Función respiratoria en niños supervivientes de neoplasia maligna
Pulmonary function in pediatric survivors of malignant neoplasty
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"apellidos" => "García García y" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "J.M." "apellidos" => "Pino García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Centro de Salud Pintor Oliva. Palencia." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Oncología. Hospital Infantil La Paz. Madrid." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Neumología. Hospital Infantil La Paz. Madrid." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Cuidados Intensivos. Hospital Infantil La Paz. Madrid" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Mariano de los Cobos, 12. 47014 Valladolid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pulmonary function in pediatric survivors of malignant neoplasty" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-05-31" "fechaAceptado" => "2000-01-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186351" "palabras" => array:5 [ 0 => "Neoplasias" 1 => "Toxicidad pulmonar" 2 => "Tratamiento antineo-plásico" 3 => "Función pulmonar" 4 => "Niños" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186352" "palabras" => array:5 [ 0 => "Neoplasia" 1 => "Pulmonary toxicity" 2 => "Antineoplastic treatment" 3 => "Pulmonary function" 4 => "Children" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar la función pulmonar postratamiento, en pacientes que padecen neoplasias malignas extrapulmona-res y su relación con la edad, tipo de tumor y tratamiento recibido</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de una cohorte de 95 pacientes pediátricos tras recibir tratamiento quimioterápico con o sin cirugía o radioterapia torácica extrapulmonar, en fase de remisión sin tratamiento, y capaces de colaborar en la realización de las pruebas de función respiratoria.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se valoraron antecedentes personales y de exposición a factores o hábitos nocivos. Se realizaron controles clínicos, radiografía de tórax, gammagrafía pulmonar, pul-xiosimetría basal y de esfuerzo, espirometría forzada, plestimografía corporal total y transferencia de CO (TLCO).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los pacientes presentaron una edad media al diagnóstico de 5 ± 3,3 años, duración del tratamiento de 2,4 ± 1,3 años y un tiempo sin tratamiento de 4,3 ± 3,3 años; 36 de ellos fueron revisados dos años y medio después del primer control; 39 correspondieron a leucemia linfoblástica aguda y 57 a tumores sólidos. El 60% de los que fueron sometidos a cirugía torácica presentaron deformidad responsable de restricción funcional. La asociación de ésta con radioterapia (6 pacientes) no condicionó peores resultados funcionales. El 43% presentaron inicialmente alteración de la TLCO, el 19 % SatO2 basal inferior al 93% y el 16% un descenso de ésta con el ejercicio. Estas alteraciones mejoraron con el tiempo. Por el contrario, la alteración restrictiva que estuvo presente inicialmente en el 11,5% persistió en el segundo control. Los pacientes exclusivamente irradiados no presentaron alteración restrictiva con más frecuencia. Los menores de 8 años y los que sufrieron tratamientos más prolongados tendieron a presentar peores valores de TLCO. Los neuroblastomas presentaron mayor alteración restrictiva, mientras que la alteración de la TLCO fue más frecuente en los linfo-mas tipo Burkitt y en otros pacientes tratados con ciclo-fosfamida.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Ni los antecedentes personales, los antecedentes familiares de enfermedad respiratoria ni la presencia de síntomas como la tos sirvieron para identificar el riesgo de alteración funcional. Los pacientes sometidos a cirugía torácica presentaron patología restrictiva; su asociación con tratamiento radioterápico no pareció influir negativamente. Los neuroblastomas presentaron los peores resultados respecto a otro tipo de tumores. Es necesario hacer un seguimiento respiratorio funcional en estos niños a fin de prever posibles secuelas restrictivas.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">To evaluate post-treatment pulmonary function in patients with malignant extrapulmonary neoplasia and its relationship with age, type of neoplasty and treatment received.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Cohort study of 95 pediatric patients after chemotherapy with or without surgery or extrapulmonary thoracic radiotherapy. The patients were in remission without treatment and able to undergo pulmonary function testing. Personal history and exposure to risk factors or toxic habits were evaluated. Clinical examination, chest radiographs, pulmonary gammography, basal and stress pulmometry, forced spirometry, whole body phletismography and car-bonmonoxide transfer test were performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Mean age at diagnosis was 5 ± 3.3 years. Treatment duration was 2.4 ± 1.3 years and time without treatment 4.3 ± 3.3 years. Thirty-six patients were reviewed two and a half years after the first control. Thirty-nine patients had acute lymphoblastic leukemia and 57 had solid tumors. Sixty percent showed functional restriction due to chest deformity after undergoing chest surgery. The association between functional restriction and radiotherapy (6 patients) did not produce poorer functional results. Forty-three percent showed initial change in TLCO. Nineteen percent showed basal hemoglobin saturation under 93% which in 16% fell after physical exercise. These alterations improved with time. However, restrictive change initially present in 11.5% persisted at the second evaluation. Thoracic surgery was the main cause of thoracic deformity and therefore of restrictive change. The children under 8 years old and those who received longer treatments tended to show the worst TLCO values. The patients with neuroblastoma showed greater restrictive change while the change in TLCO was more frequent in patients with Burkitt's lymphoma and in those treated with cyclophosphamide.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Neither personal or family history of respiratory disease nor the presence of symptoms such as cough served to identify risk of functional change. Restrictive change in pulmonary function was greater in patients who had undergone thoracic surgery. Functional values were worse in patients with neuroblastoma. Pulmonary function should be followed up in pediatric survivors of malignant neoplasia in order to prevent restrictive alterations</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sobrevivientes de neo-plasias sólidas propias de la niñez. Clínicas pediátricas de Norteamérica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.C. Carter" 1 => "E.I. Thompson" 2 => "J.V. Simone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "paginaInicial" => "519" "serieVolumen" => "2" "serieTitulo" => "Clínicas pediátricas de Norteamérica" "serieFecha" => "1991" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "induced pulmonary disease. Parte 1. Citotoxic Drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A.D. Cooper Jr." 1 => "D.A. White" 2 => "R.A. Matthay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1986.133.2.321" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1986" "volumen" => "133" "paginaInicial" => "321" "paginaFinal" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3511808" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary function after treatment for acute lymphoblastic leukaemia in childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Nysom" 1 => "K. Holm" 2 => "J.H. Olsen" 3 => "H. Hertz" 4 => "B. Hesse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1998" "volumen" => "78" "paginaInicial" => "21" "paginaFinal" => "27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9717987" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late pulmonary toxicity after treatment for Hodgkin's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "F. Villani" 1 => "P. De Maria" 2 => "V. Bonfante" 3 => "S. Viviani" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anticancer Res" "fecha" => "1997" "volumen" => "17" "paginaInicial" => "4739" "paginaFinal" => "4742" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9494599" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term pulmonary sequelae after treatment of childhood Hodgkin's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Bossi" 1 => "I. Cerveri" 2 => "E. Volpini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Oncol" "fecha" => "1997" "volumen" => "Supl" "paginaInicial" => "19" "paginaFinal" => "24" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late-onset pulmonary fibrosis and chest deformity in two children treated with cyclophosphamide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.S. Alvarado" 1 => "T.F. Boat" 2 => "A. Newman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1978" "volumen" => "92" "paginaInicial" => "443" "paginaFinal" => "446" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/273085" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B.R. O'Driscoll" 1 => "P.S. Hasleton" 2 => "P.H. Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199008093230604" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1990" "volumen" => "323" "paginaInicial" => "378" "paginaFinal" => "382" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2370889" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary morbidity 10-18 years after irradiation for Hodgkin's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.A.M. Hassink" 1 => "T.S. Souren" 2 => "L.J. Boersma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Cancer" "fecha" => "1993" "volumen" => "29" "paginaInicial" => "343" "paginaFinal" => "347" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Recomendaciones SEPAR 2. Normativa sobre gasometría ar­terial. Barcelona: Ed Doyma S.A., 1987." ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardized lung function testing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "PhH. Quanjer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Bula Eur Physiopathol Respir Clin Respir Physiol" "fecha" => "1983" "volumen" => "19" "numero" => "Supl 5" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Recomendaciones SEPAR 1. Normativa para la espirometría forzada. Barcelona: Ed. Doyma SA, 1985." ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Polgar" 1 => "V. Promadhat" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Pulmonary function testing in children: techniques and standards" "fecha" => "1971" "editorial" => "W. B. Saunders" "editorialLocalizacion" => "Londres y Filadelfia" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed pulmonary fibrosis after nitrosourea Therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.H. Limper" 1 => "J.A. Mcdonal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199008093230609" "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1990" "volumen" => "323" "paginaInicial" => "407" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2370891" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Salaffi" 1 => "P. Manganelli" 2 => "M. Carotti" 3 => "S. Subiaco" 4 => "G. lamanna" 5 => "C. Cervini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "1997" "volumen" => "16" "paginaInicial" => "296" "paginaFinal" => "304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9184269" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factor for reduced pulmonary function after malignant lymphoma in chilhood" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Nysom" 1 => "K. Holm" 2 => "H. Hertz" 3 => "B. Hesse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Pediatr Oncol" "fecha" => "1998" "volumen" => "30" "paginaInicial" => "240" "paginaFinal" => "248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9473759" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary Function in patients receiving long term low-dose methotrexate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V. Cottin" 1 => "J. Tébib" 2 => "B. Massonnet" 3 => "P.J. Souquet" 4 => "J.P. Bernad" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1996" "volumen" => "109" "paginaInicial" => "933" "paginaFinal" => "938" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8635373" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung function impairment in long-term survivors of Hgkin's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.B. Lund" 1 => "J. Kongerud" 2 => "O. Nome" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Oncol" "fecha" => "1995" "volumen" => "6" "paginaInicial" => "495" "paginaFinal" => "501" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary function abnormalities in long-term survivors of childhood cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R.W. Miller" 1 => "J.E. Fusnes" 2 => "R.J. Fink" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Pediatr Oncol" "fecha" => "1986" "volumen" => "14" "paginaInicial" => "202" "paginaFinal" => "207" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3747939" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung function following treament of malignant tumors with surgery, radiotherapy or ciclophoaphamide in childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Mäkipernaa" 1 => "M. Meino" 2 => "L.A. Laitinem" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1989" "volumen" => "63" "paginaInicial" => "625" "paginaFinal" => "630" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2914269" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary function in survivors of Wilm's tumor" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.J. Shaw" 1 => "O.B. Eden" 2 => "M.E. Jeney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediat Hemathol Oncol" "fecha" => "1991" "volumen" => "8" "paginaInicial" => "131" "paginaFinal" => "137" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term pulmonary toxicity of multiagent chemotherapy including bleomycin and cyclophosphamide in osteosarcoma survivors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V.S. Kharasch" 1 => "S. lipsitz" 2 => "W. Santis" 3 => "J.A. Hallowell" 4 => "A. Goorin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1096-911X(199608)27:2<85::AID-MPO4>3.0.CO;2-P" "Revista" => array:6 [ "tituloSerie" => "Med Pediatr Oncol" "fecha" => "1996" "volumen" => "27" "paginaInicial" => "85" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8649325" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Restrictive lung disease following treatment for malignant brain tumors: a potential late effect of craniospinal irradiation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Jakacki" 1 => "C.M. Schramm" 2 => "B.R. Donahue" 3 => "F. Haas" 4 => "J.C. Allen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1995.13.6.1478" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1995" "volumen" => "13" "paginaInicial" => "1478" "paginaFinal" => "1485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7751895" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of treatment for Hodgkin's disease on pulmonary function: results of a prospective Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.J. Horning" 1 => "A. Adhikari" 2 => "N. Rizk" 3 => "R.T. Hoppe" 4 => "R.A. Olshen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1994.12.2.297" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1994" "volumen" => "12" "paginaInicial" => "297" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7509383" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory function tests after Mantle Irradiation in Patients with Hodgkin's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Cionini" 1 => "P. Pacini" 2 => "E. De Paola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Radiologica" "fecha" => "1984" "volumen" => "23" "paginaInicial" => "401" "paginaFinal" => "409" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect on lung function of methotrexate and non-steroid antiinflammatory drugs in children with juvenile rheumatoide arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Camiciottoli" 1 => "S. Trapani" 2 => "W. castellani" 3 => "R. Ginanni" 4 => "M. Ermini" 5 => "F. Falcini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "1998" "volumen" => "18" "paginaInicial" => "11" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9672993" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary function in patients with trophoblastic disease treated with low-dose methotrexate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.M. Gillespie" 1 => "P.C. Lorigan" 2 => "C.R. Radstone" 3 => "J.C. Waterhouse" 4 => "R.E. Coleman" 5 => "B.W. Hancock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1997" "volumen" => "76" "paginaInicial" => "1382" "paginaFinal" => "1386" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9374387" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low dose Methotrexate may cause air trapping in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.S. Dayton" 1 => "D.A. Schwartz" 2 => "N.L. Sprince" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.151.4.7697251" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1995" "volumen" => "151" "paginaInicial" => "1189" "paginaFinal" => "1193" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7697251" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary function in rheumatoid arthritis treated with low-dose methotrexate: a longitudinal study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Beyeler" 1 => "B. Jordi" 2 => "N.J. Gerber" 3 => "V. Mi Hof" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BR J Rheumatol" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "446" "paginaFinal" => "452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8646435" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/16954033/0000005200000006/v1_201307051505/S1695403300773942/v1_201307051505/es/main.assets" "Apartado" => array:4 [ "identificador" => "14282" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16954033/0000005200000006/v1_201307051505/S1695403300773942/v1_201307051505/es/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773942?idApp=UINPBA00005H" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 15 | 21 |
| 2024 Octubre | 43 | 71 | 114 |
| 2024 Septiembre | 58 | 59 | 117 |
| 2024 Agosto | 72 | 91 | 163 |
| 2024 Julio | 46 | 44 | 90 |
| 2024 Junio | 53 | 33 | 86 |
| 2024 Mayo | 44 | 34 | 78 |
| 2024 Abril | 36 | 45 | 81 |
| 2024 Marzo | 44 | 50 | 94 |
| 2024 Febrero | 31 | 61 | 92 |
| 2024 Enero | 27 | 39 | 66 |
| 2023 Diciembre | 23 | 22 | 45 |
| 2023 Noviembre | 42 | 40 | 82 |
| 2023 Octubre | 40 | 36 | 76 |
| 2023 Septiembre | 33 | 26 | 59 |
| 2023 Agosto | 22 | 29 | 51 |
| 2023 Julio | 24 | 36 | 60 |
| 2023 Junio | 23 | 24 | 47 |
| 2023 Mayo | 42 | 25 | 67 |
| 2023 Abril | 24 | 19 | 43 |
| 2023 Marzo | 17 | 33 | 50 |
| 2023 Febrero | 11 | 20 | 31 |
| 2023 Enero | 18 | 18 | 36 |
| 2022 Diciembre | 31 | 27 | 58 |
| 2022 Noviembre | 33 | 32 | 65 |
| 2022 Octubre | 30 | 36 | 66 |
| 2022 Septiembre | 25 | 32 | 57 |
| 2022 Agosto | 27 | 56 | 83 |
| 2022 Julio | 26 | 40 | 66 |
| 2022 Junio | 19 | 38 | 57 |
| 2022 Mayo | 27 | 29 | 56 |
| 2022 Abril | 25 | 46 | 71 |
| 2022 Marzo | 24 | 39 | 63 |
| 2022 Febrero | 17 | 36 | 53 |
| 2022 Enero | 25 | 43 | 68 |
| 2021 Diciembre | 19 | 45 | 64 |
| 2021 Noviembre | 32 | 46 | 78 |
| 2021 Octubre | 33 | 38 | 71 |
| 2021 Septiembre | 21 | 39 | 60 |
| 2021 Agosto | 21 | 21 | 42 |
| 2021 Julio | 17 | 25 | 42 |
| 2021 Junio | 20 | 29 | 49 |
| 2021 Mayo | 20 | 32 | 52 |
| 2021 Abril | 55 | 68 | 123 |
| 2021 Marzo | 75 | 26 | 101 |
| 2021 Febrero | 70 | 22 | 92 |
| 2021 Enero | 34 | 12 | 46 |
| 2020 Diciembre | 45 | 18 | 63 |
| 2020 Noviembre | 17 | 15 | 32 |
| 2020 Octubre | 23 | 6 | 29 |
| 2020 Septiembre | 22 | 2 | 24 |
| 2020 Agosto | 12 | 8 | 20 |
| 2020 Julio | 23 | 7 | 30 |
| 2020 Junio | 24 | 15 | 39 |
| 2020 Mayo | 26 | 20 | 46 |
| 2020 Abril | 33 | 12 | 45 |
| 2020 Marzo | 23 | 15 | 38 |
| 2020 Febrero | 18 | 9 | 27 |
| 2020 Enero | 37 | 16 | 53 |
| 2019 Diciembre | 26 | 20 | 46 |
| 2019 Noviembre | 22 | 5 | 27 |
| 2019 Octubre | 20 | 8 | 28 |
| 2019 Septiembre | 17 | 13 | 30 |
| 2019 Agosto | 28 | 15 | 43 |
| 2019 Julio | 20 | 19 | 39 |
| 2019 Junio | 24 | 25 | 49 |
| 2019 Mayo | 32 | 52 | 84 |
| 2019 Abril | 17 | 24 | 41 |
| 2019 Marzo | 24 | 17 | 41 |
| 2019 Febrero | 21 | 13 | 34 |
| 2019 Enero | 8 | 6 | 14 |
| 2018 Diciembre | 24 | 18 | 42 |
| 2018 Noviembre | 27 | 14 | 41 |
| 2018 Octubre | 37 | 7 | 44 |
| 2018 Septiembre | 19 | 5 | 24 |
| 2018 Junio | 1 | 0 | 1 |
| 2018 Mayo | 4 | 0 | 4 |
| 2018 Abril | 5 | 0 | 5 |
| 2018 Marzo | 5 | 0 | 5 |
| 2018 Febrero | 11 | 0 | 11 |
| 2018 Enero | 5 | 0 | 5 |
| 2017 Diciembre | 6 | 0 | 6 |
| 2017 Noviembre | 10 | 0 | 10 |
| 2017 Octubre | 6 | 0 | 6 |
| 2017 Septiembre | 11 | 0 | 11 |
| 2017 Agosto | 5 | 0 | 5 |
| 2017 Julio | 15 | 2 | 17 |
| 2017 Junio | 21 | 15 | 36 |
| 2017 Mayo | 27 | 12 | 39 |
| 2017 Abril | 18 | 8 | 26 |
| 2017 Marzo | 16 | 6 | 22 |
| 2017 Febrero | 8 | 9 | 17 |
| 2017 Enero | 11 | 4 | 15 |
| 2016 Diciembre | 25 | 8 | 33 |
| 2016 Noviembre | 41 | 11 | 52 |
| 2016 Octubre | 36 | 6 | 42 |
| 2016 Septiembre | 31 | 9 | 40 |
| 2016 Agosto | 22 | 6 | 28 |
| 2016 Julio | 21 | 13 | 34 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Febrero | 2 | 0 | 2 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Octubre | 1 | 0 | 1 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Julio | 13 | 0 | 13 |
| 2015 Junio | 9 | 0 | 9 |
| 2015 Mayo | 8 | 0 | 8 |
| 2015 Abril | 9 | 0 | 9 |
| 2015 Marzo | 7 | 0 | 7 |
| 2015 Febrero | 7 | 0 | 7 |
| 2015 Enero | 7 | 0 | 7 |
| 2014 Diciembre | 6 | 1 | 7 |
| 2014 Noviembre | 5 | 0 | 5 |
| 2014 Octubre | 7 | 0 | 7 |
| 2014 Septiembre | 3 | 1 | 4 |
| 2014 Agosto | 3 | 0 | 3 |
| 2014 Julio | 4 | 0 | 4 |
| 2014 Junio | 6 | 0 | 6 |
| 2014 Mayo | 18 | 1 | 19 |
| 2014 Abril | 11 | 2 | 13 |
| 2014 Marzo | 14 | 4 | 18 |
| 2014 Febrero | 11 | 3 | 14 |
| 2014 Enero | 16 | 7 | 23 |
| 2013 Diciembre | 16 | 6 | 22 |
| 2013 Noviembre | 14 | 4 | 18 |
| 2013 Octubre | 13 | 5 | 18 |
| 2013 Septiembre | 14 | 7 | 21 |
| 2013 Agosto | 15 | 5 | 20 |
| 2013 Julio | 3 | 2 | 5 |
| 2013 Junio | 1 | 2 | 3 |
| 2013 Mayo | 4 | 2 | 6 |
| 2013 Abril | 1 | 2 | 3 |
| 2013 Marzo | 5 | 3 | 8 |
| 2013 Febrero | 19 | 2 | 21 |
| 2013 Enero | 13 | 2 | 15 |
| 2012 Diciembre | 10 | 1 | 11 |
| 2012 Noviembre | 8 | 4 | 12 |
| 2012 Octubre | 5 | 1 | 6 |
| 2012 Septiembre | 2 | 1 | 3 |
| 2012 Agosto | 0 | 1 | 1 |
| 2000 Mayo | 868 | 0 | 868 |
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