Evolución respiratoria de 4 pacientes con fibrosis quística receptores de trasplante hepático
Pulmonary function after liver transplantation in cystic fibrosis. Report of four cases
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Concheiro Guisán, J.J. García García, E.P. Díaz González, C. Luaces Cubells, J. Pou Fernández" "autores" => array:5 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Concheiro Guisán" ] 1 => array:2 [ "nombre" => "J.J." "apellidos" => "García García" ] 2 => array:2 [ "nombre" => "E.P." "apellidos" => "Díaz González" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Luaces Cubells" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Pou Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301775194?idApp=UINPBA00005H" "url" => "/16954033/0000005400000003/v1_201307051543/S1695403301775194/v1_201307051543/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403301775170" "issn" => "16954033" "doi" => "10.1016/S1695-4033(01)77517-0" "estado" => "S300" "fechaPublicacion" => "2001-03-01" "aid" => "77517" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2001;54:222-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6088 "formatos" => array:3 [ "EPUB" => 87 "HTML" => 5146 "PDF" => 855 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Semiología inicial del neuroblastoma torácico" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "222" "paginaFinal" => "227" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Clinical findings in thoracic neuroblastomas" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Díaz Fernández, E. Quiroga Cantero" "autores" => array:2 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Díaz Fernández" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Quiroga Cantero" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301775170?idApp=UINPBA00005H" "url" => "/16954033/0000005400000003/v1_201307051543/S1695403301775170/v1_201307051543/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Evolución respiratoria de 4 pacientes con fibrosis quística receptores de trasplante hepático" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "228" "paginaFinal" => "232" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. Urgellés Fajardo, M.<span class="elsevierStyleSup">a</span>I. Barrio Gómez de Agüero, M.<span class="elsevierStyleSup">a</span>C. Martinez Carrasco, P. Jara Vega, C. Antelo Landeira" "autores" => array:5 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Urgellés Fajardo" "email" => array:1 [ 0 => "elena_urgelles@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>I." "apellidos" => "Barrio Gómez de Agüero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>C." "apellidos" => "Martinez Carrasco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Jara Vega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Antelo Landeira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidades de Neumología. Hospital Infantil La Paz. Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidades de Hepatología. Hospital Infantil La Paz. Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: 2421 Crystal Bay SW. 55902 Rochester. Minnesota. Estados Unidos" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pulmonary function after liver transplantation in cystic fibrosis. Report of four cases" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-31" "fechaAceptado" => "2000-09-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186603" "palabras" => array:4 [ 0 => "Trasplante hepático" 1 => "Función pulmonar" 2 => "Aspergilosis broncopulmonar alérgica" 3 => "Fibrosis quística" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186604" "palabras" => array:4 [ 0 => "Liver transplantation" 1 => "Pulmonary function" 2 => "Allergic bronchopulmonary aspergillosis" 3 => "Cystic fibrosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio es evaluar la función respiratoria de 4 pacientes con fibrosis quística sometidos a trasplante hepático</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Entre 1993 y 1997, 4 pacientes con fibrosis quística, 3 varones y 1mujer, de edades comprendidas entre los 12 y los 15 años, con cirrosis e hipertensión portal, fueron sometidos a un trasplante hepático. Tres tenían antecedentes de sangrado por varices gastroesofágicas. Antes del trasplante, 3 casos presentaban una capacidad vital forzada (FVC) y un volumen respiratorio máximo en el primer segundo (FEV1) superiores al 80 y 75 %, respectivamente, con respecto a los valores teóricos; el cuarto caso presentaba una FVC del 37 % y un FEV1 del 26 %. Dos pacientes presentaron un brote de aspergilosis broncopulmonar alérgica en los meses previos al trasplante. Sólo un paciente estaba colonizado de forma crónica en esputo por <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> multirresistente y ninguno por <span class="elsevierStyleItalic">Burkholderia cepacia</span>.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tras el trasplante hepático sólo el paciente colonizado por <span class="elsevierStyleItalic">P.aeruginosa</span> y peor función pulmonar presentó una evolución más tórpida precisando ventilación mecánica durante 43 días y ventilación nasal no invasiva durante 8 meses, y falleció a los 19 meses del trasplante. Los otros 3 casos, con mejor función pulmonar pretrasplante, presentaron una evolución sin complicaciones importantes y en la actualidad llevan una vida normal.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El trasplante hepático es bien tolerado en niños con fibrosis quística y afectación pulmonar leve-moderada, pudiendo incluso mejorar su función pulmonar. En los casos de afectación pulmonar grave debe considerarse la realización de un trasplante combinado hepatopulmonar.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to evaluate pulmonary function in four patients with cystic fibrosis (CF) after liver transplantation.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">From 1993 to 1997 three males and one female, aged 12 to 15 years, required liver transplantation for CF with cirrhosis and portal hypertension. Three had a history of esophageal variceal bleeding. In three patients, forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) before liver transplantation were over 80 and 75 % of predicted values, respectively; in the fourth patient FVC was 37 % and FEV1 was 26%. Two patients presented allergic bronchopulmonary aspergillosis before transplantation. Only one patient was chronically infected in sputum with multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> and none had <span class="elsevierStyleItalic">Burkholderia cepacea</span>.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">After liver transplantation, only the patient with <span class="elsevierStyleItalic">P. aeruginosa</span> in sputum culture and the worst pulmonary function presented a complicated course requiring mechanical ventilation for 43 days followed by non-invasive nasal ventilation for 8months. This patient died 19 months after transplantation. The remaining three patients, with better pulmonary function before transplantation, presented an uncomplicated course and currently lead normal lives.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We conclude that liver transplantation can improve pulmonary function and is well tolerated in children with CF and mild or moderate pulmonary involvement. When pulmonary involvement is severe, combined lung and liver transplantation should be considered.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improved results of lung transplantation for patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T.M. Egan" 1 => "F.C. Detterbeck" 2 => "M.R. Mill" 3 => "L.J. Paradowski" 4 => "R.P. Lackner" 5 => "W.D. Ogden" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0022-5223(95)70383-7" "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "1995" "volumen" => "109" "paginaInicial" => "224" "paginaFinal" => "235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7531796" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005400000003/v1_201307051543/S1695403301775182/v1_201307051543/es/main.assets" "Apartado" => array:4 [ "identificador" => "14282" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005400000003/v1_201307051543/S1695403301775182/v1_201307051543/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403301775182?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 12 | 18 |
| 2024 Octubre | 33 | 64 | 97 |
| 2024 Septiembre | 31 | 36 | 67 |
| 2024 Agosto | 46 | 78 | 124 |
| 2024 Julio | 31 | 44 | 75 |
| 2024 Junio | 46 | 42 | 88 |
| 2024 Mayo | 39 | 38 | 77 |
| 2024 Abril | 34 | 39 | 73 |
| 2024 Marzo | 20 | 42 | 62 |
| 2024 Febrero | 31 | 38 | 69 |
| 2024 Enero | 25 | 29 | 54 |
| 2023 Diciembre | 23 | 19 | 42 |
| 2023 Noviembre | 26 | 22 | 48 |
| 2023 Octubre | 28 | 30 | 58 |
| 2023 Septiembre | 22 | 32 | 54 |
| 2023 Agosto | 26 | 15 | 41 |
| 2023 Julio | 30 | 28 | 58 |
| 2023 Junio | 28 | 24 | 52 |
| 2023 Mayo | 26 | 28 | 54 |
| 2023 Abril | 23 | 19 | 42 |
| 2023 Marzo | 17 | 34 | 51 |
| 2023 Febrero | 14 | 16 | 30 |
| 2023 Enero | 15 | 33 | 48 |
| 2022 Diciembre | 21 | 28 | 49 |
| 2022 Noviembre | 28 | 28 | 56 |
| 2022 Octubre | 28 | 46 | 74 |
| 2022 Septiembre | 19 | 49 | 68 |
| 2022 Agosto | 24 | 48 | 72 |
| 2022 Julio | 27 | 61 | 88 |
| 2022 Junio | 20 | 52 | 72 |
| 2022 Mayo | 18 | 42 | 60 |
| 2022 Abril | 35 | 47 | 82 |
| 2022 Marzo | 31 | 64 | 95 |
| 2022 Febrero | 23 | 29 | 52 |
| 2022 Enero | 33 | 41 | 74 |
| 2021 Diciembre | 21 | 39 | 60 |
| 2021 Noviembre | 24 | 43 | 67 |
| 2021 Octubre | 29 | 61 | 90 |
| 2021 Septiembre | 15 | 47 | 62 |
| 2021 Agosto | 11 | 25 | 36 |
| 2021 Julio | 18 | 36 | 54 |
| 2021 Junio | 19 | 40 | 59 |
| 2021 Mayo | 29 | 40 | 69 |
| 2021 Abril | 41 | 32 | 73 |
| 2021 Marzo | 68 | 21 | 89 |
| 2021 Febrero | 48 | 11 | 59 |
| 2021 Enero | 25 | 23 | 48 |
| 2020 Diciembre | 33 | 12 | 45 |
| 2020 Noviembre | 20 | 14 | 34 |
| 2020 Octubre | 31 | 8 | 39 |
| 2020 Septiembre | 6 | 7 | 13 |
| 2020 Agosto | 19 | 10 | 29 |
| 2020 Julio | 29 | 19 | 48 |
| 2020 Junio | 20 | 18 | 38 |
| 2020 Mayo | 22 | 17 | 39 |
| 2020 Abril | 32 | 16 | 48 |
| 2020 Marzo | 23 | 13 | 36 |
| 2020 Febrero | 25 | 11 | 36 |
| 2020 Enero | 20 | 10 | 30 |
| 2019 Diciembre | 37 | 24 | 61 |
| 2019 Noviembre | 29 | 10 | 39 |
| 2019 Octubre | 25 | 3 | 28 |
| 2019 Septiembre | 29 | 21 | 50 |
| 2019 Agosto | 34 | 8 | 42 |
| 2019 Julio | 39 | 31 | 70 |
| 2019 Junio | 41 | 49 | 90 |
| 2019 Mayo | 51 | 32 | 83 |
| 2019 Abril | 55 | 18 | 73 |
| 2019 Marzo | 24 | 10 | 34 |
| 2019 Febrero | 19 | 12 | 31 |
| 2019 Enero | 26 | 12 | 38 |
| 2018 Diciembre | 19 | 12 | 31 |
| 2018 Noviembre | 25 | 19 | 44 |
| 2018 Octubre | 37 | 23 | 60 |
| 2018 Septiembre | 24 | 5 | 29 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Mayo | 3 | 0 | 3 |
| 2018 Abril | 13 | 0 | 13 |
| 2018 Marzo | 9 | 0 | 9 |
| 2018 Febrero | 7 | 0 | 7 |
| 2018 Enero | 8 | 0 | 8 |
| 2017 Diciembre | 8 | 0 | 8 |
| 2017 Noviembre | 23 | 0 | 23 |
| 2017 Octubre | 8 | 1 | 9 |
| 2017 Septiembre | 9 | 0 | 9 |
| 2017 Agosto | 7 | 0 | 7 |
| 2017 Julio | 14 | 0 | 14 |
| 2017 Junio | 27 | 17 | 44 |
| 2017 Mayo | 20 | 5 | 25 |
| 2017 Abril | 14 | 5 | 19 |
| 2017 Marzo | 14 | 3 | 17 |
| 2017 Febrero | 8 | 7 | 15 |
| 2017 Enero | 7 | 2 | 9 |
| 2016 Diciembre | 20 | 7 | 27 |
| 2016 Noviembre | 32 | 5 | 37 |
| 2016 Octubre | 18 | 9 | 27 |
| 2016 Septiembre | 16 | 7 | 23 |
| 2016 Agosto | 13 | 7 | 20 |
| 2016 Julio | 10 | 10 | 20 |
| 2016 Marzo | 5 | 0 | 5 |
| 2016 Febrero | 2 | 0 | 2 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Septiembre | 0 | 10 | 10 |
| 2015 Julio | 7 | 7 | 14 |
| 2015 Junio | 9 | 0 | 9 |
| 2015 Mayo | 10 | 2 | 12 |
| 2015 Abril | 9 | 7 | 16 |
| 2015 Marzo | 11 | 2 | 13 |
| 2015 Febrero | 8 | 3 | 11 |
| 2015 Enero | 8 | 1 | 9 |
| 2014 Diciembre | 11 | 4 | 15 |
| 2014 Noviembre | 11 | 3 | 14 |
| 2014 Octubre | 14 | 1 | 15 |
| 2014 Septiembre | 15 | 2 | 17 |
| 2014 Agosto | 17 | 2 | 19 |
| 2014 Julio | 29 | 1 | 30 |
| 2014 Junio | 51 | 3 | 54 |
| 2014 Mayo | 37 | 3 | 40 |
| 2014 Abril | 41 | 5 | 46 |
| 2014 Marzo | 22 | 3 | 25 |
| 2014 Febrero | 15 | 5 | 20 |
| 2014 Enero | 21 | 9 | 30 |
| 2013 Diciembre | 29 | 8 | 37 |
| 2013 Noviembre | 29 | 4 | 33 |
| 2013 Octubre | 36 | 10 | 46 |
| 2013 Septiembre | 20 | 5 | 25 |
| 2013 Agosto | 29 | 12 | 41 |
| 2013 Julio | 16 | 4 | 20 |
| 2013 Junio | 1 | 3 | 4 |
| 2013 Mayo | 5 | 1 | 6 |
| 2013 Abril | 2 | 3 | 5 |
| 2013 Marzo | 10 | 6 | 16 |
| 2013 Febrero | 8 | 4 | 12 |
| 2013 Enero | 6 | 1 | 7 |
| 2012 Diciembre | 8 | 2 | 10 |
| 2012 Noviembre | 6 | 3 | 9 |
| 2012 Octubre | 1 | 0 | 1 |
| 2012 Septiembre | 2 | 1 | 3 |
| 2001 Marzo | 850 | 0 | 850 |
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