Anticuerpo antitransglutaminasa: utilidad en el diagnóstico de la enfermedad celíaca
The tissue transglutaminase antibody: usefulness in the diagnosis of celiac disease
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"apellidos" => "Palacios Sarrasqueta" "email" => array:1 [ 0 => "mpalacis@cfnavarra.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Rivero Marcotegui" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "F." "apellidos" => "Sánchez-Valverde Visus" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "E." 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"etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicios de Pediatría y Hospital Virgen del Camino. 31008 Pamplona." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicios de Genética. Hospital Virgen del Camino. Pamplona" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servicio de Bioquímica Clínica. Hospital Virgen del Camino. 31008 Pamplona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The tissue transglutaminase antibody: usefulness in the diagnosis of celiac disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-03-31" "fechaAceptado" => "2000-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186523" "palabras" => array:4 [ 0 => "Enfermedad celíaca" 1 => "Anticuerpos antigliadina" 2 => "Anticuerpos antiendomisio" 3 => "Anticuerpos antitransglutaminasa" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec186522" "palabras" => array:4 [ 0 => "Coeliac disease" 1 => "Antigliadin antibodies" 2 => "Antiendomysial antibodies" 3 => "Anti-transglutaminase antibodies" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hasta ahora los anticuerpos de clase IgA antiendomisio (AEm-IgA) y antigliadina (AAG-IgA) se consideraban unos marcadores sensibles y específicos de enfermedad celíaca. Recientemente se ha identificado un nuevo anticuerpo, el antitransglutaminasa (TGt-IgA), como un marcador si no mejor, sí más práctico en el cribado de dicha enfermedad, sobre todo como una prueba muy útil de detección en grandes poblaciones. El objetivo de este trabajo ha sido evaluar la utilidad del TGt-IgA como prueba de diagnóstico y cribado de la enfermedad celíaca y observar la relación existente entre este anticuerpo y los otros más conocidos y sobradamente utilizados como el AAG-IgA y el anticuerpo antiendomisio (AEm-IgA).</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El estudio se ha realizado en 115 niños divididos en 3 grupos: 31 pacientes diagnosticados de enfermedad celíaca según los criterios de la ESPGAN, 21 pacientes celíacos en fase de dieta libre de gluten y 63 considerados grupo control. Se emplearon dos métodos inmunoenzimáticos comerciales (ELISA para detectar los AAG-IgA e IgA- TGt, respectivamente. Los AEm-IgA se cuantificaron mediante un método de fluorescencia indirecta utilizando porción distal de esófago de mono como antígeno</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En el grupo global de 115 pacientes, el TGt-IgA presentó una concordancia del 91 % con el AEm-IgA y del 85% con el AAG-IgA. Cuando el grupo estudiado era el de enfermos celíacos esta concordancia era del 84 y 61 %, respectivamente. Por otra parte, el TGt-IgA presentó una sensibilidad de 83 frente al 94% de los AEm-IgA y el 74% de los AAG-IgA. Los tres anticuerpos presentaron una especificidad similar</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El uso de un método ELISA para determinar los TGt-IgA muestra una buena correlación con las determinaciones de AAG y AEm y podría representar una nueva prueba de detección en la enfermedad celíaca. La técnica es sencilla, presenta una buena especificidad y sensibilidad respecto a los clásicos AAG y AEm, no está sometida a la subjetividad de la persona que evalúa la prueba, es barata y muy práctica en programas de cribado generalizado.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Until now IgA-EmA and IgA-AGA antibodies have been considered to be specific and sensitive markers of celiac disease. A new antibody, the tissue transglutaminase (IgA-tTG), antibody has recently been identified, which is believed to be if not a better marker then a more practical one in screening for celiac disease, especially in large populations. To evaluate the usefulness of the IgA-tTG antibody in the diagnosis and screening of celiac disease and to determine the relationship between this antibody and other better-known and overused antibodies, antigliadin (IgA-AGA) and anti-endomysial (IgA-EmA)</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The study was performed in 115 children divided into three groups: 31 patients diagnosed with the celiac disease, according to the ESPGAN criteria; 21 patients with celiac disease following a gluten-free diet, and 63 considered as control group. Two enzyme linked immunoabsorbent assays (ELISA) were used to detect AGA and tTG antibodies, respectively. EmA antibodies were determined by using an indirect immunofluorescence technique with commercial sections of distal monkey oesophagus as antigen</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In the 115 patients taken as a whole, the tTG antibody showed 91 % agreement with the EmA antibody and 85 % agreement with the AGA antibody. In the celiac group, agreement was 84 % and 61 % respectively. Sensitivity of the tTG antibody was 83 % compared with 94 % for EmA and 74 % for AGA. Specificity was similar in all three tests.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The ELISA test for tTG correlates well with the traditional AGA and EmA tests and could be used as a new test for celiac disease. The procedure is simple and shows high specificity and sensitivity compared with classical EmA and AGA tests and does not involve subjective scoring. It is cheap and very well suited for large-scale screening for celiac disease</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliographía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gluten, major histocompatibility, complex, and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity (“coeliac sprue”)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.N. 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| año/Mes | Html | Total | |
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| 2021 Mayo | 141 | 139 | 280 |
| 2021 Abril | 237 | 216 | 453 |
| 2021 Marzo | 149 | 150 | 299 |
| 2021 Febrero | 110 | 83 | 193 |
| 2021 Enero | 96 | 57 | 153 |
| 2020 Diciembre | 97 | 67 | 164 |
| 2020 Noviembre | 100 | 57 | 157 |
| 2020 Octubre | 112 | 58 | 170 |
| 2020 Septiembre | 69 | 66 | 135 |
| 2020 Agosto | 77 | 32 | 109 |
| 2020 Julio | 53 | 43 | 96 |
| 2020 Junio | 52 | 20 | 72 |
| 2020 Mayo | 63 | 32 | 95 |
| 2020 Abril | 57 | 15 | 72 |
| 2020 Marzo | 43 | 19 | 62 |
| 2020 Febrero | 55 | 18 | 73 |
| 2020 Enero | 71 | 26 | 97 |
| 2019 Diciembre | 78 | 38 | 116 |
| 2019 Noviembre | 54 | 23 | 77 |
| 2019 Octubre | 60 | 14 | 74 |
| 2019 Septiembre | 35 | 25 | 60 |
| 2019 Agosto | 33 | 15 | 48 |
| 2019 Julio | 47 | 47 | 94 |
| 2019 Junio | 56 | 37 | 93 |
| 2019 Mayo | 91 | 47 | 138 |
| 2019 Abril | 64 | 49 | 113 |
| 2019 Marzo | 25 | 20 | 45 |
| 2019 Febrero | 38 | 20 | 58 |
| 2019 Enero | 43 | 25 | 68 |
| 2018 Diciembre | 50 | 21 | 71 |
| 2018 Noviembre | 39 | 39 | 78 |
| 2018 Octubre | 66 | 14 | 80 |
| 2018 Septiembre | 18 | 26 | 44 |
| 2018 Julio | 2 | 0 | 2 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 3 | 0 | 3 |
| 2018 Abril | 27 | 0 | 27 |
| 2018 Marzo | 29 | 0 | 29 |
| 2018 Febrero | 13 | 0 | 13 |
| 2018 Enero | 16 | 0 | 16 |
| 2017 Diciembre | 10 | 0 | 10 |
| 2017 Noviembre | 21 | 0 | 21 |
| 2017 Octubre | 23 | 0 | 23 |
| 2017 Septiembre | 20 | 0 | 20 |
| 2017 Agosto | 24 | 0 | 24 |
| 2017 Julio | 37 | 6 | 43 |
| 2017 Junio | 34 | 50 | 84 |
| 2017 Mayo | 48 | 74 | 122 |
| 2017 Abril | 26 | 47 | 73 |
| 2017 Marzo | 22 | 42 | 64 |
| 2017 Febrero | 21 | 28 | 49 |
| 2017 Enero | 14 | 28 | 42 |
| 2016 Diciembre | 33 | 11 | 44 |
| 2016 Noviembre | 44 | 22 | 66 |
| 2016 Octubre | 41 | 16 | 57 |
| 2016 Septiembre | 40 | 29 | 69 |
| 2016 Agosto | 43 | 20 | 63 |
| 2016 Julio | 22 | 29 | 51 |
| 2016 Mayo | 1 | 0 | 1 |
| 2016 Abril | 4 | 0 | 4 |
| 2016 Marzo | 1 | 0 | 1 |
| 2016 Febrero | 2 | 0 | 2 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 8 | 0 | 8 |
| 2015 Junio | 12 | 0 | 12 |
| 2015 Mayo | 12 | 0 | 12 |
| 2015 Abril | 16 | 0 | 16 |
| 2015 Marzo | 10 | 0 | 10 |
| 2015 Febrero | 9 | 0 | 9 |
| 2015 Enero | 5 | 0 | 5 |
| 2014 Diciembre | 10 | 1 | 11 |
| 2014 Noviembre | 11 | 0 | 11 |
| 2014 Octubre | 10 | 0 | 10 |
| 2014 Septiembre | 8 | 0 | 8 |
| 2014 Agosto | 8 | 1 | 9 |
| 2014 Julio | 11 | 1 | 12 |
| 2014 Junio | 17 | 1 | 18 |
| 2014 Mayo | 13 | 1 | 14 |
| 2014 Abril | 14 | 5 | 19 |
| 2014 Marzo | 17 | 12 | 29 |
| 2014 Febrero | 7 | 10 | 17 |
| 2014 Enero | 12 | 17 | 29 |
| 2013 Diciembre | 22 | 16 | 38 |
| 2013 Noviembre | 21 | 10 | 31 |
| 2013 Octubre | 28 | 13 | 41 |
| 2013 Septiembre | 22 | 11 | 33 |
| 2013 Agosto | 20 | 16 | 36 |
| 2013 Julio | 5 | 7 | 12 |
| 2013 Junio | 3 | 2 | 5 |
| 2013 Mayo | 5 | 6 | 11 |
| 2013 Abril | 8 | 4 | 12 |
| 2013 Marzo | 9 | 2 | 11 |
| 2013 Febrero | 19 | 4 | 23 |
| 2013 Enero | 15 | 1 | 16 |
| 2012 Diciembre | 1 | 1 | 2 |
| 2012 Noviembre | 1 | 3 | 4 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2000 Diciembre | 3580 | 0 | 3580 |
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