Journal Information
Vol. 58. Issue 3.
Pages 217-221 (1 March 2003)
Share
Share
Download PDF
More article options
Vol. 58. Issue 3.
Pages 217-221 (1 March 2003)
Full text access
Monitorización continua de glucosa en la diabetes mellitus tipo 1
Continuous glucose monitoring with type 1 diabetes mellitus
Visits
10660
J.P. López-Siguero, M.aJ. García Arias
Corresponding author
majosega@eresmas.com

Correspondencia: Avda. Pío Baroja, 20, 7.º A. 29017 Málaga. España
, A. del Pino de la Fuente, J.A. Moreno Molina
Sección de Endocrinología Pediátrica. Hospital Materno-Infantil. Complejo Hospitalario Carlos Haya. Málaga. España
This item has received
Article information
Antecedentes

El buen control metabólico de los nios con diabetes mellitus (DM) tipo 1 se basa en deter inaciones frecuentes de glucemia capilar. Este método ofrece una informacin parcial sobre las fluctuaciones de la glucemia, pasando desapercibidos episodios de hiperglucemia posprandiales y de hipoglucemias, principalmente nocturnas. El Continuous Glucose Monitoring System (CGMS?) de Minimed aporta informacin de los valores de glucosa intersticial durante aproximadamente 72 h.

Objetivos

Analizar los valores de glucosa preprandiales y pos-prandiales, presencia y duración de las hipoglucemias, en niños diabéticos mayores de 8 años con más de un año de evolución.

Métodos

Se monitorizaron con CGMS? 17 pacientes con DM tipo 1 de ambos sexos, durante días laborables. La edad media fue de 12 años. Se registraron los valores de gluco-sa preprandial y posprandial máximos (1-3 h) tras el de-sayuno, el almuerzo y la cena. Los datos se descargaron mediante una Comstation.

Resultados

La duración media de monitorización fue de 2,97 días.La media de los valores de glucosa preprandial estuvo entre 144,9 y 160,5 mg%, y los posprandiales entre 230,4 y 248,8 mg%. El número medio de hipoglucemias detectadas con el sensor fue de 4,9 y con glucómetro 1,8 (p < 0,05). Se detectaron hipoglucemias asintomáti-cas, principalmente nocturnas, con duración media de 145 min durante la noche y de 75 min de día.

Conclusiones

La monitorización continua de glucosa intersticial pone de manifiesto que con la terapia insulínica habitual no se alcanzan los objetivos glucémicos y se producen un número elevado de hipoglucemias, la mayoría asintomáticas.

Palabras clave:
Diabetes mellitus tipo 1
Niños
Monitorización continua de glucosa
Hipoglucemia
Background

Appropriate metabolic control of children with type 1 diabetes mellitus (DM) is based on frequent measure-ments of capillary glycemia. However, this method offers only partial information on fluctuations in glycemia dur-ing the day, while episodes of postprandial hyperglycemia and hypoglycemia, mainly nocturnal, go unnoticed.

Objectives

To analyze pre and postprandial blood glucose levels, as well as the presence and duration of hypoglycemic episodes in diabetic children aged more than 8 years old with more than one year of disease duration.

Methods

Seventeen patients of both sexes (mean age: 12 years old) with type 1 DM were monitored with the continuous glucose monitoring system (CGMS?) during working days.Maximum values of pre- and postprandial glucose (1-3 hours after breakfast, lunch and dinner) were registered.Data were downloaded with a Com-station.

Results

The mean duration of sensor-wearing was 2.97 days. Pre-and postprandial values were high: mean preprandial values were between 144.9 and 160.5mg% and mean postprandial values were between 230.4 and 248.8 mg%. The mean num-ber of hypoglycemic episodes detected with the sensor was 4.9 compared with 1.8 detected with the glucometer (p < 0.05). Episodes of mainly nocturnal asymptomatic hy-poglycemia were detected with a mean duration of 145minutes during the night and 75minutes during the day.

Conclusions

The use of continuous subcutaneous glucose monitoring demonstrates that glycemic objectives are not achieved by conventional insulin therapy. It also shows that there are a high number of hypoglycemic episodes, most of which are asymptomatic.

Key words:
Type 1 diabetes mellitus
Children
Continuous glucose monitoring
Hypoglycemia
Full text is only aviable in PDF
Bibliografía
[1.]
Diabetes control and complications trial research group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin dependent diabetes mellitus.
N Engl J Med, 392 (1993), pp. 977-986
[2.]
UK Prospective Diabetes Study (UKPDS) Group. Intensive blood- glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes.
Lancet, 652 (1998), pp. 837-853
[3.]
A.L. Peters, M.B. Davidson, D.L. Schriger, V. Hasselblad.
A clinical approach for the diagnosis of diabetes mellitus: An analysis using glycosylated hemoglobin levels. Meta-analysis Research Group on the Diagnosis of Diabetes Using Glycated Hemoglobin Levels.
Jama, 276 (1996), pp. 1246-1252
[4.]
Diabetes control and complications trial research group. Effect of intensive diabetes treatment on the development of longterm complications in adolescent with insulin dependent diabetes mellitus.
J Pediatr, 125 (1994), pp. 177-188
[5.]
M. Beresgszászi, N. Tubiana-Rufi, K. Benali, M. Nöel, J. Bloch, P. Czernichow.
Nocturnal hypoglucemic in children and adolescents with insulin-dependent diabetes mellitus: Prevalence and risk factors.
J Pediatr, 131 (1997), pp. 27-33
[6.]
J. Bolinder, E. Hagstrom-Toft, U. Ungerstedt, P. Arner.
Self- monitoring of blood glucose in type I diabetic patients: Comparison with continuous microdialysis measurements of glucose in subcutaneous adipose tissue during ordinary life conditions.
Diabetes Care, 20 (1997), pp. 64-70
[7.]
P.A. Porter, B. Keating, G. Byrne, T.W. Jones.
Incidence and predictive criteria of nocturnal hypoglycemia in young children with insulin-dependent diabetes mellitus.
J Pediatr, 130 (1997), pp. 339-341
[8.]
S.K. Garg, S.J. Fermi, R.O. Potts, J.A. Tamada, N.R. Ackerman, H.P. Chase.
Correlation of fingerstick blood glucose measurements with glucowatch biographer glucose results in young subjects with type 1 diabetes.
Diabetes Care, 22 (1999), pp. 1706-1714
[9.]
A. Maran, C. Crepaldi, A. Tiengo, G. Grassi, E. Vitalli, G. Pagano.
Continuous subcutaneous glucose monitoring in diabetic patients.
Diabetes Care, 25 (2002), pp. 347-352
[10.]
T. Gross, B. Bode, D. Einhorn, D. Kayne, J. Reed, N. White.
Performance evaluation of the Minimed continuous glucose monitoring system during patient home use.
Diabetes Technol Ther, 2 (2000), pp. 49-56
[11.]
E. Boland, T. Monsod, M. Delucia, C.A. Brandt, S. Fernando, W.V. Tamborlane.
Limitations of conventional methods of self-monitoring of blood glucose.
Diabetes Care, 24 (2001), pp. 1858-1862
[12.]
A. Ceriello.
The postprandial state and cardiovascular disease: Relevance to diabetes mellitus.
Diabete Metab Rev, 16 (2000), pp. 125-132
[13.]
F. Kaufman, L. Gibson, M. Halvorson.
A pilot study of the continuous glucose monitoring system: Clinical decisions and glycemic control after its use in pediatric type 1 diabetic subjects.
Diabetes Care, 24 (2001), pp. 2030-2034
[14.]
Z. Amnon, Z. Zadik.
Continuous subcutaneous glucose monitoring in children type 1 diabetes.
Diabetes Care, 25 (2002), pp. 346
[15.]
T.P. Monsod, D.E. Flanagan, F. Rife, R. Saenz, S. Caprio, R. Sherwin.
Do sensor glucose levels accurately predict plasma glucose concentrations during hypoglycemia and hyperinsulinemiaα.
Diabetes Care, 25 (2002), pp. 889-893
[16.]
K.A. Matyka, C. Crawford, L. Wiggs, D.B. Dunger, G. Stores.
Alterations in sleep physiology in young children with insulin-dependent diabetes mellitus: Relationship to nocturnal hypoglycemia.
J Pediatr, 137 (2000), pp. 233-238
[17.]
K.A. Matyka, L. Wigg, S. Pramming, G. Stores, D.B. Dunger.
Cognitive function and mood after profound nocturnal hypoglycemia in prepubertal children with conventional insulin treatment for diabetes.
Arch Dis Child, 81 (1999), pp. 138-142
[18.]
M. Metzger, G. Leibowitz, J. Wainstein, B. Glaser, I. Raz.
Reproducibility of glucose measurements using the glucose sensor.
Diabetes Care, 25 (2002), pp. 1185-1191
Copyright © 2003. Asociación Española de Pediatría
Download PDF
Idiomas
Anales de Pediatría (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?