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El estudio genotípico consistió en la secuenciación de alto rendimiento del genoma completo mediante la preparación de librerías pair-end, usando el kit comercial NexteraTM DNA Flex Library Preparation Kit (Illumina Inc, San Diego, CA, EE.UU.) y secuenciación en el equipo NextSeq (Illumina). El ADN se extrajo con el sistema automatizado Maxwell RSC (Promega, Madison, Wisconsin, EE.UU.). El ensamblado de las secuencias obtenidas se realizó utilizando SPAdes 3.15.4 y PROKKA v1.12. Para el análisis de clusters se empleó el software Ridom SeqSphere<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>vs. 6.0.2 usando el esquema definido para <span class="elsevierStyleItalic">Escherichia coli</span> (2.528 alelos) y estableciendo un punto de corte de 10 alelos para la detección de agrupamientos.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Álvaro Vázquez-Pérez, Silvia Herrera-León, Juan Luis Santos-Pérez, José Gutiérrez-Fernández" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Vázquez-Pérez" ] 1 => array:2 [ "nombre" => "Silvia" "apellidos" => "Herrera-León" ] 2 => array:2 [ "nombre" => "Juan Luis" "apellidos" => "Santos-Pérez" ] 3 => array:2 [ "nombre" => "José" "apellidos" => "Gutiérrez-Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S234128792300282X" "doi" => "10.1016/j.anpede.2023.12.001" "estado" => "S300" 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Treatment parameters: 42 °C, 6 min + injection of 0.5% bupivacaine and triamcinolone.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pablo Oliver Goicolea, Maria Pilar Plou Garcia, Ana Belen Adell Pérez, Ane Etxart Lopetegi, Estibaliz Achurra Adán" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Pablo" "apellidos" => "Oliver Goicolea" ] 1 => array:2 [ "nombre" => "Maria Pilar" "apellidos" => "Plou Garcia" ] 2 => array:2 [ "nombre" => "Ana Belen" "apellidos" => "Adell Pérez" ] 3 => array:2 [ "nombre" => "Ane" "apellidos" => "Etxart Lopetegi" ] 4 => array:2 [ "nombre" => "Estibaliz" "apellidos" => "Achurra Adán" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1695403323001832" "doi" => "10.1016/j.anpedi.2023.08.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403323001832?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287923002922?idApp=UINPBA00005H" "url" => "/23412879/0000010000000001/v1_202401141514/S2341287923002922/v1_202401141514/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Infecciones pediátricas por <span class="elsevierStyleItalic">Shigella sonnei</span> multirresistente en un hospital del sur de España" "tieneTextoCompleto" => true "saludo" => "To the editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "61" "paginaFinal" => "62" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Álvaro Vázquez-Pérez, Silvia Herrera-León, Juan Luis Santos-Pérez, José Gutiérrez-Fernández" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Álvaro" "apellidos" => "Vázquez-Pérez" "email" => array:1 [ 0 => "alvaro.vazquez.sspa@juntadeandalucia.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Silvia" "apellidos" => "Herrera-León" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Juan Luis" "apellidos" => "Santos-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "José" "apellidos" => "Gutiérrez-Fernández" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Pediatría, Hospital Universitario Materno Infantil Virgen de las Nieves, Instituto de Investigación Biosanitaria, Granada, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centro Nacional de Microbiología, Majadahonda, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria, Granada, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Departamento de Microbiología, Universidad de Granada, Instituto de Investigación Biosanitaria, Granada, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Multidrug-resistant <span class="elsevierStyleItalic">Shigella sonnei</span> pediatric infections attended in a hospital in southern Spain" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1065 "Ancho" => 1258 "Tamanyo" => 66030 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Whole genome analysis of the two clinical isolates of <span class="elsevierStyleItalic">Shigella sonnei.</span> Comparison with three reference genomes: SRR16940973, SRR17405911 andSRR1713130663, and genomic analysis of antimicrobial resistance genotype. Genotyping was performed by high-throughput whole-genome sequencing with pair-end reads using the commercial kit NexteraTM DNA Flex Library Preparation Kit and the NextSeq sequencing system (Illumina Inc, San Diego, CA, USA). The DNA was extracted with the Maxwell RSC automated platform (Promega, Madison, Wisconsin, USA). The obtained sequences were assembled with the software tools SPAdesversion 3.15.4 and PROKKA version 1.12. Clustering was carried out with the software Ridom SeqSphere + version 6.0.2 using the scheme defined for <span class="elsevierStyleItalic">Escherichia coli</span> (2528 loci) and establishing a threshold of 10 alleles for the detection of clusters.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Shigella</span> is a gram-negative non-capsulated non-motile bacillus of the <span class="elsevierStyleItalic">Enterobacteriaceae</span> family. It causes bacillary dysentery and it is transmitted by the faecal-oral route. It has a low infective dose that facilitates its dissemination.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The genus comprises 4 species: <span class="elsevierStyleItalic">Shigella dysenteriae, Shigella flexneri</span>, <span class="elsevierStyleItalic">Shigella boydii</span> y <span class="elsevierStyleItalic">Shigella sonnei</span>. The latter accounts for up to 80% de of infections in Europe and North America and is considered an emergent pathogen.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Most paediatric infections are asymptomatic or manifest with mild symptoms. However, it can also cause bacteraemia, encephalopathy, intestinal perforation and peritonitis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Antibiotherapy is recommended to control outbreaks, in patients who attend a child care centre or live in residential facilities and to reduce the duration of diarrhoea in cases of complicated dysentery.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In high-income countries, these infections are associated with sexual transmission in men who have sex with men (MSM).<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In 2022, the European Centre for Disease Prevention and Contro (ECDC) warned of an increase in extensively-drug resistant <span class="elsevierStyleItalic">S sonnei</span> infections in several European countries, chiefly in MSM.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In Spain, previous studies had reported the emergence of infections by multidrug-resistant (MDR) <span class="elsevierStyleItalic">S sonnei</span> associated with transmission among MSM.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present two cases of infection by MDR <span class="elsevierStyleItalic">S sonnei</span> in children who were, to our knowledge, the first paediatric cases with an MDR profile reported in Spain.<span class="elsevierStyleEnunciation" id="enun0005"><span class="elsevierStyleLabel">Case 1</span><p id="par0015" class="elsevierStylePara elsevierViewall">Girl aged 4 years who presented with a typical febrile seizure, fever of 39.4 °C, vomiting and abundant watery diarrhoea. A blood panel was ordered that revealed elevation of markers of infection (C-reactive protein [CRP], 168 mg/L; procalcitonin [PCT], 7.53 ng/mL), prompting initiation of treatment with cefotaxime at a dose of 200 mg/kg/day, which the patient received for 3 days. The blood culture was negative. <span class="elsevierStyleItalic">Shigella sonnei</span> was isolated from the stool culture, and the isolate was found to be resistant to ampicillin, cefotaxime, amoxicillin, trimethoprim-sulfamethoxazole, azithromycin and levofloxacin, and sensitive to amoxicillin-clavulanic acid, piperacillin-tazobactam, tigecycline and carbapenems. Since the patient exhibited clinical improvement, she was discharged after 4 days, and completed one week of treatment with oral amoxicillin-clavulanic acid.</p></span><span class="elsevierStyleEnunciation" id="enun0010"><span class="elsevierStyleLabel">Case 2</span><p id="par0020" class="elsevierStylePara elsevierViewall">Girl aged 4 years managed in the same primary care centre as the previous case. She presented with fever of up to 39.5 °C of 24 h’ duration and watery and abandoned diarrhoea with onset one week prior. There was an outbreak of gastroenteritis in her school. After ensuring that the patient was clinically stable, she was discharged home, and a stool culture ordered. <span class="elsevierStyleItalic">Shigella sonnei</span> was isolated from culture, with the same antimicrobial susceptibility profile as the previous case. In this case, the patient had a favourable outcome with resolution of symptoms at the time of follow-up at the primary care centre, Once the results of the stool culture were available, and she did not receive any antibiotic treatment.</p></span></p><p id="par0025" class="elsevierStylePara elsevierViewall">Both isolates of MDR <span class="elsevierStyleItalic">S sonnei</span> were sequenced and analysed by means of cgMLST (core/whole genome multilocus sequence typing). The comparison of the 2 isolates with the reference genomes available through the ECDC showed that these cases could be included in the same genetic cluster with a maximum difference of 3 alleles, and the presence of the same IncFII plasmid carrying the blaCTX-M-27 gene, which evinced the geographical spread of this strain (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The number of episodes of enteritis caused by MDR pathogens is increasing in Spain.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> A retrospective and descriptive study carried out our hospital of all the cases of shigellosis reported between January 2016 and April 2022<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> only identified two other paediatric cases with isolation of <span class="elsevierStyleItalic">Shigella</span> species, both in male patients with diarrhoea containing blood and mucus in 2019, and both involving strains that were not MDR. The first case corresponded to a boy from Angola aged 5 years, and the <span class="elsevierStyleItalic">Shigella</span> strain was only found to be resistant to ampicillin and trimethoprim-sulfamethoxazole and was sensitive to cefotaxime and ciprofloxacin, as well as all other tested antibiotics. The second, a boy aged 8 years with infection by a multisensitive <span class="elsevierStyleItalic">Shigella</span> species that was only resistant to ampicillin. However, the 2 more recent cases that we present in this article, detected in November 2022, exhibited a MDR profile.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Due to the increasing prevalence of resistance to trimethoprim-sulfamethoxazole, ampicillin, sulphonamides and tetracyclines, the World Health Organization (WHO) recommends fluoroquinolones as first-line treatment for patients of any age with shigellosis.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The increase of MDR in <span class="elsevierStyleItalic">Shigella</span> spp, mainly to third-generation cephalosporins, azithromycin and fluoroquinolones, as observed in the cases presented here, is a concern in developed countries.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The ECDC underscores the importance of early detection and the prevention of the sexual transmission of <span class="elsevierStyleItalic">Shigella.</span> However, given the nature of this infection and the magnitude of the problem in Europe, we need to improve our knowledge of the epidemiology of <span class="elsevierStyleItalic">Shigella</span> infections in children. Many outbreaks of shigellosis take place in nurseries and schools.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Young children are most vulnerable to the potential complications of <span class="elsevierStyleItalic">Shigella</span> infections.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Empirical treatments for acute enteritis by enteroinvasive strains could not be effective, which poses a particularly serious risk to immunocompromised patients. All of this poses a threat to public health, so measures need to be developed for the early detection of infection and the prevention of transmission that contemplate the paediatric population.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1065 "Ancho" => 1258 "Tamanyo" => 66030 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Whole genome analysis of the two clinical isolates of <span class="elsevierStyleItalic">Shigella sonnei.</span> Comparison with three reference genomes: SRR16940973, SRR17405911 andSRR1713130663, and genomic analysis of antimicrobial resistance genotype. Genotyping was performed by high-throughput whole-genome sequencing with pair-end reads using the commercial kit NexteraTM DNA Flex Library Preparation Kit and the NextSeq sequencing system (Illumina Inc, San Diego, CA, USA). The DNA was extracted with the Maxwell RSC automated platform (Promega, Madison, Wisconsin, USA). The obtained sequences were assembled with the software tools SPAdesversion 3.15.4 and PROKKA version 1.12. Clustering was carried out with the software Ridom SeqSphere + version 6.0.2 using the scheme defined for <span class="elsevierStyleItalic">Escherichia coli</span> (2528 loci) and establishing a threshold of 10 alleles for the detection of clusters.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outbreak of sexually transmitted, extensively drug-resistant <span class="elsevierStyleItalic">Shigella sonnei</span> in the UK, 2021–22: a descriptive epidemiological study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Charles" 1 => "M. Prochazka" 2 => "K. Thorley" 3 => "A. Crewdson" 4 => "D.R. Greig" 5 => "C. Jenkins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1473-3099(22)00370-X" "Revista" => array:7 [ "tituloSerie" => "Lancet Infect Dis." "fecha" => "2022" "volumen" => "22" "numero" => "10" "paginaInicial" => "1503" "paginaFinal" => "1510" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35809593" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification and management of <span class="elsevierStyleItalic">Shigella</span> infection in children with diarrhoea: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K.D. Tickell" 1 => "R.L. Brander" 2 => "H.E. Atlas" 3 => "J.M. Pernica" 4 => "J.L. Walson" 5 => "P.B. Pavlinac" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S2214-109X(17)30392-3" "Revista" => array:7 [ "tituloSerie" => "Lancet Glob Health." "fecha" => "2017" "volumen" => "5" "numero" => "12" "paginaInicial" => "e1235" "paginaFinal" => "e1248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29132613" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "ECDC. Increase in Extensively-Drug Resistant <span class="elsevierStyleItalic">Shigella</span> sonnei Infections in Men Who Have Sex with Men in the EU/EEA and the UK: 23 February 2022. <a target="_blank" href="https://www.ecdc.europa.eu/sites/default/files/documents/shigella-infections-men-sex-men-february-2022-erratum.pdf">https://www.ecdc.europa.eu/sites/default/files/documents/shigella-infections-men-sex-men-february-2022-erratum.pdf</a>." ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Shigellosis attended in the emergency department of a regional hospital in southeastern Spain: from their presence to multiresistance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Rodríguez-Guerrero" 1 => "S. Herrera-León" 2 => "E. Gómez-Vicente" 3 => "J.M. Navarro-Marí" 4 => "J. Gutiérrez-Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.37201/req/121.2022" "Revista" => array:7 [ "tituloSerie" => "Rev Esp Quimioter" "fecha" => "2023" "volumen" => "36" "numero" => "3" "paginaInicial" => "282" "paginaFinal" => "290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36942425" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multidrug-resistant <span class="elsevierStyleItalic">Shigella</span> infection in pediatric patients with diarrhea from central Iran" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Abbasi" 1 => "H. Abtahi" 2 => "A. van Belkum" 3 => "E. Ghaznavi-Rad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/IDR.S203654" "Revista" => array:5 [ "tituloSerie" => "Infect Drug Resist." "fecha" => "2019" "volumen" => "12" "paginaInicial" => "1535" "paginaFinal" => "1544" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Burden and risk factors of <span class="elsevierStyleItalic">Shigella sonnei</span> shigellosis among children aged 0–59 months in hyperendemic communities in Israel" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Cohen" 1 => "H. Korin" 2 => "R. Bassal" 3 => "M.P. Markovich" 4 => "Y. Sivan" 5 => "S. Goren" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijid.2019.02.031" "Revista" => array:6 [ "tituloSerie" => "Int J Infect Dis" "fecha" => "2019" "volumen" => "82" "paginaInicial" => "117" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30831222" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000010000000001/v1_202401141514/S234128792300282X/v1_202401141514/en/main.assets" "Apartado" => array:4 [ "identificador" => "38181" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000010000000001/v1_202401141514/S234128792300282X/v1_202401141514/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S234128792300282X?idApp=UINPBA00005H" ]
Year/Month | Html | Total | |
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