Originales
Factores de riesgo y prevalencia familiar de la dermatitis atópica en España (estudio ELIHO)
Risk factors for atopic dermatitis and familial prevalence in spain (eliho study)
A. Blanco Quirósa,
, J.M.ª Díaz Castellab, M. Balañá Vilanovac, N. Valveny Llobetd
Autor para correspondencia
ablanco@ped.uva.es
Correspondencia: Dr. A. Blanco Quirós. Área de Pediatría. Facultad de Medicina. Ramón y Cajal, 5. 47005 Valladolid. España.
Correspondencia: Dr. A. Blanco Quirós. Área de Pediatría. Facultad de Medicina. Ramón y Cajal, 5. 47005 Valladolid. España.
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"apellidos" => "Blanco Quirós" "email" => array:1 [ 0 => "ablanco@ped.uva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "J.M.ª" "apellidos" => "Díaz Castella" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Balañá Vilanova" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "N." "apellidos" => "Valveny Llobet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Facultad de Medicina. Universidad de Valladolid. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Novartis Farmacéutica, S.A.Departamento I + D. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "CDC Spain. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Infociencia S.L. Barcelona. España" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. A. Blanco Quirós. Área de Pediatría. Facultad de Medicina. Ramón y Cajal, 5. 47005 Valladolid. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Risk factors for atopic dermatitis and familial prevalence in spain (eliho study)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-08-31" "fechaAceptado" => "2005-08-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186260" "palabras" => array:8 [ 0 => "Dermatitis atópica" 1 => "Eccema" 2 => "Epidemiología" 3 => "Hipersensibilidad" 4 => "Genética" 5 => "Clima" 6 => "Acné" 7 => "Factores de riesgo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186259" "palabras" => array:7 [ 0 => "Atopic dermatitis" 1 => "Eczema" 2 => "Epidemiology" 3 => "Hypersensitivity.Genetics" 4 => "Climate" 5 => "Acne vulgaris" 6 => "Risk factors" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La dermatitis atópica (DA) es una enfermedad de etiología desconocida, con clara predisposición genética y una probable participación de factores ambientales. El objetivo del estudio era evaluar los factores de riesgo asociados al diagnóstico y aparición de brotes de DA en niños españoles.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio observacional, multicéntrico, retrospectivo de casos y control que incluyó una muestra de 4.243 niños menores de 14 años afectados de DA y 978 controles ajustados por edad y sexo. Se recogieron datos de antecedents familiares y características del entorno familiar en ambos grupos y características clínicas de la DA en los pacientes.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los factores de riesgo significativos para la aparición de DA fueron los antecedentes familiares y las infecciones concomitantes de la piel. La prevalencia de DA en familiars de primer grado fue del 39 % y en familiares de Segundo grado, del 19 % (superior en línea materna que paterna).a edad media de los niños afectados fue de 4,2 (desviación estándar [DE] 3,4) años y la edad media en el diagnóstico fue de 1,5 (DE 2,2) años, con un número medio de brotes de la enfermedad de 2,9 (DE 2,6) en el año previo. En las zonas de España con clima más frío (cantábrico y continental) se observó mayor número de brotes.Los niños con DA presentaron mayor coincidencia de enfermedades cutáneas e infecciosas que los niños control.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La DA es una enfermedad con una gran predisposición genética, modulada por factores climáticos y que acarrea alteraciones inmunológicas. Por el contrario no encontramos influencias significativas de factores ambientales domésticos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Atopic dermatitis (AD) is a cutaneous disease of unknown etiology. It shows a clear genetic predisposition with probable environmental modulation. This study evaluated risk factors associated with diagnosis and flares of AD in Spanish children.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed an observational, multicenter, retrospective case-control study that included 4243 children aged less than 14 years old with AD and 978 controls matched for age and sex. Family history of disease and environmental variables were collected in both groups and clinical history of AD was recorded in the case group.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Significant risk factors for AD were: a family history of the disease and concomitant cutaneous infections. The prevalence of AD in first degree relatives was 39 % and that in second degree relatives was 19 % (higher in maternal than paternal lines). The mean age of children with AD was 4.2 (SD 3.4) years and the mean age at diagnosis was 1.5 (SD 2.2) years, with a mean of 2.9 (SD 2.6) flares during the previous year. Cold weather (Cantabrian and Continental Iberian Peninsula areas) was related to a greater number of flares. Children with AD had a greater number of concomitant cutaneous diseases and infections than children in the control group.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">AD is mainly a genetic disease, with climatic factors involved in severity modulation, and with important immunological alterations. In contrast, this study found no domestic environmental factors that were associated with disease onset.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Declaración de conflicto de intereses: Este trabajo ha sido realizado con el apoyo económico de Novartis Farmacéutica, S.A.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
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| 2021 Noviembre | 63 | 88 | 151 |
| 2021 Octubre | 41 | 81 | 122 |
| 2021 Septiembre | 26 | 82 | 108 |
| 2021 Agosto | 28 | 53 | 81 |
| 2021 Julio | 27 | 52 | 79 |
| 2021 Junio | 20 | 34 | 54 |
| 2021 Mayo | 26 | 49 | 75 |
| 2021 Abril | 49 | 96 | 145 |
| 2021 Marzo | 66 | 99 | 165 |
| 2021 Febrero | 60 | 37 | 97 |
| 2021 Enero | 31 | 32 | 63 |
| 2020 Diciembre | 46 | 37 | 83 |
| 2020 Noviembre | 30 | 24 | 54 |
| 2020 Octubre | 42 | 16 | 58 |
| 2020 Septiembre | 20 | 5 | 25 |
| 2020 Agosto | 31 | 16 | 47 |
| 2020 Julio | 53 | 22 | 75 |
| 2020 Junio | 41 | 10 | 51 |
| 2020 Mayo | 39 | 46 | 85 |
| 2020 Abril | 24 | 25 | 49 |
| 2020 Marzo | 26 | 28 | 54 |
| 2020 Febrero | 30 | 22 | 52 |
| 2020 Enero | 34 | 27 | 61 |
| 2019 Diciembre | 39 | 25 | 64 |
| 2019 Noviembre | 38 | 22 | 60 |
| 2019 Octubre | 33 | 30 | 63 |
| 2019 Septiembre | 31 | 30 | 61 |
| 2019 Agosto | 40 | 25 | 65 |
| 2019 Julio | 83 | 39 | 122 |
| 2019 Junio | 85 | 27 | 112 |
| 2019 Mayo | 130 | 45 | 175 |
| 2019 Abril | 150 | 59 | 209 |
| 2019 Marzo | 71 | 34 | 105 |
| 2019 Febrero | 43 | 17 | 60 |
| 2019 Enero | 37 | 16 | 53 |
| 2018 Diciembre | 29 | 21 | 50 |
| 2018 Noviembre | 45 | 27 | 72 |
| 2018 Octubre | 54 | 24 | 78 |
| 2018 Septiembre | 14 | 12 | 26 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Julio | 4 | 0 | 4 |
| 2018 Junio | 2 | 0 | 2 |
| 2018 Mayo | 1 | 0 | 1 |
| 2018 Abril | 11 | 0 | 11 |
| 2018 Marzo | 9 | 0 | 9 |
| 2018 Febrero | 8 | 0 | 8 |
| 2018 Enero | 9 | 0 | 9 |
| 2017 Diciembre | 10 | 0 | 10 |
| 2017 Noviembre | 10 | 0 | 10 |
| 2017 Octubre | 13 | 0 | 13 |
| 2017 Septiembre | 8 | 0 | 8 |
| 2017 Agosto | 7 | 0 | 7 |
| 2017 Julio | 12 | 1 | 13 |
| 2017 Junio | 12 | 25 | 37 |
| 2017 Mayo | 17 | 29 | 46 |
| 2017 Abril | 12 | 19 | 31 |
| 2017 Marzo | 11 | 26 | 37 |
| 2017 Febrero | 6 | 14 | 20 |
| 2017 Enero | 9 | 10 | 19 |
| 2016 Diciembre | 9 | 25 | 34 |
| 2016 Noviembre | 22 | 33 | 55 |
| 2016 Octubre | 31 | 31 | 62 |
| 2016 Septiembre | 24 | 21 | 45 |
| 2016 Agosto | 31 | 16 | 47 |
| 2016 Julio | 22 | 23 | 45 |
| 2016 Junio | 2 | 20 | 22 |
| 2016 Mayo | 1 | 47 | 48 |
| 2016 Abril | 2 | 0 | 2 |
| 2016 Marzo | 2 | 18 | 20 |
| 2016 Febrero | 3 | 0 | 3 |
| 2016 Enero | 2 | 0 | 2 |
| 2015 Diciembre | 2 | 23 | 25 |
| 2015 Noviembre | 2 | 0 | 2 |
| 2015 Octubre | 5 | 29 | 34 |
| 2015 Septiembre | 4 | 0 | 4 |
| 2015 Agosto | 1 | 21 | 22 |
| 2015 Julio | 10 | 16 | 26 |
| 2015 Junio | 12 | 0 | 12 |
| 2015 Mayo | 8 | 0 | 8 |
| 2015 Abril | 27 | 26 | 53 |
| 2015 Marzo | 16 | 18 | 34 |
| 2015 Febrero | 15 | 14 | 29 |
| 2015 Enero | 30 | 2 | 32 |
| 2014 Diciembre | 47 | 4 | 51 |
| 2014 Noviembre | 37 | 4 | 41 |
| 2014 Octubre | 31 | 5 | 36 |
| 2014 Septiembre | 35 | 4 | 39 |
| 2014 Agosto | 53 | 2 | 55 |
| 2014 Julio | 73 | 7 | 80 |
| 2014 Junio | 104 | 3 | 107 |
| 2014 Mayo | 122 | 6 | 128 |
| 2014 Abril | 73 | 3 | 76 |
| 2014 Marzo | 65 | 6 | 71 |
| 2014 Febrero | 66 | 11 | 77 |
| 2014 Enero | 80 | 6 | 86 |
| 2013 Diciembre | 103 | 6 | 109 |
| 2013 Noviembre | 112 | 6 | 118 |
| 2013 Octubre | 112 | 6 | 118 |
| 2013 Septiembre | 64 | 9 | 73 |
| 2013 Agosto | 70 | 16 | 86 |
| 2013 Julio | 42 | 6 | 48 |
| 2013 Junio | 3 | 4 | 7 |
| 2013 Mayo | 5 | 1 | 6 |
| 2013 Abril | 6 | 2 | 8 |
| 2013 Marzo | 5 | 1 | 6 |
| 2013 Febrero | 22 | 1 | 23 |
| 2013 Enero | 19 | 0 | 19 |
| 2012 Diciembre | 13 | 0 | 13 |
| 2012 Noviembre | 17 | 1 | 18 |
| 2012 Octubre | 3 | 1 | 4 |
| 2012 Septiembre | 2 | 0 | 2 |
| 2012 Agosto | 2 | 0 | 2 |
| 2005 Diciembre | 2151 | 0 | 2151 |
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