Enfermedad de Graves-Basedow en la infancia y la adolescencia: aspectos clinicobiológicos en 49 casos
Grave's disease in childhood and adolescence: clinical and biochemical aspects in 49 patients
Sección de Endocrinología. Unitat Integrada Hospital Sant Joan de Déu/Hospital Clínic y Laboratorio Hormonal. Hospital Sant Joan de Déu.
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"apellidos" => "Mañé Herrero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Cedó Rigalt" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital de Nens de Barcelona." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centre de Medicina Diagnóstica. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Grave's disease in childhood and adolescence: clinical and biochemical aspects in 49 patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-01-31" "fechaAceptado" => "2000-04-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186391" "palabras" => array:3 [ 0 => "Hipertiroidismo" 1 => "Graves-Basedow" 2 => "Radioyodo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186392" "palabras" => array:3 [ 0 => "Hyperthyroidism" 1 => "Graves' disease" 2 => "Radioiodine" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La enfermedad de Graves-Basedow es rara en la infancia y la adolescencia.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han evaluado 6 niños y 43 niñas, con edades comprendidas entre 2 y 18 años. Todos presentaban un bocio difuso y sintomatología de hipertiroidismo. Las concentraciones de T4, FT4, T3 y TSH se determinaron por radioinmunoanálisis con diferente sensibilidad a lo largo del tiempo y los anticuerpos, por hemaglutinación. Todos fueron tratados con fármacos antitiroideos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En 5 casos se detectó un aumento de la velocidad de crecimiento y en otros 5 había una asociación con otras autoinmunopatías. El índice de Quetelet estaba entre los percentiles 90 y 97 en 5 casos, y entre 3 y 10 en 8 casos. Los resultados bioquímicos fueron: T4 282,41 ± 1,1 nmol/l; FT4 62,98 ± 1,1 pmol/l; T3 4,92 ± 0,07 nmol/l; TSH 0,002 mU/l. Los valores de TSI/TRAb fueron 33,23 ± 1,95 U/l. Sehan obtenido 4 remisiones totales y una parcial. En 4 ocasionesse recurrió a cirugía y 8 pacientes recibieron 131I.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se han obtenido pocas remisiones con el tratamiento médico y el radioyodo parece ser una terapéutica alternativa.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Graves' disease is rare in childhood and adolescence.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Six boys and 43 girls between the ages of 2 and 18 years were evaluated. All presented diffuse goiter and symptomatology of hyperthyroidism. Concentrations of T4, FT4, T3 and TSH were determined by RIA with various sensitivities during the study. Thyroid antibodies were determined by hemagglutination. All patients were treated with antithyroid drugs.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In five patients, growth velocity increased. In a further five patients association with other autoimmune diseases was detected. Quetelet's index was between the 90th and 97th percentiles in five patients and between 3th and 10th in eight. Biochemical results were as follows: T4: 282.41 ± 1.1 nmol/1; FT4: 62.98 ± 1.1 pmol/l; T3: 4.92 ±0.07 nmol/l) and TSH: > 0.002-0.001 mU/l. Values of TSI/TRAb were 33.23 ± 1.95 U/l. Four total remissions and 1 partial remission were observed. Four patients underwent surgery and eight received radioiodine.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Few remissions were obtained with medical treatment.Radioiodine seems to be a therapeutic alternative.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid physiology and pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.G. Walfish" 1 => "K.H. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 11 | 15 | 26 |
| 2024 Octubre | 62 | 65 | 127 |
| 2024 Septiembre | 74 | 57 | 131 |
| 2024 Agosto | 95 | 83 | 178 |
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| 2024 Junio | 71 | 64 | 135 |
| 2024 Mayo | 88 | 43 | 131 |
| 2024 Abril | 66 | 40 | 106 |
| 2024 Marzo | 43 | 50 | 93 |
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| 2024 Enero | 31 | 57 | 88 |
| 2023 Diciembre | 34 | 49 | 83 |
| 2023 Noviembre | 47 | 55 | 102 |
| 2023 Octubre | 54 | 54 | 108 |
| 2023 Septiembre | 33 | 27 | 60 |
| 2023 Agosto | 49 | 30 | 79 |
| 2023 Julio | 46 | 34 | 80 |
| 2023 Junio | 61 | 31 | 92 |
| 2023 Mayo | 56 | 26 | 82 |
| 2023 Abril | 47 | 27 | 74 |
| 2023 Marzo | 27 | 31 | 58 |
| 2023 Febrero | 17 | 10 | 27 |
| 2023 Enero | 17 | 35 | 52 |
| 2022 Diciembre | 36 | 29 | 65 |
| 2022 Noviembre | 39 | 57 | 96 |
| 2022 Octubre | 29 | 53 | 82 |
| 2022 Septiembre | 23 | 31 | 54 |
| 2022 Agosto | 29 | 46 | 75 |
| 2022 Julio | 32 | 43 | 75 |
| 2022 Junio | 24 | 41 | 65 |
| 2022 Mayo | 31 | 42 | 73 |
| 2022 Abril | 34 | 49 | 83 |
| 2022 Marzo | 27 | 61 | 88 |
| 2022 Febrero | 31 | 29 | 60 |
| 2022 Enero | 33 | 44 | 77 |
| 2021 Diciembre | 38 | 49 | 87 |
| 2021 Noviembre | 45 | 47 | 92 |
| 2021 Octubre | 46 | 62 | 108 |
| 2021 Septiembre | 30 | 38 | 68 |
| 2021 Agosto | 21 | 33 | 54 |
| 2021 Julio | 29 | 37 | 66 |
| 2021 Junio | 36 | 42 | 78 |
| 2021 Mayo | 40 | 27 | 67 |
| 2021 Abril | 51 | 55 | 106 |
| 2021 Marzo | 75 | 32 | 107 |
| 2021 Febrero | 80 | 49 | 129 |
| 2021 Enero | 41 | 18 | 59 |
| 2020 Diciembre | 30 | 13 | 43 |
| 2020 Noviembre | 25 | 19 | 44 |
| 2020 Octubre | 41 | 14 | 55 |
| 2020 Septiembre | 26 | 4 | 30 |
| 2020 Agosto | 30 | 10 | 40 |
| 2020 Julio | 22 | 15 | 37 |
| 2020 Junio | 30 | 11 | 41 |
| 2020 Mayo | 24 | 17 | 41 |
| 2020 Abril | 35 | 12 | 47 |
| 2020 Marzo | 29 | 10 | 39 |
| 2020 Febrero | 34 | 16 | 50 |
| 2020 Enero | 23 | 10 | 33 |
| 2019 Diciembre | 37 | 26 | 63 |
| 2019 Noviembre | 29 | 18 | 47 |
| 2019 Octubre | 17 | 8 | 25 |
| 2019 Septiembre | 25 | 23 | 48 |
| 2019 Agosto | 15 | 16 | 31 |
| 2019 Julio | 19 | 35 | 54 |
| 2019 Junio | 25 | 31 | 56 |
| 2019 Mayo | 27 | 52 | 79 |
| 2019 Abril | 45 | 47 | 92 |
| 2019 Marzo | 21 | 19 | 40 |
| 2019 Febrero | 19 | 17 | 36 |
| 2019 Enero | 19 | 13 | 32 |
| 2018 Diciembre | 13 | 22 | 35 |
| 2018 Noviembre | 23 | 22 | 45 |
| 2018 Octubre | 31 | 19 | 50 |
| 2018 Septiembre | 25 | 4 | 29 |
| 2018 Julio | 1 | 0 | 1 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Abril | 11 | 0 | 11 |
| 2018 Marzo | 6 | 0 | 6 |
| 2018 Febrero | 5 | 0 | 5 |
| 2018 Enero | 5 | 0 | 5 |
| 2017 Diciembre | 3 | 0 | 3 |
| 2017 Noviembre | 10 | 0 | 10 |
| 2017 Octubre | 8 | 0 | 8 |
| 2017 Septiembre | 9 | 0 | 9 |
| 2017 Agosto | 5 | 0 | 5 |
| 2017 Julio | 12 | 2 | 14 |
| 2017 Junio | 16 | 38 | 54 |
| 2017 Mayo | 19 | 34 | 53 |
| 2017 Abril | 13 | 39 | 52 |
| 2017 Marzo | 15 | 29 | 44 |
| 2017 Febrero | 9 | 46 | 55 |
| 2017 Enero | 7 | 42 | 49 |
| 2016 Diciembre | 31 | 26 | 57 |
| 2016 Noviembre | 23 | 62 | 85 |
| 2016 Octubre | 32 | 58 | 90 |
| 2016 Septiembre | 31 | 55 | 86 |
| 2016 Agosto | 41 | 29 | 70 |
| 2016 Julio | 24 | 29 | 53 |
| 2016 Junio | 2 | 0 | 2 |
| 2016 Mayo | 1 | 0 | 1 |
| 2016 Marzo | 3 | 0 | 3 |
| 2016 Febrero | 3 | 0 | 3 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Octubre | 1 | 0 | 1 |
| 2015 Septiembre | 2 | 11 | 13 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 16 | 0 | 16 |
| 2015 Junio | 7 | 0 | 7 |
| 2015 Mayo | 13 | 0 | 13 |
| 2015 Abril | 13 | 0 | 13 |
| 2015 Marzo | 8 | 0 | 8 |
| 2015 Febrero | 7 | 0 | 7 |
| 2015 Enero | 9 | 0 | 9 |
| 2014 Diciembre | 8 | 2 | 10 |
| 2014 Noviembre | 9 | 0 | 9 |
| 2014 Octubre | 5 | 0 | 5 |
| 2014 Septiembre | 9 | 2 | 11 |
| 2014 Agosto | 12 | 1 | 13 |
| 2014 Julio | 10 | 5 | 15 |
| 2014 Junio | 13 | 1 | 14 |
| 2014 Mayo | 20 | 4 | 24 |
| 2014 Abril | 15 | 2 | 17 |
| 2014 Marzo | 8 | 6 | 14 |
| 2014 Febrero | 8 | 7 | 15 |
| 2014 Enero | 16 | 4 | 20 |
| 2013 Diciembre | 22 | 21 | 43 |
| 2013 Noviembre | 9 | 7 | 16 |
| 2013 Octubre | 22 | 6 | 28 |
| 2013 Septiembre | 15 | 7 | 22 |
| 2013 Agosto | 13 | 8 | 21 |
| 2013 Julio | 4 | 2 | 6 |
| 2013 Junio | 1 | 4 | 5 |
| 2013 Mayo | 1 | 9 | 10 |
| 2013 Abril | 1 | 4 | 5 |
| 2013 Marzo | 12 | 2 | 14 |
| 2013 Febrero | 14 | 3 | 17 |
| 2013 Enero | 8 | 2 | 10 |
| 2012 Diciembre | 4 | 2 | 6 |
| 2012 Noviembre | 6 | 3 | 9 |
| 2012 Octubre | 5 | 2 | 7 |
| 2012 Septiembre | 3 | 1 | 4 |
| 2000 Junio | 2992 | 0 | 2992 |
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