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Images in Paediatrics
Post-vaccinal exanthema: Urticaria multiforme and thrombocytopenic purpura
Exantema post-vacunal: urticaria multiforme y púrpura trombocitopénica
Ana Rubio Granda, M. Agustina Alonso Álvarez
Corresponding author
maruchi.al.al@gmail.com

Corresponding author.
, Sara Delgado Nicolás, Estíbaliz Garrido García
Sección de Urgencias de Pediatría, Área de Gestión Clínica de Pediatría, Hospital Universitario Central de Asturias, Asturias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A boy aged 15 months presented with exanthema of several days&#8217; duration&#46; He had been vaccinated against varicella 14 days prior&#46; He appeared to be in excellent general health&#44; had swelling of the eyelids and feet&#44; and generalised exanthema with 2 types of elements&#58; &#40;1&#41; erythematous macules&#44; appearing as hives or plaques in some areas&#44; with a purplish centre in some and pale centre in others&#44; without vesicles or central necrosis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; and &#40;2&#41; disseminated petechiae &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; In the complete blood count&#44; the platelet concentration was 30&#8239;000&#8239;platelets&#47;&#956;L&#59; the remaining counts and levels of acute phase reactants were normal and virus detection tests negative&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The patient received 1 dose of prednisolone&#44; and 24&#8239;h later there was marked improvement of the cutaneous manifestations &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; and the platelet count had increased to 47&#8239;000 platelets&#47;&#956;L&#46; The platelet count was normal 10 days later&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Urticaria multiforme and thrombocytopenic purpura are diseases that may be&#44; although infrequently&#44; triggered by vaccination&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> The combined presence of both is surprising&#44; and we were not able to establish a causal relationship&#46; The former is very similar to erythema multiforme&#44; but does not involve the entire body&#46; Vaccine-induced thrombocytopenic purpura is usually self-limited but still carries a risk of bleeding&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> The care team discussed whether it would be appropriate to administer the second dose of the vaccine due to the risk of thrombocytopenia&#59; although this risk is generally low&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> given the significant symptoms in the patient and the concern of the family&#44; the care team recommended against it&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">This research did not receive any external funding&#46;</p></span></span>"
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Anales de Pediatría (English Edition)