Procalcitonina: un nuevo marcador de infección bacteriana
Procalcitonin. A new marker for bacterial infection
J. Casado Floresa,
, A. Blanco Quirósb
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jcasadof@line_pro.es
Correspondencia: Servicio de Cuidados Intensivos Pediátricos. Hospital Universitario del Niño Jesús. Avda. Menéndez Pelayo, 65. 28009 Madrid
Correspondencia: Servicio de Cuidados Intensivos Pediátricos. Hospital Universitario del Niño Jesús. Avda. Menéndez Pelayo, 65. 28009 Madrid
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"apellidos" => "Casado Flores" "email" => array:1 [ 0 => "jcasadof@line_pro.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Blanco Quirós" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Cuidados Intensivos Pediátricos. Hospital Universitario del Niño Jesús. Universidad Autónoma de Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Área de Pediatría. Universidad de Valladolid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servicio de Cuidados Intensivos Pediátricos. Hospital Universitario del Niño Jesús. Avda. Menéndez Pelayo, 65. 28009 Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Procalcitonin. A new marker for bacterial infection" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-07-31" "fechaAceptado" => "2000-10-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186560" "palabras" => array:5 [ 0 => "rocalcitonina" 1 => "Sepsis" 2 => "Shock séptico" 3 => "Meningitis" 4 => "Infección bacteriana" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186559" "palabras" => array:5 [ 0 => "rocalcitonin" 1 => "Sepsis" 2 => "Sepsis shock" 3 => "Meningitis" 4 => "Bacterial infection" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La procalcitonina (PCT) es un polipéptido sérico que se encuentra en el plasma en cantidades mínimas (, 0,5 ng/ml) y se eleva intensamente a las pocas horas de la administración de endotoxina en voluntarios humanos, así como en las infecciones bacterianas sistémicas graves (sepsis, shock séptico y meningitis).</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La PCT aumenta moderadamente en las infecciones bacterianas localizadas (neumonía y pielonefritis) y no se modifica ni en las infecciones víricas, ni en la colonización bacteriana. El incremento de la PCT aparece en las infecciones bacterianas graves de los recién nacidos, lactantes, niños mayores y adultos, siendo en la actualidad el mejor marcador de infección bacteriana, mejor que la fórmula y recuento leucocitario, interleucinas o proteína C reactiva. Este último puede ser normal en la primera fase de la sepsis grave, y puede incrementarse también en algunas infecciones víricas.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nosotros hemos comprobado en 54 niños con sepsis grave que los valores plasmáticos de PCT están correlacionados con el número de fármacos vasoactivos empleados para el soporte cardiocirculatorio.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La PCT puede determinarse de manera semicuantitativa en la cabecera del enfermo en cualquier momento y en cualquier hospital sin necesidad de aparatos de medida, utilizando un sencillo test, que permite en menos de 30 min discernir el tipo de infección y la indicación o no de antibioterapia.</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Procalcitonin is a polypeptide present in the plasma of healthy subjects in minimal levels (, 0.5 ng/ml). Serum procalcitonin is markedly increased a few hours after the administration of endotoxin to human volunteers and in invasive bacterial infection (sepsis, septic shock, meningitis). Procalcitonin is moderately increased in local bacterial infection (pneumonia, pyelonephritis) and is unchanged in viral infections or bacterial colonization. Procalcitonin is increased in serious bacterial infections in neonates, children and adults and is currently the best diagnostic marker of severe bacterial infection, being better than leukocyte, interleukin or C-reactive protein counts. C-reactive protein levels can be normal in severe sepsis and some viral infections. We studied 54 children with sepsis in whom plasma procalcitonin levels showed a positive correlation with the vasoactive drugs necessary to maintain cardiovascular activity. The semiquantitative procalcitonin test is simple and easy to use at the bedside at any time and in any hospital as no instruments are required. Within 30 minutes, the test identifies the type of infection and whether antibiotics are indicated.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliogrífia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High serum procalcitonin concentrations in patients with sepsis and infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Assicot" 1 => "D. Gendrel" 2 => "H. Carsin" 3 => "J. Raymond" 4 => "J. Guilbaud" 5 => "C. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 14 | 22 | 36 |
| 2024 Octubre | 92 | 191 | 283 |
| 2024 Septiembre | 106 | 139 | 245 |
| 2024 Agosto | 117 | 215 | 332 |
| 2024 Julio | 102 | 200 | 302 |
| 2024 Junio | 117 | 201 | 318 |
| 2024 Mayo | 119 | 239 | 358 |
| 2024 Abril | 96 | 214 | 310 |
| 2024 Marzo | 103 | 202 | 305 |
| 2024 Febrero | 86 | 168 | 254 |
| 2024 Enero | 167 | 187 | 354 |
| 2023 Diciembre | 112 | 155 | 267 |
| 2023 Noviembre | 120 | 186 | 306 |
| 2023 Octubre | 108 | 185 | 293 |
| 2023 Septiembre | 105 | 172 | 277 |
| 2023 Agosto | 113 | 167 | 280 |
| 2023 Julio | 181 | 141 | 322 |
| 2023 Junio | 166 | 151 | 317 |
| 2023 Mayo | 199 | 199 | 398 |
| 2023 Abril | 123 | 137 | 260 |
| 2023 Marzo | 166 | 194 | 360 |
| 2023 Febrero | 156 | 182 | 338 |
| 2023 Enero | 129 | 186 | 315 |
| 2022 Diciembre | 123 | 163 | 286 |
| 2022 Noviembre | 153 | 202 | 355 |
| 2022 Octubre | 153 | 220 | 373 |
| 2022 Septiembre | 146 | 226 | 372 |
| 2022 Agosto | 139 | 255 | 394 |
| 2022 Julio | 98 | 199 | 297 |
| 2022 Junio | 96 | 293 | 389 |
| 2022 Mayo | 123 | 254 | 377 |
| 2022 Abril | 176 | 274 | 450 |
| 2022 Marzo | 166 | 365 | 531 |
| 2022 Febrero | 226 | 315 | 541 |
| 2022 Enero | 225 | 227 | 452 |
| 2021 Diciembre | 198 | 239 | 437 |
| 2021 Noviembre | 247 | 329 | 576 |
| 2021 Octubre | 255 | 311 | 566 |
| 2021 Septiembre | 228 | 304 | 532 |
| 2021 Agosto | 250 | 282 | 532 |
| 2021 Julio | 205 | 212 | 417 |
| 2021 Junio | 212 | 222 | 434 |
| 2021 Mayo | 221 | 193 | 414 |
| 2021 Abril | 534 | 322 | 856 |
| 2021 Marzo | 395 | 122 | 517 |
| 2021 Febrero | 257 | 105 | 362 |
| 2021 Enero | 215 | 153 | 368 |
| 2020 Diciembre | 215 | 102 | 317 |
| 2020 Noviembre | 191 | 134 | 325 |
| 2020 Octubre | 212 | 159 | 371 |
| 2020 Septiembre | 203 | 149 | 352 |
| 2020 Agosto | 210 | 163 | 373 |
| 2020 Julio | 260 | 173 | 433 |
| 2020 Junio | 278 | 194 | 472 |
| 2020 Mayo | 210 | 254 | 464 |
| 2020 Abril | 204 | 189 | 393 |
| 2020 Marzo | 273 | 136 | 409 |
| 2020 Febrero | 155 | 148 | 303 |
| 2020 Enero | 221 | 142 | 363 |
| 2019 Diciembre | 224 | 101 | 325 |
| 2019 Noviembre | 199 | 146 | 345 |
| 2019 Octubre | 159 | 131 | 290 |
| 2019 Septiembre | 205 | 172 | 377 |
| 2019 Agosto | 150 | 173 | 323 |
| 2019 Julio | 426 | 151 | 577 |
| 2019 Junio | 504 | 154 | 658 |
| 2019 Mayo | 332 | 172 | 504 |
| 2019 Abril | 452 | 260 | 712 |
| 2019 Marzo | 1321 | 262 | 1583 |
| 2019 Febrero | 714 | 148 | 862 |
| 2019 Enero | 507 | 111 | 618 |
| 2018 Diciembre | 359 | 74 | 433 |
| 2018 Noviembre | 492 | 92 | 584 |
| 2018 Octubre | 498 | 38 | 536 |
| 2018 Septiembre | 236 | 23 | 259 |
| 2018 Julio | 1 | 0 | 1 |
| 2018 Mayo | 15 | 0 | 15 |
| 2018 Abril | 67 | 1 | 68 |
| 2018 Marzo | 32 | 1 | 33 |
| 2018 Febrero | 38 | 0 | 38 |
| 2018 Enero | 41 | 0 | 41 |
| 2017 Diciembre | 28 | 1 | 29 |
| 2017 Noviembre | 30 | 1 | 31 |
| 2017 Octubre | 19 | 1 | 20 |
| 2017 Septiembre | 21 | 1 | 22 |
| 2017 Agosto | 15 | 0 | 15 |
| 2017 Julio | 15 | 6 | 21 |
| 2017 Junio | 26 | 34 | 60 |
| 2017 Mayo | 24 | 26 | 50 |
| 2017 Abril | 18 | 22 | 40 |
| 2017 Marzo | 17 | 56 | 73 |
| 2017 Febrero | 14 | 30 | 44 |
| 2017 Enero | 10 | 10 | 20 |
| 2016 Diciembre | 48 | 13 | 61 |
| 2016 Noviembre | 89 | 29 | 118 |
| 2016 Octubre | 77 | 19 | 96 |
| 2016 Septiembre | 85 | 46 | 131 |
| 2016 Agosto | 105 | 58 | 163 |
| 2016 Julio | 69 | 73 | 142 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Mayo | 1 | 0 | 1 |
| 2016 Abril | 2 | 0 | 2 |
| 2016 Marzo | 1 | 0 | 1 |
| 2016 Febrero | 3 | 0 | 3 |
| 2015 Diciembre | 5 | 0 | 5 |
| 2015 Noviembre | 1 | 0 | 1 |
| 2015 Octubre | 3 | 0 | 3 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Agosto | 5 | 0 | 5 |
| 2015 Julio | 12 | 0 | 12 |
| 2015 Junio | 7 | 0 | 7 |
| 2015 Mayo | 19 | 0 | 19 |
| 2015 Abril | 12 | 0 | 12 |
| 2015 Marzo | 15 | 0 | 15 |
| 2015 Febrero | 12 | 0 | 12 |
| 2015 Enero | 7 | 0 | 7 |
| 2014 Diciembre | 13 | 0 | 13 |
| 2014 Noviembre | 6 | 0 | 6 |
| 2014 Octubre | 6 | 0 | 6 |
| 2014 Septiembre | 5 | 2 | 7 |
| 2014 Agosto | 5 | 1 | 6 |
| 2014 Julio | 12 | 2 | 14 |
| 2014 Junio | 11 | 4 | 15 |
| 2014 Mayo | 16 | 2 | 18 |
| 2014 Abril | 9 | 3 | 12 |
| 2014 Marzo | 12 | 5 | 17 |
| 2014 Febrero | 7 | 11 | 18 |
| 2014 Enero | 7 | 7 | 14 |
| 2013 Diciembre | 14 | 17 | 31 |
| 2013 Noviembre | 11 | 4 | 15 |
| 2013 Octubre | 15 | 7 | 22 |
| 2013 Septiembre | 15 | 9 | 24 |
| 2013 Agosto | 11 | 5 | 16 |
| 2013 Julio | 4 | 5 | 9 |
| 2013 Junio | 4 | 1 | 5 |
| 2013 Mayo | 1 | 4 | 5 |
| 2013 Abril | 3 | 3 | 6 |
| 2013 Marzo | 6 | 2 | 8 |
| 2013 Febrero | 17 | 2 | 19 |
| 2013 Enero | 15 | 1 | 16 |
| 2012 Diciembre | 14 | 3 | 17 |
| 2012 Noviembre | 6 | 2 | 8 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2012 Agosto | 2 | 0 | 2 |
| 2001 Enero | 4006 | 0 | 4006 |
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