Hipertiroidismo inducido por amiodarona
Amiodarone-induced hyperthyroidism
Leído
12615
Vecesse ha leído el artículo
3506
Total PDF
9109
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1695403300774832" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77483-2" "estado" => "S300" "fechaPublicacion" => "2000-10-01" "aid" => "77483" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2002" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2000;53:377-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6477 "formatos" => array:3 [ "EPUB" => 100 "HTML" => 5336 "PDF" => 1041 ] ] "itemSiguiente" => array:18 [ "pii" => "S1695403300774844" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77484-4" "estado" => "S300" "fechaPublicacion" => "2000-10-01" "aid" => "77484" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2000;53:380-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 7629 "formatos" => array:3 [ "EPUB" => 93 "HTML" => 6288 "PDF" => 1248 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Eritema figurado "tipo profundo"" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "380" "paginaFinal" => "382" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => ""Deep" figurate erythema" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "F. Martinón-Torres" "autores" => array:1 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Martinón-Torres" ] ] ] 1 => array:2 [ "autoresLista" => "J.M. Martinón Sánchez, A. Pérez Muñuzuri, M. Bravo Mata, F. Martinón Sánchez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Martinón Sánchez" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Pérez Muñuzuri" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Bravo Mata" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Martinón Sánchez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774844?idApp=UINPBA00005H" "url" => "/16954033/0000005300000004/v1_201307051520/S1695403300774844/v1_201307051520/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1695403300774820" "issn" => "16954033" "doi" => "10.1016/S1695-4033(00)77482-0" "estado" => "S300" "fechaPublicacion" => "2000-10-01" "aid" => "77482" "copyright" => "Asociación Española de Pediatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "An Pediatr (Barc). 2000;53:372-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2591 "formatos" => array:3 [ "EPUB" => 75 "HTML" => 1990 "PDF" => 526 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Prostaciclina nebulizada como tratamiento de la hipertensión pulmonar primaria en una niña de 2 años" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "372" "paginaFinal" => "376" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nebulized prostacyclin treatment for pulmonary hypertension in a 2-year-old girl" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Puigarnau Vallhonrat, M. Pons Ódena, E. Carballo Ruano" "autores" => array:3 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Puigarnau Vallhonrat" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Pons Ódena" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Carballo Ruano" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774820?idApp=UINPBA00005H" "url" => "/16954033/0000005300000004/v1_201307051520/S1695403300774820/v1_201307051520/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Hipertiroidismo inducido por amiodarona" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "377" "paginaFinal" => "379" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "M.A. Pérez Parras, M. Marín Patón, A.M. Negrillo Cantero, E. Caro Cruz, F. González Rivera" "autores" => array:5 [ 0 => array:4 [ "nombre" => "M.A." "apellidos" => "Pérez Parras" "email" => array:1 [ 0 => "amnegrillo@colmedjaen.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Marín Patón" ] 2 => array:2 [ "nombre" => "A.M." "apellidos" => "Negrillo Cantero" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Caro Cruz" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "González Rivera" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Pediatría. Hospital General de Especialidades Ciudad de Jaén" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Avda. de Andalucía, 35, 1.° B. 23006 Jaén" ] ] ] 1 => array:3 [ "autoresLista" => "A. Moreno Carazo" "autores" => array:1 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Moreno Carazo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Endocrinología. Hospital General de Especialidades Ciudad de Jaén" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Amiodarone-induced hyperthyroidism" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-31" "fechaAceptado" => "2000-06-30" "PalabrasClave" => array:1 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186469" "palabras" => array:3 [ 0 => "Amiodarone" 1 => "Hyperthyroidism" 2 => "Antiarrhytmics" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186470" "palabras" => array:3 [ 0 => "Hipertirodismo" 1 => "Amiodarona" 2 => "Niños" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La amiodarona es un fármaco utilizado extensamente en la práctica cardiológica por sus excelentes propiedades antiarrítmicas. Produce alteraciones funcionales tiroideas por su alto contenido en yodo, contiene un 37% de yodo y es estructuralmente similar a las hormonas tiroideas. Produce inhibición hepática de la 5'desyodas.</p><p id="spar0265" class="elsevierStyleSimplePara elsevierViewall">El hipertiroidismo secundario a amiodarona presenta una incidencia ente el 6-12% de los pacientes tratados, siendo en la infancia las cifras de incidencias similares.</p><p id="spar0270" class="elsevierStyleSimplePara elsevierViewall">La determinación de niveles de T3, T4, TSH juegan un papel importante por el seguimiento y diagnóstico de las alteraciones tiroideas.</p><p id="spar0275" class="elsevierStyleSimplePara elsevierViewall">Las opciones de tratamiento del hipertiroidismo inducido por amiodarona en niños incluyen: tionamidas, perclorato potásico y prednisona.</p><p id="spar0280" class="elsevierStyleSimplePara elsevierViewall">Presentamos un caso de hipertiroidismo secundario a amiodarona en un varón de 10 años con síndrome de Marfan que presenta varios ingresos por crisis de taquicardia paroxística supraventricular y fibrilación auricular. Tras tratamiento con amiodarona presenta un cuadro clínico y analítico de hipertiroidismo con cifras de TSH muy disminuidas y de T4 libre aumentadas. La ecografía y gammagrafía tiroideas fueron normales.</p><p id="spar0285" class="elsevierStyleSimplePara elsevierViewall">Se inicia tratamiento con tiamazol no cediendo el cuadro, que se normaliza tras la administración de prednisona. Actualmente se retira lentamente la prednisona</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Amiodarone is extensively used in cardiology practice because of its excellent antiarrhythmic properties. It produces alterations in thyroid functional because it contains 37% iodine and it is structurally similar to the thyroid hormones. Amiodarone inhibits 5'–deiodinase in theliver. The incidence of amiodarone-induced hyperthyroidism is between 6% and 12% of treated patients. The figures for pediatric patients are similar. Determination of tri-iodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) plays an important role in the diagnosis and follow-up of thyroid alterations. Treatment options in amiodarone-induced hyperthyroidism in children include thionamide, potassium perchlorate, and prednisone</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We present the case of hyperthyroidism secondary to amiodarone in a 10-year-old boy with Marfan's syndrome who was admitted several times for crises of paroxysmal supraventricular tachycardia and atrial fibrillation. After amiodarone treatment he presented a clinical and analytical picture of hyperthyroidism with very low TSH levels and increased free-T4 levels. Thyroid echography and scintigraphy were normal. Treatment with thiamazole did not alter the clinical picture, which returned to normal after prednisone administration. Currently, prednisone is being slowly withdrawn</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disfunción tiroidea inducida por amiodarona" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Posadas" 1 => "R. Olguin" 2 => "E. Baltazares" 3 => "L. Molina" 4 => "C. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Archs Inst Cardiol Mex" "fecha" => "1985" "volumen" => "55" "paginaInicial" => "399" "paginaFinal" => "404" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimal management of amiodarone therapy: efficacy and side effects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Hilleman" 1 => "M.A. Miller" 2 => "R. Parker" 3 => "P. Doering" 4 => "J.A. Pieper" 5 => "J.A. Pieper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pharmacotherapy" "fecha" => "1998" "volumen" => "18" "paginaInicial" => "138" "paginaFinal" => "145" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A classification of antiarrhytmic actions reassessed after a decade of news drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.M. Vaughan Willians" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pharmacol" "fecha" => "1984" "volumen" => "24" "paginaInicial" => "129" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6144698" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Amiodarone and the thyroid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Kenedy" 1 => "H. Griffiths" 2 => "T.A. Gray" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1989" "volumen" => "35" "paginaInicial" => "1882" "paginaFinal" => "1887" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2673586" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A retrospective study for the analysis of collateral effects of amiodarone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.L. Colin Lizalde" 1 => "T. Febles Palenzuela" 2 => "F. Crespo Mancebo" 3 => "J.L. García González" 4 => "A. Méndez Ruiz" 5 => "P. Iturralde Torres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Archs Inst Cardiol Mex" "fecha" => "1990" "volumen" => "60" "paginaInicial" => "455" "paginaFinal" => "460" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid function in patiens chronically treated whid amiodarone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Borghi" 1 => "R.G. Gheri" 2 => "E. Pratesi" 3 => "F. Bassi" 4 => "G. Cappelli" 5 => "S. Paladini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "G Ital Cardiol" "fecha" => "1983" "volumen" => "13" "paginaInicial" => "139" "paginaFinal" => "145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6363190" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Amiodarone and thyroid function: clinical implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Binz" 1 => "A. Burger" 2 => "M.B. Vallotton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Schweiz Med Wochenschr" "fecha" => "1998" "volumen" => "128" "paginaInicial" => "1051" "paginaFinal" => "1058" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9700779" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid dysfunction related to amiodarone. Prospective survey whith 116 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.L. Wemeau" 1 => "C. Bauters" 2 => "R. Coviaux" 3 => "A. Anouilh" 4 => "T. Maillez" 5 => "M. D'herbomez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Med Interne" "fecha" => "1993" "volumen" => "14" "paginaInicial" => "955" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8009051" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term efficacy and tolerability of amiodarone in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Bosser" 1 => "F. Marcon" 2 => "J.P. Lethor" 3 => "A.M. Worms" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Mal Coeur Vais" "fecha" => "1995" "volumen" => "88" "paginaInicial" => "731" "paginaFinal" => "736" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arritmias cardiacas: utilidad de la farmacoterapia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Klizner" 1 => "W.F. Friedman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Cardiol North Am (ed. esp.)" "fecha" => "1989" "volumen" => "2" "paginaInicial" => "325" "paginaFinal" => "344" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Amiodarona en niños. Impacto en el crecimiento" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Ardura" 1 => "F. Hermoso" 2 => "J. Bermejo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1987" "volumen" => "27" "paginaInicial" => "179" "paginaFinal" => "182" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3426007" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Amiodarone therapy effects on childhood thyroid function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.C. Costigan" 1 => "F.J. Holland" 2 => "D. Daneman" 3 => "P.S. Hesselein" 4 => "M. Vogel" 5 => "G. Ellis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1986" "volumen" => "77" "paginaInicial" => "703" "paginaFinal" => "708" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3703637" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of amiodarone on thyroid funtion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Caron" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Presse Med" "fecha" => "1995" "volumen" => "37" "paginaInicial" => "1747" "paginaFinal" => "1751" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dysthyroidism caused by amiodarone. Frequency and diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Simonin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Mal Coeur Vaiss" "fecha" => "1989" "volumen" => "10" "paginaInicial" => "1747" "paginaFinal" => "1750" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of amiodarone on thyroid function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K.J. Harjai" 1 => "A.A. Licata" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1997" "volumen" => "126" "paginaInicial" => "63" "paginaFinal" => "73" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8992925" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and treatment of thyrotoxicosis in childhood. A European questionaire study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Perrild" 1 => "A. Gruters-Kieslich" 2 => "U. Feldt-Rasmussen" 3 => "D. Grant" 4 => "E. Martino" 5 => "L. Kayser" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Endocrinol" "fecha" => "1994" "volumen" => "131" "paginaInicial" => "467" "paginaFinal" => "473" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7952157" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of amiodarone-induced thyrotoxicosis a difficult challenge: long-term prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Bartalena" 1 => "S. Brogioni" 2 => "L. Grasso" 3 => "F. Bogazzi" 4 => "U.N. Burelli" 5 => "E. Martino" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Endocrinol" "fecha" => "1996" "volumen" => "81" "paginaInicial" => "2930" "paginaFinal" => "2933" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tiroidectomia subtotal. Una posibilidad de tratamiento para la tirotoxicosis inducida por amiodarona" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.R. López Mínguez" 1 => "F. Díaz PérezDíaz Pérez" 2 => "J.M. García Andoain" 3 => "J.J. García Guerrero" 4 => "F. Morales Pérez" 5 => "J.M. Álvarez Suárez-Barcenas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "1996" "volumen" => "49" "paginaInicial" => "474" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8753914" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of amiodarone-induced hyperthyroidism: corticosteroids or potassium perchlorate? What value do interleukin-6 levels have?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Martin-Du Pran" 1 => "O. Konfino" 2 => "M. Zimmermann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Med Suisse Romande" "fecha" => "1997" "volumen" => "117" "paginaInicial" => "805" "paginaFinal" => "810" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9441365" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005300000004/v1_201307051520/S1695403300774832/v1_201307051520/es/main.assets" "Apartado" => array:4 [ "identificador" => "14441" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Notas clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005300000004/v1_201307051520/S1695403300774832/v1_201307051520/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300774832?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 4 | 13 | 17 |
| 2024 Octubre | 49 | 57 | 106 |
| 2024 Septiembre | 54 | 43 | 97 |
| 2024 Agosto | 86 | 86 | 172 |
| 2024 Julio | 78 | 49 | 127 |
| 2024 Junio | 101 | 50 | 151 |
| 2024 Mayo | 84 | 52 | 136 |
| 2024 Abril | 54 | 26 | 80 |
| 2024 Marzo | 54 | 45 | 99 |
| 2024 Febrero | 47 | 60 | 107 |
| 2024 Enero | 77 | 54 | 131 |
| 2023 Diciembre | 146 | 60 | 206 |
| 2023 Noviembre | 96 | 62 | 158 |
| 2023 Octubre | 83 | 72 | 155 |
| 2023 Septiembre | 29 | 28 | 57 |
| 2023 Agosto | 54 | 39 | 93 |
| 2023 Julio | 65 | 86 | 151 |
| 2023 Junio | 84 | 63 | 147 |
| 2023 Mayo | 61 | 49 | 110 |
| 2023 Abril | 40 | 38 | 78 |
| 2023 Marzo | 36 | 43 | 79 |
| 2023 Febrero | 46 | 36 | 82 |
| 2023 Enero | 49 | 32 | 81 |
| 2022 Diciembre | 67 | 27 | 94 |
| 2022 Noviembre | 73 | 42 | 115 |
| 2022 Octubre | 61 | 41 | 102 |
| 2022 Septiembre | 37 | 38 | 75 |
| 2022 Agosto | 66 | 51 | 117 |
| 2022 Julio | 63 | 47 | 110 |
| 2022 Junio | 59 | 39 | 98 |
| 2022 Mayo | 53 | 31 | 84 |
| 2022 Abril | 64 | 51 | 115 |
| 2022 Marzo | 65 | 39 | 104 |
| 2022 Febrero | 38 | 27 | 65 |
| 2022 Enero | 53 | 36 | 89 |
| 2021 Diciembre | 49 | 67 | 116 |
| 2021 Noviembre | 59 | 56 | 115 |
| 2021 Octubre | 75 | 66 | 141 |
| 2021 Septiembre | 51 | 65 | 116 |
| 2021 Agosto | 59 | 42 | 101 |
| 2021 Julio | 64 | 39 | 103 |
| 2021 Junio | 57 | 55 | 112 |
| 2021 Mayo | 90 | 42 | 132 |
| 2021 Abril | 186 | 104 | 290 |
| 2021 Marzo | 139 | 40 | 179 |
| 2021 Febrero | 103 | 36 | 139 |
| 2021 Enero | 68 | 37 | 105 |
| 2020 Diciembre | 69 | 31 | 100 |
| 2020 Noviembre | 81 | 25 | 106 |
| 2020 Octubre | 55 | 9 | 64 |
| 2020 Septiembre | 38 | 15 | 53 |
| 2020 Agosto | 72 | 30 | 102 |
| 2020 Julio | 54 | 21 | 75 |
| 2020 Junio | 58 | 17 | 75 |
| 2020 Mayo | 58 | 21 | 79 |
| 2020 Abril | 57 | 16 | 73 |
| 2020 Marzo | 36 | 13 | 49 |
| 2020 Febrero | 41 | 15 | 56 |
| 2020 Enero | 50 | 29 | 79 |
| 2019 Diciembre | 46 | 26 | 72 |
| 2019 Noviembre | 40 | 20 | 60 |
| 2019 Octubre | 39 | 14 | 53 |
| 2019 Septiembre | 35 | 27 | 62 |
| 2019 Agosto | 27 | 13 | 40 |
| 2019 Julio | 41 | 34 | 75 |
| 2019 Junio | 51 | 58 | 109 |
| 2019 Mayo | 85 | 91 | 176 |
| 2019 Abril | 73 | 73 | 146 |
| 2019 Marzo | 34 | 32 | 66 |
| 2019 Febrero | 27 | 30 | 57 |
| 2019 Enero | 22 | 15 | 37 |
| 2018 Diciembre | 20 | 11 | 31 |
| 2018 Noviembre | 35 | 13 | 48 |
| 2018 Octubre | 35 | 22 | 57 |
| 2018 Septiembre | 15 | 5 | 20 |
| 2018 Julio | 2 | 0 | 2 |
| 2018 Mayo | 4 | 0 | 4 |
| 2018 Abril | 13 | 0 | 13 |
| 2018 Marzo | 12 | 0 | 12 |
| 2018 Febrero | 7 | 0 | 7 |
| 2018 Enero | 12 | 0 | 12 |
| 2017 Diciembre | 8 | 0 | 8 |
| 2017 Noviembre | 11 | 0 | 11 |
| 2017 Octubre | 8 | 0 | 8 |
| 2017 Septiembre | 9 | 0 | 9 |
| 2017 Agosto | 3 | 0 | 3 |
| 2017 Julio | 10 | 2 | 12 |
| 2017 Junio | 13 | 32 | 45 |
| 2017 Mayo | 20 | 38 | 58 |
| 2017 Abril | 14 | 13 | 27 |
| 2017 Marzo | 18 | 17 | 35 |
| 2017 Febrero | 7 | 52 | 59 |
| 2017 Enero | 6 | 13 | 19 |
| 2016 Diciembre | 13 | 18 | 31 |
| 2016 Noviembre | 38 | 31 | 69 |
| 2016 Octubre | 39 | 44 | 83 |
| 2016 Septiembre | 33 | 36 | 69 |
| 2016 Agosto | 47 | 20 | 67 |
| 2016 Julio | 28 | 30 | 58 |
| 2015 Diciembre | 1 | 0 | 1 |
| 2015 Noviembre | 1 | 0 | 1 |
| 2015 Septiembre | 2 | 0 | 2 |
| 2015 Julio | 14 | 0 | 14 |
| 2015 Junio | 15 | 0 | 15 |
| 2015 Mayo | 15 | 8 | 23 |
| 2015 Abril | 13 | 0 | 13 |
| 2015 Marzo | 8 | 0 | 8 |
| 2015 Febrero | 11 | 0 | 11 |
| 2015 Enero | 5 | 0 | 5 |
| 2014 Diciembre | 7 | 2 | 9 |
| 2014 Noviembre | 10 | 0 | 10 |
| 2014 Octubre | 6 | 1 | 7 |
| 2014 Septiembre | 11 | 4 | 15 |
| 2014 Agosto | 22 | 1 | 23 |
| 2014 Julio | 22 | 4 | 26 |
| 2014 Junio | 24 | 6 | 30 |
| 2014 Mayo | 32 | 3 | 35 |
| 2014 Abril | 28 | 3 | 31 |
| 2014 Marzo | 19 | 24 | 43 |
| 2014 Febrero | 11 | 7 | 18 |
| 2014 Enero | 14 | 11 | 25 |
| 2013 Diciembre | 17 | 14 | 31 |
| 2013 Noviembre | 17 | 11 | 28 |
| 2013 Octubre | 23 | 8 | 31 |
| 2013 Septiembre | 23 | 8 | 31 |
| 2013 Agosto | 18 | 20 | 38 |
| 2013 Julio | 2 | 3 | 5 |
| 2013 Junio | 4 | 4 | 8 |
| 2013 Mayo | 6 | 4 | 10 |
| 2013 Abril | 7 | 5 | 12 |
| 2013 Marzo | 11 | 11 | 22 |
| 2013 Febrero | 16 | 3 | 19 |
| 2013 Enero | 34 | 1 | 35 |
| 2012 Diciembre | 38 | 2 | 40 |
| 2012 Noviembre | 22 | 3 | 25 |
| 2012 Octubre | 19 | 1 | 20 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2000 Septiembre | 3716 | 0 | 3716 |
Mostrar todo
