Estudio clínico epidemiológico de los defectos del tubo neural clasificados por los cinco puntos de cierre del mismo
Clinic-epidemiological study of neural tube defects classified according to the five sites of closure
A. Sanchis Calvoa,
, M.aL. Martínez-Fríasb
Autor para correspondencia
mcsanchis@digitel.es
Correspondencia: Dra. A. Sanchis Calvo. Servicio de Pediatría. Hospital Universitario Dr. Peset. Valencia 46017.
Correspondencia: Dra. A. Sanchis Calvo. Servicio de Pediatría. Hospital Universitario Dr. Peset. Valencia 46017.
Leído
22338
Vecesse ha leído el artículo
3715
Total PDF
18623
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1695403301786730" "issn" => "16954033" "doi" => "10.1016/S1695-4033(01)78673-0" "estado" => "S300" "fechaPublicacion" => "2001-02-01" "aid" => "78673" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2001;54:165-73" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 17112 "formatos" => array:3 [ "EPUB" => 73 "HTML" => 15986 "PDF" => 1053 ] ] "itemSiguiente" => array:18 [ "pii" => "S1695403301786742" "issn" => "16954033" "doi" => "10.1016/S1695-4033(01)78674-2" "estado" => "S300" "fechaPublicacion" => "2001-02-01" "aid" => "78674" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2001;54:174-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 7168 "formatos" => array:3 [ "EPUB" => 84 "HTML" => 5968 "PDF" => 1116 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Hipomagnesemia familiar con hipercalciuria y nefrocalcinosis" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "174" "paginaFinal" => "177" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Familial hypermagnesemia with hypercalciuria and nephrocalcinosis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.J. Martín Aguado, A. Canals Baeza, L. Sanguino López, C. Gavilán Martín, J. Flores Serrano" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "Martín Aguado" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Canals Baeza" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Sanguino López" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Gavilán Martín" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Flores Serrano" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301786742?idApp=UINPBA00005H" "url" => "/16954033/0000005400000002/v1_201307051539/S1695403301786742/v1_201307051539/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403301786729" "issn" => "16954033" "doi" => "10.1016/S1695-4033(01)78672-9" "estado" => "S300" "fechaPublicacion" => "2001-02-01" "aid" => "78672" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2001;54:160-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4756 "formatos" => array:3 [ "EPUB" => 65 "HTML" => 4177 "PDF" => 514 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Bacteriemias verticales: ¿tratar o no tratar?" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "160" "paginaFinal" => "164" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Vertically transmitted bacteriemias: to treat or not to treat?" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. López Almaraz, M.<span class="elsevierStyleSup">a</span>J. Hernández González, E. Doménech Martínez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "López Almaraz" ] 1 => array:2 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>J." "apellidos" => "Hernández González" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Doménech Martínez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301786729?idApp=UINPBA00005H" "url" => "/16954033/0000005400000002/v1_201307051539/S1695403301786729/v1_201307051539/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Estudio clínico epidemiológico de los defectos del tubo neural clasificados por los cinco puntos de cierre del mismo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "165" "paginaFinal" => "173" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Sanchis Calvo, M.<span class="elsevierStyleSup">a</span>L. Martínez-Frías" "autores" => array:2 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Sanchis Calvo" "email" => array:1 [ 0 => "mcsanchis@digitel.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>L." "apellidos" => "Martínez-Frías" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Pediatría. Hospital Universitario Dr. Peset. Valencia" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Estudio Colaborativo Español de Malformaciones Congénitas (ECEMC). Departamento de Farmacología. Facultad de Medicina. Universidad Complutense. Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dra. A. Sanchis Calvo. Servicio de Pediatría. Hospital Universitario Dr. Peset. Valencia 46017." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinic-epidemiological study of neural tube defects classified according to the five sites of closure" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-01" "fechaAceptado" => "2000-11-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186570" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Defectos del tubo neural</span>" 1 => "<span class="elsevierStyleItalic">Múltiples puntos de cierre del tubo neural</span>" 2 => "<span class="elsevierStyleItalic">Epidemiología</span>" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186569" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Neural tube defects</span>" 1 => "<span class="elsevierStyleItalic">Multi-site closure of the neural tube</span>" 2 => "<span class="elsevierStyleItalic">Epidemiology</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la prevalencia al nacimiento de los defectos del tubo neural (DTN) en población española, tanto en su conjunto como clasificados según el fallo de los distintos puntos de cierre, aplicando la teoría del cierre múltiple del tubo neural. Analizar las características epidemiológicas de éstos.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han utilizado los datos del Estudio Colaborativo Español de Defectos Congénitos (ECEMC) correspondientes al período comprendido entre abril de 1976 y marzo de 1995, en el que se han detectado 784 recién nacidos con un DTN entre un total de 1.222.698 recién nacidos vivos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nuestra población tiene una prevalencia de DTN de 1,01 por 1.000 nacimientos. Solamente el 5,74 % de los DTN diagnosticados tienen una etiología conocida, génica (2,17%), cromosómica (1,27 %) y ambiental (2,29 %). Una vez excluidos los DTN de origen génico y cromosómico, los restantes se presentan clínicamente como DTN aislados (propiamente multifactoriales) en su mayoría y en menor proporción (16,78 %) como polimalformados. El punto 1, el inicio del cierre del tubo neural es el que causa más DTN por fallo en el propio cierre, casi la cuarta parte del total. Sin embargo, más de la mitad de los DTN se producen en la zona donde dos cierres confluyen.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Al igual que en otras poblaciones con baja prevalencia de DTN de nacimiento, se ha observado una disminución al nacimiento de estos defectos, coincidente con la posibilidad de aborto tras diagnóstico prenatal. Todos los DTN se han podido clasificar aplicando la teoría del cierre múltiple del tubo neural, incluidos 13 pacientes con DTN por afectación de varios puntos de cierre no contiguos. Se observan dos distribuciones de los DTN, una en la que el fallo de cierre se produce propiamente en el área del punto de cierre, y otra resultante del fallo de dos cierres para encontrarse.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To identify the frequency at birth of neural tube defects (NTD) in the Spanish population. NTDs were considered as a whole as well as according to the different sites of closure failure, following the theory of multi-site closure of the neural tube. To analyze the epidemiological characteristics of the different sites.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Data derived from the Spanish Collaborative Study of Congenital Malformations (ECEMC), from April 1976 to March 1995. Among the 1,222,698 live births during this period, 784 infants had NTD were controlled. Among these, 784 infants had NTD.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The prevalence of NTD in our population was 1.01 per 1,000 births, a frequency which is considered mediumto-low. Only 5.74 % of the NTD were of known etiology: 2.17 % were genic, 1.27 % were chromosomic and 2.29% were environmental. Excluding NTD of genetic etiology, whether genic or chromosomic, most of the remaining were isolated defects (multifactorial) and 16.78 % multiple malformations. Site 1, where the closure of the neural tube starts, represented 24 % of all the affected sites. However, more than 50 % of the NTDs corresponded to closure failure at the junction of two sites.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">As in other populations with a low prevalence of NTD at birth, the prevalence of these defects in our population showed a trend to decrease with time, due to the possibility of interrupting gestation after prenatal diagnosis. All the NTD could be classified according to the theory of multi-site closure of the neural tube, including 13 cases with several non-contiguous affected sites. Two types of NTD were observed: in the first, closure failed to occur and in the second, two closures failed to meet.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographical variation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Little" 1 => "M. Elwood" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Epidemiology and control of neural tube defects" "paginaInicial" => "96" "paginaFinal" => "145" "serieFecha" => "1992" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etiologic heterogeneity of neural tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.B. Holmes" 1 => "S.G. Driscoll" 2 => "L. Atkins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM197602122940704" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1976" "volumen" => "294" "paginaInicial" => "365" "paginaFinal" => "369" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1107843" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etiologic heterogeneity of neural tube defects: clues from epidemiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.J. Khoury" 1 => "J.D. Erickson" 2 => "L.M. James" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "1982" "volumen" => "115" "paginaInicial" => "538" "paginaFinal" => "548" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7041633" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical, genetic and epidemiological factors in neural tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.G. Hall" 1 => "J.M. Friedman" 2 => "B.A. Kenna" 3 => "J. Popkin" 4 => "M. Jawanda" 5 => "W. Arnold" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "1988" "volumen" => "43" "paginaInicial" => "827" "paginaFinal" => "837" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3195584" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutral tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.D. Botto" 1 => "C.A. Moore" 2 => "M.J. Khoury" 3 => "J.D. Erickson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199911113412006" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "341" "paginaInicial" => "1509" "paginaFinal" => "1519" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10559453" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Possible prevention of neural tube defects by periconceptional vitamin supplementation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.W. Smithells" 1 => "S. Sheppard" 2 => "C.J. Schorah" 3 => "M.J. Seller" 4 => "N.C. Nevin" 5 => "R. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1980" "volumen" => "1" "paginaInicial" => "339" "paginaFinal" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2563504" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of neural tube defects: results of the Medical Research Council Vitamin study" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "MRC (Medical Research Council) Vitamin study research group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1991" "volumen" => "338" "paginaInicial" => "131" "paginaFinal" => "137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1677062" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of the first ocurrence of neural tube defects by periconceptional vitamine supplementation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.E. Czeizel" 1 => "I. Dudás" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199212243272602" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1992" "volumen" => "327" "paginaInicial" => "1832" "paginaFinal" => "1835" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1307234" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of neural tube defects with folic acid in China" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.J. Berry" 1 => "M.P. Zhu Li" 2 => "J.D. Erickson" 3 => "D.D.S. Song Li" 4 => "C.A. Moore" 5 => "Hong Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199911113412001" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "341" "paginaInicial" => "1485" "paginaFinal" => "1490" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10559448" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutated 5,10 methylenehydrofolate reductase as a risk factor for spina bífida" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Van der Put" 1 => "R. Steegers-Theunissen" 2 => "P. Frosst" 3 => "F. Trijbels" 4 => "T.K. Eskes" 5 => "L.P. Van den Heuvel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1995" "volumen" => "346" "paginaInicial" => "1070" "paginaFinal" => "1071" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7564788" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural tube defects?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.M. Van der Put" 1 => "F. Gabreels" 2 => "E.M. Stevens" 3 => "J.A. Smeitink" 4 => "F.J. Trijbels" 5 => "T.K. Eskes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Human Genet" "fecha" => "1998" "volumen" => "62" "paginaInicial" => "1044" "paginaFinal" => "1051" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital malformations worlwide" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "International Clearinghouse for Birth Defects Monitoring Systems (ICBDM)" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1991" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EUROCAT Report 4: Surveillance of congenital anomalies 1980-1988" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "EUROCAT Working Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1991" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impacto del diagnóstico prenatal sobre la frecuencia al nacimiento de los defectos del tubo neural en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.L. Martínez-Frías" 1 => "E. Bermejo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Progr Diag Pren" "fecha" => "1995" "volumen" => "6" "paginaInicial" => "397" "paginaFinal" => "406" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalencia de los defectos del tubo neural en Asturias, 1987-1993" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. García López" 1 => "F. Ariza Hevia" 2 => "J. Fernández Toral" 3 => "A. Franganillo Fernández" 4 => "C. Moro Bayón" 5 => "C. Mosquera Tenreiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1995" "volumen" => "42" "paginaInicial" => "285" "paginaFinal" => "289" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impacto del diagnóstico prenatal sobre la prevalencia al nacimiento de defectos del tubo neural. Pediatrics (ed" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.E. Roberts" 1 => "C.A. Moore" 2 => "J.D. Cragan" 3 => "P.M. Fernhoff" 4 => "M.J. Khoury" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "esp.)" "fecha" => "1995" "volumen" => "40" "paginaInicial" => "279" "paginaFinal" => "282" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of neutral tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.P. Oakley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "341" "paginaInicial" => "1546" "paginaFinal" => "1547" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10577109" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence for multi-site closure of the neural tube in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.I. Van Allen" 1 => "D.K. Kalousek" 2 => "G.F. Chernoff" 3 => "D. Juriloff" 4 => "M. Harris" 5 => "B.C. McGillivray" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajmg.1320470528" "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "1993" "volumen" => "47" "paginaInicial" => "723" "paginaFinal" => "743" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8267004" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anterior neural tube closure in the mouse: fuel for disagreement with the classical theory" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Golden" 1 => "G.F. Chernoff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Clinical Research" "fecha" => "1983" "volumen" => "31" "paginaInicial" => "127A" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical teratology and consultation case report. Two distinct anterior neural tubedefects in a human fetus: evidence for an intermittent pattern of neural tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.J. Busam" 1 => "D.J. Roberts" 2 => "J.A. Golden" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/tera.1420480503" "Revista" => array:6 [ "tituloSerie" => "Teratology" "fecha" => "1993" "volumen" => "48" "paginaInicial" => "399" "paginaFinal" => "403" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7508150" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Description of the characteristics of cases with noncontiguous neural tube defects identified in a series of consecutive births" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.L. Martínez-Frías" 1 => "A. Sanchis" 2 => "P. Aparicio" 3 => "M. Blanco" 4 => "M.J. García" 5 => "J. Gómez-Ullate" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1096-9926(199801)57:1<13::AID-TERA3>3.0.CO;2-8" "Revista" => array:6 [ "tituloSerie" => "Teratology" "fecha" => "1998" "volumen" => "57" "paginaInicial" => "13" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9516747" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manual Operacional" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.L. Martínez-Frías" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1995" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Teoría de los múltiples puntos de cierre del tubo neural. Tipos y análisis de las frecuencias de los defectos de los diferentes puntos de cierre" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.L. Martínez-Frías" 1 => "A. Sanchis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Progr Diag Prenat" "fecha" => "1996" "volumen" => "8" "paginaInicial" => "161" "paginaFinal" => "172" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiologic characteristics of phenotipically distinct neural tube defcts among 0.7 million California births, 1983-1987" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.M. Shaw" 1 => "N.G. Jensvold" 2 => "C.R. Wasserman" 3 => "E.J. Lammer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/tera.1420490210" "Revista" => array:6 [ "tituloSerie" => "Teratology" "fecha" => "1994" "volumen" => "49" "paginaInicial" => "143" "paginaFinal" => "149" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8016745" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elevated rates of severe neural tube defects in a high-prevalence area in Northern China" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "C.A. Moore" 1 => "L.i. Song" 2 => "L.i. Zhu" 3 => "G.u. Shi-xin Hong, Hai-qin" 4 => "R.J. Berry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "1997" "volumen" => "73" "paginaInicial" => "113" "paginaFinal" => "118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9409858" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidencia de los defectos del tubo neural en la provincia de Sevilla. Posibles causas de su descenso" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Cañada" 1 => "J.M. Bedoya" 2 => "A. Bermejo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Prog Diagn Pren" "fecha" => "1991" "volumen" => "3" "paginaInicial" => "121" "paginaFinal" => "129" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalencia de los defectos de tubo neural en Asturias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. García-Miñaur" 1 => "J. Salvador" 2 => "C. Mosquera" 3 => "V. Castro" 4 => "A. Plasencia" 5 => "E. García López" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1996" "volumen" => "44" "paginaInicial" => "525" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8928983" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Martínez-Frías ML, Gómez-Ullate J, Valdor C, Bermejo E. Frecuencias de DTN y síndrome de Down en recién nacidos en Santander. Significado de las cifras de frecuencia corregidas y no corregidas por las interrupciones de la gestación tras el diagnóstico prenatal de esos defectos congénitos. (Prog Obst Ginecol). En prensa." ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of prenatal diagnosis and selective pregnancy termination because of fetal neural tube defects in The Netherlands in comparison to other European countries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.C. Cornel" 1 => "P. Leurquin" 2 => "H.E. De Walle" 3 => "A.L. Staal-Schreinemachers" 4 => "J.R. Beekhuis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ned Tijdschr Geneeskd" "fecha" => "1997" "volumen" => "141" "paginaInicial" => "2239" "paginaFinal" => "2244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9550786" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of prenatal diagnosis and elective termination on prevalence and risk estimates of neural tube defects in California, 1989-1991" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.M. Velie" 1 => "G.M. Shaw" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "1996" "volumen" => "144" "paginaInicial" => "473" "paginaFinal" => "479" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8781462" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neural tube defects 1974-1994–down but not out" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Murphy" 1 => "V. Seagroatt" 2 => "K. Hey" 3 => "M. O'Donnell" 4 => "M. Godden" 5 => "N. Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dis Child Fetal Neonatal-Ed" "fecha" => "1996" "volumen" => "75" "paginaInicial" => "F133" "paginaFinal" => "F134" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8949699" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multisite neural tube closure in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.I. Van Allen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Birth Defects" "fecha" => "1996" "volumen" => "30" "paginaInicial" => "203" "paginaFinal" => "225" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9125329" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Studies in neural tube defects I. Epidemiologic and etiologic aspects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N.C. Myrianthopoulos" 1 => "M. Melnick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajmg.1320260405" "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "1987" "volumen" => "26" "paginaInicial" => "783" "paginaFinal" => "796" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3296753" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple sites of anterior neural tube closure in humans: evidence from anterior neural tube defects (Anencephaly)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Golden" 1 => "G.F. Chernoff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1995" "volumen" => "95" "paginaInicial" => "506" "paginaFinal" => "510" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7700749" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sites of neural tube closure failure. A new approach to the epdemiology of neural tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.A. Moore" 1 => "L.i. Song" 2 => "Shi-xin Hong" 3 => "M.I. Van Allen" 4 => "L.i. Zhu" 5 => "R.J. Berry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Proceeding of the Greenwood Genetic Center" "fecha" => "1995" "volumen" => "14" "paginaInicial" => "48" "paginaFinal" => "49" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anencephaly and faciocranioschisis: evidence of complete failure of closure 3 of the neural tube in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Urioste" 1 => "A. Rosa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "1998" "volumen" => "75" "paginaInicial" => "4" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9450848" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sex, neural tube defects, and multisite closure of human neutral tube" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. Seller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajmg.1320580406" "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "1995" "volumen" => "58" "paginaInicial" => "332" "paginaFinal" => "336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8533841" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aneuploidy among prenatally detected neural tube defects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.r. Hume RF" 1 => "A. Drugan" 2 => "A. Reichler" 3 => "J. Lampinem" 4 => "L.S. Martin" 5 => "M.P. Johnson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1096-8628(19960111)61:2<171::AID-AJMG14>3.0.CO;2-R" "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "1996" "volumen" => "61" "paginaInicial" => "171" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8669447" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neural tube defects in chromosomally normal and abnormal human embryos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W. Coerdt" 1 => "K. Miller" 2 => "W. Holzgreve" 3 => "R. Rauskolb" 4 => "E. Schwinger" 5 => "H. Rehder" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1469-0705.1997.10060410.x" "Revista" => array:6 [ "tituloSerie" => "Ultrasound Obstet Gynecol" "fecha" => "1997" "volumen" => "10" "paginaInicial" => "410" "paginaFinal" => "415" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9476327" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neural tube defects, chromosome abnormalities and multiple closure sites for the human neural tube" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. Seller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Dysmorphol" "fecha" => "1995" "volumen" => "4" "paginaInicial" => "202" "paginaFinal" => "207" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7551155" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005400000002/v1_201307051539/S1695403301786730/v1_201307051539/es/main.assets" "Apartado" => array:4 [ "identificador" => "14234" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Medicina fetal y neonatología" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005400000002/v1_201307051539/S1695403301786730/v1_201307051539/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301786730?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 7 | 11 | 18 |
| 2024 Octubre | 64 | 65 | 129 |
| 2024 Septiembre | 57 | 53 | 110 |
| 2024 Agosto | 78 | 114 | 192 |
| 2024 Julio | 63 | 62 | 125 |
| 2024 Junio | 91 | 99 | 190 |
| 2024 Mayo | 79 | 68 | 147 |
| 2024 Abril | 73 | 60 | 133 |
| 2024 Marzo | 34 | 51 | 85 |
| 2024 Febrero | 47 | 46 | 93 |
| 2024 Enero | 30 | 41 | 71 |
| 2023 Diciembre | 22 | 33 | 55 |
| 2023 Noviembre | 38 | 55 | 93 |
| 2023 Octubre | 35 | 55 | 90 |
| 2023 Septiembre | 27 | 29 | 56 |
| 2023 Agosto | 68 | 47 | 115 |
| 2023 Julio | 56 | 48 | 104 |
| 2023 Junio | 30 | 66 | 96 |
| 2023 Mayo | 49 | 31 | 80 |
| 2023 Abril | 47 | 31 | 78 |
| 2023 Marzo | 57 | 52 | 109 |
| 2023 Febrero | 36 | 32 | 68 |
| 2023 Enero | 26 | 38 | 64 |
| 2022 Diciembre | 36 | 45 | 81 |
| 2022 Noviembre | 70 | 50 | 120 |
| 2022 Octubre | 68 | 62 | 130 |
| 2022 Septiembre | 33 | 57 | 90 |
| 2022 Agosto | 80 | 65 | 145 |
| 2022 Julio | 56 | 50 | 106 |
| 2022 Junio | 31 | 76 | 107 |
| 2022 Mayo | 54 | 58 | 112 |
| 2022 Abril | 60 | 77 | 137 |
| 2022 Marzo | 42 | 60 | 102 |
| 2022 Febrero | 38 | 27 | 65 |
| 2022 Enero | 29 | 46 | 75 |
| 2021 Diciembre | 32 | 46 | 78 |
| 2021 Noviembre | 46 | 53 | 99 |
| 2021 Octubre | 49 | 49 | 98 |
| 2021 Septiembre | 28 | 44 | 72 |
| 2021 Agosto | 33 | 39 | 72 |
| 2021 Julio | 29 | 38 | 67 |
| 2021 Junio | 34 | 42 | 76 |
| 2021 Mayo | 32 | 45 | 77 |
| 2021 Abril | 65 | 115 | 180 |
| 2021 Marzo | 70 | 41 | 111 |
| 2021 Febrero | 48 | 44 | 92 |
| 2021 Enero | 48 | 31 | 79 |
| 2020 Diciembre | 49 | 26 | 75 |
| 2020 Noviembre | 29 | 24 | 53 |
| 2020 Octubre | 48 | 22 | 70 |
| 2020 Septiembre | 53 | 17 | 70 |
| 2020 Agosto | 27 | 23 | 50 |
| 2020 Julio | 51 | 26 | 77 |
| 2020 Junio | 29 | 9 | 38 |
| 2020 Mayo | 34 | 25 | 59 |
| 2020 Abril | 37 | 18 | 55 |
| 2020 Marzo | 40 | 18 | 58 |
| 2020 Febrero | 33 | 18 | 51 |
| 2020 Enero | 49 | 27 | 76 |
| 2019 Diciembre | 57 | 17 | 74 |
| 2019 Noviembre | 32 | 14 | 46 |
| 2019 Octubre | 24 | 32 | 56 |
| 2019 Septiembre | 19 | 31 | 50 |
| 2019 Agosto | 20 | 23 | 43 |
| 2019 Julio | 33 | 39 | 72 |
| 2019 Junio | 43 | 52 | 95 |
| 2019 Mayo | 43 | 61 | 104 |
| 2019 Abril | 63 | 76 | 139 |
| 2019 Marzo | 18 | 22 | 40 |
| 2019 Febrero | 18 | 12 | 30 |
| 2019 Enero | 16 | 16 | 32 |
| 2018 Diciembre | 26 | 13 | 39 |
| 2018 Noviembre | 22 | 16 | 38 |
| 2018 Octubre | 34 | 17 | 51 |
| 2018 Septiembre | 23 | 10 | 33 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 4 | 0 | 4 |
| 2018 Abril | 10 | 0 | 10 |
| 2018 Marzo | 10 | 0 | 10 |
| 2018 Febrero | 7 | 0 | 7 |
| 2018 Enero | 8 | 0 | 8 |
| 2017 Diciembre | 4 | 0 | 4 |
| 2017 Noviembre | 8 | 0 | 8 |
| 2017 Octubre | 6 | 0 | 6 |
| 2017 Septiembre | 13 | 0 | 13 |
| 2017 Agosto | 7 | 0 | 7 |
| 2017 Julio | 10 | 0 | 10 |
| 2017 Junio | 19 | 20 | 39 |
| 2017 Mayo | 17 | 37 | 54 |
| 2017 Abril | 19 | 18 | 37 |
| 2017 Marzo | 8 | 25 | 33 |
| 2017 Febrero | 8 | 9 | 17 |
| 2017 Enero | 6 | 10 | 16 |
| 2016 Diciembre | 26 | 24 | 50 |
| 2016 Noviembre | 45 | 47 | 92 |
| 2016 Octubre | 35 | 51 | 86 |
| 2016 Septiembre | 42 | 27 | 69 |
| 2016 Agosto | 54 | 28 | 82 |
| 2016 Julio | 38 | 25 | 63 |
| 2016 Junio | 2 | 0 | 2 |
| 2016 Mayo | 3 | 0 | 3 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 6 | 31 | 37 |
| 2016 Febrero | 3 | 0 | 3 |
| 2016 Enero | 3 | 0 | 3 |
| 2015 Diciembre | 5 | 0 | 5 |
| 2015 Noviembre | 1 | 0 | 1 |
| 2015 Octubre | 2 | 0 | 2 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Agosto | 2 | 0 | 2 |
| 2015 Julio | 10 | 0 | 10 |
| 2015 Junio | 7 | 0 | 7 |
| 2015 Mayo | 11 | 0 | 11 |
| 2015 Abril | 9 | 0 | 9 |
| 2015 Marzo | 6 | 27 | 33 |
| 2015 Febrero | 6 | 0 | 6 |
| 2015 Enero | 9 | 0 | 9 |
| 2014 Diciembre | 16 | 1 | 17 |
| 2014 Noviembre | 12 | 0 | 12 |
| 2014 Octubre | 7 | 2 | 9 |
| 2014 Septiembre | 8 | 5 | 13 |
| 2014 Agosto | 18 | 1 | 19 |
| 2014 Julio | 6 | 1 | 7 |
| 2014 Junio | 20 | 1 | 21 |
| 2014 Mayo | 27 | 2 | 29 |
| 2014 Abril | 20 | 2 | 22 |
| 2014 Marzo | 22 | 14 | 36 |
| 2014 Febrero | 17 | 16 | 33 |
| 2014 Enero | 15 | 11 | 26 |
| 2013 Diciembre | 17 | 9 | 26 |
| 2013 Noviembre | 35 | 10 | 45 |
| 2013 Octubre | 45 | 23 | 68 |
| 2013 Septiembre | 39 | 20 | 59 |
| 2013 Agosto | 38 | 26 | 64 |
| 2013 Julio | 5 | 9 | 14 |
| 2013 Junio | 4 | 5 | 9 |
| 2013 Mayo | 3 | 1 | 4 |
| 2013 Abril | 2 | 4 | 6 |
| 2013 Marzo | 4 | 5 | 9 |
| 2013 Febrero | 22 | 6 | 28 |
| 2013 Enero | 63 | 3 | 66 |
| 2012 Diciembre | 17 | 2 | 19 |
| 2012 Noviembre | 11 | 4 | 15 |
| 2012 Octubre | 4 | 1 | 5 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2012 Agosto | 1 | 0 | 1 |
| 2001 Febrero | 14437 | 0 | 14437 |
Mostrar todo
