Trasplante de progenitores hematopoyéticos de sangre de cordón umbilical en niños
Transplantation of umbilical cord blood hematopoietic progenitor cells in children
I. Badell Serraa,
, T. Olivé Oliverasb, L. Madero Lópezc, A. Muñoz Villad, A. Martínez Rubioe, A. Verdeguer Mirallesf, C. Díaz de Heredia Rubiob, M.A. Díaz Perezc, J. Cubells Rieróa, M.S. Maldonado Regaladod, J.J. Ortega Aramburub, por el Grupo Español para el Trasplante de Medula Ósea en niños (GETMON)
Autor para correspondencia
ibadell@hsp.santpau.es
Correspondencia:Dra. I. Badell Serra. Servicio de Pediatría. Hospital de la Santa Creu i Sant Pau. Avda. Sant Antoni M. Claret, 167. 08025 Barcelona.
Correspondencia:Dra. I. Badell Serra. Servicio de Pediatría. Hospital de la Santa Creu i Sant Pau. Avda. Sant Antoni M. Claret, 167. 08025 Barcelona.
Leído
7362
Vecesse ha leído el artículo
2702
Total PDF
4660
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1695403300774923" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77492-3" "estado" => "S300" "fechaPublicacion" => "2000-12-01" "aid" => "77492" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;53:513-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3426 "formatos" => array:3 [ "EPUB" => 74 "HTML" => 2732 "PDF" => 620 ] ] "itemSiguiente" => array:18 [ "pii" => "S1695403300774935" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77493-5" "estado" => "S300" "fechaPublicacion" => "2000-12-01" "aid" => "77493" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "An Pediatr (Barc). 2000;53:520-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3392 "formatos" => array:3 [ "EPUB" => 72 "HTML" => 2709 "PDF" => 611 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Estudio clinicoepidemiológico de la bronquiolitis aguda" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "520" "paginaFinal" => "526" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical-epidemiological study of acute bronchiolitis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "H. González García, F.M. García García, J.E. Fernández Alonso" "autores" => array:3 [ 0 => array:2 [ "nombre" => "H." "apellidos" => "González García" ] 1 => array:2 [ "nombre" => "F.M." "apellidos" => "García García" ] 2 => array:2 [ "nombre" => "J.E." "apellidos" => "Fernández Alonso" ] ] ] 1 => array:2 [ "autoresLista" => "B. Izquierdo López, A. Pino Vázquez, A. Blanco Quirós" "autores" => array:3 [ 0 => array:2 [ "nombre" => "B." "apellidos" => "Izquierdo López" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Pino Vázquez" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Blanco Quirós" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774935?idApp=UINPBA00005H" "url" => "/16954033/0000005300000006/v1_201307051530/S1695403300774935/v1_201307051530/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403300774911" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77491-1" "estado" => "S300" "fechaPublicacion" => "2000-12-01" "aid" => "77491" "copyright" => "Asociación Española de Pediatría" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "An Pediatr (Barc). 2000;53:509-12" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3061 "formatos" => array:3 [ "EPUB" => 65 "HTML" => 2497 "PDF" => 499 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Evolución de las estrategias diagnósticas en la enfermedad celíaca" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "509" "paginaFinal" => "512" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Varea" "autores" => array:1 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Varea" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774911?idApp=UINPBA00005H" "url" => "/16954033/0000005300000006/v1_201307051530/S1695403300774911/v1_201307051530/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Trasplante de progenitores hematopoyéticos de sangre de cordón umbilical en niños" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "513" "paginaFinal" => "519" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Badell Serra, T. Olivé Oliveras, L. Madero López, A. Muñoz Villa, A. Martínez Rubio, A. Verdeguer Miralles, C. Díaz de Heredia Rubio, M.A. Díaz Perez, J. Cubells Rieró, M.S. Maldonado Regalado, J.J. Ortega Aramburu" "autores" => array:12 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Badell Serra" "email" => array:1 [ 0 => "ibadell@hsp.santpau.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "T." "apellidos" => "Olivé Oliveras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "L." "apellidos" => "Madero López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Muñoz Villa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Martínez Rubio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "nombre" => "A." "apellidos" => "Verdeguer Miralles" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 6 => array:3 [ "nombre" => "C." "apellidos" => "Díaz de Heredia Rubio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "M.A." "apellidos" => "Díaz Perez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 8 => array:3 [ "nombre" => "J." "apellidos" => "Cubells Rieró" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 9 => array:3 [ "nombre" => "M.S." "apellidos" => "Maldonado Regalado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 10 => array:3 [ "nombre" => "J.J." "apellidos" => "Ortega Aramburu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 11 => array:1 [ "colaborador" => "por el Grupo Español para el Trasplante de Medula Ósea en niños (GETMON)" ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Servicios de Pediatría.Hospital de la Santa Creu i Sant Pau y" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Vall d’Hebron. Barcelona." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital Niño Jesús," "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Hospital Ramón y Cajal y" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Hospital La Paz. Madrid." "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Hospital La Fe. Valencia" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia:Dra. I. Badell Serra. Servicio de Pediatría. Hospital de la Santa Creu i Sant Pau. Avda. Sant Antoni M. Claret, 167. 08025 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Transplantation of umbilical cord blood hematopoietic progenitor cells in children" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-31" "fechaAceptado" => "2000-08-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186533" "palabras" => array:5 [ 0 => "Trasplante de progenitores hematopoyéticos" 1 => "Trasplan-te de sangre de cordón umbilical" 2 => "Leucemia" 3 => "Inmunodefi-ciencia congénita" 4 => "Niños" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186532" "palabras" => array:5 [ 0 => "Stem cell transplantation" 1 => "Cord blood transplantation" 2 => "Leukemia" 3 => "Congenital immunodeficiency" 4 => "Children" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de los resultados del trasplante de progenitores hematopoyéticos de sangre de cordón umbilical en España.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Veintiocho niños con edad media de 6,5 años y peso medio de 25 kg recibieron un trasplante de sangre de cordón umbilical entre julio de 1994 y mayo de 1998 en distintos centros pertenecientes al Grupo Español para el Trasplan-te de Medula Ósea en niños (GETMON).</p><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">El donante fue en 2 pacientes un hermano HLA-idéntico, en otros 2 pacientes un familiar no idéntico y en los 24 restantes un donante no emparentado. Entre éstos, la identidad antigénica HLA (A, B y DR) 6/6 sólo se observaba en 3 pacientes. Los trasplantes se realizaron en su mayoría por leucemia (21 pacientes, 75%) y en fase avanzada. Los restantes 7 pacientes se trasplantaron por una enfermedad genética, en su mayoría inmunodeficiencia congénita. El tratamiento de acondicionamiento incluyó irradiación corporal total en 10 pacientes y poliquimioterapia en los restantes. La profilaxis de la enfermedad del injerto contra huésped aguda se realizó con ciclosporina en todos los casos añadiendo corticoides o metotrexato en los trasplantes sin identidad HLA. La media de células perfun-didas fue de 53,4×10<span class="elsevierStyleSup">6</span>/kg.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El fallo de implante de la sangre de cordón umbilical se observó en 9 pacientes. Presentaron enfermedad del injerto contra huésped aguda superior al grado II 18 pacientes (64,3%). Ocho (28,6%) presentaron EICH grave. La supervivencia actuarial libre de enfermedad (SLE) de la serie global fue del 34,4±9% a 3 años, con una media de seguimiento de 16,6 meses. Se observó una mejor SLE en las enfermedades congénitas, con una SLE del 71±17% y también en los pacientes que recibieron trasplante de sangre de cordón umbilical con una identidad HLA A, B y DR 6/6, en los que la SLE fue del 66±19%.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los mejores resultados se obtuvieron en las enfermeda-des genéticas. Se ha observado una correlación inversa en-tre la SLE y la disparidad antigénica HLA. La incidencia relativamente alta de la enfermedad injerto contra huésped aguda en esta serie, podría relacionarse con la escasa precisión de la tipificación HLA efectuada en algunos pacientes.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Retrospective study of the outcome of cord blood trans-plantation (CBT) in children in Spain.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Twenty-eight patients (mean age 6.5 years; mean weight 25 kg) received a CBT between July 1994 and May 1998 in several centres of the Spanish Pediatric Bone Marrow Transplant Group. In 2 patients the donor was an identical human leukocyte antigen (HLA)-sibling and in two the donor was a mismatched family donor. In 24 patients the donor was unrelated, and 21 of these received an HLA-mismatched CBT. Twenty-one patients (75%) received a CBT for leukemia mainly in advanced phase. Seven patients were transplanted for genetic disease. Of these, five had congenital immunodeficiency. The conditioning treatment included total body irradiation in ten patients and combined chemotherapy in the remaining patients. In all patients graft-versus-host disease (GVHD) prophylaxis was performed with cyclosporine, and corticosteroids or methotrexate were added in patients with HLA-mismatched donors. The mean number of nucleated cells infused was 53.4×10<span class="elsevierStyleSup">6</span>/kg.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Graft failure was observed in nine patients. Eighteen patients (64.3%) developed grade II-IV acute GVHD. Eight patients (28.6%) developed severe GVHD. Actuarial event-free survival (EFS) of all the patients was 34.4±69% at 3 years, with a mean followup of 16.6 months. EFS was more favorable in patients with genetic disease (71±17%) and in those with an HLA (A, B and DR) identical donor (6/6) (66±19%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The most favorable results were obtained in patients with genetic diseases. We observed an inverse correlation between EFS and patients with HLA-identical donors. The high incidence of severe acute GVHD could have been related to a lack of accuracy in the HLA-typography of some patients.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Haematopoietic reconstitution in a patient with Fanconi anemia by means of umbilical cord blood from an HLA-identical sibling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Gluckman" 1 => "H.E. Broxmeyer" 2 => "A.D. Auerbach" 3 => "H.S. Friedman" 4 => "G.W. Douglas" 5 => "A. Devergie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198910263211707" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1989" "volumen" => "321" "paginaInicial" => "1174" "paginaFinal" => "1178" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2571931" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allogeneic sibling cord blood transplantation in forty four children with malignant and no malignant disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.E. Wagner" 1 => "N.A. Kernan" 2 => "M. Steinbuch" 3 => "H.E. Broxmeyer" 4 => "E. Gluckman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1995" "volumen" => "346" "paginaInicial" => "214" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7616801" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.E. Wagner" 1 => "J. Rosenthal" 2 => "M. Sweetman" 3 => "X.O. Shu" 4 => "S.M. Davies" 5 => "N.K. Ramsay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1996" "volumen" => "88" "paginaInicial" => "795" "paginaFinal" => "802" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8704232" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Kurtzberg" 1 => "M. Laughlin" 2 => "M.L. Graham" 3 => "C. Smith" 4 => "J.F. Olson" 5 => "E.C. Halperin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1996" "volumen" => "333" "paginaInicial" => "157" "paginaFinal" => "166" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of cord blood transplantation from related and unrelated donors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Gluckman" 1 => "V. Rocha" 2 => "A. Boyer-Chammard" 3 => "F. Locatelli" 4 => "W. Arcese" 5 => "R. Pasquini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199708073370602" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1997" "volumen" => "337" "paginaInicial" => "373" "paginaFinal" => "381" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9241126" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome among 562 recipients of placental- blood transplants from unrelated donors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Rubinstein" 1 => "C. Carrier" 2 => "A. Scaradavou" 3 => "J. Kurtzberg" 4 => "J. Adamson" 5 => "A.R. Migliaccio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199811263392201" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1998" "volumen" => "339" "paginaInicial" => "1565" "paginaFinal" => "1577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9828244" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors associated with outcome after cord blood transplantation in children with acute leukemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Locatelli" 1 => "V. Rocha" 2 => "C. Chastang" 3 => "W. Atcese" 4 => "G. Michel" 5 => "M. Abecasis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1999" "volumen" => "93" "paginaInicial" => "3662" "paginaFinal" => "3671" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10339472" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unrelated donor marrow transplantation in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Balduzzi" 1 => "T. Gooley" 2 => "C. Anasetti" 3 => "J.E. Sanders" 4 => "PJ. Martin" 5 => "E.W. Petersdorf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1995" "volumen" => "86" "paginaInicial" => "3247" "paginaFinal" => "3256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7579422" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unrelated donor bone marrow transplantation for children with acute leukemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.M. Davies" 1 => "J.E. Wagner" 2 => "X.O. Shu" 3 => "B.R. Blazar" 4 => "E. Katsanis" 5 => "P.J. Orchard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1997.15.2.557" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "557" "paginaFinal" => "565" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9053477" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unrelated donor bone marrow transplantation for children with relapsed acute lymphoblastic leukaemia in second complete remission" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Oakhill" 1 => "D.H. Pamphilon" 2 => "M.N. Potter" 3 => "C.G. Steward" 4 => "S. Goodman" 5 => "A. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Haematol" "fecha" => "1996" "volumen" => "94" "paginaInicial" => "574" "paginaFinal" => "578" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8790160" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcomes of transplantation with matched-sibling and unrelated donor bone marrow in children with leukemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Hongeng" 1 => "R.A. Krance" 2 => "L.C. Bowman" 3 => "D.K. Srivastava" 4 => "J.M. Cunningham" 5 => "E.M. Horwitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(97)03098-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1997" "volumen" => "350" "paginaInicial" => "767" "paginaFinal" => "771" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9297996" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unrelated donor or autologous marrow transplantation for treatment of acute leukemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Busca" 1 => "C. Anasetti" 2 => "G. Anderson" 3 => "F.R. Appelbaum" 4 => "C.D. Buckner" 5 => "K. Doney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1994" "volumen" => "83" "paginaInicial" => "3077" "paginaFinal" => "3084" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8180404" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia. The effect of leukemic burden, donor HLA-matching, and marrow cell dose" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Sierra" 1 => "B. Storer" 2 => "J.A. Hansen" 3 => "J.W. Bjerke" 4 => "P.J. Martin" 5 => "E.W. Petersdorf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1997" "volumen" => "89" "paginaInicial" => "4226" "paginaFinal" => "4235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9166868" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of allogeneic bone marrow transplants for leukemia using donors others than HLA-identical siblings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Szydlo" 1 => "J.M. Goldman" 2 => "J.P. Klein" 3 => "R.P. Gale" 4 => "R.C. Ash" 5 => "F.H. Bach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Cliin Oncol" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "1767" "paginaFinal" => "1777" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High resolution HLA matching associated with decreased mortality after unrelated bone marrow transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.E. Speiser" 1 => "J.M. Tiercy" 2 => "N. Rufer" 3 => "C. Grundschober" 4 => "A. Gratwohl" 5 => "B. Chapuis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1996" "volumen" => "87" "paginaInicial" => "4455" "paginaFinal" => "4462" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8639808" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Umbilical cord blood transplant from unrelated HLA-mismatched donors in children with high risk leukemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W. Arcese" 1 => "C. Guglielmi" 2 => "A.P. Iori" 3 => "M. Screnci" 4 => "D. Carmini" 5 => "A.M. Testi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bmt.1701615" "Revista" => array:6 [ "tituloSerie" => "Bone Marrow Transplant" "fecha" => "1999" "volumen" => "23" "paginaInicial" => "549" "paginaFinal" => "554" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10217184" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005300000006/v1_201307051530/S1695403300774923/v1_201307051530/es/main.assets" "Apartado" => array:4 [ "identificador" => "14282" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005300000006/v1_201307051530/S1695403300774923/v1_201307051530/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774923?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 22 | 30 |
| 2024 Octubre | 32 | 51 | 83 |
| 2024 Septiembre | 40 | 52 | 92 |
| 2024 Agosto | 56 | 92 | 148 |
| 2024 Julio | 30 | 54 | 84 |
| 2024 Junio | 39 | 46 | 85 |
| 2024 Mayo | 50 | 62 | 112 |
| 2024 Abril | 44 | 42 | 86 |
| 2024 Marzo | 32 | 46 | 78 |
| 2024 Febrero | 52 | 47 | 99 |
| 2024 Enero | 40 | 36 | 76 |
| 2023 Diciembre | 33 | 19 | 52 |
| 2023 Noviembre | 31 | 44 | 75 |
| 2023 Octubre | 32 | 27 | 59 |
| 2023 Septiembre | 16 | 28 | 44 |
| 2023 Agosto | 23 | 17 | 40 |
| 2023 Julio | 34 | 38 | 72 |
| 2023 Junio | 22 | 26 | 48 |
| 2023 Mayo | 34 | 34 | 68 |
| 2023 Abril | 24 | 24 | 48 |
| 2023 Marzo | 24 | 31 | 55 |
| 2023 Febrero | 19 | 23 | 42 |
| 2023 Enero | 23 | 34 | 57 |
| 2022 Diciembre | 26 | 23 | 49 |
| 2022 Noviembre | 57 | 39 | 96 |
| 2022 Octubre | 30 | 38 | 68 |
| 2022 Septiembre | 40 | 38 | 78 |
| 2022 Agosto | 35 | 48 | 83 |
| 2022 Julio | 18 | 41 | 59 |
| 2022 Junio | 27 | 34 | 61 |
| 2022 Mayo | 23 | 38 | 61 |
| 2022 Abril | 41 | 43 | 84 |
| 2022 Marzo | 32 | 41 | 73 |
| 2022 Febrero | 19 | 32 | 51 |
| 2022 Enero | 23 | 39 | 62 |
| 2021 Diciembre | 28 | 40 | 68 |
| 2021 Noviembre | 28 | 47 | 75 |
| 2021 Octubre | 44 | 49 | 93 |
| 2021 Septiembre | 30 | 53 | 83 |
| 2021 Agosto | 21 | 33 | 54 |
| 2021 Julio | 22 | 41 | 63 |
| 2021 Junio | 29 | 37 | 66 |
| 2021 Mayo | 20 | 44 | 64 |
| 2021 Abril | 62 | 100 | 162 |
| 2021 Marzo | 53 | 45 | 98 |
| 2021 Febrero | 69 | 27 | 96 |
| 2021 Enero | 41 | 34 | 75 |
| 2020 Diciembre | 39 | 15 | 54 |
| 2020 Noviembre | 24 | 18 | 42 |
| 2020 Octubre | 21 | 16 | 37 |
| 2020 Septiembre | 51 | 15 | 66 |
| 2020 Agosto | 62 | 21 | 83 |
| 2020 Julio | 38 | 18 | 56 |
| 2020 Junio | 36 | 17 | 53 |
| 2020 Mayo | 39 | 28 | 67 |
| 2020 Abril | 27 | 13 | 40 |
| 2020 Marzo | 30 | 14 | 44 |
| 2020 Febrero | 21 | 11 | 32 |
| 2020 Enero | 40 | 11 | 51 |
| 2019 Diciembre | 43 | 23 | 66 |
| 2019 Noviembre | 18 | 15 | 33 |
| 2019 Octubre | 9 | 11 | 20 |
| 2019 Septiembre | 25 | 22 | 47 |
| 2019 Agosto | 26 | 21 | 47 |
| 2019 Julio | 27 | 29 | 56 |
| 2019 Junio | 27 | 31 | 58 |
| 2019 Mayo | 47 | 48 | 95 |
| 2019 Abril | 50 | 32 | 82 |
| 2019 Marzo | 18 | 12 | 30 |
| 2019 Febrero | 15 | 8 | 23 |
| 2019 Enero | 19 | 19 | 38 |
| 2018 Diciembre | 16 | 24 | 40 |
| 2018 Noviembre | 32 | 18 | 50 |
| 2018 Octubre | 39 | 16 | 55 |
| 2018 Septiembre | 15 | 8 | 23 |
| 2018 Julio | 2 | 0 | 2 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 3 | 0 | 3 |
| 2018 Abril | 14 | 0 | 14 |
| 2018 Marzo | 4 | 0 | 4 |
| 2018 Febrero | 5 | 1 | 6 |
| 2018 Enero | 7 | 0 | 7 |
| 2017 Diciembre | 7 | 0 | 7 |
| 2017 Noviembre | 10 | 0 | 10 |
| 2017 Octubre | 8 | 0 | 8 |
| 2017 Septiembre | 11 | 0 | 11 |
| 2017 Agosto | 5 | 0 | 5 |
| 2017 Julio | 13 | 0 | 13 |
| 2017 Junio | 10 | 15 | 25 |
| 2017 Mayo | 20 | 14 | 34 |
| 2017 Abril | 13 | 8 | 21 |
| 2017 Marzo | 8 | 11 | 19 |
| 2017 Febrero | 9 | 12 | 21 |
| 2017 Enero | 9 | 4 | 13 |
| 2016 Diciembre | 17 | 14 | 31 |
| 2016 Noviembre | 28 | 7 | 35 |
| 2016 Octubre | 31 | 9 | 40 |
| 2016 Septiembre | 25 | 6 | 31 |
| 2016 Agosto | 24 | 5 | 29 |
| 2016 Julio | 18 | 9 | 27 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 3 | 0 | 3 |
| 2016 Febrero | 1 | 0 | 1 |
| 2016 Enero | 1 | 0 | 1 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Agosto | 2 | 0 | 2 |
| 2015 Julio | 9 | 7 | 16 |
| 2015 Junio | 20 | 0 | 20 |
| 2015 Mayo | 12 | 2 | 14 |
| 2015 Abril | 19 | 8 | 27 |
| 2015 Marzo | 11 | 0 | 11 |
| 2015 Febrero | 9 | 7 | 16 |
| 2015 Enero | 9 | 1 | 10 |
| 2014 Diciembre | 6 | 2 | 8 |
| 2014 Noviembre | 6 | 0 | 6 |
| 2014 Octubre | 6 | 3 | 9 |
| 2014 Septiembre | 9 | 2 | 11 |
| 2014 Agosto | 10 | 8 | 18 |
| 2014 Julio | 13 | 1 | 14 |
| 2014 Junio | 22 | 6 | 28 |
| 2014 Mayo | 24 | 3 | 27 |
| 2014 Abril | 15 | 2 | 17 |
| 2014 Marzo | 14 | 3 | 17 |
| 2014 Febrero | 9 | 23 | 32 |
| 2014 Enero | 6 | 11 | 17 |
| 2013 Diciembre | 21 | 11 | 32 |
| 2013 Noviembre | 22 | 5 | 27 |
| 2013 Octubre | 18 | 8 | 26 |
| 2013 Septiembre | 8 | 12 | 20 |
| 2013 Agosto | 11 | 8 | 19 |
| 2013 Julio | 5 | 3 | 8 |
| 2013 Junio | 1 | 1 | 2 |
| 2013 Mayo | 2 | 4 | 6 |
| 2013 Abril | 2 | 3 | 5 |
| 2013 Marzo | 5 | 1 | 6 |
| 2013 Febrero | 19 | 2 | 21 |
| 2013 Enero | 22 | 2 | 24 |
| 2012 Diciembre | 18 | 2 | 20 |
| 2012 Noviembre | 5 | 1 | 6 |
| 2012 Octubre | 5 | 1 | 6 |
| 2012 Septiembre | 2 | 1 | 3 |
| 2012 Agosto | 1 | 0 | 1 |
| 2000 Diciembre | 1541 | 0 | 1541 |
Mostrar todo
