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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0115" class="elsevierStylePara elsevierViewall">Respiratory syncytial virus &#40;RSV&#41; is one of the leading causes of severe respiratory disease and hospital admission in healthy infants without known risk factors&#46; Monoclonal antibody prophylaxis has been available for more than 20 years&#44; but due to their high cost and short half-life&#44; they have only been used in at-risk neonates and infants&#46; Recently&#44; monoclonal antibodies with higher potency&#44; longer half-life and lower cost have become available&#44; allowing their universal use not only in high-risk groups but also in healthy neonates and infants&#46; Nirsevimab&#44; a new long-acting monoclonal antibody&#44; has exhibited a high efficacy and a good safety profile in clinical trials&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> and its use was approved in the European Union on November 3&#44; 2022&#46; On May 9&#44; 2023&#44; the Ministry of Health of Spain approved the recommendations for the use of nirsevimab during the 2023&#8211;24 epidemic season in infants at high risk of severe RSV disease&#44; and on July 12&#44; 2023 approved its routine use in infants aged less than 6 months &#40;born between April 1&#44; 2023 and March 31&#44; 2024&#41; at the beginning or during the RSV season&#46; In September of 2023&#44; the Sociedad Espa&#241;ola de Neonatolog&#237;a &#40;SENeo&#44; Spanish Society of Neonatology&#41; published its recommendations&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">To assess the effectiveness of this approach&#44; a Joint Vaccination Register was established for the COVID-19 vaccination strategy and a working group formed in the framework of the Vaccination Strategy&#44; Registration and Evaluation Committee to evaluate the RSV vaccination&#47;immunisation programme in the paediatric and adult populations&#44; taking into account currently available and soon to be authorised vaccines and monoclonal antibodies for the prevention of medically attended RSV&#46; The excellent outcomes observed in this evaluation&#44; with a mean immunisation coverage of over 90&#37; in infants born during the season and 87&#37; in infants born before season onset&#44; with an effectiveness against RSV-related hospitalisations of around 80&#37; and an excellent safety profile&#44; motivated the issuing of new recommendations for prophylaxis against RSV infection for the 2024&#8211;2025 season in Spain by the Interterritorial Council of the Ministry of Health&#44; which were approved by the Public Health Commission on March 14&#44; 2024 and the Vaccination Strategy&#44; Registration and Evaluation Committee on February 29&#44; 2024 and reviewed by the Working Group on Paediatric RSV of the Vaccination Strategy&#44; Registration and Evaluation Committee&#44; essentially leaving unchanged the previous recommendations issued for the 2023-2024 season&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In light of the excellent results of the universal prophylaxis campaign in the 2023&#8211;2024 season&#44; the SENeo recommends maintaining the same universal prophylaxis schedule with monoclonal antibodies for the 2024&#8211;2025 season&#44; including a modification in the dosage of nirsevimab for patients who require its administration for a second season&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> as can be seen in <a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span>"
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                  \t\t\t\t"><span class="elsevierStyleItalic">Group of healthy infants born at or after 35 weeks&#39; gestation&#58;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Routine administration of a single dose to all infants aged less than 6 months at the start of the season &#40;defined as October 1&#44; 2024 to March 31&#44; 2025&#41;&#46; This includes all infants born during the season and those born between April 1&#44; 2024 and September 30&#44; 2024&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0005" class="elsevierStylePara elsevierViewall">One dose before age 12 months at the start of the season&#46; In this group&#44; the use of nirsevimab is recommended as a substitute for palivizumab&#46;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">a</span><p id="par0010" class="elsevierStylePara elsevierViewall">Infants born preterm before 35 weeks &#40;including those with gestational age &#60; 29 weeks&#41;&#46;</p></li></ul></p></li></ul>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">2</span><p id="par0015" class="elsevierStylePara elsevierViewall">One dose per year until age 24 months &#40;2 seasons&#41;&#44; given before season onset&#46;<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">a</span><p id="par0020" class="elsevierStylePara elsevierViewall">Patients with bronchopulmonary dysplasia &#40;BPD&#41;&#46; Especially those with grade 2 and 3 moderate&#47;severe BPD&#44; giving priority to those who have required treatment for their underlying disease in the 6 months preceding season onset&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">b</span><p id="par0025" class="elsevierStylePara elsevierViewall">Patients with other underlying diseases that carry a high risk of severe bronchiolitis due to RSV&#58; severe immunosuppression&#44; inborn errors of metabolism&#44; neuromuscular diseases&#44; severe pulmonary malformations&#44; genetic syndromes with clinically significant respiratory manifestations&#44; Down syndrome&#44; cystic fibrosis&#46;</p></li></ul></p></li></ul>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0030"><p id="par0030" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nirsevimab should be administered&#58;<ul class="elsevierStyleList" id="lis0035"><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#9675;</span><p id="par0040" class="elsevierStylePara elsevierViewall">In the group of <span class="elsevierStyleItalic">healthy infants born at or after 35 weeks&#8217; gestation during the RSV season</span>&#44; as early as possible before discharge from the maternity ward&#44; and those born in the 6 months before the start of the season as soon as possible after season onset&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">&#9675;</span><p id="par0045" class="elsevierStylePara elsevierViewall">In the group of <span class="elsevierStyleItalic">preterm infants born before 35 weeks&#8217; gestation and patients with grade 2&#8211;3 BPD</span> discharged from hospital&#44; as soon as possible if discharge takes place during the RSV season or&#44; otherwise&#44; at least 2&#8211;3 weeks before season onset&#46;</p></li></ul></p></li></ul></p></li></ul>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><ul class="elsevierStyleList" id="lis0040"><li class="elsevierStyleListItem" id="lsti0050"><p id="par0050" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0045"><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">&#8226;</span><p id="par0055" class="elsevierStylePara elsevierViewall">To <span class="elsevierStyleItalic">infants hospitalised in neonatal units</span>&#44; during the RSV season&#44; preferably <span class="elsevierStyleItalic">as soon as the clinical condition of the patient allows it after birth&#44; and always at least 4&#8211;6 days before hospital discharge or&#44; if discharge happens earlier&#44; as soon as possible</span>&#46; There are no safety data for its administration to infants weighing less than 1000<span class="elsevierStyleHsp" style=""></span>g&#44; so in this group it is prudent to wait until the infant achieves a weight of more than 1000<span class="elsevierStyleHsp" style=""></span>g before prophylaxis is administered&#46;</p></li></ul></p></li></ul>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><ul class="elsevierStyleList" id="lis0050"><li class="elsevierStyleListItem" id="lsti0060"><p id="par0060" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0055"><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Establishment of a follow-up register is recommended&#44; especially in risk groups&#44; to evaluate the effectiveness of nirsevimab under real-world conditions&#46;</p></li></ul></p></li></ul>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Presentation and dose&#58;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><ul class="elsevierStyleList" id="lis0060"><li class="elsevierStyleListItem" id="lsti0070"><p id="par0070" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0065"><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">&#8226;</span><p id="par0075" class="elsevierStylePara elsevierViewall">For infants with weights of less than 5<span class="elsevierStyleHsp" style=""></span>kg&#58;<ul class="elsevierStyleList" id="lis0070"><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">&#9675;</span><p id="par0080" class="elsevierStylePara elsevierViewall">Beyfortus 50<span class="elsevierStyleHsp" style=""></span>mg &#40;single dose&#41;&#58; preloaded syringe with purple plunger rod for intramuscular delivery&#46; It contains 50<span class="elsevierStyleHsp" style=""></span>mg of nirsevimab in 0&#46;5<span class="elsevierStyleHsp" style=""></span>mL &#40;100<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#41;&#46;</p></li></ul></p></li></ul></p></li></ul>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><ul class="elsevierStyleList" id="lis0075"><li class="elsevierStyleListItem" id="lsti0085"><p id="par0085" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0080"><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">&#8226;</span><p id="par0090" class="elsevierStylePara elsevierViewall">For infants with weights of 5<span class="elsevierStyleHsp" style=""></span>kg or greater&#46;<ul class="elsevierStyleList" id="lis0085"><li class="elsevierStyleListItem" id="lsti0095"><span class="elsevierStyleLabel">&#9675;</span><p id="par0095" class="elsevierStylePara elsevierViewall">Beyfortus 100<span class="elsevierStyleHsp" style=""></span>mg &#40;single dose&#41;&#58; preloaded syringe with light blue plunger rod for intramuscular delivery&#46; It contains 100<span class="elsevierStyleHsp" style=""></span>mg of nirsevimab in 1<span class="elsevierStyleHsp" style=""></span>mL &#40;100<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#41;&#46;</p></li></ul></p></li></ul></p></li></ul>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><ul class="elsevierStyleList" id="lis0090"><li class="elsevierStyleListItem" id="lsti0100"><p id="par0100" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0095"><li class="elsevierStyleListItem" id="lsti0105"><span class="elsevierStyleLabel">&#8226;</span><p id="par0105" class="elsevierStylePara elsevierViewall">Infants requiring prophylaxis for a second season&#58;<ul class="elsevierStyleList" id="lis0100"><li class="elsevierStyleListItem" id="lsti0110"><span class="elsevierStyleLabel">&#9675;</span><p id="par0110" class="elsevierStylePara elsevierViewall">Beyfortus 100<span class="elsevierStyleHsp" style=""></span>mg in those with a body weight of less than 10<span class="elsevierStyleHsp" style=""></span>kg or 200<span class="elsevierStyleHsp" style=""></span>mg &#40;2 doses of 100<span class="elsevierStyleHsp" style=""></span>mg administered at different sites&#41; in those with a weight of 10<span class="elsevierStyleHsp" style=""></span>kg or greater&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p></li></ul></p></li></ul></p></li></ul>&nbsp;\t\t\t\t\t\t\n
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