Journal Information
Vol. 53. Issue 1.
Pages 25-29 (1 July 2000)
Share
Share
Download PDF
More article options
Vol. 53. Issue 1.
Pages 25-29 (1 July 2000)
Full text access
Los antisépticos yodados no son inocuos
Iodine antiseptics are not harmless
Visits
11208
J. Arena Ansoteguia,
Corresponding author
jarena@chdo.osakidetza.net

Correspondencia: Servicio de Pediatría. Hospital Aránzazu. P. Dr. Beguiristáin, s/n. 20014 San Sebastián
, J.I. Emparanza Knörrb
a Unidad de Metabolopatías. Servicio de Pediatría. Hospital Aránzazu. San Sebastián
b Unidad de Epidemiología Clínica. Hospital Aránzazu. San Sebastián
This item has received
Article information

El uso de antisépticos yodados es una práctica aún extendida en nuestras maternidades. La aplicación de antisépticos yodados tanto a la madre en los momentos previos al parto como al recién nacido provoca una sobrecarga yodada incontrolada.

La absorción del yodo a través de la piel de la madre es tan rápida que la yodemia en sangre de cordón aumenta en un 50% tras la aplicación en los momentos previos al expulsivo de antisépticos yodados a la madre.

La sobrecarga yodada en la madre se manifiesta con aumento de la yoduria y del contenido de yodo en la leche hasta 10 veces en los días inmediatamente posteriores al parto, si las curas de la episiotomía se realizan con povidona yodada. La elevada concentración de yodo en la leche agrava la sobrecarga al recién nacido.

Especialmente en zonas con déficit nutricional de yodo, esta sobrecarga yodada puede provocar un bloqueo transitorio del tiroides neonatal que tiene repercusiones negativas sobre el programa de detección del hipotiroidismo congénito, aumentando el número de falsos positivos, y sus inmediatas consecuencias: ansiedad de los padres y un importante aumento de los costes del programa. Más graves son las consecuencias que este bloqueo puede producir en el desarrollo del recién nacido.

Parece ineludible realizar una llamada de atención sobre las alteraciones que provocan los antisépticos yoda-dos y desaconsejar su uso en el período perinatal

Palabras clave:
Povidona-yodada
Yodo
Hormonas tiroideas
Hipotiroidismo
Recién nacido

The use of iodine-containing antiseptics is still common in obstetrics and neonatology. Topical iodine given both to the mother before delivery and to the neonate causes iodine overload.

The absorption of maternal iodine through the skin is so fast that iodine in the blood of the umbilical cord increases by 50% a few minutes before delivery.

Iodine overload also occurs in the mother. Urinary and breast-milk iodine are increased more than 10-fold in the days after delivery if providone-iodine is used in episiotomy.

The overload in the neonate is even higher if breast-fed. Particularly in iodine-deficient areas, this overload can produce thyroid blockade with undesirable effects in congenital hypothyroidism screening, raising the number of false positives and its consequences: parental anxiety and screening costs. The potential effects that this thyroid blockade can produce in the neonate are even more serious.

Attention should be drawn to the undesirable effects of iodine antiseptics and their use in the perinatal period should be avoided

Key words:
Providone-iodine
Iodine
Thyroid hormones
Hypothyroidism
Newborn
Full text is only aviable in PDF
Bibliografía
[1.]
J. Arena, J. Emparanza, M.J. San Millán, A. Garrido, I. Eguileor.
Sobrecarga yodada al recién nacido por utilizar PVP-yodada para la preparación perineal materna en el parto vaginal.
An Esp Pediatr, 30 (1989), pp. 23-26
[2.]
J. Arena, I. Eguileor, J. Emparanza.
Repercusión sobre la fun ción tiroidea del recién nacido a término de la aplicación de povidona yodada al muñón umbilical.
An Esp Pediatr, 23 (1985), pp. 562-568
[3.]
S. Ares, I. Pastor, J. Quero, G. Morreale.
Thyroid complications, including overt hypothyroidism, related to the use of non-ra-diopaque silastic catheters for parenteral feeding in prematures requiring injection of small amounts of an iodinated contrast medium.
Acta Paediatr, 84 (1995), pp. 579-581
[4.]
T.W. AvRuskin, E. Greenfield, V. Prasad, F. Greig, C.S. Juan.
De-creased T3 and T4 levels following topical application of po-vidone-iodine in premature neonates.
J Pediatr Endocrinol, 7 (1994), pp. 205-209
[5.]
L.K. Bachrach, G.N. Burrow, D.J. Gare.
Maternal-fetal absorption of povidone-iodine.
J Pediatr, 104 (1984), pp. 158-159
[6.]
M. Barakat, D. Carson, A.M. Hetherton, P. Smyth, H. Leslie.
Hy pothyroidism secondary to topical iodine treatment in infants with spina bifida.
Acta Paediatr, 83 (1994), pp. 741-743
[7.]
H. Castaing, J.P. Fournet, F.A. Leger, F. Kiesgen, C. Piette, M.C. Dupard.
Thyroide du nouveau-ne et surcharge en iode aprs la naissance.
Arch Fr Pediatr, 36 (1979), pp. 356-368
[8.]
J.P. Chabrolle, A. Rossier.
Transient neonatal hypothyroidism.
Pediatrics, 62 (1978), pp. 857
[9.]
J.P. Chabrolle, A. Rossier.
Goitre and hypothyroidism in the newborn after cutaneous absorption of iodine.
Arch Dis Child, 53 (1978), pp. 495-498
[10.]
J.P. Chabrolle, N. Monod, P. Plouin, H. Leloc'h, G. De Montis, A. Rossier.
Surcharge iodee post-natale avec hypothyroidie et pauses respiratoires. Danger de l'application cutanee de pro-duits iodes.
Arch Fr Pediatr, 35 (1978), pp. 432-437
[11.]
J.P. Chanoine, A. Pardou, P. Bourdoux, F. Delange.
Withdrawal of iodinated disinfectants at delivery decreases the recall rate at neonatal screening for congenital hypothyroidism.
Arch Dis Child, 63 (1988), pp. 1297-1298
[12.]
J.P. Chanoine, M. Boulvain, P. Bourdoux, A. Pardou, H.V. Van Thi, A.M. Ermans.
Increased recall rate at screening for congenital hypothyroidism in breast fed infants born to iodine overloaded mothers.
Arch Dis Child, 63 (1988), pp. 1207-1210
[13.]
P.C. Clemens, R.S. Neumann.
Influence of iodine overloading on neonatal thyroid screening results.
J Endocrinol Invest, 12 (1989), pp. 841
[14.]
B.C. Cosman, J.N. Schullinger, J.J. Bell, J.A. Regan.
Hypothyroidism caused by topical povidone-iodine in a newborn with omphalocele.
J Pediatr Surg, 23 (1988), pp. 356-358
[15.]
Y. Danziger, A. Pertzelan, M. Mimouni.
Transient congenital hypothyroidism after topical iodine in pregnancy and lactation.
Arch Dis Child, 62 (1987), pp. 295-296
[16.]
F. Delange, J.P. Chanoine, C. Abrassart, P. Bourdoux.
Topical iodine, breastfeeding, and neonatal hypothyroidism.
Arch Dis Child, 63 (1988), pp. 106-107
[17.]
E. Parravicini, C. Fontana, G.L. Paterlini, P. Tagliabue, F. Rovelli, K. Leung.
Iodine, thyroid function, and very low birth weight infants.
Pediatrics, 98 (1996), pp. 730-734
[18.]
A. Gruters, D. l'Allemand, P.H. Heidemann, P. Schurnbrand.
Incidence of iodine contamination in neonatal transient hyperthyrotropinemia.
Eur J Pediatr, 140 (1983), pp. 299-300
[19.]
Y. Koga, H. Sano, Y. Kikukawa, T. Ishigouoka, M. Kawamura.
Effect on neonatal thyroid function of povidone-iodine used on mothers during perinatal period.
J Obstet Gynaecol, 21 (1995), pp. 581-585
[20.]
D. l'Allemand, A. Gruters, P. Heidemann, P. Schurnbrand.
Iodine- induced alterations of thyroid function in newborn infants after prenatal and perinatal exposure to povidone iodine.
J Pediatr, 102 (1983), pp. 935-938
[21.]
D. l'Allemand, A. Gruters, P. Beyer, B. Weber.
Iodine in contrast agents and skin disinfectants is the major cause for hypothyroidism in premature infants during intensive care.
Horm Res, 28 (1987), pp. 42-49
[22.]
J. Leger, P. Czernichow.
Hyperthyrotropinemie neonatale transitoire.
Arch Fr Pediatr, 45 (1988), pp. 783-786
[23.]
C.P. Lin, W. Chen, K.W. Wu.
Povidone-iodine in umbilical cord care interferes with neonatal screening for hypothyroidism.
Eur J Pediatr, 153 (1994), pp. 756-758
[24.]
N. Linder, N. Davidovitch, B. Reichman, J. Kuint, D. Lubin, J. Meyerovitch.
Topical iodine-containing antiseptics and subclinical hypothyroidism in pre-term infants.
J Pediatr, 131 (1997), pp. 434-439
[25.]
J.B. López-Sastre, M.F. Rivas-Crespo.
The newborn should be protected from dangerous transient induced hypothyroidism.
Acta Paediatr, 84 (1995), pp. 1211
[26.]
J.M. Novaes, M.M. Biancalana, S.A. García, I. Rassi, J.H. Romaldini.
Elevation of cord blood TSH concentration in newborn infants of mothers exposed to acute povidone iodine during delivery.
J Endocrinol Invest, 17 (1994), pp. 805-808
[27.]
G. Robuschi, M. Montermini, A. Alboni, E. Borciani, G. Cersosimo, L. Negrotti.
Cord blood iodothyronine and thyrotropin concentrations in newborns of mothers exposed to povidone iodine in the last trimester.
J Endocrinol Invest, 10 (1987), pp. 183-186
[28.]
P. Smerdely, A. Lim, S.C. Boyages, K. Waite, D. Wu, V. Roberts.
Topical iodine-containing antiseptics and neonatal hypothyroidism in very-low-birth weight infants.
Lancet, 2 (1989), pp. 661-664
[29.]
E. Vilain, Y. Bompard, K. Clement, S. Laplanche, S. De Kermadec, C. Aufrant.
Application brève d'antiseptique iodé en soins intensifs néonatals: conséquences sur la function thyroïdienne.
Arch Pediatr, 1 (1994), pp. 795-800
[30.]
H. Vorherr, U.F. Vorherr, P. Mehta, J.A. Ulrich, R.H. Messer.
Vaginal absorption of povidone-iodine.
Jama, 244 (1980), pp. 2628-2629
[31.]
G. Weber, M.C. Vigone, A. Rapa, G. Bona, G. Chiumello.
Neonatal transient hypothyroidism: aetiological study. Italian Collaborative Study on Transient Hypothyroidism.
Arch Dis Child (Fetal Neonatal Ed.), 79 (1998), pp. F70-F72
[32.]
A. Zahidi, M. Draoui, M. Mestassi.
Statut en iode et utilisation d'antiseptiques iodes chez le couple mere/nouveaune.
Therapie, 54 (1999), pp. 545-548
[33.]
Y. Koga, H. Sano, Y. Kikukawa, T. Ishigouoka, M. Kawamura.
Effect on neonatal thyroid function of povidoneiodine used on mothers during perinatal period.
J Obstet Gynecol, 21 (1995), pp. 581-585
[34.]
G. Briggs, R. Freeman, S. Yaffe.
Drugs in pregnancy and lacta-tion (4.a ed.), Willians & Wilkins, (1994),
[35.]
H. Vorherr, U.F. Vorherr, P. Mehta, J.A. Ulrich, R.H. Messer.
Vaginal absorption of povidone-iodine.
Jama, 244 (1980), pp. 2628-2629
[36.]
American Academy of Pediatrics, AAP Section on Endocrinology and Committee on Genetics Newborn Screening for Congenital Hypothyroidism: Recommended Guidelines.
Pediatrics, 91 (1993), pp. 1203-1209
[37.]
S. Harada, N. Ichihara, J. Arai, H. Honma, N. Matsuura, K. Fugieda.
Influence of iodine excess due to iodine-containing antiseptics on neonatal screening for congenital hypothyroidism in Hokkaido prefectura, Japan.
Screening, 3 (1994), pp. 115-123
[38.]
A. Cassio, C. Colli, S. Piazzi, D. Bozza, F. Zappulla, S. Salardi.
Results of screening of congenital hypothyroidism and iodine excess in neonatal age.
Annali dell Istututo Superiora di Sanita, 34 (1998), pp. 337-341
[39.]
A. Grüters, D. Lallemend, P. Heideman, H. Helge.
Thyroid function and iodine concentrations in newborns and their mothers after vaginal PVP-iodine treatment in obstetrics.
Neonatal Screening, pp. 54-55
[40.]
L.F. Oliver, P.A. Azpeitia, S.L. Alfonso, L.G. González, V.C. Gutiérrez, A.J. Rodríguez.
Hipotiroidismo neonatal secundario a la utilización de povidona yodada.
Cir Pediatr, 2 (1989), pp. 168-171
[41.]
I. Francis, A. Weldon, J. Connelly.
Effect of Betadine treatment to umbilical cords on screening test for congenital hypothyroidism.
Neonatal screening, pp. 52-53
[42.]
J.P. Chanoine.
Iodine intake is a main determinant of thyroid hypersensitivity to acute iodine overload.
Clin Pediatr (Phila), 37 (1998), pp. 212-213
[43.]
A.M. Sainz, M.P. Bachiller, J.R. Saenz, M.A. Cia, M.I. Fernández, M.J. Barcia.
Povidona iodada 10% versus clorhexidina 0,5% en el control de la infección de la episiotomía.
Farm Clin, 7 (1990), pp. 525-527
[44.]
D.G. Maki, M. Ringer, P. Alvarado.
Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters.
Lancet, 338 (1991), pp. 339-343
[45.]
J.S. Garland, R.K. Buck, P. Maloney, D.M. Durkin, S. Toth-Lloyd, M. Duffy.
Comparison of 10% povidone-iodine and 0.5% chlorhexidine gluconate for the prevention of peripheral intravenous catheter colonization in neonates: a prospective trial.
Pediatr Infect Dis J, 14 (1995), pp. 510-516
[46.]
I. Malathi, M.R. Millar, J.P. Leeming, A. Hedges, N. Marlow.
Skin disinfection in preterm infants.
Arch Dis Child, 69 (1993), pp. 312-316
[47.]
WHO, UNICEF, ICCIDD.
Indicators for assessing iodine deficiency disorders and their control programmes, pp. 1-62
[48.]
OMS, PAHO, UNICEF, ICCIDD.
Indicadores para evaluar los trastornos por carencia de yodo y su control mediante yodación de la sal, pp. 1-62
[49.]
J.J. Arrizabalaga, S. Gaztambide, J.A. Vázquez, I Helguera.
Prevalencia de bocio y estado nutricional de yodo en los escolares.
de la Comunidad Autónoma Vasca. Endocrinología, 40 (1993), pp. 278-283
[50.]
F. Delange, P. Bourdoux, P. Ketelbant-balasse, A.V. Humskerken, D. Glinoer.
Transient primary hypothyroidism in the newborn.
Congenital hypothyroidism. Nueva York, 2 (1983), pp. 275-301
[51.]
F. Delange.
The disorders induced by iodine deficiency.
Thyroid, 4 (1994), pp. 107-128
[52.]
F. Delange, P. Bourdoux, M. Laurence, L. Peneva, P. Walfish.
Iodine deficiency in Europa.
A continuing concern. Nueva York: Plenum Press, 12 (1993), pp. 199-220
[53.]
WHO. Recomendad iodine levels in salt and guidelines for monitoring their adequacy and effectiveness.
WHO/NUT, 96 (1996), pp. 1-10
[54.]
WHO. Iodine and Health.
WHO/NUT, 94 (1994), pp. 1-7
[55.]
F. Escobar del Rey, G. Morreale.
Yodación universal de la sal: un derecho humano de la infancia.
Endocrinol Nutr, 45 (1998), pp. 3-16
Copyright © 2000. Asociación Española de Pediatría
Download PDF
Idiomas
Anales de Pediatría (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?