Tabaquismo en adolescentes, valores de cotinina en saliva y enfermedad respiratoria
Smoking in adolescents, saliva cotinine concentrations and respiratory disease
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García-Marcos Álvarez, A. Martínez Torres, J.J. Guillén Pérez, A. Martínez Victoria" "autores" => array:4 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "García-Marcos Álvarez" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Martínez Torres" ] 2 => array:2 [ "nombre" => "J.J." "apellidos" => "Guillén Pérez" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Martínez Victoria" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301786614?idApp=UINPBA00005H" "url" => "/16954033/0000005400000002/v1_201307051539/S1695403301786614/v1_201307051539/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Tabaquismo en adolescentes, valores de cotinina en saliva y enfermedad respiratoria" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "114" "paginaFinal" => "119" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R.G. Suárez López de Vergara, C. Galván Fernández, C. Oliva Fernández, E. Doménech Martínez, F. Barroso Guerrero" "autores" => array:5 [ 0 => array:4 [ "nombre" => "R.G." "apellidos" => "Suárez López de Vergara" "email" => array:1 [ 0 => "jmdorta@arquired.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Galván Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Oliva Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Doménech Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "F." "apellidos" => "Barroso Guerrero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Centros de Salud Finca España y Laguna-Geneto. La Laguna" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital de Nuestra Señora de la Candelaria. Santa Cruz de Tenerife" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Facultad de Medicina de La Laguna. Tenerife" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dra. R.G. Suárez López de Vergara. Urbanización Guajara Delta, 55. 38205 La Laguna. Santa Cruz de Tenerife." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Smoking in adolescents, saliva cotinine concentrations and respiratory disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-01-01" "fechaAceptado" => "2000-10-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186576" "palabras" => array:4 [ 0 => "<span class="elsevierStyleItalic">Adolescencia</span>" 1 => "<span class="elsevierStyleItalic">Hábito tabáquico</span>" 2 => "<span class="elsevierStyleItalic">Cotinina en saliva</span>" 3 => "<span class="elsevierStyleItalic">Enfermedad respiratoria</span>" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186575" "palabras" => array:4 [ 0 => "<span class="elsevierStyleItalic">Adolescence</span>" 1 => "<span class="elsevierStyleItalic">Smoking habits</span>" 2 => "<span class="elsevierStyleItalic">Saliva cotinine concentrations</span>" 3 => "<span class="elsevierStyleItalic">Respiratory disease</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la cotinina en saliva en adolescentes y su relación con el hábito de fumar y la enfermedad respiratoria.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 420 adolescentes, de ambos sexos, con edades entre 14 y 21 años (media, 16,4 ± 1,32) de colegios públicos y privados de Tenerife. El 54,7 % eran varones y el 45,3 %, mujeres. Se trata de una encuesta individualizada, según modelo de la American Thoracic Society y determinación de cotinina en saliva (RIA). Según el hábito tabáquico los adolescentes estaban distribuidos de la siguiente forma: 26,5 %, fumadores habituales; 11 %, fumadores esporádicos; 3,6 %, ex fumadores; 45,6%, fumadores pasivos, y 13,4 %, no expuestos al humo del tabaco.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La media de cotinina en saliva en los fumadores habituales fue 225,4 ± 167,4 ng/ml; en los fumadores esporádicos, 19,5 ± 44,9 ng/ml; en ex fumadores, 17,4 ± 51,1 ng/ml; en fumadores pasivos, 4,2 ± 15,0 ng/ml, y en los no expuestos, 2,2 ± 5,8 ng/ml. Se encontró relación entre los valores de cotinina en saliva y el hábito tabáquico (p = 0,0001).</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La media de cotinina en los fumadores de menos de 10 cigarrillos al día fue de 142,7 ± 131,5 ng/ml y en los de más de 10 cigarrillos al día de 340,1 ± 144,9 ng/ml, (p = 0,0001). Asimismo, se encontró significación entre los valores de cotinina y el número de cigarrillos fumados habitualmente y en las últimas 24 horas antes de la obtención de la muestra (p = 0,0001).</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se observó mayor número de infecciones de vías bajas de repetición (p = 0,0001), tos crónica (p = 0,0001) y broncospasmo al ejercicio (p = 0,0001), en los adolescentes con mayores valores de cotinina.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La cotinina en saliva se eleva con el mayor grado de consumo y de exposición al tabaco. Los adolescentes con infecciones de vías respiratoria bajas de repetición, tos crónica y broncospasmo al ejercicio, presentan concentraciones superiores de cotinina en saliva.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess cotinine levels in the saliva of adolescents and the relationship between these levels, smoking habits and respiratory disease.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We studied 420 adolescents (54.7 % boys and 45.3% girls) aged between 14 and 21 years (mean age, 16.4 ± 1.32), from state and private schools in Tenerife. An individualized survey, based on the American Thoracic Society's model, was carried out and saliva cotinine concentrations were determined by radioimmunoassay.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution according to smoking habits was as follows: 26.5 % were regular smokers, 11 % were sporadic smokers, 3.6% were former smokers, 45.6% were passive smokers, and 13.4% were not exposed to smoking. Mean cotinine levels were 225.4 ng/ml in regular smokers, 19.5 ng/ml in sporadic smokers, 17.4 ng/ml in former smokers, 4.2 ng/ml in passive smokers and 2.2 ng/ml in individuals not exposed to tobacco smoke, which de-monstrated the correlation between saliva cotinine concentrations and smoking habits (p = 0.0001). The cotinine level in smokers of < 10 cigarettes/day was 142,7 ng/ml and in smokers of > 10 cigarettes/day it was 341,1 ng/ml (p = 0.0001). A significant correlation was also found between cotinine concentrations and the number of cigarettes smoked regularly and in the last 24 hours before sample collection (p = 0.0001). Lower respiratory tract infection (p = 0.0001), chronic cough (p = 0.0001) and bronchospasm on physical exercise (p = 0.0001) were more frequent in adolescents with higher cotinine concentrations.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Higher saliva cotinine concentrations were correlated with greater tobacco consumption and exposure to tobacco smoke. Adolescents with lower respiratory tract infections, chronic cough and bronchospasm on physical exercise had higher saliva cotinine concentrations.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tabaquismo escolar. Estudio epidemiológico transversal en una población de 4.281 escolares" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.F. Pascual Lledó" 1 => "J.L. Viejo Bañuelos" 2 => "F. Gallo Marín" 3 => "C. De Abajo Cucurrull" 4 => "A. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 7 | 12 | 19 |
| 2024 Octubre | 62 | 41 | 103 |
| 2024 Septiembre | 43 | 36 | 79 |
| 2024 Agosto | 62 | 82 | 144 |
| 2024 Julio | 39 | 39 | 78 |
| 2024 Junio | 57 | 41 | 98 |
| 2024 Mayo | 44 | 29 | 73 |
| 2024 Abril | 40 | 30 | 70 |
| 2024 Marzo | 48 | 32 | 80 |
| 2024 Febrero | 46 | 36 | 82 |
| 2024 Enero | 53 | 38 | 91 |
| 2023 Diciembre | 54 | 31 | 85 |
| 2023 Noviembre | 51 | 27 | 78 |
| 2023 Octubre | 60 | 31 | 91 |
| 2023 Septiembre | 29 | 30 | 59 |
| 2023 Agosto | 26 | 32 | 58 |
| 2023 Julio | 27 | 32 | 59 |
| 2023 Junio | 24 | 36 | 60 |
| 2023 Mayo | 45 | 27 | 72 |
| 2023 Abril | 20 | 22 | 42 |
| 2023 Marzo | 25 | 46 | 71 |
| 2023 Febrero | 17 | 19 | 36 |
| 2023 Enero | 26 | 30 | 56 |
| 2022 Diciembre | 46 | 23 | 69 |
| 2022 Noviembre | 47 | 38 | 85 |
| 2022 Octubre | 34 | 45 | 79 |
| 2022 Septiembre | 32 | 37 | 69 |
| 2022 Agosto | 38 | 45 | 83 |
| 2022 Julio | 25 | 52 | 77 |
| 2022 Junio | 29 | 48 | 77 |
| 2022 Mayo | 26 | 72 | 98 |
| 2022 Abril | 30 | 46 | 76 |
| 2022 Marzo | 54 | 46 | 100 |
| 2022 Febrero | 38 | 39 | 77 |
| 2022 Enero | 57 | 55 | 112 |
| 2021 Diciembre | 42 | 55 | 97 |
| 2021 Noviembre | 32 | 42 | 74 |
| 2021 Octubre | 51 | 54 | 105 |
| 2021 Septiembre | 46 | 47 | 93 |
| 2021 Agosto | 37 | 24 | 61 |
| 2021 Julio | 47 | 48 | 95 |
| 2021 Junio | 60 | 35 | 95 |
| 2021 Mayo | 39 | 46 | 85 |
| 2021 Abril | 76 | 52 | 128 |
| 2021 Marzo | 80 | 27 | 107 |
| 2021 Febrero | 70 | 35 | 105 |
| 2021 Enero | 48 | 23 | 71 |
| 2020 Diciembre | 61 | 22 | 83 |
| 2020 Noviembre | 37 | 24 | 61 |
| 2020 Octubre | 29 | 17 | 46 |
| 2020 Septiembre | 47 | 18 | 65 |
| 2020 Agosto | 37 | 10 | 47 |
| 2020 Julio | 35 | 13 | 48 |
| 2020 Junio | 29 | 19 | 48 |
| 2020 Mayo | 35 | 12 | 47 |
| 2020 Abril | 26 | 13 | 39 |
| 2020 Marzo | 34 | 7 | 41 |
| 2020 Febrero | 46 | 14 | 60 |
| 2020 Enero | 60 | 17 | 77 |
| 2019 Diciembre | 31 | 16 | 47 |
| 2019 Noviembre | 30 | 14 | 44 |
| 2019 Octubre | 19 | 10 | 29 |
| 2019 Septiembre | 48 | 25 | 73 |
| 2019 Agosto | 27 | 16 | 43 |
| 2019 Julio | 25 | 34 | 59 |
| 2019 Junio | 72 | 39 | 111 |
| 2019 Mayo | 80 | 38 | 118 |
| 2019 Abril | 80 | 18 | 98 |
| 2019 Marzo | 35 | 11 | 46 |
| 2019 Febrero | 16 | 8 | 24 |
| 2019 Enero | 37 | 11 | 48 |
| 2018 Diciembre | 21 | 12 | 33 |
| 2018 Noviembre | 26 | 19 | 45 |
| 2018 Octubre | 22 | 11 | 33 |
| 2018 Septiembre | 17 | 6 | 23 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Mayo | 5 | 0 | 5 |
| 2018 Abril | 11 | 0 | 11 |
| 2018 Marzo | 12 | 0 | 12 |
| 2018 Febrero | 7 | 0 | 7 |
| 2018 Enero | 5 | 0 | 5 |
| 2017 Diciembre | 11 | 0 | 11 |
| 2017 Noviembre | 12 | 0 | 12 |
| 2017 Octubre | 15 | 0 | 15 |
| 2017 Septiembre | 8 | 0 | 8 |
| 2017 Agosto | 13 | 0 | 13 |
| 2017 Julio | 18 | 0 | 18 |
| 2017 Junio | 20 | 8 | 28 |
| 2017 Mayo | 15 | 10 | 25 |
| 2017 Abril | 15 | 6 | 21 |
| 2017 Marzo | 11 | 10 | 21 |
| 2017 Febrero | 9 | 3 | 12 |
| 2017 Enero | 14 | 1 | 15 |
| 2016 Diciembre | 30 | 7 | 37 |
| 2016 Noviembre | 54 | 7 | 61 |
| 2016 Octubre | 31 | 5 | 36 |
| 2016 Septiembre | 23 | 6 | 29 |
| 2016 Agosto | 26 | 11 | 37 |
| 2016 Julio | 14 | 15 | 29 |
| 2016 Abril | 2 | 0 | 2 |
| 2016 Marzo | 4 | 15 | 19 |
| 2016 Febrero | 1 | 0 | 1 |
| 2016 Enero | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Octubre | 1 | 0 | 1 |
| 2015 Agosto | 3 | 0 | 3 |
| 2015 Julio | 9 | 0 | 9 |
| 2015 Junio | 6 | 0 | 6 |
| 2015 Mayo | 7 | 0 | 7 |
| 2015 Abril | 9 | 0 | 9 |
| 2015 Marzo | 4 | 0 | 4 |
| 2015 Febrero | 10 | 0 | 10 |
| 2015 Enero | 2 | 0 | 2 |
| 2014 Diciembre | 7 | 1 | 8 |
| 2014 Noviembre | 3 | 0 | 3 |
| 2014 Octubre | 6 | 0 | 6 |
| 2014 Septiembre | 4 | 1 | 5 |
| 2014 Agosto | 10 | 2 | 12 |
| 2014 Julio | 7 | 2 | 9 |
| 2014 Junio | 6 | 2 | 8 |
| 2014 Mayo | 15 | 1 | 16 |
| 2014 Abril | 5 | 2 | 7 |
| 2014 Marzo | 7 | 7 | 14 |
| 2014 Febrero | 9 | 7 | 16 |
| 2014 Enero | 11 | 8 | 19 |
| 2013 Diciembre | 14 | 9 | 23 |
| 2013 Noviembre | 19 | 12 | 31 |
| 2013 Octubre | 16 | 9 | 25 |
| 2013 Septiembre | 18 | 6 | 24 |
| 2013 Agosto | 18 | 9 | 27 |
| 2013 Julio | 4 | 4 | 8 |
| 2013 Junio | 1 | 5 | 6 |
| 2013 Mayo | 2 | 4 | 6 |
| 2013 Abril | 3 | 1 | 4 |
| 2013 Marzo | 9 | 2 | 11 |
| 2013 Febrero | 30 | 2 | 32 |
| 2013 Enero | 36 | 2 | 38 |
| 2012 Diciembre | 20 | 3 | 23 |
| 2012 Noviembre | 30 | 1 | 31 |
| 2012 Octubre | 25 | 1 | 26 |
| 2012 Septiembre | 4 | 1 | 5 |
| 2012 Agosto | 1 | 0 | 1 |
| 2001 Febrero | 2567 | 0 | 2567 |
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