Correlación entre carga viral elevada y concentraciones de TNF-α y cICAM-1 en el plasma de niños infectados por el VIH-1
Relationship between high plasma viral load and levels of tnf-a and cicam-1 in vertically hiv-1 infected children
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Curley, H.L. Halliday" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A.E." "apellidos" => "Curley" ] 1 => array:2 [ "nombre" => "H.L." "apellidos" => "Halliday" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403300773917?idApp=UINPBA00005H" "url" => "/16954033/0000005200000006/v1_201307051505/S1695403300773917/v1_201307051505/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Correlación entre carga viral elevada y concentraciones de TNF-α y cICAM-1 en el plasma de niños infectados por el VIH-1" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "501" "paginaFinal" => "506" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. Resino, J.L. Jiménez, J.M. Bellón, D. Gurbindo, M.A. Muñoz-Fernández" "autores" => array:5 [ 0 => array:3 [ "nombre" => "S." "apellidos" => "Resino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "J.L." "apellidos" => "Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J.M." "apellidos" => "Bellón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "D." "apellidos" => "Gurbindo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:4 [ "nombre" => "M.A." "apellidos" => "Muñoz-Fernández" "email" => array:1 [ 0 => "Mmunoz@cbm.uam.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Secciones de Inmunología Hospital General Universitario Gregorio Marañón. Madrid." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Inmuno-Pediatría. Hospital General Universitario Gregorio Marañón. Madrid." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Hospital General Universitario Gregorio Marañón. División de Inmunología. Dr. Esquerdo, 46. 28007 Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Relationship between high plasma viral load and levels of tnf-a and cicam-1 in vertically hiv-1 infected children" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-02-29" "fechaAceptado" => "2000-04-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186374" "palabras" => array:5 [ 0 => "VIH" 1 => "Niños" 2 => "Carga viral" 3 => "TNF-α" 4 => "cICAM-1" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186373" "palabras" => array:5 [ 0 => "HIV" 1 => "Children" 2 => "Viral load" 3 => "TNF-a" 4 => "cICAM-1" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar si existe relación entre los valores plasmáticos del factor de necrosis tumoral (TNF-α) y la molécula de adhesión intercelular circulante tipo 1 (cICAM-1) con valores de carga viral plasmática (CV) en niños infectados verticalmente por el VIH.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudiamos 44 niños VIH-1 y un grupo control de 38 niños no infectados por el VIH-1. Las subpoblaciones celulares se realizaron por citometría de flujo, las concentraciones de TNF-α y cICAM-1 se cuantificaron por técnicas de enzimoinmunoanálisis y la CV se cuantificó mediante un análisis molecular estándar comercial.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los niños infectados por el VIH-1 presentaron valores significativamente más altos de TNF-α y cICAM-1 que los niños del grupo control. Dividimos a los niños VIH-1 según los valores de CV. Los niños VIH-1 con CV mayor de 50.000 copias/ml produjeron más TNF-α (12,83; IC del 95%: 24,71-0,95 pg/ml) y cICAM-1 (248,94; IC del 95%: 419,01-78,84 ng/ml) que los niños VIH-1 con CV inferior a 50.000 copias/ml, de tal forma que se producía un incremento de 6,57 pg/ml de TNF-α y de 119,97 ng/ml de cICAM-1 por cada log10 de CV.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nuestros datos indican que a medida que en el plasma de los niños VIH-1 se incrementan los valores de CV también se incrementan los valores de TNF-α y cICAM-1.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To assess the relationship among plasma TNF-α and cICAM-1 levels and plasma viral load (VL) in HIV-infected children and to compare these values with those of healthy non-HIV infected children.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We studied 44 HIV-infected children and 38 non-HIV-infected children. The VL was quantified using standard molecular assay. CD4 and CD8 lymphocyte subpopulations were determined by flow cytometry. TNF-α and cICAM-1 were quantified using commercially available specific enzyme-linked immunosorbent assay (ELISA).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Levels of TNF-α and cICAM-1 were higher in HIV-infect-ed children than in non-HIV infected children. HIV-infected children with VL > 50000 copies/ml had higher levels of TNF-α (12.83; 95% CI: 24.71 to 0.95 pg/ml) and cICAM-1 (248.94; 95% CI: 419.01 to 78.84 ng/ml) than HIV-infected children with VL < 50000 copies/ml. Interestingly, we found an increase of 6.57 pg/ml of TNF-α and 119.97 ng/ml of cICAM-1 levels for each log10 of VL.</p> <span class="elsevierStyleSectionTitle">conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">HIV-infected children had higher levels of TNF-α and cICAM-1 than healthy controls. Our data indicate a positive correlation among plasma TNF-a and cICAM-1 and VL levels.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Pantaleo" 1 => "C. Graziosi" 2 => "J.F. Demarest" 3 => "L. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 7 | 16 | 23 |
| 2024 Octubre | 37 | 56 | 93 |
| 2024 Septiembre | 53 | 68 | 121 |
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| 2024 Marzo | 36 | 47 | 83 |
| 2024 Febrero | 40 | 56 | 96 |
| 2024 Enero | 34 | 57 | 91 |
| 2023 Diciembre | 45 | 68 | 113 |
| 2023 Noviembre | 50 | 58 | 108 |
| 2023 Octubre | 33 | 36 | 69 |
| 2023 Septiembre | 21 | 32 | 53 |
| 2023 Agosto | 29 | 26 | 55 |
| 2023 Julio | 43 | 52 | 95 |
| 2023 Junio | 25 | 69 | 94 |
| 2023 Mayo | 46 | 60 | 106 |
| 2023 Abril | 29 | 44 | 73 |
| 2023 Marzo | 18 | 39 | 57 |
| 2023 Febrero | 29 | 22 | 51 |
| 2023 Enero | 24 | 41 | 65 |
| 2022 Diciembre | 27 | 44 | 71 |
| 2022 Noviembre | 39 | 49 | 88 |
| 2022 Octubre | 38 | 77 | 115 |
| 2022 Septiembre | 26 | 42 | 68 |
| 2022 Agosto | 32 | 58 | 90 |
| 2022 Julio | 23 | 54 | 77 |
| 2022 Junio | 28 | 53 | 81 |
| 2022 Mayo | 24 | 38 | 62 |
| 2022 Abril | 42 | 60 | 102 |
| 2022 Marzo | 35 | 71 | 106 |
| 2022 Febrero | 22 | 50 | 72 |
| 2022 Enero | 40 | 48 | 88 |
| 2021 Diciembre | 34 | 58 | 92 |
| 2021 Noviembre | 56 | 51 | 107 |
| 2021 Octubre | 80 | 68 | 148 |
| 2021 Septiembre | 50 | 53 | 103 |
| 2021 Agosto | 53 | 49 | 102 |
| 2021 Julio | 44 | 62 | 106 |
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| 2021 Abril | 70 | 116 | 186 |
| 2021 Marzo | 103 | 29 | 132 |
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| 2021 Enero | 66 | 33 | 99 |
| 2020 Diciembre | 68 | 35 | 103 |
| 2020 Noviembre | 25 | 17 | 42 |
| 2020 Octubre | 32 | 23 | 55 |
| 2020 Septiembre | 40 | 22 | 62 |
| 2020 Agosto | 19 | 10 | 29 |
| 2020 Julio | 26 | 15 | 41 |
| 2020 Junio | 28 | 18 | 46 |
| 2020 Mayo | 24 | 20 | 44 |
| 2020 Abril | 27 | 19 | 46 |
| 2020 Marzo | 15 | 24 | 39 |
| 2020 Febrero | 18 | 12 | 30 |
| 2020 Enero | 31 | 23 | 54 |
| 2019 Diciembre | 27 | 25 | 52 |
| 2019 Noviembre | 23 | 14 | 37 |
| 2019 Octubre | 16 | 12 | 28 |
| 2019 Septiembre | 22 | 50 | 72 |
| 2019 Agosto | 29 | 19 | 48 |
| 2019 Julio | 40 | 45 | 85 |
| 2019 Junio | 30 | 25 | 55 |
| 2019 Mayo | 36 | 78 | 114 |
| 2019 Abril | 26 | 22 | 48 |
| 2019 Marzo | 33 | 7 | 40 |
| 2019 Febrero | 38 | 15 | 53 |
| 2019 Enero | 33 | 13 | 46 |
| 2018 Diciembre | 27 | 15 | 42 |
| 2018 Noviembre | 29 | 21 | 50 |
| 2018 Octubre | 33 | 15 | 48 |
| 2018 Septiembre | 14 | 0 | 14 |
| 2018 Julio | 1 | 0 | 1 |
| 2018 Mayo | 5 | 0 | 5 |
| 2018 Abril | 16 | 0 | 16 |
| 2018 Marzo | 10 | 0 | 10 |
| 2018 Febrero | 11 | 0 | 11 |
| 2018 Enero | 13 | 0 | 13 |
| 2017 Diciembre | 11 | 0 | 11 |
| 2017 Noviembre | 15 | 0 | 15 |
| 2017 Octubre | 8 | 0 | 8 |
| 2017 Septiembre | 18 | 0 | 18 |
| 2017 Agosto | 10 | 0 | 10 |
| 2017 Julio | 15 | 0 | 15 |
| 2017 Junio | 32 | 12 | 44 |
| 2017 Mayo | 25 | 5 | 30 |
| 2017 Abril | 17 | 21 | 38 |
| 2017 Marzo | 20 | 5 | 25 |
| 2017 Febrero | 15 | 5 | 20 |
| 2017 Enero | 14 | 1 | 15 |
| 2016 Diciembre | 20 | 9 | 29 |
| 2016 Noviembre | 46 | 8 | 54 |
| 2016 Octubre | 42 | 10 | 52 |
| 2016 Septiembre | 46 | 4 | 50 |
| 2016 Agosto | 30 | 5 | 35 |
| 2016 Julio | 18 | 7 | 25 |
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