Dermatomiositis en la infancia
Dermatomyositis in childhood
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"apellidos" => "Mateos González" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "López-Laso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Gómez Reino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "R." "apellidos" => "Simón de las Heras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "F." "apellidos" => "Mateos Beato" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Neurología Pediátrica." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Reumatología Pediátrica. Departamento de Pediatría. Hospital 12 de Octubre. Madrid." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Unidad de Neurología Pediátrica. Departamento de Pediatría. Hospital 12 de Octubre. Ctra. de Andalucía, km. 5,400. 28041 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Dermatomyositis in childhood" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-09-30" "fechaAceptado" => "2000-02-29" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186342" "palabras" => array:4 [ 0 => "Dermatomiositis juvenil" 1 => "Niños" 2 => "Dermatomiositis-tratamiento" 3 => "Miopatías inflamatorias" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186341" "palabras" => array:4 [ 0 => "Juvenile Dermatomyositis" 1 => "Children" 2 => "Dermatomyositisdrug therapy" 3 => "Inflammatory myopathies" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Análisis descriptivo de los datos clínicos, exploraciones complementarias y régimen terapéutico de los pacientes diagnosticados de dermatomiositis juvenil en nuestro centro, un hospital terciario.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de las historias clínicas de los niños con diagnóstico definitivo de dermatomiositis juvenil seguidos en la consulta de reumatología pediátrica de nuestro centro, desde 1986 hasta julio de 1999.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Del total de 9 casos recogidos, 3 han sido varones y 6 mujeres. La edad media al diagnóstico fue de 7 años. Los síntomas y signos que demandaron atención hospitalaria fueron: debilidad y dolor muscular asociados a síndrome constitucional en 4 casos (44%); debilidad muscular aislada en 2 casos; dolor muscular y síndrome constitucional en un caso, y monoartritis en otro. Un paciente presentó clínica exclusivamente cutánea al inicio. Presentaron calcinosis 3 pacientes. En 8 casos se produjo una elevación de la creatinfosfocinasa sérica y la lactatodeshidrogenasa en 8 pacientes; en 7 casos, una elevación de la aldolasa, y en 6 casos, en 8 pacientes un aumento de las aminotransferasas. Los autoanticuerpos fueron negativos en todos los pacientes. El electromiograma objetivó un patrón miopático o mixto en los 5 casos en que se realizó. La biopsia muscular fue diagnóstica en todos los casos. Siete pacientes recibieron tratamiento con corticoides y 2 pacientes corticoides, metotrexato y gammaglobulina. En cuanto a la evolución, 6 pacientes se encuentran asintomáticos, en 2 persiste debilidad muscular leve aislada y un paciente ha fallecido.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los resultados en nuestra serie concuerdan con la bibliografía. La dermatomiositis juvenil debe ser sospechada en niños con debilidad muscular y afectación del estado general. Se recomienda comenzar precozmente el tratamiento con corticoides.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The aim of this study is to review the presenting signs and symptoms, laboratory findings and therapeutic regimens of juvenile dermatomyositis in a tertiary hospital.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We reviewed retrospectively the available medical records of patients who met the clinicopathologic criteria of Bohan and Peter for definite juvenile dermatomyositis. They were followed between 1986 and july 1999 at the pediatric rheumatology section at our institution.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The patient population included 3 male and 6 female patients. The mean age at diagnosis was 7 years. Clinical features demanding medical attention at the hospital were: muscle weakness and pain, with associated general symptoms in 4 cases; isolated muscle weakness in 2 cases; muscle weakness associated to general symptoms in 1 case; and monoarthritis in another case. One patient presented initially only with cutaneous rash. Three patients developed calcinosis. Serum CPK and LDH levels were elevated in 8 patients, aldolase in 7 and aminotransferases in 6. Autoantibodies were undetectable in all the patients. Electomyography demonstrated myopatic or mixed pattern in the 5 patients it was practiced. Muscle biopsy showed features of inflammatory myopathy in all the cases. Seven patients were treated exclusively with steroids and 2 patients with steroids, methotrexate and intravenous gammaglobuline. Actually, 6 patients are asymptomatic, 2 have mild muscle weakness, and 1 has died.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The results of our review agree with other series reported. Juvenile dermatomyositis suspicious should be made upon muscle weakness and general symptoms.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Treatment with steroids should be started promptly.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Biblografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Demography of a regional pediatric rheumatology patient population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B.A. DeNardo" 1 => "L.B. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 15 | 23 |
| 2024 Octubre | 87 | 64 | 151 |
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| 2023 Septiembre | 99 | 29 | 128 |
| 2023 Agosto | 85 | 27 | 112 |
| 2023 Julio | 79 | 56 | 135 |
| 2023 Junio | 86 | 46 | 132 |
| 2023 Mayo | 122 | 34 | 156 |
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| 2023 Marzo | 120 | 25 | 145 |
| 2023 Febrero | 95 | 31 | 126 |
| 2023 Enero | 77 | 39 | 116 |
| 2022 Diciembre | 81 | 34 | 115 |
| 2022 Noviembre | 114 | 51 | 165 |
| 2022 Octubre | 81 | 55 | 136 |
| 2022 Septiembre | 109 | 30 | 139 |
| 2022 Agosto | 141 | 74 | 215 |
| 2022 Julio | 117 | 61 | 178 |
| 2022 Junio | 62 | 60 | 122 |
| 2022 Mayo | 111 | 64 | 175 |
| 2022 Abril | 150 | 42 | 192 |
| 2022 Marzo | 112 | 77 | 189 |
| 2022 Febrero | 94 | 33 | 127 |
| 2022 Enero | 83 | 56 | 139 |
| 2021 Diciembre | 79 | 67 | 146 |
| 2021 Noviembre | 74 | 48 | 122 |
| 2021 Octubre | 75 | 87 | 162 |
| 2021 Septiembre | 88 | 67 | 155 |
| 2021 Agosto | 93 | 44 | 137 |
| 2021 Julio | 83 | 73 | 156 |
| 2021 Junio | 109 | 61 | 170 |
| 2021 Mayo | 70 | 63 | 133 |
| 2021 Abril | 148 | 135 | 283 |
| 2021 Marzo | 130 | 59 | 189 |
| 2021 Febrero | 128 | 37 | 165 |
| 2021 Enero | 110 | 38 | 148 |
| 2020 Diciembre | 79 | 35 | 114 |
| 2020 Noviembre | 99 | 43 | 142 |
| 2020 Octubre | 80 | 42 | 122 |
| 2020 Septiembre | 75 | 34 | 109 |
| 2020 Agosto | 71 | 24 | 95 |
| 2020 Julio | 90 | 33 | 123 |
| 2020 Junio | 78 | 26 | 104 |
| 2020 Mayo | 104 | 20 | 124 |
| 2020 Abril | 45 | 15 | 60 |
| 2020 Marzo | 65 | 25 | 90 |
| 2020 Febrero | 67 | 38 | 105 |
| 2020 Enero | 98 | 57 | 155 |
| 2019 Diciembre | 102 | 28 | 130 |
| 2019 Noviembre | 56 | 24 | 80 |
| 2019 Octubre | 49 | 31 | 80 |
| 2019 Septiembre | 59 | 24 | 83 |
| 2019 Agosto | 35 | 31 | 66 |
| 2019 Julio | 54 | 44 | 98 |
| 2019 Junio | 74 | 59 | 133 |
| 2019 Mayo | 115 | 111 | 226 |
| 2019 Abril | 50 | 76 | 126 |
| 2019 Marzo | 30 | 43 | 73 |
| 2019 Febrero | 23 | 26 | 49 |
| 2019 Enero | 23 | 36 | 59 |
| 2018 Diciembre | 22 | 30 | 52 |
| 2018 Noviembre | 33 | 29 | 62 |
| 2018 Octubre | 46 | 15 | 61 |
| 2018 Septiembre | 26 | 19 | 45 |
| 2018 Julio | 4 | 0 | 4 |
| 2018 Mayo | 9 | 0 | 9 |
| 2018 Abril | 6 | 0 | 6 |
| 2018 Marzo | 10 | 0 | 10 |
| 2018 Febrero | 13 | 0 | 13 |
| 2018 Enero | 4 | 0 | 4 |
| 2017 Diciembre | 11 | 0 | 11 |
| 2017 Noviembre | 9 | 1 | 10 |
| 2017 Octubre | 11 | 0 | 11 |
| 2017 Septiembre | 13 | 1 | 14 |
| 2017 Agosto | 6 | 0 | 6 |
| 2017 Julio | 8 | 3 | 11 |
| 2017 Junio | 27 | 67 | 94 |
| 2017 Mayo | 17 | 56 | 73 |
| 2017 Abril | 24 | 52 | 76 |
| 2017 Marzo | 15 | 91 | 106 |
| 2017 Febrero | 9 | 78 | 87 |
| 2017 Enero | 14 | 30 | 44 |
| 2016 Diciembre | 17 | 30 | 47 |
| 2016 Noviembre | 43 | 46 | 89 |
| 2016 Octubre | 37 | 38 | 75 |
| 2016 Septiembre | 55 | 50 | 105 |
| 2016 Agosto | 54 | 25 | 79 |
| 2016 Julio | 39 | 41 | 80 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 1 | 0 | 1 |
| 2016 Febrero | 1 | 0 | 1 |
| 2016 Enero | 1 | 0 | 1 |
| 2015 Diciembre | 1 | 0 | 1 |
| 2015 Noviembre | 2 | 0 | 2 |
| 2015 Octubre | 7 | 0 | 7 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 19 | 0 | 19 |
| 2015 Junio | 9 | 0 | 9 |
| 2015 Mayo | 10 | 0 | 10 |
| 2015 Abril | 9 | 0 | 9 |
| 2015 Marzo | 10 | 0 | 10 |
| 2015 Febrero | 14 | 0 | 14 |
| 2015 Enero | 17 | 1 | 18 |
| 2014 Diciembre | 17 | 2 | 19 |
| 2014 Noviembre | 12 | 1 | 13 |
| 2014 Octubre | 12 | 0 | 12 |
| 2014 Septiembre | 13 | 6 | 19 |
| 2014 Agosto | 13 | 1 | 14 |
| 2014 Julio | 13 | 1 | 14 |
| 2014 Junio | 25 | 3 | 28 |
| 2014 Mayo | 22 | 2 | 24 |
| 2014 Abril | 21 | 4 | 25 |
| 2014 Marzo | 21 | 12 | 33 |
| 2014 Febrero | 16 | 6 | 22 |
| 2014 Enero | 17 | 8 | 25 |
| 2013 Diciembre | 20 | 11 | 31 |
| 2013 Noviembre | 25 | 6 | 31 |
| 2013 Octubre | 33 | 8 | 41 |
| 2013 Septiembre | 31 | 10 | 41 |
| 2013 Agosto | 14 | 7 | 21 |
| 2013 Julio | 5 | 2 | 7 |
| 2013 Junio | 3 | 2 | 5 |
| 2013 Mayo | 6 | 4 | 10 |
| 2013 Abril | 5 | 3 | 8 |
| 2013 Marzo | 5 | 4 | 9 |
| 2013 Febrero | 27 | 2 | 29 |
| 2013 Enero | 27 | 3 | 30 |
| 2012 Diciembre | 40 | 3 | 43 |
| 2012 Noviembre | 35 | 4 | 39 |
| 2012 Octubre | 44 | 1 | 45 |
| 2012 Septiembre | 11 | 1 | 12 |
| 2012 Agosto | 1 | 0 | 1 |
| 2000 Abril | 4337 | 0 | 4337 |
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