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    "titulo" => "Alteraciones en la función gonadal en varones pospuberales supervivientes de leucemia linfoblástica aguda y enfermedad de Hodgkin"
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            0 => "Funci&#243;n gonadal"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar la funci&#243;n gonadal en varones supervivientes de leucemia linfobl&#225;stica aguda &#40;LLA&#41; y enfermedad de Hodgkin &#40;EH&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 13 varones pospuberales &#40;estadio V de Tanner&#41;&#44; 9 con LLA y 4 con EH&#44; que hab&#237;an recibido poliquimioterapia durante el per&#237;odo prepuberal&#46; El grupo control lo constituyeron 13 varones voluntarios de edad similar y de desarrollo puberal completo&#46; Se determin&#243;&#58; tama&#241;o testicular&#44; espermiograma&#44; valores s&#233;ricos de hormonas foliculoestimulante &#40;FSH&#41; y luteinizante &#40;LH&#41;&#44; basales y tras est&#237;mulo con GnRH &#40;hormona liberadora de gonadotropinas&#41;&#44; y testosterona basal &#40;T1&#41;&#46; Se consider&#243; que exist&#237;a da&#241;o del epitelio germinal cuando se encontr&#243;&#44; al menos&#44; uno de los siguientes criterios&#58; a&#41; oligospermia&#47;azoospermia&#59; b&#41; aumento de FSH basal o tras GnRH&#44; o c&#41; reducci&#243;n del volumen testicular&#46; Se consider&#243; que exist&#237;a lesi&#243;n de las c&#233;lulas de Leydig cuando los valores plasm&#225;sticos de testosterona basal se encontraron disminuidos&#44; o los valores de LH&#44; basales o tras est&#237;mulo&#44; aumentados&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los pacientes diagnosticados de EH presentaron una clara alteraci&#243;n de la funci&#243;n germinal y&#44; en menor medida&#44; de la funci&#243;n de las c&#233;lulas de Leydig&#44; con diferencias significativas respecto al grupo control &#40;p &#60; 0&#44;001&#41; en&#58; pico de FSH &#40;19&#44;7 &#177; 18 frente a 4&#44;8 &#177; 1&#44;8 mU&#47;ml&#41;&#44; pico de LH &#40;49&#44;2 &#177; 31 frente a 33&#44;4 &#177; 10&#44;0 mU&#47;ml&#41;&#44; testosterona &#40;4&#44;1 &#177; 0&#44;6 ng&#47;ml frente a 5&#44;9 &#177; 0&#44;3 ng&#47;ml&#41; y volumen testicular &#40;16&#44;6 &#177; 2&#44;8 frente a 22&#44;5 &#177; 2&#44;4 ml&#41;&#46; De los 4 pacientes con EH&#44; tres presentaron azoospermia y uno oligoespermia&#46; Los pacientes supervivientes de LLA no presentaron diferencias significativas en ninguno de los par&#225;metros bioqu&#237;micos y cl&#237;nicos con el grupo control&#44; si bien&#44; de los 9 pacientes estudiados&#44; dos presentaron oligospermia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los protocolos quimioter&#225;picos empleados en el tratamiento de la EH y la LLA producen una elevada incidencia de da&#241;o germinal y de alteraci&#243;n subcl&#237;nica de las c&#233;lulas de Leydig en los varones con EH&#59; mientras que en los pacientes diagnosticados de LLA se encuentra s&#243;lo una afectaci&#243;n leve de la l&#237;nea germinal&#46; El estado prepuberal no protege los test&#237;culos del efecto nocivo de la quimioterapia&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study gonadal function in male patients surviving acute lymphoblastic leukemia &#40;ALL&#41; or Hodgkin&#39;s disease &#40;HD&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Thirteen postpubertal males were studied &#40;Tanner stage V&#41;&#44; 9 with ALL and 4 with HD&#44; who had received poly chemotherapy during the pre-puberal period&#46; The control group was composed of 13 male volunteers of similar ages and with complete pubertal development&#46; Testicular size&#44; spermiogram&#44; serum levels of follicle-stimulating hormone &#40;FSH&#41; and luteinizing hormone &#40;LH&#41; before and after stimulus with gonadotropin-releasing hormone &#40;GnRH&#41;&#44; and serum testosterone levels were determined&#46; The germinal epithelium was believed to be damaged when at least one of the following criteria was present&#58; 1&#41; oligospermia&#47;azoospermia&#44; 2&#41; increase in serum FSH levels before or after GnRH&#44; or 3&#41; reduction in testicular volume&#46; Lesions in Leydig&#39;s cells were thought to exist when serum testosterone levels were reduced or when serum LH levels&#44; before or after stimulus&#44; increased&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Patients with HD presented clear alterations in germinal function and&#44; to a lesser degree&#44; in the function of Leydig&#39;s cells&#46; Significant differences compared with the control group &#40;p &#60; 0&#46;001&#41; were found in peak FSH &#40;19&#46;7 &#177; 18 vs 4&#46;8 &#177; 1&#46;8 &#63;&#63;&#63;&#47;mL&#41;&#44; peak LH &#40;49&#46;2 &#177; 31 vs 33&#46;4 &#177; 10&#46;0 pUI&#47;mL&#41;&#44; serum testosterone &#40;4&#46;1 &#177; 0&#46;6 vs 5&#46;9 &#177; 0&#46;3 ng&#47;mL&#41; and testicular volume &#40;16&#46;6 &#177; 2&#46;8 vs 22&#46;5 &#177; 2&#46;4 mL&#41;&#46; Of the four patients with HD&#44; three presented azoospermia and one oligospermia&#46; No significant differences in any of the clinical or biochemical parameters studied were found in patients surviving ALL compared with the control group&#44; but two of the nine patients studied presented oligospermia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The chemotherapy protocols used in the treatment of HD and ALL produced a high incidence of germinal cell damage and subclinical alterations in the Leydig&#39;s cell function in males with HD&#46; In patients with ALL&#44; the germinal line was only mildly affected&#46; Prepubertal state does not protect the testes from the harmful effects of chemotherapy&#46;</p>"
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Alteraciones en la función gonadal en varones pospuberales supervivientes de leucemia linfoblástica aguda y enfermedad de Hodgkin
Alterations in gonadal function in post-pubertal male survivors of acute lymphoblastic leukemia and hodgkin's disease
L. Soriano Guillén, M.T. Muñoz Calvo*, J. Pozo Román, T. Contra Gómez, M. Buño Soto, J. Argente Oliver
Secciones de Endocrinología y Oncología Pediátricas. Hospital Universitario Niño Jesús. Universidad Autónoma. Madrid
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar la funci&#243;n gonadal en varones supervivientes de leucemia linfobl&#225;stica aguda &#40;LLA&#41; y enfermedad de Hodgkin &#40;EH&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 13 varones pospuberales &#40;estadio V de Tanner&#41;&#44; 9 con LLA y 4 con EH&#44; que hab&#237;an recibido poliquimioterapia durante el per&#237;odo prepuberal&#46; El grupo control lo constituyeron 13 varones voluntarios de edad similar y de desarrollo puberal completo&#46; Se determin&#243;&#58; tama&#241;o testicular&#44; espermiograma&#44; valores s&#233;ricos de hormonas foliculoestimulante &#40;FSH&#41; y luteinizante &#40;LH&#41;&#44; basales y tras est&#237;mulo con GnRH &#40;hormona liberadora de gonadotropinas&#41;&#44; y testosterona basal &#40;T1&#41;&#46; Se consider&#243; que exist&#237;a da&#241;o del epitelio germinal cuando se encontr&#243;&#44; al menos&#44; uno de los siguientes criterios&#58; a&#41; oligospermia&#47;azoospermia&#59; b&#41; aumento de FSH basal o tras GnRH&#44; o c&#41; reducci&#243;n del volumen testicular&#46; Se consider&#243; que exist&#237;a lesi&#243;n de las c&#233;lulas de Leydig cuando los valores plasm&#225;sticos de testosterona basal se encontraron disminuidos&#44; o los valores de LH&#44; basales o tras est&#237;mulo&#44; aumentados&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los pacientes diagnosticados de EH presentaron una clara alteraci&#243;n de la funci&#243;n germinal y&#44; en menor medida&#44; de la funci&#243;n de las c&#233;lulas de Leydig&#44; con diferencias significativas respecto al grupo control &#40;p &#60; 0&#44;001&#41; en&#58; pico de FSH &#40;19&#44;7 &#177; 18 frente a 4&#44;8 &#177; 1&#44;8 mU&#47;ml&#41;&#44; pico de LH &#40;49&#44;2 &#177; 31 frente a 33&#44;4 &#177; 10&#44;0 mU&#47;ml&#41;&#44; testosterona &#40;4&#44;1 &#177; 0&#44;6 ng&#47;ml frente a 5&#44;9 &#177; 0&#44;3 ng&#47;ml&#41; y volumen testicular &#40;16&#44;6 &#177; 2&#44;8 frente a 22&#44;5 &#177; 2&#44;4 ml&#41;&#46; De los 4 pacientes con EH&#44; tres presentaron azoospermia y uno oligoespermia&#46; Los pacientes supervivientes de LLA no presentaron diferencias significativas en ninguno de los par&#225;metros bioqu&#237;micos y cl&#237;nicos con el grupo control&#44; si bien&#44; de los 9 pacientes estudiados&#44; dos presentaron oligospermia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los protocolos quimioter&#225;picos empleados en el tratamiento de la EH y la LLA producen una elevada incidencia de da&#241;o germinal y de alteraci&#243;n subcl&#237;nica de las c&#233;lulas de Leydig en los varones con EH&#59; mientras que en los pacientes diagnosticados de LLA se encuentra s&#243;lo una afectaci&#243;n leve de la l&#237;nea germinal&#46; El estado prepuberal no protege los test&#237;culos del efecto nocivo de la quimioterapia&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study gonadal function in male patients surviving acute lymphoblastic leukemia &#40;ALL&#41; or Hodgkin&#39;s disease &#40;HD&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Thirteen postpubertal males were studied &#40;Tanner stage V&#41;&#44; 9 with ALL and 4 with HD&#44; who had received poly chemotherapy during the pre-puberal period&#46; The control group was composed of 13 male volunteers of similar ages and with complete pubertal development&#46; Testicular size&#44; spermiogram&#44; serum levels of follicle-stimulating hormone &#40;FSH&#41; and luteinizing hormone &#40;LH&#41; before and after stimulus with gonadotropin-releasing hormone &#40;GnRH&#41;&#44; and serum testosterone levels were determined&#46; The germinal epithelium was believed to be damaged when at least one of the following criteria was present&#58; 1&#41; oligospermia&#47;azoospermia&#44; 2&#41; increase in serum FSH levels before or after GnRH&#44; or 3&#41; reduction in testicular volume&#46; Lesions in Leydig&#39;s cells were thought to exist when serum testosterone levels were reduced or when serum LH levels&#44; before or after stimulus&#44; increased&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Patients with HD presented clear alterations in germinal function and&#44; to a lesser degree&#44; in the function of Leydig&#39;s cells&#46; Significant differences compared with the control group &#40;p &#60; 0&#46;001&#41; were found in peak FSH &#40;19&#46;7 &#177; 18 vs 4&#46;8 &#177; 1&#46;8 &#63;&#63;&#63;&#47;mL&#41;&#44; peak LH &#40;49&#46;2 &#177; 31 vs 33&#46;4 &#177; 10&#46;0 pUI&#47;mL&#41;&#44; serum testosterone &#40;4&#46;1 &#177; 0&#46;6 vs 5&#46;9 &#177; 0&#46;3 ng&#47;mL&#41; and testicular volume &#40;16&#46;6 &#177; 2&#46;8 vs 22&#46;5 &#177; 2&#46;4 mL&#41;&#46; Of the four patients with HD&#44; three presented azoospermia and one oligospermia&#46; No significant differences in any of the clinical or biochemical parameters studied were found in patients surviving ALL compared with the control group&#44; but two of the nine patients studied presented oligospermia&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The chemotherapy protocols used in the treatment of HD and ALL produced a high incidence of germinal cell damage and subclinical alterations in the Leydig&#39;s cell function in males with HD&#46; In patients with ALL&#44; the germinal line was only mildly affected&#46; Prepubertal state does not protect the testes from the harmful effects of chemotherapy&#46;</p>"
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ISSN: 16954033
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Idiomas
Anales de Pediatría