Rentabilidad de la baciloscopia y el cultivo en muestras de jugo gástrico para el diagnóstico de la tuberculosis
Effectiveness of smears and cultures in gastric aspirate samples in the diagnosis of tuberculosis
D. Gómez-Pastrana Durána,
, R. Torronteras Santiagob, P. Caro Mateoc, A.M. López-Barrioc, P. Macías Mardonesd, A. Andrés Martína, M. Pineda Mantecona, J. Navarro Gonzáleza
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pastrana@nexo.es
Correspondencia: Dr. D. Gómez-Pastrana Durán. Avda. de Sudámerica, 7, 5.° A. Urbanización Los Cedros. 11407 Jerez de la Frontera (Cádiz).
Correspondencia: Dr. D. Gómez-Pastrana Durán. Avda. de Sudámerica, 7, 5.° A. Urbanización Los Cedros. 11407 Jerez de la Frontera (Cádiz).
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Urbanización Los Cedros. 11407 Jerez de la Frontera (Cádiz)." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effectiveness of smears and cultures in gastric aspirate samples in the diagnosis of tuberculosis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-03-01" "fechaAceptado" => "2000-09-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186507" "palabras" => array:5 [ 0 => "<span class="elsevierStyleItalic">Tuberculosis</span>" 1 => "<span class="elsevierStyleItalic">Niños</span>" 2 => "<span class="elsevierStyleItalic">Diagnóstico</span>" 3 => "<span class="elsevierStyleItalic">Cultivo</span>" 4 => "<span class="elsevierStyleItalic">Baciloscopia</span>" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186506" "palabras" => array:5 [ 0 => "<span class="elsevierStyleItalic">Tuberculosis</span>" 1 => "<span class="elsevierStyleItalic">Children</span>" 2 => "<span class="elsevierStyleItalic">Diagnosis</span>" 3 => "<span class="elsevierStyleItalic">Culture</span>" 4 => "<span class="elsevierStyleItalic">Smears</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar el rendimiento diagnóstico de la baciloscopia y el cultivo en muestras de jugo gástrico en la tuberculosis pulmonar infantil y analizar la relación existente con parámetros clínicos, radiológicos y epidemiológicos de niños con tuberculosis.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo, controlado y ciego de 421 muestras de aspirado gástrico procedentes de 139 niños remitidos por sospecha de tuberculosis. Los niños se clasificaron atendiendo a factores clinicorradiológicos, sin tener en cuenta los resultados microbiológicos y realizando un seguimiento prolongado de los pacientes para confirmar el diagnóstico clínico.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La baciloscopia fue positiva en 6 de los 46 niños con tuberculosis activa (sensibilidad, 13%) y en 3 de los 93 niños de los grupos de control (especificidad, 96,8%). El cultivo fue positivo en 15 pacientes con tuberculosis activa (sensibilidad, 32,6%), y su rendimiento fue mayor cuando el parénquima pulmonar estaba afectado en la radiografía de tórax. Mycobacterium tuberculosis también se aisló en 2 niños con infección tuberculosa sin enfermedad aparente y en uno de ellos se realizó tomografía computarizada (TC) que mostró adenopatías mediastínicas que no eran visibles en la radiografía de tórax. El tiempo medio de crecimiento de los cultivos positivos fue de 42 días.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La baciloscopia y el cultivo tienen baja sensibilidad en muestras de aspirado gástrico de niños con tuberculosis pulmonar. El resultado del cultivo requiere varias semanas y la baciloscopia puede presentar falsos positivos. Algunos niños con infección tuberculosa sin enfermedad aparente presentan actividad microbiológica que puede ser secundaria a adenopatías mediastínicas no visibles en la radiografía de tórax.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To evaluate the effectiveness of smears and cultures in gastric juice samples in the diagnosis of childhood pulmonary tuberculosis and to assess the relationship between clinical, radiological and epidemiological parameters in children with tuberculosis.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Blind, prospective, controlled study of 421 gastric aspirate samples from 139 children referred because of suspected tuberculosis. Children were classified according to clinico-radiological factors, irrespective of microbiological results. To verify the clinical diagnosis an extended follow- up was carried out.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Smears were positive in 6 of the 46 children with active tuberculosis (sensitivity: 13%) and in 3 of the 93 children in the control groups (specificity: 96.8%). Cultures were positive in 15 children with active disease (sensitivity: 32.6%) and effectiveness was greater when the chest radiograph showed parenchymal involvement. Mycobacterium tuberculosis was also isolated in two children with tuberculous infection who showed no apparent signs of the disease and in one of these children, CT-scan revealed mediastinal adenopathies which were not evident on the chest radiograph. Mean growth time for positive cultures was 42 days.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The sensitivity of smears and cultures in gastric aspirate samples of children with pulmonary tuberculosis is low. Results of culture take several weeks and smears can give false positive results. Some children with tuberculous infection without apparent signs of the disease show microbiological activity that can be caused by mediastinal adenopathies that are not evident on chest radiographs.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resurgence of tuberculosis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.R. Starke" 1 => "R.F. Jacobs" 2 => "J. Jereb" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1992" "volumen" => "120" "paginaInicial" => "839" "paginaFinal" => "855" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1593343" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consenso nacional para el control de la tuberculosis en España" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Grupo de Trabajo sobre Tuberculosis" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1992" "volumen" => "98" "paginaInicial" => "24" "paginaFinal" => "31" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case definitions for public health surveillance" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Centers for Disease Control, Prevention" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "MMWR" "fecha" => "1990" "volumen" => "39" "numero" => "RR13" "paginaInicial" => "40" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of primary tuberculosis in children by amplification and detection of mycobacterial DNA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Pierre" 1 => "C. Olivier" 2 => "D. Lecossier" 3 => "Y. Boussougant" 4 => "P. Yeni" 5 => "A.J. Hance" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/147.2.420" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1993" "volumen" => "147" "paginaInicial" => "420" "paginaFinal" => "424" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8430968" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastric lavage is better than bronchoalveolar lavage for isolation of Mycobacterium tuberculosis in childhood pulmonary tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.L. Abadco" 1 => "P. Steiner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1992" "volumen" => "11" "paginaInicial" => "735" "paginaFinal" => "738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1448314" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rendimiento de la bacteriología en la tuberculosis pulmonar y pleural infantil" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Rosell" 1 => "J. Ruiz" 2 => "J.M. Monterola" 3 => "C. Rodrigo" 4 => "M. Gallego" 5 => "F. Muñoz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1992" "volumen" => "28" "numero" => "Supl 1" "paginaInicial" => "51" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.E. Snider Jr." 1 => "H.L. Rieder" 2 => "D. Combs" 3 => "A.B. Bloch" 4 => "C.H. Hayden" 5 => "M.H.D. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1988" "volumen" => "7" "paginaInicial" => "271" "paginaFinal" => "278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3285310" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis pulmonar en la infancia: a propósito de 149 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.L. Vidal" 1 => "M.J. Del Cerro" 2 => "M.J. García de Miguel" 3 => "C. Borque" 4 => "F. del Castillo" 5 => "M. de José" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1990" "volumen" => "32" "paginaInicial" => "15" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2183660" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of pediatric tuberculosis in the modern era" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Neu" 1 => "L. Saiman" 2 => "P. San Gabriel" 3 => "S. Whittier" 4 => "C. Knirsch" 5 => "C. Shapiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1999" "volumen" => "18" "paginaInicial" => "122" "paginaFinal" => "126" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10048683" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis in children younger than five years old: New York City" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.R. Driver" 1 => "J.J. Luallen" 2 => "W.E. Good" 3 => "S.E. Valway" 4 => "T.R. Frieden" 5 => "I.M. Onorato" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1995" "volumen" => "14" "paginaInicial" => "112" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7746692" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aportaciones de la fibrobroncoscopia al diagnóstico y seguimiento de las complicaciones endobronquiales de la tuberculosis infantil" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Gómez-Pastrana" 1 => "A. Andrés" 2 => "M.L. Anguita" 3 => "A.M. López" 4 => "M. Pineda" 5 => "J. Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Esp Pediatr" "fecha" => "1995" "volumen" => "51" "paginaInicial" => "39" "paginaFinal" => "43" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of flexible fiberoptic bronchoscopy in the diagnosis of childhood endobronchial tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Chan" 1 => "D.L. Abadco" 2 => "M. Steiner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1994" "volumen" => "13" "paginaInicial" => "506" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8078738" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The reliability of gastric smears by auramine-rhodamine staining technique for the diagnosis of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I.J. Strumpf" 1 => "A.Y. Tsang" 2 => "M.A. Schork" 3 => "J.G. Weg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1976.114.5.971" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1976" "volumen" => "114" "paginaInicial" => "971" "paginaFinal" => "976" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/62546" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of tuberculosis in children using fluorescence microscopic examination of gastric washings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.T. Laven" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1977.115.5.743" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1977" "volumen" => "115" "paginaInicial" => "743" "paginaFinal" => "749" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/857714" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The reliability of acid fast stained smears of gastric aspirate specimens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Berean" 1 => "F.J. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Tubercle" "fecha" => "1988" "volumen" => "9" "paginaInicial" => "205" "paginaFinal" => "208" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infecciones por micobacterias: rendimiento de la baciloscopia en diferentes muestras clínicas (1975-1988)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Elcuaz" 1 => "N. Martín" 2 => "T. González" 3 => "J. Rosselló" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1991" "volumen" => "97" "paginaInicial" => "211" "paginaFinal" => "214" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The validity of acid-fast smears of gastric aspirates as an indicador of pulmonary tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Bahamman" 1 => "S. Choudhri" 2 => "R. Long" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "1999" "volumen" => "3" "paginaInicial" => "62" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10094171" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acid-fast staining of urine and gastric contents is an excellent indicator of mycobacterial disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.A. Klotz" 1 => "R.L. Penn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/136.5.1197" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1987" "volumen" => "136" "paginaInicial" => "1197" "paginaFinal" => "1198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2445232" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Childhood tuberculosis in Alabama: epidemiology of disease and indicators of program effectiveness, 1983 to 1993" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.E. Kimerling" 1 => "E.S. Vaughn" 2 => "N.E. Dunlap" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1995" "volumen" => "14" "paginaInicial" => "678" "paginaFinal" => "684" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8532425" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Valoración de las muestras de jugo gástrico en el diagnóstico de tuberculosis pulmonar infantil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.C. Nogales" 1 => "M. Navarro" 2 => "M.V. Domínguez" 3 => "E. Martín" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1995" "volumen" => "42" "paginaInicial" => "115" "paginaFinal" => "117" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mycobacterial infection in an inner city children's hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.M. Goodyear" 1 => "J.C. Moore-Gillon" 2 => "E.H. Price" 3 => "V.F. Larcher" 4 => "M.O. Savage" 5 => "C.B.S. Wood" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dis Child" "fecha" => "1993" "volumen" => "69" "paginaInicial" => "229" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8215527" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardization of gastric aspirate technique improves yield in the diagnosis of tuberculosis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.F. Pomputius" 1 => "J. Rost" 2 => "P.H. Dennehy" 3 => "E.J. Carter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1997" "volumen" => "16" "paginaInicial" => "222" "paginaFinal" => "226" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9041605" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis in the pediatric population of Houston, Texas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.R. Starke" 1 => "K.T. Taylor-Watts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1989" "volumen" => "84" "paginaInicial" => "28" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2500637" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features, diagnosis and treatment of tuberculosis in infants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.G. Vallejo" 1 => "L.T. Ong" 2 => "J.R. Starke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1994" "volumen" => "94" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8008511" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of Mycobacterium tuberculosis in gastric aspirates collected from children: hospitalization is not necessary" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.N. Lobato" 1 => "A.M. Loeffler" 2 => "K. Furst" 3 => "B. Cole" 4 => "P.C. Hopewell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatrics" "fecha" => "1998" "volumen" => "102" "paginaInicial" => "E40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9755277" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis pulmonar multirresistente en un preescolar" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Gómez-Pastrana" 1 => "M.D. López" 2 => "J. Ortiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1999" "volumen" => "35" "paginaInicial" => "413" "paginaFinal" => "414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10548993" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary drug-resistant tuberculosis in children. Correlation of drug-susceptibility patterns of matched patient and source case strains of Mycobacterium tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Steiner" 1 => "M. Rao" 2 => "M. Mitchell" 3 => "M. Steiner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dis Child" "fecha" => "1985" "volumen" => "139" "paginaInicial" => "780" "paginaFinal" => "782" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3927707" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of Mycobacterium tuberculosis in clinical specimens from children using a polymerase chain reaction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.C. Smith" 1 => "J.R. Starke" 2 => "K. Eisenach" 3 => "L.T. Ong" 4 => "M. Denby" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1996" "volumen" => "97" "paginaInicial" => "155" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8584370" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnóstico de la tuberculosis en niños. Evaluación de la técnica reacción en cadena de la polimerasa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Muñoz" 1 => "A. Gené" 2 => "I. Pérez" 3 => "A. Mira" 4 => "J. Rocal" 5 => "C. Latorre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1997" "volumen" => "47" "paginaInicial" => "353" "paginaFinal" => "356" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9499300" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of polymerase chain reaction for improved diagnosis of tuberculosis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Delacourt" 1 => "J.D. Poveda" 2 => "C. Chureau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1995" "volumen" => "126" "paginaInicial" => "703" "paginaFinal" => "709" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7751992" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of tuberculosis in children using a polimerase chain reaction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Gomez-Pastrana" 1 => "R. Torronteras" 2 => "P. Caro" 3 => "M.L. Anguita" 4 => "A.M. López" 5 => "A. Andrés" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "1999" "volumen" => "28" "paginaInicial" => "344" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10536065" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Gomez-Pastrana D, Torronteras R, Caro P, Anguita ML, López AM, Andrés A, et al. Comparison of Amplicor, in-house PCR and conventional culture in the diagnosis of tuberculosis in children. Clin Infect Dis. En prensa." ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sensitivity and specificity of PCR for detection of Mycobacterium tuberculosis: a blind comparison study among seven laboratories" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.T. Noordhoek" 1 => "A.H.J. Kolk" 2 => "G. Bjune" 3 => "D. Catty" 4 => "J.W. Dale" 5 => "P.E.M. Fine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "1994" "volumen" => "32" "paginaInicial" => "277" "paginaFinal" => "284" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8150935" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Routine application of the polymerase chain reaction for detection of Mycobacterium tuberculosis in clinical samples" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.T. Noordhoek" 1 => "J.A. Kaan" 2 => "S. Mulder" 3 => "H. Wilke" 4 => "A.H.J. Kolk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pathol" "fecha" => "1995" "volumen" => "48" "paginaInicial" => "810" "paginaFinal" => "814" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7490312" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occult tuberculous infection in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.G. Fox" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Tubercle" "fecha" => "1977" "volumen" => "58" "paginaInicial" => "91" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/406702" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory tuberculosis in childhood: the diagnostic value of clinical features and special investigations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.S. Schaaf" 1 => "N. Beyers" 2 => "R.P. Gie" 3 => "E.D. Ned" 4 => "N.A. Swits" 5 => "F.E. Scott" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1995" "volumen" => "14" "paginaInicial" => "189" "paginaFinal" => "194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7761183" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Computed tomography with normal chest radiograph in tuberculous infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Delacourt" 1 => "T. Mamou Mani" 2 => "V. Bonnerot" 3 => "J. de Blice" 4 => "N. Sayeg" 5 => "D. Sallenand" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dis Child" "fecha" => "1993" "volumen" => "69" "paginaInicial" => "430" "paginaFinal" => "432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8259872" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tomografía computarizada y reacción en cadena de la polimerasa en la infección tuberculosa de la infancia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Gómez-Pastrana" 1 => "P. Caro" 2 => "R. Torronteras" 3 => "M.L. Anguita" 4 => "A.M. López" 5 => "A. Andrés" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1996" "volumen" => "32" "paginaInicial" => "500" "paginaFinal" => "504" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9019308" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic standards and classification of tuberculosis in adults and children" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Thoracic Society" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.161.4.16141" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "161" "paginaInicial" => "1376" "paginaFinal" => "1395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10764337" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of tuberculosis in children: increased need for better methods" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.A. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 4 | 9 |
| 2024 Octubre | 51 | 52 | 103 |
| 2024 Septiembre | 71 | 43 | 114 |
| 2024 Agosto | 87 | 92 | 179 |
| 2024 Julio | 73 | 51 | 124 |
| 2024 Junio | 94 | 53 | 147 |
| 2024 Mayo | 80 | 58 | 138 |
| 2024 Abril | 93 | 45 | 138 |
| 2024 Marzo | 39 | 43 | 82 |
| 2024 Febrero | 56 | 51 | 107 |
| 2024 Enero | 46 | 28 | 74 |
| 2023 Diciembre | 36 | 18 | 54 |
| 2023 Noviembre | 45 | 40 | 85 |
| 2023 Octubre | 48 | 37 | 85 |
| 2023 Septiembre | 29 | 26 | 55 |
| 2023 Agosto | 33 | 17 | 50 |
| 2023 Julio | 54 | 40 | 94 |
| 2023 Junio | 33 | 36 | 69 |
| 2023 Mayo | 47 | 40 | 87 |
| 2023 Abril | 37 | 20 | 57 |
| 2023 Marzo | 32 | 30 | 62 |
| 2023 Febrero | 30 | 15 | 45 |
| 2023 Enero | 37 | 32 | 69 |
| 2022 Diciembre | 30 | 24 | 54 |
| 2022 Noviembre | 44 | 47 | 91 |
| 2022 Octubre | 51 | 36 | 87 |
| 2022 Septiembre | 26 | 29 | 55 |
| 2022 Agosto | 37 | 50 | 87 |
| 2022 Julio | 27 | 57 | 84 |
| 2022 Junio | 24 | 34 | 58 |
| 2022 Mayo | 40 | 29 | 69 |
| 2022 Abril | 37 | 49 | 86 |
| 2022 Marzo | 34 | 57 | 91 |
| 2022 Febrero | 31 | 38 | 69 |
| 2022 Enero | 26 | 38 | 64 |
| 2021 Diciembre | 32 | 44 | 76 |
| 2021 Noviembre | 42 | 58 | 100 |
| 2021 Octubre | 55 | 57 | 112 |
| 2021 Septiembre | 45 | 43 | 88 |
| 2021 Agosto | 52 | 39 | 91 |
| 2021 Julio | 31 | 37 | 68 |
| 2021 Junio | 33 | 32 | 65 |
| 2021 Mayo | 29 | 32 | 61 |
| 2021 Abril | 92 | 64 | 156 |
| 2021 Marzo | 80 | 30 | 110 |
| 2021 Febrero | 99 | 10 | 109 |
| 2021 Enero | 51 | 19 | 70 |
| 2020 Diciembre | 64 | 12 | 76 |
| 2020 Noviembre | 27 | 13 | 40 |
| 2020 Octubre | 41 | 11 | 52 |
| 2020 Septiembre | 33 | 16 | 49 |
| 2020 Agosto | 25 | 4 | 29 |
| 2020 Julio | 24 | 14 | 38 |
| 2020 Junio | 27 | 10 | 37 |
| 2020 Mayo | 26 | 20 | 46 |
| 2020 Abril | 32 | 18 | 50 |
| 2020 Marzo | 35 | 20 | 55 |
| 2020 Febrero | 37 | 26 | 63 |
| 2020 Enero | 23 | 20 | 43 |
| 2019 Diciembre | 52 | 23 | 75 |
| 2019 Noviembre | 27 | 17 | 44 |
| 2019 Octubre | 26 | 15 | 41 |
| 2019 Septiembre | 29 | 23 | 52 |
| 2019 Agosto | 39 | 22 | 61 |
| 2019 Julio | 63 | 29 | 92 |
| 2019 Junio | 57 | 34 | 91 |
| 2019 Mayo | 98 | 63 | 161 |
| 2019 Abril | 81 | 71 | 152 |
| 2019 Marzo | 46 | 31 | 77 |
| 2019 Febrero | 49 | 10 | 59 |
| 2019 Enero | 40 | 15 | 55 |
| 2018 Diciembre | 35 | 15 | 50 |
| 2018 Noviembre | 48 | 26 | 74 |
| 2018 Octubre | 73 | 22 | 95 |
| 2018 Septiembre | 26 | 6 | 32 |
| 2018 Agosto | 1 | 0 | 1 |
| 2018 Julio | 3 | 0 | 3 |
| 2018 Junio | 2 | 0 | 2 |
| 2018 Mayo | 10 | 0 | 10 |
| 2018 Abril | 29 | 1 | 30 |
| 2018 Marzo | 18 | 0 | 18 |
| 2018 Febrero | 17 | 0 | 17 |
| 2018 Enero | 23 | 0 | 23 |
| 2017 Diciembre | 25 | 0 | 25 |
| 2017 Noviembre | 30 | 0 | 30 |
| 2017 Octubre | 35 | 0 | 35 |
| 2017 Septiembre | 35 | 1 | 36 |
| 2017 Agosto | 36 | 0 | 36 |
| 2017 Julio | 24 | 0 | 24 |
| 2017 Junio | 30 | 30 | 60 |
| 2017 Mayo | 34 | 39 | 73 |
| 2017 Abril | 26 | 24 | 50 |
| 2017 Marzo | 29 | 45 | 74 |
| 2017 Febrero | 75 | 35 | 110 |
| 2017 Enero | 46 | 18 | 64 |
| 2016 Diciembre | 63 | 23 | 86 |
| 2016 Noviembre | 138 | 42 | 180 |
| 2016 Octubre | 99 | 25 | 124 |
| 2016 Septiembre | 130 | 41 | 171 |
| 2016 Agosto | 99 | 34 | 133 |
| 2016 Julio | 63 | 25 | 88 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Mayo | 2 | 0 | 2 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Noviembre | 2 | 0 | 2 |
| 2015 Octubre | 0 | 12 | 12 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Agosto | 5 | 13 | 18 |
| 2015 Julio | 11 | 0 | 11 |
| 2015 Junio | 7 | 0 | 7 |
| 2015 Mayo | 17 | 7 | 24 |
| 2015 Abril | 11 | 0 | 11 |
| 2015 Marzo | 15 | 16 | 31 |
| 2015 Febrero | 7 | 7 | 14 |
| 2015 Enero | 20 | 1 | 21 |
| 2014 Diciembre | 18 | 4 | 22 |
| 2014 Noviembre | 12 | 0 | 12 |
| 2014 Octubre | 16 | 2 | 18 |
| 2014 Septiembre | 12 | 5 | 17 |
| 2014 Agosto | 15 | 1 | 16 |
| 2014 Julio | 25 | 2 | 27 |
| 2014 Junio | 30 | 3 | 33 |
| 2014 Mayo | 31 | 1 | 32 |
| 2014 Abril | 27 | 3 | 30 |
| 2014 Marzo | 21 | 9 | 30 |
| 2014 Febrero | 16 | 9 | 25 |
| 2014 Enero | 17 | 11 | 28 |
| 2013 Diciembre | 29 | 6 | 35 |
| 2013 Noviembre | 27 | 14 | 41 |
| 2013 Octubre | 30 | 13 | 43 |
| 2013 Septiembre | 34 | 13 | 47 |
| 2013 Agosto | 38 | 15 | 53 |
| 2013 Julio | 6 | 3 | 9 |
| 2013 Junio | 2 | 3 | 5 |
| 2013 Mayo | 4 | 3 | 7 |
| 2013 Abril | 2 | 1 | 3 |
| 2013 Marzo | 3 | 3 | 6 |
| 2013 Febrero | 24 | 1 | 25 |
| 2013 Enero | 36 | 3 | 39 |
| 2012 Diciembre | 11 | 2 | 13 |
| 2012 Noviembre | 13 | 1 | 14 |
| 2012 Octubre | 12 | 1 | 13 |
| 2012 Septiembre | 2 | 1 | 3 |
| 2000 Noviembre | 3932 | 0 | 3932 |
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