Transmisión vertical del virus de la hepatitis C
Vertical transmission of hepatitis C virus infection
C. Rubio Quevedo
, M.aA. Holgado Carballo, A. García Suárez, I. Martín de Lara, L. Moltó Ripoll
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Servicio de Pediatría. Hospital Materno-Infantil Virgen de las Nieves. Granada
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Fuertes Femández-Espinar, J. Meriz Rubio, C. Pardos Martínez, V. López Cortés, J.I. Ricarte Díez, E. González Pérez-Yarza" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Fuertes Femández-Espinar" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Meriz Rubio" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Pardos Martínez" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "López Cortés" ] 4 => array:2 [ "nombre" => "J.I." "apellidos" => "Ricarte Díez" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "González Pérez-Yarza" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301786444?idApp=UINPBA00005H" "url" => "/16954033/0000005400000001/v1_201307051535/S1695403301786444/v1_201307051535/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Transmisión vertical del virus de la hepatitis C" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "27" "paginaFinal" => "31" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Rubio Quevedo, M.<span class="elsevierStyleSup">a</span>A. Holgado Carballo, A. García Suárez, I. Martín de Lara, L. Moltó Ripoll" "autores" => array:5 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Rubio Quevedo" "email" => array:1 [ 0 => "claudiorq@teleline.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>A." "apellidos" => "Holgado Carballo" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "García Suárez" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Martín de Lara" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Moltó Ripoll" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Pediatría. Hospital Materno-Infantil Virgen de las Nieves. Granada" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Avda. de Barcelona, 20, 2°A. 18006 Granada" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Vertical transmission of hepatitis C virus infection" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-09-30" "fechaAceptado" => "2000-10-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186543" "palabras" => array:2 [ 0 => "ransmisión vertical" 1 => "Virus de la hepatitis C (VHC)" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186542" "palabras" => array:2 [ 0 => "ertical transmission" 1 => "Hepatitis C virus" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los estudios sobre la transmisión vertical del virus de la hepatitis C (VHC) son escasos a pesar de ser la causa más frecuente de hepatitis C en niños. Se pretende fundamentalmente conocer la tasa de transmisión vertical del VHC en recién nacidos de riesgo y el efecto de los posibles factores de riesgo.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Durante un período de 18 meses (de julio de 1997 a enero de 1999) se efectuó seguimiento prospectivo a 35 niños hijos de madres seropositivas mediante controles de anticuerpos anti-VHC con ELISA de tercera generación, ARN-VHC por RT-PCR de forma cualitativa y enzimograma hepático.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Del total de 35 niños objeto del estudio, el 100% tuvieron anticuerpos (Ac) VHC positivos al nacimiento. La edad media de negativización fue de 6 meses. En 2 niños (5,7%) se detectó infección por el virus C. Uno de ellos era hijo de una madre con coinfección VHC y VIH. De las 35 gestantes seropositivas se identificó un factor de riesgo de transmisión percutánea para el VHC (adicción a drogas por vía parenteral o transfusiones previas) en 19 (54%) y 9 (26%) tenían coinfección por VIH.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El presente estudio concuerda con otros que determinan una tasa de transmisión vertical del VHC alrededor de un 5 %, con un mayor riesgo si las madres tienen coinfección VHC/VIH o factores de riesgo parenterales. Se requieren estudios extensos para determinar la prevalencia de la infección por virus de la hepatitis C en gestantes así como la tasa exacta de transmisión vertical. Es necesario el seguimiento de los niños infectados para valorar las repercusiones de la infección por VHC.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Few studies have been published on vertical transmission of hepatitis C virus (HCV), although it is the most common cause of hepatitis C in children. We aimed to determine the rate of vertical transmission of HCV in at-risk neonates and to assess the effect of possible risk factors.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A prospective follow-up study was conducted in 35 children of seropositive mothers during an 18-month period (July 1997-January 1999). Testing for anti-HCV antibodies was performed with third-generation enzyme-linked im-munoadsorbent assay. HCV-RNA was qualitatively analyzed with reverse transcriptase-polymerase chain reaction (RT-PCR) and hepatic enzyme studies.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">All the 35 children studied were positive for HCV antibodies at birth. The children became HCV-negative at a mean age of 6 months. HCV infection was detected in two children (5.7%). The mother of one of these children had both HCV and human immunodeficiency virus (HIV) infection. Among the 35 seropositive mothers, a risk factor for percutaneous transmission of HCV (parenteral injection, drug addiction, or previous transfusions) was detected in 19 (54%) and HIV coinfection was found in 9 (26%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The present study is consistent with other studies that found a vertical HCV transmission rate of approximately 5 %, with a greater risk if the mothers had HCV/HIV coinfection or parenteral risk factors. Studies with greater numbers of subjects are required to determine the prevalence of HCV in expectant mothers and the precise rate of vertical transmission. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 10 | 11 | 21 |
| 2024 Octubre | 102 | 56 | 158 |
| 2024 Septiembre | 61 | 66 | 127 |
| 2024 Agosto | 62 | 108 | 170 |
| 2024 Julio | 67 | 54 | 121 |
| 2024 Junio | 68 | 28 | 96 |
| 2024 Mayo | 52 | 55 | 107 |
| 2024 Abril | 56 | 48 | 104 |
| 2024 Marzo | 31 | 50 | 81 |
| 2024 Febrero | 41 | 41 | 82 |
| 2024 Enero | 40 | 39 | 79 |
| 2023 Diciembre | 41 | 30 | 71 |
| 2023 Noviembre | 28 | 67 | 95 |
| 2023 Octubre | 29 | 28 | 57 |
| 2023 Septiembre | 22 | 29 | 51 |
| 2023 Agosto | 19 | 23 | 42 |
| 2023 Julio | 27 | 44 | 71 |
| 2023 Junio | 23 | 59 | 82 |
| 2023 Mayo | 27 | 31 | 58 |
| 2023 Abril | 19 | 22 | 41 |
| 2023 Marzo | 18 | 33 | 51 |
| 2023 Febrero | 14 | 27 | 41 |
| 2023 Enero | 23 | 23 | 46 |
| 2022 Diciembre | 33 | 24 | 57 |
| 2022 Noviembre | 31 | 44 | 75 |
| 2022 Octubre | 21 | 53 | 74 |
| 2022 Septiembre | 23 | 32 | 55 |
| 2022 Agosto | 23 | 50 | 73 |
| 2022 Julio | 16 | 49 | 65 |
| 2022 Junio | 20 | 47 | 67 |
| 2022 Mayo | 36 | 32 | 68 |
| 2022 Abril | 28 | 61 | 89 |
| 2022 Marzo | 34 | 55 | 89 |
| 2022 Febrero | 19 | 33 | 52 |
| 2022 Enero | 22 | 45 | 67 |
| 2021 Diciembre | 31 | 51 | 82 |
| 2021 Noviembre | 19 | 47 | 66 |
| 2021 Octubre | 32 | 37 | 69 |
| 2021 Septiembre | 26 | 43 | 69 |
| 2021 Agosto | 13 | 32 | 45 |
| 2021 Julio | 19 | 35 | 54 |
| 2021 Junio | 19 | 56 | 75 |
| 2021 Mayo | 15 | 35 | 50 |
| 2021 Abril | 77 | 73 | 150 |
| 2021 Marzo | 52 | 37 | 89 |
| 2021 Febrero | 63 | 26 | 89 |
| 2021 Enero | 29 | 18 | 47 |
| 2020 Diciembre | 32 | 16 | 48 |
| 2020 Noviembre | 22 | 17 | 39 |
| 2020 Octubre | 20 | 20 | 40 |
| 2020 Septiembre | 27 | 8 | 35 |
| 2020 Agosto | 20 | 9 | 29 |
| 2020 Julio | 16 | 15 | 31 |
| 2020 Junio | 16 | 17 | 33 |
| 2020 Mayo | 24 | 18 | 42 |
| 2020 Abril | 24 | 12 | 36 |
| 2020 Marzo | 15 | 16 | 31 |
| 2020 Febrero | 19 | 19 | 38 |
| 2020 Enero | 22 | 18 | 40 |
| 2019 Diciembre | 45 | 18 | 63 |
| 2019 Noviembre | 12 | 8 | 20 |
| 2019 Octubre | 10 | 12 | 22 |
| 2019 Septiembre | 17 | 23 | 40 |
| 2019 Agosto | 18 | 7 | 25 |
| 2019 Julio | 23 | 30 | 53 |
| 2019 Junio | 30 | 38 | 68 |
| 2019 Mayo | 49 | 37 | 86 |
| 2019 Abril | 55 | 21 | 76 |
| 2019 Marzo | 14 | 11 | 25 |
| 2019 Febrero | 8 | 5 | 13 |
| 2019 Enero | 13 | 16 | 29 |
| 2018 Diciembre | 19 | 14 | 33 |
| 2018 Noviembre | 29 | 16 | 45 |
| 2018 Octubre | 39 | 11 | 50 |
| 2018 Septiembre | 18 | 9 | 27 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 8 | 0 | 8 |
| 2018 Abril | 9 | 0 | 9 |
| 2018 Marzo | 9 | 0 | 9 |
| 2018 Febrero | 8 | 0 | 8 |
| 2018 Enero | 11 | 0 | 11 |
| 2017 Diciembre | 5 | 0 | 5 |
| 2017 Noviembre | 12 | 0 | 12 |
| 2017 Octubre | 11 | 0 | 11 |
| 2017 Septiembre | 12 | 0 | 12 |
| 2017 Agosto | 9 | 0 | 9 |
| 2017 Julio | 10 | 0 | 10 |
| 2017 Junio | 17 | 20 | 37 |
| 2017 Mayo | 23 | 17 | 40 |
| 2017 Abril | 12 | 8 | 20 |
| 2017 Marzo | 19 | 12 | 31 |
| 2017 Febrero | 9 | 7 | 16 |
| 2017 Enero | 5 | 8 | 13 |
| 2016 Diciembre | 9 | 13 | 22 |
| 2016 Noviembre | 31 | 15 | 46 |
| 2016 Octubre | 21 | 12 | 33 |
| 2016 Septiembre | 29 | 30 | 59 |
| 2016 Agosto | 47 | 28 | 75 |
| 2016 Julio | 26 | 28 | 54 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 5 | 25 | 30 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Noviembre | 1 | 0 | 1 |
| 2015 Octubre | 1 | 0 | 1 |
| 2015 Agosto | 2 | 0 | 2 |
| 2015 Julio | 10 | 0 | 10 |
| 2015 Junio | 6 | 0 | 6 |
| 2015 Mayo | 17 | 20 | 37 |
| 2015 Abril | 11 | 0 | 11 |
| 2015 Marzo | 11 | 0 | 11 |
| 2015 Febrero | 9 | 0 | 9 |
| 2015 Enero | 12 | 0 | 12 |
| 2014 Diciembre | 6 | 1 | 7 |
| 2014 Noviembre | 3 | 0 | 3 |
| 2014 Octubre | 11 | 0 | 11 |
| 2014 Septiembre | 4 | 3 | 7 |
| 2014 Agosto | 7 | 1 | 8 |
| 2014 Julio | 12 | 1 | 13 |
| 2014 Junio | 14 | 2 | 16 |
| 2014 Mayo | 17 | 2 | 19 |
| 2014 Abril | 15 | 3 | 18 |
| 2014 Marzo | 19 | 8 | 27 |
| 2014 Febrero | 6 | 9 | 15 |
| 2014 Enero | 11 | 6 | 17 |
| 2013 Diciembre | 21 | 11 | 32 |
| 2013 Noviembre | 23 | 6 | 29 |
| 2013 Octubre | 14 | 7 | 21 |
| 2013 Septiembre | 11 | 10 | 21 |
| 2013 Agosto | 12 | 5 | 17 |
| 2013 Julio | 5 | 3 | 8 |
| 2013 Junio | 2 | 3 | 5 |
| 2013 Mayo | 1 | 2 | 3 |
| 2013 Abril | 3 | 2 | 5 |
| 2013 Marzo | 5 | 2 | 7 |
| 2013 Febrero | 9 | 1 | 10 |
| 2013 Enero | 8 | 0 | 8 |
| 2012 Diciembre | 10 | 1 | 11 |
| 2012 Noviembre | 2 | 2 | 4 |
| 2012 Octubre | 4 | 0 | 4 |
| 2012 Septiembre | 5 | 1 | 6 |
| 2001 Enero | 1991 | 0 | 1991 |
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