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"autoresLista" => "Julio César Moreno Alfonso, Juan Carlos López Gutiérrez, Paloma Elena Triana Junco, María San Basilio Berenguer" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Julio César" "apellidos" => "Moreno Alfonso" "email" => array:1 [ 0 => "juliomoreno.md@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Juan Carlos" "apellidos" => "López Gutiérrez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Paloma Elena" "apellidos" => "Triana Junco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "María" "apellidos" => "San Basilio Berenguer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Cirugía Pediátrica, Hospital Universitario de Navarra, Pamplona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Cirugía Pediátrica, Cirugía Plástica y Anomalías Vasculares, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Cirugía Pediátrica, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Universidad Pública de Navarra, Pamplona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Malformación capilar del labio inferior: síndrome CLAPO" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2173 "Ancho" => 2487 "Tamanyo" => 323821 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Capillary malformation between the brows and in the lower lip (arrow) with right facial asymmetry (arrowhead). Overgrowth of the first toe of the feet (arrowhead) with bilateral sandal gap (double-headed arrow): B) right foot, C) left foot. Phenotype compatible with CLAPO syndrome.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vascular malformations constitute a broad spectrum of disorders caused by the abnormal development of blood vessels. Capillary malformations (CMs) are the most frequent type of vascular anomalies and affect up to 0.3% of the population.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a boy aged 8 months referred to us on account of a CM of the lower lip, lymphatic malformation (LM), asymmetry in the right side of the face (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A) and overgrowth of the first toe in both feet with bilateral sandal gap deformity (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B and C). A PIK3CA-related overgrowth spectrum (PROS) syndrome was suspected, prompting performance of a brain magnetic resonance scan that ruled out central nervous system involvement and leading to diagnosis of CLAPO syndrome.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">CLAPO syndrome is characterised by capillary vascular malformation of the lower lip, lymphatic malformations of the head and neck, asymmetry and partial/generalized overgrowth<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>. It is a sporadic disorder associated with somatic changes in the <span class="elsevierStyleItalic">PIK3CA</span> gene and other PROS syndromes, such as megalencephaly-capillary malformation syndrome (MCAP), which explains the overlap of the phenotypes of these two syndromes<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>. The CM of the lower lip is characteristic of CLAPO syndrome, so in the case of a CM in the gums or lower lip, it is important to monitor the patient for the development of a LM or overgrowth, while in the case of a CM of the upper lip, MCAP syndrome should be suspected and neurological involvement must be ruled out. In this sense, CMs are important findings that, based on their location, may guide the differential diagnosis with other underlying anomalies or syndromes.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">This research did not receive any external funding.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-01-25" "fechaAceptado" => "2022-03-08" "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2173 "Ancho" => 2487 "Tamanyo" => 323821 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Capillary malformation between the brows and in the lower lip (arrow) with right facial asymmetry (arrowhead). Overgrowth of the first toe of the feet (arrowhead) with bilateral sandal gap (double-headed arrow): B) right foot, C) left foot. Phenotype compatible with CLAPO syndrome.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry and partial/generalized overgrowth (CLAPO): report of six cases of a new syndrome/association" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.C. López-Gutiérrez" 1 => "P. Lapunzina" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajmg.a.32517" "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet A" "fecha" => "2008" "volumen" => "146A" "paginaInicial" => "2583" "paginaFinal" => "2588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18798326" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CLAPO syndrome: identification of somatic activating PIK3CA mutations and delineation of the natural history and phenotype" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Rodriguez-Laguna" 1 => "K. Ibañez" 2 => "G. Gordo" 3 => "S. Garcia-Minaur" 4 => "F. Santos-Simarro" 5 => "N. Agra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/gim.2017.200" "Revista" => array:5 [ "tituloSerie" => "Genet Med" "fecha" => "2018" "volumen" => "20" "paginaInicial" => "882" "paginaFinal" => "889" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000009800000004/v2_202304070152/S2341287923000558/v2_202304070152/en/main.assets" "Apartado" => array:4 [ "identificador" => "77701" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in Paediatrics" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009800000004/v2_202304070152/S2341287923000558/v2_202304070152/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287923000558?idApp=UINPBA00005H" ]
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