&#41; y las provincias con menor incidencia fueron &#193;vila &#40;83&#44;6<span class="elsevierStyleHsp" style=""></span>casos&#47;a&#241;o&#47;10<span class="elsevierStyleSup">6</span> ni&#241;os menores de 15 a&#241;os&#41; y Soria &#40;80&#44;02<span class="elsevierStyleHsp" style=""></span>casos&#47;a&#241;o&#47;10<span class="elsevierStyleSup">6</span><span class="elsevierStyleHsp" style=""></span>ni&#241;os menores de 15 a&#241;os&#41;&#46;</p><elsevierMultimedia ident="t0035"></elsevierMultimedia><p id="p0090" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#t0040">tabla 8</a> se muestran los datos de cobertura del RNTI en la Comunidad de Castilla y Le&#243;n &#40;1990&#8211;2006&#41;&#46; Se apreci&#243; una buena concordancia entre los casos por a&#241;o esperados en el Registro Nacional y la media de casos observados por c&#243;digos diagn&#243;sticos del CMBD en el presente estudio&#46;</p><elsevierMultimedia ident="t0040"></elsevierMultimedia></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p id="p0095" class="elsevierStylePara elsevierViewall">La incidencia global en nuestro estudio para el total de tumores infantiles fue de 152&#44;8 casos anuales por mill&#243;n de ni&#241;os&#44; en situaci&#243;n media con respecto a las tasas de incidencia global de otras series nacionales<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#44;25</span></a> e internacionales<a class="elsevierStyleCrossRefs" href="#bib3"><span class="elsevierStyleSup">3&#8211;13</span></a>&#46;</p><p id="p0100" class="elsevierStylePara elsevierViewall">El presente estudio se ha basado como &#250;nica fuente de informaci&#243;n en el CMBD al alta hospitalaria&#44; lo cual le confiere limitaciones&#44; ya que los estudios epidemiol&#243;gicos son una utilidad secundaria de estos registros&#44; aparte de las intr&#237;nsecas al propio registro<a class="elsevierStyleCrossRefs" href="#bib26"><span class="elsevierStyleSup">26&#44;27</span></a>&#46;</p><p id="p0105" class="elsevierStylePara elsevierViewall">Si bien los 220 casos de la serie pudieron ser clasificados en uno de los 13 grandes grupos de tumores de la clasificaci&#243;n ICCC-3<a class="elsevierStyleCrossRef" href="#bib23"><span class="elsevierStyleSup">23</span></a>&#44; 74 de los tumores infantiles &#40;33&#44;6&#37;&#41; no pudieron ser subclasificados por el tipo histol&#243;gico &#40;<a class="elsevierStyleCrossRef" href="#t0005">tabla 1</a>&#41;&#46; Esta imposibilidad para subclasificar los tumores por tipo histol&#243;gico ocurri&#243; principalmente en los tumores del SNC &#40;79&#37; de los tumores del SNC&#44; el 15&#37; del total de la serie&#41;&#46;</p><p id="p0110" class="elsevierStylePara elsevierViewall">Las frecuencias relativas y las tasas de incidencia por grandes grupos diagn&#243;sticos de c&#225;ncer infantil en nuestro estudio se aproximan a las aportadas por otras series nacionales<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#44;25</span></a> e internacionales<a class="elsevierStyleCrossRefs" href="#bib3"><span class="elsevierStyleSup">3&#44;9&#8211;11</span></a> &#40;<a class="elsevierStyleCrossRefs" href="#t0010">tablas 2&#8211;4</a>&#41;&#46; La similitud es muy notable en los grupos tumorales con mayor representatividad &#40;leucemias y tumores del SNC&#41;&#46; En contraste&#44; para los linfomas no se apreci&#243; esa similitud y durante los a&#241;os del estudio Castilla y Le&#243;n present&#243; valores m&#225;s elevados de incidencia &#40;24&#44;3 casos nuevos anuales por mill&#243;n de ni&#241;os&#41; &#40;<a class="elsevierStyleCrossRef" href="#t0020">tabla 4</a>&#41; y de frecuencia relativa &#40;15&#44;9&#37;&#41; en comparaci&#243;n con tasas nacionales &#40;incidencia 19&#44;1 y frecuencia relativa 13&#44;4&#41;<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#44;25</span></a> y m&#225;s a&#250;n con algunas tasas internacionales como las estadounidenses &#40;incidencia 15&#44;1&#41;<a class="elsevierStyleCrossRef" href="#bib3"><span class="elsevierStyleSup">3</span></a>&#44; aunque las diferencias encontradas no presentan significaci&#243;n estad&#237;sticamente significativa&#46; Por tanto&#44; la variabilidad referida para los linfomas es posible que solamente se deba a desviaciones derivadas del peque&#241;o n&#250;mero de casos incidentes de nuestra serie en este grupo&#46; Por otra parte&#44; en diferentes estudios internacionales se han documentado variaciones importantes de incidencia entre regiones europeas para los linfomas no Hodgkin &#40;LNH&#41;&#44; fen&#243;meno que no ocurre para los linfomas de Hodgkin y el resto de grupos tumorales<a class="elsevierStyleCrossRef" href="#bib28"><span class="elsevierStyleSup">28</span></a>&#46; As&#237; la incidencia en Espa&#241;a para el conjunto de LNH es superior a la incidencia en Europa y en cada una de las regiones&#44; excepto en la Sur&#46; Para los LNH no Burkitt&#44; la incidencia no es mayor en Espa&#241;a excepto comparada con la regi&#243;n Norte de Europa&#46; La incidencia del linfoma de Burkitt observada en Espa&#241;a es significativamente superior a la que presenta Europa y sus regiones&#44; con diferencias que hasta sextuplican la observada en Europa<a class="elsevierStyleCrossRef" href="#bib28"><span class="elsevierStyleSup">28</span></a>&#46; En este contexto las altas tasas de incidencia de linfomas en nuestro estudio&#44; quiz&#225;s imputables a una mayor incidencia en el grupo de edad de los 5&#8211;9 a&#241;os &#40;<a class="elsevierStyleCrossRef" href="#t0020">tabla 4</a>&#41;&#44; es posible que pudieran deberse a alg&#250;n tipo de variaci&#243;n regional de incidencia como las descritas anteriormente y muy posiblemente por variaci&#243;n de incidencia de LNH de tipo linfoma de Burkitt en nuestra comunidad aut&#243;noma&#46; Estas hip&#243;tesis podr&#237;an ser confirmadas con la implantaci&#243;n de un registro auton&#243;mico de tumores infantiles&#46;</p><p id="p0115" class="elsevierStylePara elsevierViewall">Para el resto de grupos tumorales con escasa incidencia&#44; aunque se aprecian algunas diferencias &#40;valores superiores de incidencia de tumores epiteliales en nuestra serie con respecto a series nacionales e internacionales&#41;&#44; pensamos que podr&#237;an quiz&#225;s explicarse por la variabilidad en los registros o el peque&#241;o n&#250;mero de casos de nuestra serie en estos grupos &#40;<a class="elsevierStyleCrossRefs" href="#t0010">tablas 2&#8211;4</a>&#41;&#46;</p><p id="p0120" class="elsevierStylePara elsevierViewall">La incidencia del c&#225;ncer infantil es ligeramente superior en el sexo masculino con una relaci&#243;n var&#243;n&#47;mujer que oscila entre 1&#44;1 y 1&#44;6<a class="elsevierStyleCrossRef" href="#bib14"><span class="elsevierStyleSup">14</span></a>&#44; margen dentro del cual se incluye nuestro estudio&#46; En las grandes series nacionales e internacionales el predominio del sexo masculino del c&#225;ncer infantil se mantiene en todos los grupos tumorales salvo en tumores de c&#233;lulas germinales y epiteliales<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a>&#46; Los resultados por sexo de nuestra serie &#40;<a class="elsevierStyleCrossRef" href="#t0025">tabla 5</a>&#41; donde el sexo femenino predomin&#243; en las leucemias y tumores &#243;seos&#44; podr&#237;an deberse a la variabilidad conferida por el peque&#241;o tama&#241;o de algunos subgrupos&#46;</p><p id="p0125" class="elsevierStylePara elsevierViewall">La incidencia de los tumores infantiles por grupos de edad es muy similar en la mayor&#237;a de los estudios&#44; m&#225;s alta en los ni&#241;os menores de 5 a&#241;os&#44; suele descender moderadamente en los ni&#241;os de 5 a 9 a&#241;os&#44; para volver a subir en el grupo de 10 a 14 a&#241;os sin alcanzar las tasas del primer grupo<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#8211;13</span></a>&#46; En nuestra serie la incidencia en el grupo de 0 a 4 a&#241;os fue de 170 casos anuales por mill&#243;n de ni&#241;os&#44; ligeramente inferior a otras series&#59; en el grupo de 5 a 9 a&#241;os de 145&#44;1 casos anuales por mill&#243;n de ni&#241;os&#44; moderadamente superior a otras series&#44; y el grupo de 10 a 14 a&#241;os de 145&#44;2 casos anuales por mill&#243;n de ni&#241;os&#44; tambi&#233;n moderadamente superior a otras series &#40;<a class="elsevierStyleCrossRef" href="#t0020">tabla 4</a>&#41;&#46; Los tipos de tumores predominantes var&#237;an a lo largo de la infancia&#46; Durante el primer a&#241;o de vida predominan los tumores embrionarios y a partir de esa edad predominan las leucemias&#46; En la edad escolar se observa un importante aumento de los tumores del SNC&#44; que en algunas series superan en incidencia a las leucemias en el grupo de los 10 a 14 a&#241;os<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#44;23</span></a>&#46; En nuestra serie las leucemias son las m&#225;s representativas en todos los grupos de edad&#46; Con respecto a otras series&#44; la incidencia de leucemias en el grupo de 0 a 4 a&#241;os es menor en nuestro estudio y moderadamente superior en los siguientes grupos de edad&#46; Los tumores del SNC en nuestro trabajo no igualan ni superan en ning&#250;n grupo de edad a las leucemias&#46; Llama la atenci&#243;n en nuestra serie que en el grupo de edad de los 5 a 9 a&#241;os el segundo grupo tumoral m&#225;s frecuente&#44; por delante de los tumores del SNC&#44; son los linfomas con una incidencia de 36&#44;2 casos anuales por mill&#243;n de ni&#241;os&#44; muy superior a la incidencia en otras series nacionales &#40;registro nacional de tumores&#58; 18&#44;5&#41;<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a> e internacionales &#40;serie estadounidense&#58; 13&#44;7&#41;<a class="elsevierStyleCrossRef" href="#bib3"><span class="elsevierStyleSup">3</span></a>&#46; No podemos por el momento explicar estas diferencias en la incidencia de linfomas en este grupo de edad en nuestra comunidad aut&#243;noma&#44; aunque&#44; como se discuti&#243; con anterioridad&#44; quiz&#225;s pudieran deberse en parte&#44; a la variabilidad entre regiones en la incidencia de linfomas no Hodgkin<a class="elsevierStyleCrossRef" href="#bib28"><span class="elsevierStyleSup">28</span></a>&#44; circunstancias que podr&#237;an confirmarse con la puesta en marcha de un registro auton&#243;mico de tumores infantiles&#46;</p><p id="p0130" class="elsevierStylePara elsevierViewall">Para valorar la tendencia temporal de la incidencia del c&#225;ncer infantil en general y de los diferentes tipos de tumores infantiles&#44; se requiere de amplias series y de un seguimiento prolongado de las tasas de incidencia a lo largo del tiempo que permita realizar an&#225;lisis de tendencia temporal mediante metodolog&#237;a estad&#237;stica espec&#237;fica&#46; En el estudio de la epidemiolog&#237;a de procesos tumorales es com&#250;n el empleo de la regresi&#243;n &#171;Joinpoint&#187;<a class="elsevierStyleCrossRef" href="#bib29"><span class="elsevierStyleSup">29</span></a> que describe la evoluci&#243;n temporal de las tasas de incidencia mediante la comparaci&#243;n de diferentes periodos en los que el logaritmo de las tasas sigue un comportamiento lineal&#46; Mediante este tipo de estudios se ha podido determinar un aumento anual de 1&#44;3&#37; en el c&#225;ncer infantil desde 1980 hasta 1990 documentado por el proyecto ACCIS<a class="elsevierStyleCrossRefs" href="#bib9"><span class="elsevierStyleSup">9&#44;30</span></a>&#46; En nuestra serie de 5 a&#241;os &#40;<a class="elsevierStyleCrossRef" href="#t0025">tabla 5</a>&#41; se aprecia una mayor incidencia de c&#225;ncer infantil en los dos primeros a&#241;os de estudio con una tasa estable posterior y m&#225;s concordante con la incidencia esperada&#46; Sin embargo&#44; al no disponer de los datos de incidencia de los a&#241;os precedentes y por ello no poder aplicar metodolog&#237;a estad&#237;stica espec&#237;fica&#44; la interpretaci&#243;n de esta variaci&#243;n de incidencia puede deberse simplemente a un acumulo de casos en algunos a&#241;os por incidencias bajas en los precedentes o a la inclusi&#243;n en los primeros a&#241;os de casos prevalentes&#44; con diagn&#243;stico previo al periodo de estudio&#46; La creaci&#243;n de un registro poblacional de tumores infantiles en Castilla y Le&#243;n permitir&#237;a monitorizar la tendencia temporal de la incidencia de c&#225;ncer infantil tanto en nuestra comunidad como colaborar&#44; en este sentido&#44; con registros nacionales e internacionales&#46; Tambi&#233;n de una manera descriptiva&#44; en nuestra serie se aprecia diferencias interprovinciales de incidencia de c&#225;ncer infantil en Castilla y Le&#243;n durante el periodo de estudio&#46; Es posible que estas variaciones puedan atribuirse al peque&#241;o n&#250;mero de casos incidentes en un &#225;rea geogr&#225;fica determinada y al escaso periodo de observaci&#243;n de nuestra serie&#44; lo que impide establecer conclusiones certeras&#46; La creaci&#243;n de un registro permanente de tumores infantiles permitir&#225; establecer si existen variaciones de incidencia entre diferentes regiones dentro de la comunidad&#44; e incluso valorar posibles diferencias de incidencia entre &#225;reas rurales y urbanas y entre zonas urbanas con diferentes niveles de industrializaci&#243;n&#46;</p><p id="p0135" class="elsevierStylePara elsevierViewall">Dadas las caracter&#237;sticas y objetivos del sistema de informaci&#243;n utilizado para la realizaci&#243;n de este estudio&#44; no se contempla el seguimiento de los pacientes&#44; por lo que no se pudieron aportan datos de supervivencia&#46; Por este m&#233;todo tampoco ha sido posible conocer el n&#250;mero de casos diagnosticados en nuestra comunidad aut&#243;noma que finalmente han realizado el tratamiento y seguimiento en centros ajenos a la misma&#46; La puesta en marcha de un registro de tumores infantiles en Castilla y Le&#243;n&#44; mediante b&#250;squeda activa de los casos nuevos y de seguimiento de cada caso&#44; incluir&#225;&#44; como uno de los objetivos m&#225;s importantes&#44; el estudio de supervivencia del c&#225;ncer infantil y se podr&#225;n precisar los centros &#40;auton&#243;micos o de fuera de la comunidad aut&#243;noma&#41; donde cada caso recibe los tratamientos necesarios&#46; Adem&#225;s los registros de c&#225;ncer infantil&#44; con una metodolog&#237;a estandarizada que exige criterios espec&#237;ficos de control de calidad<a class="elsevierStyleCrossRefs" href="#bib31"><span class="elsevierStyleSup">31&#8211;36</span></a>&#44; evitan las bajas tasas de clasificaci&#243;n seg&#250;n la variedad histol&#243;gica espec&#237;fica que se aprecian en nuestro estudio&#46; As&#237; los registros de tumores infantiles existentes presentan tasas de confirmaci&#243;n histol&#243;gica superiores al 95&#37;<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#8211;13</span></a>&#46;</p><p id="p0140" class="elsevierStylePara elsevierViewall">Las tasas de cobertura para la Comunidad de Castilla y Le&#243;n en el RNTI en torno al 60&#37; &#40;<a class="elsevierStyleCrossRef" href="#t0040">tabla 8</a>&#41; contrastan con la cobertura del 100&#37; en las comunidades aut&#243;nomas con registros de base poblacional &#40;1&#41;&#46; La concordancia entre los casos anuales esperados en la Comunidad de Castilla y Le&#243;n y la media anual de casos observados en nuestro estudio &#40;<a class="elsevierStyleCrossRef" href="#t0040">tabla 8</a>&#41; permite establecer cierta utilidad a los diagn&#243;sticos del alta hospitalaria del CMBD como fuente de datos en un potencial registro de c&#225;ncer infantil a nivel comunitario&#46; Sin embargo&#44; la calidad de los registros obtenidos&#44; que impiden en un alto porcentaje de casos clasificar los tumores infantiles seg&#250;n sus variedades histol&#243;gicas&#44; determinan que la utilidad que los c&#243;digos diagn&#243;sticos del CMBD pudieran tener se limita a un papel de captaci&#243;n de posibles nuevos casos y monitorizando posibles casos no informados&#46;</p><p id="p0145" class="elsevierStylePara elsevierViewall">En definitiva&#44; el presente trabajo constituye una primera aproximaci&#243;n a la incidencia de tumores infantiles en la Comunidad de Castilla y Le&#243;n que arroja incidencias de los principales tipos de tumores infantiles semejantes a las encontradas en series nacionales e internacionales&#46; Este estudio pretende ser un impulso para la creaci&#243;n de un Registro Auton&#243;mico de Tumores Infantiles de base poblacional con bases metodol&#243;gicas normalizadas y criterios espec&#237;ficos de control de calidad<a class="elsevierStyleCrossRefs" href="#bib31"><span class="elsevierStyleSup">31&#8211;36</span></a> que permitir&#237;a adem&#225;s incorporar a Castilla y Le&#243;n entre las regiones europeas que disponen de un sistema de informaci&#243;n sobre la incidencia&#44; supervivencia y tendencia temporal del c&#225;ncer infantil&#46;</p></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p id="p0150" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "palabras" => array:3 [
            0 => "C&#225;ncer infantil"
            1 => "Incidencia"
            2 => "Registro de tumores"
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        0 => array:4 [
          "clase" => "keyword"
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            0 => "Childhood cancer"
            1 => "Incidence"
            2 => "Cancer registry"
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    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Antecedentes</span><p id="sp0080" class="elsevierStyleSimplePara elsevierViewall">En Espa&#241;a desde 1980 se registran los tumores infantiles en el Registro Nacional &#40;base hospitalaria&#41; y desde 1990 cinco comunidades aut&#243;nomas poseen registros de base poblacional&#46; En la Comunidad de Castilla y Le&#243;n no existe un registro espec&#237;fico de incidencia de c&#225;ncer infantil&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="sp0085" class="elsevierStyleSimplePara elsevierViewall">Estimar la incidencia de c&#225;ncer infantil en la Comunidad de Castilla y Le&#243;n y analizar la utilidad de los diagn&#243;sticos informatizados del alta hospitalaria como fuente de datos de un potencial registro auton&#243;mico&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="sp0090" class="elsevierStyleSimplePara elsevierViewall">A trav&#233;s del Conjunto M&#237;nimo B&#225;sico de Datos &#40;CMBD&#41; al alta hospitalaria de los hospitales p&#250;blicos de la comunidad aut&#243;noma&#44; se obtuvo informaci&#243;n de los pacientes menores de 15 a&#241;os que fueron diagnosticados por primera vez de c&#225;ncer durante los a&#241;os 2003&#8211;2007&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="sp0095" class="elsevierStyleSimplePara elsevierViewall">Se han detectado 220 casos nuevos de c&#225;ncer infantil en los cinco a&#241;os del estudio&#44; con predominio del sexo masculino &#40;55&#44;5&#37;&#41;&#46; El tumor m&#225;s frecuente fue la leucemia &#40;28&#44;6&#37;&#41; seguida de los tumores del sistema nervioso central &#40;19&#44;5&#37;&#41; y los linfomas &#40;15&#44;9&#37;&#41;&#46; La incidencia anual de c&#225;ncer infantil fue de 152&#44;8 casos por mill&#243;n de ni&#241;os&#46; Los c&#243;digos diagn&#243;sticos informatizados no permitieron la clasificaci&#243;n seg&#250;n la variedad histol&#243;gica del tumor en 74 casos &#40;33&#44;6&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="sp0100" class="elsevierStyleSimplePara elsevierViewall">La incidencia por grupos diagn&#243;sticos de c&#225;ncer infantil en la Comunidad de Castilla y Le&#243;n se aproxima a las aportadas en series nacionales e internacionales&#46; En un registro de tumores el CMBD podr&#237;a ser &#250;til en la captaci&#243;n de posibles nuevos casos&#44; pero en un alto porcentaje no permite clasificar los tumores seg&#250;n su variedad histol&#243;gica&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="sp0105" class="elsevierStyleSimplePara elsevierViewall">Since 1980&#44; childhood cancer cases have been registered in Spain in the National Registry of Childhood Cancer &#40;based on hospital cases&#41; and since 1990&#44; five autonomous regions have had a population based registry&#46; There is no specific registry of childhood cancer in Castilla y Leon&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="sp0110" class="elsevierStyleSimplePara elsevierViewall">Our aim was to estimate the childhood cancer incidence in the autonomous region of Castilla y Leon and to assess the usefulness of the computerised diagnosis of hospital discharges as a source of data in a potential autonomous region population based registry&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="sp0115" class="elsevierStyleSimplePara elsevierViewall">We included patients younger than 15 years old who were diagnosed&#44; for the first time&#44; of cancer during the years 2003&#8211;2007&#46; The information collected was obtained through the Minimum Basic Data Set &#40;MBDS&#41; of the public hospitals in the autonomous region of Castilla y Leon&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="sp0120" class="elsevierStyleSimplePara elsevierViewall">In this period of 5 years &#40;2003&#8211;2007&#41;&#44; 220 cases of childhood cancer had been reported&#46; The most frequent cancer detected was leukaemia &#40;28&#46;6&#37;&#41; followed by the central nervous system tumours &#40;19&#46;5&#37;&#41; and lymphoma &#40;15&#46;9&#37;&#41;&#46; The overall rate of childhood cancer incidence was 152&#46;8 cases per million children&#46; The diagnostics codes did not allow tumours to be classified by their histological type in 74 cases &#40;33&#46;6&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="sp0125" class="elsevierStyleSimplePara elsevierViewall">The overall incidence by diagnostic groups of childhood cancer in the autonomous region of Castilla y Leon was similar to those reported by other national and international registries&#46; In a Cancer registry the MBDS could be useful as a data source in the capture of new cases&#44; but in a high percentage of cases it does not allow tumours to be classified by their histological type&#46;</p>"
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                  <a target="_blank" href="main.stripin/si0001.gif"><span class="e-comp" style="background:PowderBlue;" title="Click here to view Table Image">Click&nbsp;Here&nbsp;To&nbsp;View&nbsp;Stripin</span></a><p style="margin-bottom:0em"></p><table border="0" frame="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Casos totales</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#37; del total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Clasificaci&#243;n ICCC-3</span><a class="elsevierStyleCrossRef" href="#tblfn1a"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">a</span></span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">220</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">75</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">10</span><span class="elsevierStyleItalic">0</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">68</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">77</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">I</span>&#46; <span class="elsevierStyleItalic">Leucemias</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">63</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">28&#44;6</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">10</span><span class="elsevierStyleItalic">0</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">21</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">28</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">20</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">29&#44;4</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">22</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">28&#44;6</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aguda linfoc&#237;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aguda no linfoc&#237;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mieloide cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otras linfoc&#237;ticas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otras y no especificadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">II</span>&#46; <span class="elsevierStyleItalic">Linfomas</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Enfermedad de Hodgkin&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Linfoma de Burkit&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Otros linforreticulares&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Otras y no especificadas neoplasias&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Linfoma imposible de clasificar&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">17&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">III&#46; SNC y medula</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">43</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">19&#44;5</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">14</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">18&#44;7</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">13</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">1&#44;1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">16</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">20&#44;8</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Ependimoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Astrocitoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Neuroectod&#233;rmicos&#46; PNET&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros gliomas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros SNC especificados &#40;creneof&#46;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros SNC no especificados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">V&#46; Retinoblastomas</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Retinoblastoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Carcinoma renal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Hepatoblastoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Carninoma hep&#225;tico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Osteosarcoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Sarcoma de E wing&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Otros &#243;seos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&#211;seos no especificados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">&#211;seo imposible de clasificar</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">41&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">2&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">6&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">IX&#46; Sarc&#46; tej&#46; blandos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">8</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">3&#44;6</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">5</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">6&#44;7</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">1&#44;5</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">2&#44;6</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rabdomiosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">25&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fibrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sarcoma de Kaposi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros sarcomas de tej blandos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">12&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No especificados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sarc&#46; Tej&#46; Bland imposible de clasif</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">X&#46; Gonadal y c&#46; Germinales</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">1&#44;4</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">2</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">2&#44;7</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">0</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">1</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">1&#44;3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Cel germin endocraneal y endoespi&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros y no especificados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">Cel germin gonadales&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carcinomas gonadales&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros y no especificados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gon&#46; y c&#46; germin imposible clasificar</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">66&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">XI&#46; N&#46; epiteliales</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">15</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">6&#44;8</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">4&#44;0</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">4</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">5&#44;9</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">8</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">10&#44;4</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carcinoma adrenocortical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carcinoma tiroideo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carcinoma nasofaringeo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Melanoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carcinoma de piel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros y no especificados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">XIII&#46; Histiocitosis</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Letterer-Siwe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Otras formas histiocitosis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">XII&#46; Otros tumores</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">XIII&#46; Histiocitosis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">220</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">17&#46;838</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Arag&#243;n&#44; Catalu&#241;a&#44; Navarra y P&#46; Vasco &#40;1990&#8211;2007&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Tasa bruta&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">TEPm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">M&#47;F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">TEPm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">M&#47;F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">43&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">44&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;072&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">40&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">II&#46; Linfomas</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">15&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">24&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">22&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#40;14&#44;9&#8211;30&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">19&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">18&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">III&#46; SNC y medula</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;20&#44;9&#8211;39&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">854&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">EE&#46;UU&#46; &#40;2000&#8211;2003&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn4a"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">a</span></span></a></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t">&#8804;14 a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8804;14 a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">T&#46; bruta&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">TEPm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">TA EU&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">I&#46; Leucemias</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;33&#44;1&#8211;55&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">II&#46; Linfomas</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">V&#46; Retinoblastomas</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Tasa bruta&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">TEPm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " colspan="2" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">0&#8211;4 a&#241;os</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">5&#8211;9 a&#241;os</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">10&#8211;14 a&#241;os</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">T&#46; bruta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">TEPm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">T&#46; bruta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">T&#46; bruta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">T bruta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#241;o 2003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">171&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132&#44;0&#8211;239&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">244&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">171&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#241;o 2004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">168&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">169&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&#44;1&#8211;219&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">140&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">175&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#241;o 2005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">146&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103&#44;9&#8211;196&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">157&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#241;o 2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#44;2&#8211;180&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">192&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#241;o 2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#44;0&#8211;180&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">138&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">220&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">62&#46;042&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">194&#44;22&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">144&#44;6&#8211;243&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Zamora</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">20&#46;242&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">168&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">174&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">88&#44;7&#8211;260&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Total Castilla y Le&#243;n &#40;2003&#8211;2007&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">220</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">100</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">152&#44;8</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">155&#44;3</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">134&#44;2&#8211;176&#44;3</span>&nbsp;\t\t\t\t\t\t\n
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                  <a target="_blank" href="main.stripin/si0002.gif"><span class="e-comp" style="background:PowderBlue;" title="Click here to view Table Image">Click&nbsp;Here&nbsp;To&nbsp;View&nbsp;Stripin</span></a><p style="margin-bottom:0em"></p><table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Registro Nacional de Tumores Infantiles &#40;1990&#8211;2006&#41;</span></td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Resultados por c&#243;digos CMBD</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="5" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Cobertura en Comunidad de Castilla y Le&#243;n</span><a class="elsevierStyleCrossRef" href="#tblfn8a"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">a</span></span></a></td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Castilla y Le&#243;n 2003&#8211;2007</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Casos en el periodo</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cobertura&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Casos por a&#241;o</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Casos por a&#241;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Observados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Esperados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">O&#47;E&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Observados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Esperados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Media de casos observados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Todos los tumores infantiles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">469&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">760&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leucemias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">234&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#8211;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linfomas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">115&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#8211;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sistema Nervioso Central&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">146&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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