Scientific Letter
Streptococcus pyogenes as an etiological agent of acute epiglottitis
Streptococcus pyogenes como agente etiológico de epiglotitis aguda
María Teresa Santos Martín
, María Ruiz Camacho, Clara Rodríguez García, Marta Álvarez Triano, Lucía González Vila
Corresponding author
Hospital Juan Ramón Jiménez, Huelva, Spain
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The most frequently reported potentially severe diseases were pneumonia, necrotising fasciitis, sepsis and fulminant septic shock.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> As a result, there has been an increase in the number of paediatric deaths associated with this pathogen.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Acute epiglottitis refers to the inflammation of the epiglottis and adjacent structures, causing abrupt obstruction of the upper airway and constituting a respiratory emergency. Its aetiology is usually infectious, and <span class="elsevierStyleItalic">Haemophilus influenzae</span> type B (HIb) is the most frequent causative agent. However, thanks to the implementation of universal childhood vaccination against HIb, epidemiological trends have changed, and there has been a decrease in the incidence of disease. There have been reports of cases caused by other emerging organisms, such as other <span class="elsevierStyleItalic">H. influenzae</span> types, <span class="elsevierStyleItalic">Staphylococcus aureus</span>, <span class="elsevierStyleItalic">Streptococcus pneumoniae</span> and <span class="elsevierStyleItalic">pyogenes</span>, in addition to some viruses and fungal species.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In this article, we report a case of acute epiglottitis caused by <span class="elsevierStyleItalic">S. pyogenes</span> and review the current literature on the subject.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was a girl aged 7 years with no history of interest and correctly vaccinated that presented to the emergency department with breathing difficulty that had worsened over the past few hours. It was associated with flu-like symptoms, including sore throat and fever of up to 39 °<span class="elsevierStyleSmallCaps">C</span> of one week’s duration. At 48 h from onset, the patient had an influenza B antigen test that turned out positive. On arrival, the paediatric assessment triangle indicated that the patient was unstable and had respiratory failure. In the assessment, the patient was conscious and aware, exhibited maximum use of accessory muscles, a tripod position, sialorrhoea and a nasal voice, with global hypoventilation and stridor and inspiratory and expiratory wheezing.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient received supplemental oxygen through a non-rebreather mask. Treatment with salbutamol in continuous nebulization and intravenous steroid therapy was prescribed. The patient was transferred to the paediatric intensive care unit (PICU) to initiate respiratory support with non-invasive ventilation. Intravenous magnesium sulphate, nebulised ipratropium bromide and oseltamivir were added to the treatment. Despite optimal treatment, the severe respiratory distress persisted and the inspiratory wheezing became more pronounced. The suspicion of laryngitis or epiglottitis prompted initiation of treatment with nebulised adrenaline and empirical antibiotherapy with cefotaxime. The plain radiograph of the neck evinced narrowing of the airway. Epiglottitis was suspected, and given the progressive worsening of the patient, the decision was made to intubate her, with observation of a swollen epiglottis. The inserted tracheal tube was two sizes smaller than the size corresponding to her age, and was connected to an invasive mechanical ventilation device, which achieved resolution of respiratory distress.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The complete blood count and chemistry panel revealed leucocytosis with neutrophilia and elevation of acute phase reactants (C-reactive protein [CRP], 159.19 mg/L and procalcitonin [PCT], 100 ng/mL). Later on, <span class="elsevierStyleItalic">S. pyogenes</span> was isolated from cultures of blood and endotracheal aspirate samples. Clindamycin was added to the treatment regimen until the antibiotic susceptibility test results became available. On day 4, an evaluation in the department of otorhinolaryngology revealed that the upper airway continued to be significantly swollen, and the patient remained intubated through day 6, after which she underwent extubation without complications. The patient was discharged after completing 10 days of treatment with intravenous cefotaxime.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Epiglottitis should be considered in any paediatric patient presenting with acute upper airway obstruction. Anteroposterior radiographs of the neck show a narrowing of the air column known as the “hourglass sign” (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and lateral radiographs show the “thumb sign” produced by the swelling of the airway. Thus, tracheal intubation is one of the measures known to reduce mortality if implemented at an early stage, especially in the paediatric population, compared to watchful waiting. Supraglottic airway management devices, such as laryngeal masks, must be avoided. If intubation is not successful, the patient must undergo an emergency cricothyroidotomy.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">In the case of acute airway obstruction associated with fever, elevation of acute phase reactants and/or manifestations suggestive of sepsis, an infectious bacterial agent should be considered as the primary infectious cause. Given the current increase in the incidence of infection by <span class="elsevierStyleItalic">S. pyogenes</span>, it is important to include it in the initial differential diagnosis.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The characteristic presentation associated with invasive infection by <span class="elsevierStyleItalic">S. pyogenes</span> is relatively easy to identify: fever with leucocytosis and neutrophilia and/or elevation of acute phase reactants. However, suspecting <span class="elsevierStyleItalic">S. pyogenes</span> as the aetiological agent may be challenging unless the patient exhibits the characteristic scarlatiniform rash. Once <span class="elsevierStyleItalic">S pyogenes</span> is identified, the empirical treatment can be switched to penicillin, with addition of clindamycin in severe cases.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Given the current increase in the incidence of infection by <span class="elsevierStyleItalic">S pyogenes</span> in children, it is essential to maintain a high level of suspicion.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 460 "Ancho" => 1007 "Tamanyo" => 44525 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anteroposterior radiograph of the neck and chest with the hourglass sign.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Alerta sobre infecciones invasivas graves por <span class="elsevierStyleItalic">Streptococcus pyogenes</span>. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 81 | 46 | 127 |
| 2024 September | 84 | 42 | 126 |
| 2024 August | 111 | 74 | 185 |
| 2024 July | 111 | 37 | 148 |
| 2024 June | 80 | 35 | 115 |
| 2024 May | 107 | 46 | 153 |
| 2024 April | 78 | 35 | 113 |
| 2024 March | 79 | 31 | 110 |
| 2024 February | 86 | 35 | 121 |
| 2024 January | 112 | 36 | 148 |
| 2023 December | 143 | 52 | 195 |
| 2023 November | 124 | 54 | 178 |
