Trasplante pulmonar pediátrico
Pediatric lung transplantation
C.B. Huddlestona,
, E. Mendeloffa, G.B. Malloryb
Autor para correspondencia
huddlestonc@msnotes.wustl.edu
Correspondencia: Children's Place, Suite 5550. Children's Hospital. St. Louis, MO USA 63110.
Correspondencia: Children's Place, Suite 5550. Children's Hospital. St. Louis, MO USA 63110.
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Benito Bartolomé, C. Sánchez Fernández-Bernal" "autores" => array:2 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Benito Bartolomé" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Sánchez Fernández-Bernal" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301775431?idApp=UINPBA00005H" "url" => "/16954033/0000005400000004/v1_201307051547/S1695403301775431/v1_201307051547/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Trasplante pulmonar pediátrico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "359" "paginaFinal" => "371" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C.B. Huddleston, E. Mendeloff, G.B. Mallory" "autores" => array:3 [ 0 => array:4 [ "nombre" => "C.B." "apellidos" => "Huddleston" "email" => array:1 [ 0 => "huddlestonc@msnotes.wustl.edu" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Mendeloff" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "G.B." "apellidos" => "Mallory" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Division of Cardiothoracic Surgey. Washington University School of Medicine. St. Louis Children's Hospital, St. Louis, Estados Unidos." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital for Sick Children, Great Ormond Street, Londres, Inglaterra." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Children's Place, Suite 5550. Children's Hospital. St. Louis, MO USA 63110." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pediatric lung transplantation" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-12-31" "fechaAceptado" => "2000-12-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186641" "palabras" => array:6 [ 0 => "Trasplante pulmonar" 1 => "Niños" 2 => "Lactantes" 3 => "Fibrosis quística" 4 => "Hipertensión pulmonar" 5 => "Deficiencia de proteína B del surfactante" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186640" "palabras" => array:5 [ 0 => "Lung transplantation" 1 => "Children" 2 => "Cystic fibrosis" 3 => "Pulmonary hypertension" 4 => "Surfactant protein B deficiency" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se han efectuado aproximadamente 700 trasplantes en niños menores de 18 años de edad en todo el mundo; en cambio, se han efectuado más de 11.000 en adultos. El principal grupo diagnóstico es el de fibrosis quística. Un grupo emergente de pacientes está constituido por los niños que nacen con enfermedades pulmonares de base congénita, como la deficiencia de la proteína B del surfactante. La supervivencia de los niños es muy similar a la observada en adultos, aunque, por lo general, los niños pertenecen a una clase de riesgo más elevado. Por ejemplo, no hay niños que hayan sido sometidos a trasplante por enfermedad pulmonar obstructiva crónica (un grupo diagnóstico de bajo riesgo), en tanto que dicho diagnóstico comprende alrededor del 40 % de todos los adultos sometidosa trasplante de pulmón. La inmunosupresión consiste por lo general en ciclosporina, azatioprina y prednisona. Las complicaciones postrasplante son similares a las observadas en adultos. Alrededor del 40 % de los pacientes desarrollan una bronquiolitis obliterante hacia los 3 años postrasplante y ello sigue constituyendo el principal impedimento para la supervivencia largo plazo. La escasez de donantes también es un obstáculo significativo, sobre todo en el grupo de pacientes adolescentes. Como solución parcial a dicho problema, el trasplante pulmonar de donante vivo ha asumido mayor trascendencia en el programa. Aunque es una estrategia terapéutica compleja y costosa, el trasplante pulmonar sigue siendo el tratamiento más eficaz de las neumopatías parenquimatosas y vasculares en estadios terminales, incluso en los niños de menor edad.</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Approximately 700 transplants world-wide have been performed in patients aged less than 18 years; in contrast, over 11,000 lung transplants have been performed in adults. The major diagnostic group is cystic fibrosis. An emerging group of patients are infants born with congenitally based pulmonary diseases such as surfactant protein B deficiency. Survival in children is very similar to that in adults, although it is generally perceived that children are at higher risk. For instance, no children have been transplanted for chronic obstructive lung disease (a low-risk diagnostic group) while this disease comprises approximately 40 % of all adult lung transplantations. Immunosuppression generally consists of cyclosporine, azathioprine and prednisone. Post-transplant complications in children are similar to those observed in adults. Around 40 % of patients will develop bronchiolitis obliterans approximately 3 years after transplantation and this remains the major impediment to long term survival. Donor shortage is also a significant obstacle, especially in adolescents. As a partial solution to this problem, living donor lung transplantation has taken on a greater role in our program. Although this is a complex, expensive treatment strategy, lung transplantation remains the most effective therapy for end-stage pulmonary parenchymal and vascular diseases even in children.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:39 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The registry of the international society for heart and lung transplantation: seventeenth officialreport-2000" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.D. Hosenpud" 1 => "L.E. Bennett" 2 => "B.M. Keck" 3 => "M.M. Boucek" 4 => "R.J. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 15 | 24 |
| 2024 Octubre | 40 | 58 | 98 |
| 2024 Septiembre | 53 | 49 | 102 |
| 2024 Agosto | 69 | 83 | 152 |
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| 2024 Mayo | 46 | 35 | 81 |
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| 2024 Marzo | 42 | 34 | 76 |
| 2024 Febrero | 54 | 33 | 87 |
| 2024 Enero | 45 | 31 | 76 |
| 2023 Diciembre | 42 | 22 | 64 |
| 2023 Noviembre | 46 | 37 | 83 |
| 2023 Octubre | 49 | 28 | 77 |
| 2023 Septiembre | 31 | 27 | 58 |
| 2023 Agosto | 27 | 22 | 49 |
| 2023 Julio | 45 | 34 | 79 |
| 2023 Junio | 31 | 30 | 61 |
| 2023 Mayo | 58 | 51 | 109 |
| 2023 Abril | 31 | 16 | 47 |
| 2023 Marzo | 32 | 22 | 54 |
| 2023 Febrero | 24 | 18 | 42 |
| 2023 Enero | 22 | 26 | 48 |
| 2022 Diciembre | 50 | 22 | 72 |
| 2022 Noviembre | 41 | 42 | 83 |
| 2022 Octubre | 22 | 43 | 65 |
| 2022 Septiembre | 39 | 37 | 76 |
| 2022 Agosto | 41 | 42 | 83 |
| 2022 Julio | 22 | 48 | 70 |
| 2022 Junio | 49 | 27 | 76 |
| 2022 Mayo | 36 | 39 | 75 |
| 2022 Abril | 67 | 49 | 116 |
| 2022 Marzo | 54 | 45 | 99 |
| 2022 Febrero | 67 | 35 | 102 |
| 2022 Enero | 39 | 47 | 86 |
| 2021 Diciembre | 53 | 43 | 96 |
| 2021 Noviembre | 32 | 45 | 77 |
| 2021 Octubre | 65 | 68 | 133 |
| 2021 Septiembre | 30 | 54 | 84 |
| 2021 Agosto | 37 | 45 | 82 |
| 2021 Julio | 38 | 39 | 77 |
| 2021 Junio | 51 | 32 | 83 |
| 2021 Mayo | 43 | 27 | 70 |
| 2021 Abril | 113 | 59 | 172 |
| 2021 Marzo | 85 | 42 | 127 |
| 2021 Febrero | 117 | 20 | 137 |
| 2021 Enero | 61 | 21 | 82 |
| 2020 Diciembre | 46 | 19 | 65 |
| 2020 Noviembre | 33 | 18 | 51 |
| 2020 Octubre | 45 | 14 | 59 |
| 2020 Septiembre | 56 | 15 | 71 |
| 2020 Agosto | 30 | 13 | 43 |
| 2020 Julio | 70 | 18 | 88 |
| 2020 Junio | 59 | 16 | 75 |
| 2020 Mayo | 55 | 26 | 81 |
| 2020 Abril | 56 | 17 | 73 |
| 2020 Marzo | 40 | 15 | 55 |
| 2020 Febrero | 58 | 28 | 86 |
| 2020 Enero | 65 | 20 | 85 |
| 2019 Diciembre | 70 | 28 | 98 |
| 2019 Noviembre | 46 | 14 | 60 |
| 2019 Octubre | 36 | 12 | 48 |
| 2019 Septiembre | 54 | 21 | 75 |
| 2019 Agosto | 66 | 14 | 80 |
| 2019 Julio | 47 | 26 | 73 |
| 2019 Junio | 56 | 39 | 95 |
| 2019 Mayo | 59 | 36 | 95 |
| 2019 Abril | 36 | 21 | 57 |
| 2019 Marzo | 30 | 12 | 42 |
| 2019 Febrero | 33 | 10 | 43 |
| 2019 Enero | 43 | 9 | 52 |
| 2018 Diciembre | 49 | 27 | 76 |
| 2018 Noviembre | 45 | 12 | 57 |
| 2018 Octubre | 65 | 29 | 94 |
| 2018 Septiembre | 38 | 9 | 47 |
| 2018 Agosto | 2 | 0 | 2 |
| 2018 Julio | 1 | 1 | 2 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 10 | 0 | 10 |
| 2018 Abril | 18 | 0 | 18 |
| 2018 Marzo | 23 | 1 | 24 |
| 2018 Febrero | 14 | 0 | 14 |
| 2018 Enero | 17 | 0 | 17 |
| 2017 Diciembre | 20 | 1 | 21 |
| 2017 Noviembre | 14 | 0 | 14 |
| 2017 Octubre | 23 | 0 | 23 |
| 2017 Septiembre | 19 | 0 | 19 |
| 2017 Agosto | 15 | 0 | 15 |
| 2017 Julio | 20 | 0 | 20 |
| 2017 Junio | 34 | 11 | 45 |
| 2017 Mayo | 26 | 16 | 42 |
| 2017 Abril | 31 | 8 | 39 |
| 2017 Marzo | 26 | 41 | 67 |
| 2017 Febrero | 16 | 10 | 26 |
| 2017 Enero | 13 | 3 | 16 |
| 2016 Diciembre | 41 | 17 | 58 |
| 2016 Noviembre | 89 | 8 | 97 |
| 2016 Octubre | 73 | 10 | 83 |
| 2016 Septiembre | 65 | 11 | 76 |
| 2016 Agosto | 61 | 9 | 70 |
| 2016 Julio | 32 | 12 | 44 |
| 2016 Junio | 2 | 0 | 2 |
| 2016 Mayo | 3 | 0 | 3 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 5 | 0 | 5 |
| 2016 Febrero | 5 | 0 | 5 |
| 2016 Enero | 3 | 0 | 3 |
| 2015 Diciembre | 4 | 0 | 4 |
| 2015 Noviembre | 1 | 0 | 1 |
| 2015 Octubre | 1 | 8 | 9 |
| 2015 Agosto | 6 | 15 | 21 |
| 2015 Julio | 4 | 0 | 4 |
| 2015 Junio | 13 | 4 | 17 |
| 2015 Mayo | 10 | 6 | 16 |
| 2015 Abril | 12 | 0 | 12 |
| 2015 Marzo | 15 | 0 | 15 |
| 2015 Febrero | 11 | 6 | 17 |
| 2015 Enero | 12 | 0 | 12 |
| 2014 Diciembre | 22 | 3 | 25 |
| 2014 Noviembre | 13 | 1 | 14 |
| 2014 Octubre | 22 | 1 | 23 |
| 2014 Septiembre | 20 | 3 | 23 |
| 2014 Agosto | 24 | 1 | 25 |
| 2014 Julio | 31 | 3 | 34 |
| 2014 Junio | 46 | 1 | 47 |
| 2014 Mayo | 39 | 1 | 40 |
| 2014 Abril | 45 | 5 | 50 |
| 2014 Marzo | 52 | 8 | 60 |
| 2014 Febrero | 26 | 8 | 34 |
| 2014 Enero | 34 | 10 | 44 |
| 2013 Diciembre | 38 | 12 | 50 |
| 2013 Noviembre | 31 | 5 | 36 |
| 2013 Octubre | 47 | 11 | 58 |
| 2013 Septiembre | 32 | 5 | 37 |
| 2013 Agosto | 23 | 8 | 31 |
| 2013 Julio | 22 | 6 | 28 |
| 2013 Junio | 3 | 3 | 6 |
| 2013 Mayo | 3 | 2 | 5 |
| 2013 Abril | 3 | 4 | 7 |
| 2013 Marzo | 4 | 6 | 10 |
| 2013 Febrero | 18 | 2 | 20 |
| 2013 Enero | 11 | 2 | 13 |
| 2012 Diciembre | 8 | 1 | 9 |
| 2012 Noviembre | 10 | 4 | 14 |
| 2012 Octubre | 4 | 3 | 7 |
| 2012 Septiembre | 1 | 0 | 1 |
| 2012 Agosto | 3 | 2 | 5 |
| 2001 Marzo | 442 | 0 | 442 |
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