Citopatía mitocondrial neonatal grave por déficit aislado de COX
Severe neonatal mitochondrial cytopathy due to isolated COX defects
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"etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Princesa, 11–13, 3.<span class="elsevierStyleSup">°</span> A. 50005 Zaragoza." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Severe neonatal mitochondrial cytopathy due to isolated COX defects" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-01-31" "fechaAceptado" => "1999-03-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec186309" "palabras" => array:4 [ 0 => "Mitocondria" 1 => "Recién nacido" 2 => "Citopatía mitocondrial" 3 => "Citocromo C oxidasa" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec186310" "palabras" => array:4 [ 0 => "Mitochondria" 1 => "Neonate" 2 => "Mitochondrial cytopathy" 3 => "Cytochrome c oxidase" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Recién nacido con déficit aislado de citocromo C oxidasa (COX), con afectación multisistémica grave, en la que predominaba desde el nacimiento una encefalopatía severa, que falleció precozmente por miocardiopatía hipóxico- isquémica. Segundo hijo de un matrimonio sano no consanguíneo, con otra hija afectada de encefalopatía crónica. Presentaba además, fenotipo dismórfico, afectación hepática y muscular y una posible tubulopatía. En la valoración metabólica resaltaba una relación láctico/pirúvico aumentada. El diagnóstico se estableció por estudio enzimático muscular y por las alteraciones ultraestructurales mitocondriales, siendo normales el ADNmt y la tinción para COX. En el examen anatomopatológico se evidenció un infarto subendocárdico masivo. Se comentan aspectos de interés sobre esta entidad, dada la importancia de su conocimiento para el correspondiente consejo genético.</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We report a neonate with isolated cytochrome c oxidase (COX) defect and severe multisystemic involvement. The patient had severe encephalopathy, predominant since birth, and died due to hypoxic-ischemic myocardiopathy. He was the second son of non-consanguineous, healthy parents who also had a daughter with chronic encephalopathy. The neonate presented dysmorphic phenotype, hepatic and muscular involvement, and possibly tubular involvement. Metabolic studies revealed markedly increased lactic/pyruvic concentrations. Diagnosis was based on muscular enzymatic studies and ultrastructural mitochondrial anomalies, while the mitochondrial DNA and results of the COX technique were normal. Histological examination revealed a massive subendocardial infarction. Aspects of this entity with relevance for genetic counseling are discussed.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| 2024 Noviembre | 14 | 16 | 30 |
| 2024 Octubre | 148 | 49 | 197 |
| 2024 Septiembre | 141 | 61 | 202 |
| 2024 Agosto | 140 | 73 | 213 |
| 2024 Julio | 122 | 40 | 162 |
| 2024 Junio | 119 | 40 | 159 |
| 2024 Mayo | 132 | 50 | 182 |
| 2024 Abril | 98 | 53 | 151 |
| 2024 Marzo | 94 | 59 | 153 |
| 2024 Febrero | 125 | 45 | 170 |
| 2024 Enero | 102 | 28 | 130 |
| 2023 Diciembre | 116 | 32 | 148 |
| 2023 Noviembre | 170 | 27 | 197 |
| 2023 Octubre | 167 | 44 | 211 |
| 2023 Septiembre | 104 | 45 | 149 |
| 2023 Agosto | 118 | 27 | 145 |
| 2023 Julio | 129 | 49 | 178 |
| 2023 Junio | 127 | 57 | 184 |
| 2023 Mayo | 173 | 57 | 230 |
| 2023 Abril | 118 | 37 | 155 |
| 2023 Marzo | 121 | 50 | 171 |
| 2023 Febrero | 144 | 39 | 183 |
| 2023 Enero | 140 | 41 | 181 |
| 2022 Diciembre | 96 | 34 | 130 |
| 2022 Noviembre | 211 | 76 | 287 |
| 2022 Octubre | 117 | 59 | 176 |
| 2022 Septiembre | 126 | 33 | 159 |
| 2022 Agosto | 98 | 59 | 157 |
| 2022 Julio | 75 | 40 | 115 |
| 2022 Junio | 86 | 35 | 121 |
| 2022 Mayo | 92 | 39 | 131 |
| 2022 Abril | 75 | 34 | 109 |
| 2022 Marzo | 64 | 49 | 113 |
| 2022 Febrero | 76 | 32 | 108 |
| 2022 Enero | 91 | 37 | 128 |
| 2021 Diciembre | 89 | 55 | 144 |
| 2021 Noviembre | 106 | 53 | 159 |
| 2021 Octubre | 89 | 52 | 141 |
| 2021 Septiembre | 113 | 60 | 173 |
| 2021 Agosto | 73 | 39 | 112 |
| 2021 Julio | 65 | 59 | 124 |
| 2021 Junio | 43 | 57 | 100 |
| 2021 Mayo | 71 | 65 | 136 |
| 2021 Abril | 114 | 130 | 244 |
| 2021 Marzo | 114 | 82 | 196 |
| 2021 Febrero | 105 | 68 | 173 |
| 2021 Enero | 78 | 42 | 120 |
| 2020 Diciembre | 65 | 31 | 96 |
| 2020 Noviembre | 60 | 24 | 84 |
| 2020 Octubre | 43 | 15 | 58 |
| 2020 Septiembre | 43 | 24 | 67 |
| 2020 Agosto | 55 | 8 | 63 |
| 2020 Julio | 44 | 27 | 71 |
| 2020 Junio | 43 | 13 | 56 |
| 2020 Mayo | 61 | 22 | 83 |
| 2020 Abril | 32 | 23 | 55 |
| 2020 Marzo | 44 | 14 | 58 |
| 2020 Febrero | 56 | 19 | 75 |
| 2020 Enero | 50 | 29 | 79 |
| 2019 Diciembre | 69 | 14 | 83 |
| 2019 Noviembre | 43 | 9 | 52 |
| 2019 Octubre | 28 | 17 | 45 |
| 2019 Septiembre | 46 | 38 | 84 |
| 2019 Agosto | 35 | 25 | 60 |
| 2019 Julio | 26 | 23 | 49 |
| 2019 Junio | 79 | 46 | 125 |
| 2019 Mayo | 121 | 59 | 180 |
| 2019 Abril | 113 | 15 | 128 |
| 2019 Marzo | 28 | 15 | 43 |
| 2019 Febrero | 26 | 3 | 29 |
| 2019 Enero | 16 | 10 | 26 |
| 2018 Diciembre | 18 | 10 | 28 |
| 2018 Noviembre | 28 | 17 | 45 |
| 2018 Octubre | 55 | 19 | 74 |
| 2018 Septiembre | 13 | 6 | 19 |
| 2018 Junio | 2 | 0 | 2 |
| 2018 Mayo | 4 | 0 | 4 |
| 2018 Abril | 11 | 0 | 11 |
| 2018 Marzo | 9 | 0 | 9 |
| 2018 Febrero | 10 | 0 | 10 |
| 2018 Enero | 9 | 0 | 9 |
| 2017 Diciembre | 4 | 0 | 4 |
| 2017 Noviembre | 7 | 0 | 7 |
| 2017 Octubre | 10 | 0 | 10 |
| 2017 Septiembre | 17 | 0 | 17 |
| 2017 Agosto | 5 | 0 | 5 |
| 2017 Julio | 5 | 1 | 6 |
| 2017 Junio | 19 | 10 | 29 |
| 2017 Mayo | 13 | 4 | 17 |
| 2017 Abril | 10 | 2 | 12 |
| 2017 Marzo | 9 | 4 | 13 |
| 2017 Febrero | 4 | 4 | 8 |
| 2017 Enero | 3 | 0 | 3 |
| 2016 Diciembre | 20 | 3 | 23 |
| 2016 Noviembre | 31 | 4 | 35 |
| 2016 Octubre | 28 | 7 | 35 |
| 2016 Septiembre | 30 | 1 | 31 |
| 2016 Agosto | 17 | 1 | 18 |
| 2016 Julio | 18 | 2 | 20 |
| 2016 Abril | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Septiembre | 3 | 0 | 3 |
| 2015 Agosto | 4 | 0 | 4 |
| 2015 Julio | 10 | 0 | 10 |
| 2015 Junio | 10 | 0 | 10 |
| 2015 Mayo | 21 | 0 | 21 |
| 2015 Abril | 10 | 5 | 15 |
| 2015 Marzo | 11 | 0 | 11 |
| 2015 Febrero | 13 | 0 | 13 |
| 2015 Enero | 11 | 0 | 11 |
| 2014 Diciembre | 20 | 2 | 22 |
| 2014 Noviembre | 10 | 0 | 10 |
| 2014 Octubre | 14 | 0 | 14 |
| 2014 Septiembre | 11 | 0 | 11 |
| 2014 Agosto | 11 | 0 | 11 |
| 2014 Julio | 7 | 0 | 7 |
| 2014 Junio | 15 | 0 | 15 |
| 2014 Mayo | 32 | 1 | 33 |
| 2014 Abril | 20 | 3 | 23 |
| 2014 Marzo | 18 | 7 | 25 |
| 2014 Febrero | 9 | 4 | 13 |
| 2014 Enero | 16 | 6 | 22 |
| 2013 Diciembre | 16 | 9 | 25 |
| 2013 Noviembre | 13 | 6 | 19 |
| 2013 Octubre | 27 | 5 | 32 |
| 2013 Septiembre | 19 | 4 | 23 |
| 2013 Agosto | 23 | 9 | 32 |
| 2013 Julio | 4 | 1 | 5 |
| 2013 Junio | 1 | 3 | 4 |
| 2013 Mayo | 3 | 2 | 5 |
| 2013 Abril | 4 | 1 | 5 |
| 2013 Marzo | 4 | 3 | 7 |
| 2013 Febrero | 15 | 4 | 19 |
| 2013 Enero | 20 | 1 | 21 |
| 2012 Diciembre | 21 | 1 | 22 |
| 2012 Noviembre | 13 | 2 | 15 |
| 2012 Octubre | 3 | 1 | 4 |
| 2012 Septiembre | 2 | 1 | 3 |
| 2000 Marzo | 2295 | 0 | 2295 |
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