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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">There has been a striking increase in the number of newly diagnosed cases of type 1 diabetes in children in the context of the coronavirus disease 2019 &#40;COVID-19&#41; pandemic&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">With the aim of assessing short-term pancreatic function in children with mild infection by SARS-CoV-2&#44; we conducted a multicentre prospective study in 4 Spanish hospitals between September 2020 and June 2021&#46; The study included 89 patients with a diagnosis of SARS-CoV-2 infection by RT-PCR or antigen testing of nasopharyngeal samples&#46; Thirty days after the diagnosis&#44; having obtained informed consent&#44; we collected a fasting venous blood sample for the following tests&#58; lipid profile&#44; complete blood count and chemistry panel&#44; basal insulin and C-peptide levels &#40;chemiluminescence immunoassay&#41; and concentration of glycated haemoglobin &#40;HbA<span class="elsevierStyleInf">1c</span>&#41; &#40;ion-exchange reverse-phase high performance liquid chromatography&#59; normal range&#44; 4&#37;&#8211;5&#46;7&#37;&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The mean duration of symptoms at the time of diagnosis was 1&#46;8 days &#40;standard deviation &#91;SD&#93;&#44; 1&#46;8&#41;&#46; The most frequent manifestations were respiratory symptoms &#40;51&#46;7&#37;&#41; and fever &#40;48&#46;3&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Only one patient was hospitalised due to suspicion of paediatric inflammatory multisystem syndrome&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The mean concentration of HbA<span class="elsevierStyleInf">1c</span> was 5&#46;2&#37; &#40;significantly lower in female patients&#58; 5&#46;1&#37; versus 5&#46;3&#37;&#59; <span class="elsevierStyleItalic">P</span> &#61; 0&#46;006&#41; with a statistically significant correlation between age and the HbA<span class="elsevierStyleInf">1c</span> concentration &#40;Pearson <span class="elsevierStyleItalic">r</span>&#44; 0&#46;452&#59; <span class="elsevierStyleItalic">P</span> &#60; 0&#46;001&#41;&#46; None of the patients had HbA<span class="elsevierStyleInf">1c</span> levels of 6&#46;5&#37; or greater &#40;range&#44; 4&#46;3&#37;&#8211;5&#46;9&#37;&#41;&#59; however&#44; 5 patients &#40;5&#46;5&#37;&#41; had values of 5&#46;7&#37; or greater &#40;80&#37; with a body mass index &#91;IMC&#93; above the 90<span class="elsevierStyleSup">th</span> percentile&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The mean level of C-peptide was 1&#46;3 ng&#47;mL &#40;SD&#44; 0&#46;7&#41;&#44; with no differences based on sex &#40;<span class="elsevierStyleItalic">P</span> &#61; 0&#46;289&#41;&#46; Thirty-seven percent of patients had levels of less than 1 ng&#47;dL&#59; in this subset&#44; the mean HbA<span class="elsevierStyleInf">1c</span> concentration was 5&#37;&#46; We found a statistically significant correlation between age and C-peptide levels &#40;Pearson <span class="elsevierStyleItalic">r</span>&#44; 0&#46;456&#59; <span class="elsevierStyleItalic">P</span> &#60; 0&#46;001&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mean blood insulin level was 8&#46;5 &#956;U&#47;mL &#40;SD&#44; 6&#41;&#44; without differences based on sex &#40;<span class="elsevierStyleItalic">P</span> &#61; 0&#46;289&#41;&#46; We found a weak correlation between blood insulin levels and age &#40;Pearson <span class="elsevierStyleItalic">r</span>&#44; 0&#46;392&#59; <span class="elsevierStyleItalic">P</span> &#60; 0&#46;001&#41; and a moderate correlation between insulin levels and BMI &#40;Pearson <span class="elsevierStyleItalic">r</span>&#44; 0&#46;477&#59; <span class="elsevierStyleItalic">P</span> &#60; 0&#46;001&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The mean fasting blood glucose level was 88&#46;2 mg&#47;dL &#40;SD&#44; 10&#46;2&#41;&#46; None of the patients met the criteria for diabetes&#46; In 6 patients &#40;6&#46;6&#37;&#41;&#44; we found abnormal fasting glucose levels &#40;values ranging from 100 to 125 mg&#47;dL&#41;&#59; 3 of these patients &#40;50&#37;&#41; had a BMI above the 97<span class="elsevierStyleSup">th</span> percentile&#44; although none had dyslipidaemia and all had HbA<span class="elsevierStyleInf">1c</span> concentrations below 5&#46;7&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Based on our current knowledge on the pathophysiology of COVID-19&#44; some authors have attributed a direct role in the development of type 1 diabetes to SARS-CoV-2&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The virus uses the angiotensin converting enzyme 2 receptor to enter and infect host cells&#44; and this receptor is expressed both in the lung and in the endocrine pancreas&#46; There is ample documentation of the pancreatic damage caused by SARS-CoV-2 in adults&#44; but when it comes to the paediatric population&#44; this issue remains to be elucidated&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A recently published study by the Centers for Disease Control and Prevention of the United States analysed the risk of newly diagnosed diabetes &#40;type 1&#44; 2 or other&#41; more than 30 days after the diagnosis of acute SARS-CoV-2 infection in patients aged less than 18 years&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and found a significantly greater incidence of diabetes in patients with COVID-19&#46; However&#44; as the authors themselves noted&#44; a percentage of these new cases of diabetes probably occurred in patients with prediabetes&#44; a condition that is present in 1 out of 5 adolescents in the United States&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Our findings suggest that the hypothetical pancreatic damage induced by SARS-CoV-2 would be transient and mild&#46; None of the patients had HbA<span class="elsevierStyleInf">1c</span> or fasting glucose levels meeting the criteria for diagnosis of diabetes&#44; and while 5 patients had HbA<span class="elsevierStyleInf">1c</span> concentrations of 5&#46;7&#37; or greater and 6 patients fasting glucose levels in the abnormal range&#44; this was more likely related to their BMI rather than the infection by SARS-CoV-2&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Although the study was conducted in several centres&#44; the sample was small and could not be considered representative of the general population of paediatric patients affected by COVID-19&#46; Since similar studies have not been published before&#44; we were unable to compare our findings with those of other researchers&#46; We also do not know whether the cases in our sample were caused by the same variant of the virus or different variants&#46; This could be relevant&#44; since&#44; as has occurred with other RNA retroviruses&#44; as the pandemic has evolved&#44; so has the genome of the virus and&#44; consequently&#44; its intrinsic characteristics related to its transmissibility or virulence&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; in this case series we did not find evidence of SARS-CoV-2 infection in children causing significant changes in pancreatic function or glucose metabolism&#44; at least in the short term&#46; Our results should be confirmed in larger population-based studies&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005"><a class="elsevierStyleCrossRef" href="#sec0005">Appendix A</a> lists the members of the Research Group on Urgent Paediatric Endocrinological Diseases&#46;</p>"
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            "apendice" => "<p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Coordinator&#58;</span> Miguel &#193;ngel Molina Guti&#233;rrez &#40;Paediatric Emergency Department&#44; Hospital Universitario La Paz&#41;&#46;</p> <p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Secretary&#58;</span> Bel&#233;n Sagastiz&#225;bal Cardel&#250;s &#40;Department of Paediatrics&#44; Hospital Universitario de Getafe&#41;&#46;</p> <p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Members&#58;</span> Ana Castel-Ru&#237;z Molinelli &#40;Department of Paediatrics&#44; Hospital Universitario de Getafe&#41;&#44; Blanca Guijo Alonso &#40;Department of Paediatrics&#44; Hospital Universitario Ram&#243;n y Cajal&#41;&#44; Sinziana Stanescu &#40;Metabolic Disease Unit&#44; Department of Paediatrics&#44; Hospital Universitario Ram&#243;n y Cajal&#41;&#44; Isabel Gonz&#225;lez Casado &#40;Department of Paediatric Endocrinology&#44; Hospital Universitario La Paz&#41;&#44; Jos&#233; Antonio Ru&#237;z Dom&#237;nguez &#40;Paediatric Emergency Department&#44; Hospital Universitario La Paz&#41;&#44; Mar&#237;a Jos&#233; Alc&#225;zar Villar &#40;Department of Paediatrics&#44; Hospital Universitario de Fuenlabrada&#41;&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Research Group on Urgent Paediatric Endocrinological Diseases"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">PIMS&#44; paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2&#46;</p>"
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                  \t\t\t\t">46 &#40;51&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43 &#40;48&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;7&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3-6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;3&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">37 &#40;41&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Characteristics of SARS-CoV-2 infection</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fever&nbsp;\t\t\t\t\t\t\n
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Scientific Letter
Analysis of pancreatic function in pediatric patients with COVID-19
Análisis de la función pancreática en pacientes pediátricos con COVID-19
Miguel Ángel Molina Gutiérreza,
Corresponding author
malacatin@hotmail.com

Corresponding author.
, María José Alcázar Villarb, José Antonio Ruíz Domínguezc, Belén Sagastizábal Cardelúsd, Beatríz García Cuarteroe, on behalf of the Research Group on Urgent Paediatric Endocrinological Diseases 1
a Servicio de Urgencias Pediátricas, Hospital Universitario La Paz, Madrid, Spain
b Servicio de Pediatría, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain
c Servicio de Urgencias Pediátricas, Hospital Universitario La Paz, Madrid, Spain
d Servicio de Pediatría, Hospital Universitario de Getafe, Getafe, Madrid, Spain
e Unidad de Endocrinología y Diabetes Pediátrica, Servicio de Pediatría, Hospital Universitario Ramón y Cajal, Madrid, Spain
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basal insulin and C-peptide levels &#40;chemiluminescence immunoassay&#41; and concentration of glycated haemoglobin &#40;HbA<span class="elsevierStyleInf">1c</span>&#41; &#40;ion-exchange reverse-phase high performance liquid chromatography&#59; normal range&#44; 4&#37;&#8211;5&#46;7&#37;&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The mean duration of symptoms at the time of diagnosis was 1&#46;8 days &#40;standard deviation &#91;SD&#93;&#44; 1&#46;8&#41;&#46; The most frequent manifestations were respiratory symptoms &#40;51&#46;7&#37;&#41; and fever &#40;48&#46;3&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Only one patient was hospitalised due to suspicion of paediatric inflammatory multisystem syndrome&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The mean concentration of HbA<span class="elsevierStyleInf">1c</span> was 5&#46;2&#37; &#40;significantly lower in female patients&#58; 5&#46;1&#37; versus 5&#46;3&#37;&#59; <span class="elsevierStyleItalic">P</span> &#61; 0&#46;006&#41; with a statistically significant correlation between age and the HbA<span class="elsevierStyleInf">1c</span> concentration &#40;Pearson <span class="elsevierStyleItalic">r</span>&#44; 0&#46;452&#59; <span class="elsevierStyleItalic">P</span> &#60; 0&#46;001&#41;&#46; None of the patients had HbA<span class="elsevierStyleInf">1c</span> levels of 6&#46;5&#37; or greater &#40;range&#44; 4&#46;3&#37;&#8211;5&#46;9&#37;&#41;&#59; however&#44; 5 patients &#40;5&#46;5&#37;&#41; had values of 5&#46;7&#37; or greater &#40;80&#37; with a body mass index &#91;IMC&#93; above the 90<span class="elsevierStyleSup">th</span> percentile&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The mean level of C-peptide was 1&#46;3 ng&#47;mL &#40;SD&#44; 0&#46;7&#41;&#44; with no differences based on sex &#40;<span class="elsevierStyleItalic">P</span> &#61; 0&#46;289&#41;&#46; Thirty-seven percent of patients had levels of less than 1 ng&#47;dL&#59; in this subset&#44; the mean HbA<span class="elsevierStyleInf">1c</span> concentration was 5&#37;&#46; We found a statistically significant correlation between age and C-peptide levels &#40;Pearson <span class="elsevierStyleItalic">r</span>&#44; 0&#46;456&#59; <span class="elsevierStyleItalic">P</span> &#60; 0&#46;001&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mean blood insulin level was 8&#46;5 &#956;U&#47;mL &#40;SD&#44; 6&#41;&#44; without differences based on sex &#40;<span class="elsevierStyleItalic">P</span> &#61; 0&#46;289&#41;&#46; We found a weak correlation between blood insulin levels and age &#40;Pearson <span class="elsevierStyleItalic">r</span>&#44; 0&#46;392&#59; <span class="elsevierStyleItalic">P</span> &#60; 0&#46;001&#41; and a moderate correlation between insulin levels and BMI &#40;Pearson <span class="elsevierStyleItalic">r</span>&#44; 0&#46;477&#59; <span class="elsevierStyleItalic">P</span> &#60; 0&#46;001&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The mean fasting blood glucose level was 88&#46;2 mg&#47;dL &#40;SD&#44; 10&#46;2&#41;&#46; None of the patients met the criteria for diabetes&#46; In 6 patients &#40;6&#46;6&#37;&#41;&#44; we found abnormal fasting glucose levels &#40;values ranging from 100 to 125 mg&#47;dL&#41;&#59; 3 of these patients &#40;50&#37;&#41; had a BMI above the 97<span class="elsevierStyleSup">th</span> percentile&#44; although none had dyslipidaemia and all had HbA<span class="elsevierStyleInf">1c</span> concentrations below 5&#46;7&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Based on our current knowledge on the pathophysiology of COVID-19&#44; some authors have attributed a direct role in the development of type 1 diabetes to SARS-CoV-2&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The virus uses the angiotensin converting enzyme 2 receptor to enter and infect host cells&#44; and this receptor is expressed both in the lung and in the endocrine pancreas&#46; There is ample documentation of the pancreatic damage caused by SARS-CoV-2 in adults&#44; but when it comes to the paediatric population&#44; this issue remains to be elucidated&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A recently published study by the Centers for Disease Control and Prevention of the United States analysed the risk of newly diagnosed diabetes &#40;type 1&#44; 2 or other&#41; more than 30 days after the diagnosis of acute SARS-CoV-2 infection in patients aged less than 18 years&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and found a significantly greater incidence of diabetes in patients with COVID-19&#46; However&#44; as the authors themselves noted&#44; a percentage of these new cases of diabetes probably occurred in patients with prediabetes&#44; a condition that is present in 1 out of 5 adolescents in the United States&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Our findings suggest that the hypothetical pancreatic damage induced by SARS-CoV-2 would be transient and mild&#46; None of the patients had HbA<span class="elsevierStyleInf">1c</span> or fasting glucose levels meeting the criteria for diagnosis of diabetes&#44; and while 5 patients had HbA<span class="elsevierStyleInf">1c</span> concentrations of 5&#46;7&#37; or greater and 6 patients fasting glucose levels in the abnormal range&#44; this was more likely related to their BMI rather than the infection by SARS-CoV-2&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Although the study was conducted in several centres&#44; the sample was small and could not be considered representative of the general population of paediatric patients affected by COVID-19&#46; Since similar studies have not been published before&#44; we were unable to compare our findings with those of other researchers&#46; We also do not know whether the cases in our sample were caused by the same variant of the virus or different variants&#46; This could be relevant&#44; since&#44; as has occurred with other RNA retroviruses&#44; as the pandemic has evolved&#44; so has the genome of the virus and&#44; consequently&#44; its intrinsic characteristics related to its transmissibility or virulence&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; in this case series we did not find evidence of SARS-CoV-2 infection in children causing significant changes in pancreatic function or glucose metabolism&#44; at least in the short term&#46; Our results should be confirmed in larger population-based studies&#46;</p></span>"
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                            0 => "B&#46; Li"
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                            2 => "F&#46; Zhao"
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                            5 => "L&#46; Liu"
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                            4 => "V&#46; Botea"
                            5 => "O&#46; Albai"
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ISSN: 23412879
Original language: English
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Anales de Pediatría (English Edition)
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?