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Se comparó cada uno de los profesionales: cinco pediatras, tres médicos de urgencias y tres médicos residentes, con nuestro radiólogo de referencia pediátrico.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Manuel Rius Peris, Ana Isabel Maraña Pérez, Ana Valiente Armero, Jorge Mateo Sotos, Leonor Guardia Nieto, Ana María Torres, Elisa María Cueto Calvo" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Juan Manuel" "apellidos" => "Rius Peris" ] 1 => array:2 [ "nombre" => "Ana Isabel" "apellidos" => "Maraña Pérez" ] 2 => array:2 [ "nombre" => "Ana" "apellidos" => "Valiente Armero" ] 3 => array:2 [ "nombre" => "Jorge" "apellidos" => "Mateo Sotos" ] 4 => array:2 [ "nombre" => "Leonor" "apellidos" => "Guardia Nieto" ] 5 => array:2 [ "nombre" => "Ana María" "apellidos" => "Torres" ] 6 => array:2 [ "nombre" => "Elisa María" "apellidos" => "Cueto Calvo" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2341287921000107" "doi" 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class="elsevierStyleTextfn">Original Article</span>" "titulo" => "The chest <span class="elsevierStyleSmallCaps">x</span>-ray in acute bronchiolitis: technical quality, findings, and an assessment of its reliability" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "129" "paginaFinal" => "135" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juan Manuel Rius Peris, Ana Isabel Maraña Pérez, Ana Valiente Armero, Jorge Mateo Sotos, Leonor Guardia Nieto, Ana María Torres, Elisa María Cueto Calvo" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Juan Manuel" "apellidos" => "Rius Peris" "email" => array:1 [ 0 => "jmrius@sescam.jccm.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => 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array:3 [ "nombre" => "Ana" "apellidos" => "María Torres" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "Elisa María" "apellidos" => "Cueto Calvo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital Virgen de la Luz, Cuenca, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto de Tecnología, Universidad de Castilla-La Mancha, Cuenca, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La radiografía de tórax en la bronquiolitis aguda: calidad técnica, hallazgos y evaluación de su fiabilidad" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1775 "Ancho" => 3285 "Tamanyo" => 226288 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluation by the radiologist of the presence of the different radiographic signs.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Acute bronchiolitis (AB) is a disease that entails a substantial utilization of health care services and resources in each epidemic season.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> The plain chest radiograph (CXR) has been and continues to be a widely used diagnostic tool.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The most recent clinical practice guidelines and systematic reviews on AB recommend against using CXR in most of these patients<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5–7</span></a> to avoid an increase in health care costs, reduce waiting times in the emergency department and avoid unnecessary exposure to ionising radiation and irrational use of antibiotherapy.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In the past few years, significant efforts have been made to adhere to these recommendations.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> A diagnostic test must offer an adequate validity, safety, reliability and precision to be recommended for use in clinical practice.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The reliability and precision are determined by how reproducible the test is in different clinical contexts. The reproducibility of diagnostic tests is assessed by means of interobserver agreement analyses.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Most of the previous studies on the reliability and precision of CXR in children have not focused on infants with AB, but in patients with a broad age range (infants and children) with all sorts of lower respiratory tract infections. In addition, they mainly compared only 2 observers. As a consequence, the results of different studies are quite heterogeneous.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> We only found one study in the literature assessing these aspects and specifically focused on infants with AB.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The main objective of our study was to determine whether CXR is reliable enough to be used in our setting for diagnosis of AB, exploring whether the medical speciality of the observer and the level of professional experience affected the degree of agreement with the reference radiologist. As secondary objectives, we aimed to describe the radiological findings in a sample of infants admitted to hospital with AB and assess the technical quality of the radiographs.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study design and sample</span><p id="par0010" class="elsevierStylePara elsevierViewall">We conducted a cross-sectional, observational and analytical study in a secondary level hospital (Appendix <a class="elsevierStyleCrossRef" href="#sec0070">B</a>) and included physicians that interpreted CXRs of infants with a diagnosis of AB. The data collection was prospective between 2009 and 2017, including infants aged 12 or fewer months admitted with AB (based on the McConnochie criteria adjusted for age),<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">12</span></a> and retrospective between 2006 and 2008, by reviewing the health records of all infants aged 12 or fewer months, and including those with a diagnosis of AB based on the International Classification of Diseases, ninth revision (ICD-9), specifically with a documented diagnostic code of 466.11 or 466.19.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Observers</span><p id="par0015" class="elsevierStylePara elsevierViewall">The study involved a total of 12 observers: 5 paediatricians (P1, P2, P3, P4 y P5), 3 emergency doctors (ED1, ED2 and ED3), 2 medical residents in the speciality of Family and Community Medicine (R1, R2 and R3) and 1 paediatric radiologist (PR). With the aim of analysing the potential association between the amount of professional experience of the observing paediatricians and the degree of agreement with the radiologist that served as reference, we classified their professional experience based on an arbitrary breakdown of the years of professional experience following completion of the residency: less than 10 years (low experience), 10–19 years (intermediate experience) and 20 or more years (high experience). Based on this classification, paediatricians P2 and P5 had the least experience, P1 had intermediate experience and P3 and P4 were most experienced. We considered the PR the reference in the interpretation of the CXR. She was specifically trained on paediatric radiology during her residency and has been exclusively devoted to paediatric radiology in our hospital in the past 12 years. All the included physicians that performed as observers gave their verbal consent to participate in the study.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Radiographs included in the study</span><p id="par0020" class="elsevierStylePara elsevierViewall">Out of a total of 281 infants, 129 (45.9%) underwent at least one CXR. A total of 140 CXRs were performed in this group, either during the initial contact with the emergency department or during the hospital stay. All of them were anteroposterior CXRs.</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Variables under study</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Protocol for observation and interpretation of radiographs</span><p id="par0025" class="elsevierStylePara elsevierViewall">For the purpose of observation and interpretation, each of the 140 CXRs was displayed in the same digital format and in a different order for each of the 12 observers. We set up a computer in each of the departments where the collaborating observers were affiliated to. To prevent the potential identification of the images and potential communication between observers, we changed the sequence of the CXRs to be examined for each observer, although all of them interpreted the same images. During the period in which the X-ray films were available for interpretation, the observers were not allowed to talk to each other or to access any other external source of information. They were also denied access to the health records of the patients and all they knew about the patients was that they were infants with a diagnosis of AB. The films were viewed on a 24-inch screen with 1920 × 1080 full high-definition resolution. Each observer had to assess each and every radiograph for the presence or absence of the following 10 radiographic signs: hyperinflated lungs, hilar enlargement, perihilar or peribronchial infiltrates, diffuse interstitial infiltrates, subsegmental atelectasis, pulmonary infiltrates or major atelectasis, cardiomegaly, pneumomediastinum, pneumothorax and foreign body. The presence of any of these radiographic signs did not exclude the others. We considered the first 5 signs compatible with “simple or uncomplicated AB”. We considered the presence of the sixth sign compatible with “complicated AB”, and the remaining 4 signs suggestive of a “possible alternative diagnosis other than AB”. When none of these 10 signs were present, the radiograph was considered a “normal CXR”. The categories we used to classify the CXRs taken in infants with AB do not constitute a validated approach but were established by consensus by the research team following the reading and analysis of similar studies in the previous literature.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10–15</span></a> In addition, the PR evaluated another 4 features that are indicative of the quality of the image: inclusion of the entire ribcage in the image, proper centring/alignment of the image, adequate hardness/depth of penetration and adequate inspiration. These features were agreed on by the research team after consulting the literature on the subject.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">16</span></a> All radiographic signs were documented as dichotomous variables with the possible values yes/no.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">We have summarised the data as absolute frequencies and percentages with the corresponding 95% confidence intervals (CIs). We assessed the agreement between 2 observers with the Cohen kappa<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">17,18</span></a> and the agreement between 3 or more observers with the Fleiss kappa. The latter is a generalization of the Cohen kappa that can be applied to multinomial data (more than 2 categories), ordinal data, more than 2 observers, incomplete designs and the combination of all of the above, generalizations that involve more complex calculations but resulting in a statistic that is interpreted the same way.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">18,19</span></a> The statistical analysis was performed with the software MATLAB 2018. To interpret the kappa statistic ( κ) with a widely accepted approach, we took as reference the standards of strength of agreement proposed by Landis and Koch,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">20</span></a> which have since been endorsed in the scientific literature.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">21</span></a> According to these standards, kappa values of less than 0.00 indicate poor agreement, 0.00−0.20 slight agreement, 0.21−0.40 fair agreement, 0.41−0.60 moderate agreement, 0.61−0.80 substantial agreement and 0.81–1.00 near perfect agreement.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Calculation of precision for the sample size</span><p id="par0035" class="elsevierStylePara elsevierViewall">Based on the article published by AB Cantor<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">22</span></a> and using the Epidat 4.2 software, we estimated the precision of the kappa statistics given the obtained sample size (140 radiographs). Assuming an expected value of 0.4, with a proportion of positives of 0.8 in observer 1 and 0.5 in observer 2, with a 95% level of confidence and a sample size of 140, the precision of the obtained kappa coefficient would be 0.903.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">At least 1 CXR was ordered in 129 of the 281 hospitalised infants (45.9%). One radiograph was ordered in 120 infants, two in 7 infants and three in 2 infants. A total of 140 CXRs were performed and included in the analysis. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarises the main characteristics of the sample under study. When it came to the technical quality of the radiographs, we found adequate inspiration in 96.4% (95% CI, 94.9–97.8), adequate penetration in 90.7% (95% CI, 86.5–94.9) and inclusion of the full ribcage in the image in 86.4% (95% CI, 81.1–91.7). However, only 22.1% (95% CI, 15.0–29.2) were properly centred. <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> presents the assessment of the presence or absence of the different radiographic signs made by the reference radiologist for the total sample of CXRs. The PR found radiographic signs compatible with complicated AB in 8.5% of the images (95% CI, 3.7–13.3). There were signs compatible with alternative diagnoses other than AB in 2.1% of the radiographs (95% CI, 0.3–4.6), in 2 due to evidence of pneumothorax and in 1 due to indirect signs suggestive of the presence of a foreign body in the airway. Lastly, 92.8% (95% CI, 89.3–96.3) of the radiographs only featured signs compatible with simple or uncomplicated AB and 5.7% (95% CI, 1.7–9.6) were considered normal. For most of the signs under study, the strength of the agreement between the different providers was fair, with kappa values ranging from 0.20 to 0.40, as can be seen in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. We only found slight agreement for the hyperinflation sign, with kappa values ranging from 0.00 to 0.20. Specifically, we found a kappa of 0.17 (0.15−0.18) for paediatricians, a kappa of 0.05 (0.02−0.07) for emergency physicians and a kappa of 0.02 (≤ 0.00−0.04) for medical residents. The strongest agreement corresponded to the foreign body sign, with a kappa of 0.32 (0.32−0.32) for paediatricians, a kappa of 0.34 (0.34−0.34) for emergency physicians and a kappa of 0.32 (0.32−0.33) for medical residents (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). We also assessed the strength of agreement between each of the 11 observers (5 paediatricians, 3 emergency physicians and 3 medical residents) and the PR. <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a> shows that all the paediatricians but one (P5) were in moderate agreement with the radiologist for most of the signs, with kappa values between 0.40 and 0.60. Nevertheless, and while one of the most experienced paediatricians (P3) exhibited a strong agreement with the PR, the next most experienced paediatrician (P4) ranked fourth when it came to the strength of agreement with the PR, as P1 and P2 exhibited greater agreement with the radiologist. Emergency physicians achieved kappa values that ranged from 0.20 to 0.40, and 2 of the 3 medical residents exhibited weaker agreement compared to the emergency physicians, with kappa values ranging from –0.20 to 0.20. The kappa values for the remaining medical resident were comparable to the kappa values of the paediatricians. Furthermore, and overall, all professionals exhibited lower agreement with the radiologist in the detection of radiographic signs of uncomplicated AB compared to other signs (complicated AB, other possible diagnoses and normal radiographic findings) (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">In our study, 77.8% of the CXRs were not properly centred in the opinion of the PR. This is one of the basic characteristics used to assess the technical quality of the image, and poor alignment is a frequent cause of false interpretations in paediatric chest radiographs.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">23</span></a> Our findings regarding the proportion of radiographs with signs compatible with complicated AB, which was of 8.5% in our sample, or suggestive of an alternative diagnosis, which corresponded to 2.1% of the radiographs, were similar to those of other authors. Thus, Schuh et al. reported a proportion of radiographs compatible with complicated AB of 6.9% and a proportion suggestive of alternative diagnoses of 0.7% in a sample of 265 radiographs of patients with AB.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">24</span></a> A similar study in 140 patients found a percentage compatible with complicated AB of 16% and a percentage compatible with other diagnoses of 0.7%.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">25</span></a> This already suggests that multiple CXRs and exposure of many infants with a clinical diagnosis of AB to radiation is required to identify signs that would change the diagnosis or the approach to treatment. Studies that analyse interobserver agreement are quite heterogeneous not only in terms of the patients and disorders that they focus on, but also in the radiographic signs chosen to assess the specialists interpreting the radiographs and their level of professional experience, but also the methodology used, for instance the comparison of only 2 observers or 3 or more observers at the same time.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">13,14,26,27</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Under these circumstances, studies yield highly heterogeneous results that are difficult to compare, and some report considerable agreement between observeres<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,14</span></a> while others report moderate or fair levels of agreement with kappa values ranging from 0.20 to 0.60,<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">13,15,27</span></a> similar to the levels that we found. In our study, when we analysed the agreement within each group of medical providers, we found fair agreement with Fleiss kappa values within a narrow range from 0.20 to 0.40 for all signs but one, as can be seen in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. However, we found greater variability in the strength of agreement, with Cohen kappa values ranging from –0.20 to 0.60, when we compared the agreement between each professional and the paediatric radiologist, as can be seen in <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>. Our findings were consistent with those of Lewinsky et al.,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">15</span></a> as we found an association between the strength of the agreement with the reference and the speciality of the observer (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>), with an overall stronger agreement in paediatricians compared emergency physicians and medical residents. Other authors have suggested that the substantial interrater variability observed could be attributed to the different levels of clinical experience,<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">15,27</span></a> so that more experienced observers would exhibit stronger agreement with the reference.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">15</span></a> However, our findings do not support this hypothesis, as the strength of agreement with the reference found in paediatric providers was not directly proportional to their level of clinical experience, as one of the paediatricians with substantial experience (P4) exhibited a lower agreement compared to 3 of the 5 paediatricians in the study (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). There are limitations to our study, such as the observers knowing from the outset that the radiographs that they would be interpreting corresponded to patients with AB. Although this could have resulted in an increased agreement between observers, this was not the case. Furthermore, our study focused on the reliability of this diagnostic test through the analysis of interobserver agreement, and the information would have been more comprehensive if we had also analysed intraobserver agreement. We also ought to highlight the fact that only one radiologist was used for reference, although she was the only full-time paediatric radiologist in the hospital, and therefore seemed the best possible choice for the purpose of the study. There are also strengths to our study, such as the homogeneous sample of patients, all of them infants aged less than 12 months admitted to hospital with bronchiolitis, and collection of data throughout 11 epidemic seasons. We have found only one other study in the previous literature analysing the reliability of CXR exclusively in infants with AB.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In our study, we found poor to fair interobserver agreement in the interpretation of CXR used for diagnosis of AB in infants. We also described factors that may be related to the low reproducibility observed in our study, such as the quality of the image, the radiographic signs under assessment, the medical speciality of the observer, the clinical experience of the observer and the method used to assess interobserver agreement, comparing 2 observers or 3 or more observers at a time. Based on these findings, CXR offers a low reliability as a diagnostic test in the assessment of infants with AB, and therefore its routine use is not recommended.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None of the researchers have any conflicts of interest to declare. In addition, none have received a grant or any other form of external funding to carry out this study.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1473720" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1341824" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1473721" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1341823" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Material and methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study design and sample" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Observers" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Radiographs included in the study" ] ] ] 6 => array:3 [ "identificador" => "sec0030" "titulo" => "Variables under study" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Protocol for observation and interpretation of radiographs" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Statistical analysis" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Calculation of precision for the sample size" ] ] ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Results" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflicts of interest" ] 10 => array:2 [ "identificador" => "xack516430" "titulo" => "Acknowledgments" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-01-21" "fechaAceptado" => "2020-03-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1341824" "palabras" => array:4 [ 0 => "Bronchiolitis" 1 => "Chest x-ray" 2 => "Reproducibility" 3 => "Between-observer variability" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1341823" "palabras" => array:4 [ 0 => "Bronquiolitis" 1 => "Radiografía de tórax" 2 => "Reproductibilidad" 3 => "Variabilidad entre observadores" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Despite the recommendations of the current Clinical Practice Guidelines, the chest x-ray continues to be a widely used diagnostic test in the assessment of infants with acute bronchiolitis (AB). However, there have not been many studies that have assessed its reproducibility in these patients. In the present study, an evaluation is made on the radiographs, describing their quality, their radiological findings, and provides new evidence on the agreement between observers.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Out of a total of 281 infants admitted due to acute bronchiolitis, 140 chest x-rays were performed. Twelve doctors from different specialities evaluated the presence or absence of 10 radiological signs previously agreed by consensus. The level of agreement between 2 observers, and in groups of 3 or more, were analysed using the Cohen and Fleiss kappa index, respectively.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Only 8.5% of the radiographs showed evidence of a complicated AB. The between-observer agreement in groups of 3 or more was medium, and with little variability (kappa: 0.20−0.40). However, between 2 observers, specialists in radiology, the variability was wider, (kappa: −0.20 to 0.60). This level of agreement was associated with factors including, the sign to evaluate, the medical specialty, and level of professional experience.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The low levels of agreement between observers and the wide variability, makes the chest x-ray an unreliable diagnostic tool, and is not recommended for the assessment of infants with AB.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">A pesar de las recomendaciones de las actuales Guías de Práctica Clínica, la radiografía de tórax sigue siendo una prueba diagnóstica ampliamente utilizada en la evaluación de lactantes con bronquiolitis aguda. No obstante, su reproductibilidad en estos pacientes no ha sido muy estudiada. En la presente investigación, se evalúan radiografías describiéndose su calidad técnica, hallazgos radiológicos en las mismas y se aportan nuevas evidencias sobre la concordancia entre observadores.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Método</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Sobre un total de 281 lactantes ingresados por bronquiolitis aguda, 140 radiografías de tórax fueron realizadas. 12 médicos de diferentes especialidades evaluaron la presencia o ausencia de 10 signos radiográficos previamente consensuados. El nivel de concordancia entre 2 observadores y en grupos de 3 o más, fue estudiado mediante el índice kappa de Cohen y de Fleiss respectivamente.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Únicamente en el 8,5% de las radiografías se evidenciaron signos de BA complicada. La concordancia entre observadores en grupos de 3 o más fue mediana y con escasa variabilidad (kappa: 0,20−0,40), sin embargo, entre 2 observadores, especialista con radiólogo de referencia, la variabilidad fue más amplia, (kappa: −0,20 to 0,60). Este nivel de concordancia se relacionaba con factores tales como el signo a evaluar, la especialidad médica y el grado de experiencia profesional, entre otros.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Los bajos niveles de concordancia entre observadores y su amplia variabilidad, convierten a la radiografía de tórax en una herramienta diagnóstica poco fiable y no recomendable para la evaluación de lactantes con BA.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as: Rius Peris JM, Maraña Pérez AI, Valiente Armero A, Mateo Sotos J, Guardia Nieto L, María Torres A, et al. La radiografía de tórax en la bronquiolitis aguda: calidad técnica, hallazgos y evaluación de su fiabilidad. An Pediatr (Barc). 2021;94:129–135.</p>" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0085" class="elsevierStylePara elsevierViewall">The following is Supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0070" ] ] ] ] "multimedia" => array:5 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1775 "Ancho" => 3285 "Tamanyo" => 226288 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluation by the radiologist of the presence of the different radiographic signs.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1738 "Ancho" => 3187 "Tamanyo" => 284055 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Strength of agreement, measured by means of the Fleiss kappa, between observers grouped by professional category: 5 paediatricians, 3 emergency physicians and 3 medical residents. The strength of agreement categories are shown in the horizontal axis.</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">AB, acute bronchiolitis.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1556 "Ancho" => 3185 "Tamanyo" => 313590 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Interobserver agreement measured with the Cohen kappa for 2 observers. We compared each of the professionals (5 paediatricians, 3 emergency physicians and 3 medical residents) with the paediatric radiologist that served as reference.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">ABX, antibiotherapy; CXR, chest radiograph; LOS, length of stay; PICU, paediatric intensive care unit; RSV, respiratory syncytial virus; SaO<span class="elsevierStyleInf">2</span>, oxygen saturation.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Sex (female)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">122 (43.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Nationality</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Spanish \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">242 (86.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>South/Central American \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (1.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Moroccan \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (4.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Romanian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (7.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>other \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Age ≤ 28 days</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34 (12.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Age ≤ 3 months</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">161 (57.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Age ≤ 6 months</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">230 (81.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Age (months)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.5 (1.5−5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">CXR performed</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">129 (45.9)<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">RSV-positive</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">158 (60)<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">SaO<span class="elsevierStyleInf">2</span> ≤ 90% at admission</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55 (39.3)<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Required PICU admission</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (2.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Required ABX</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 (12.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">LOS</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.48 (2.37) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2535629.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">In some patients, more than one chest radiograph was performed during the hospital stay.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Tests for detection of RSV in nasal secretions performed in 93.6% of patients.</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Although oxygen saturation was measured in every patient, it was only documented in 49.8% of cases.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Principal characteristics of the sample.</p>" ] ] 4 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.zip" "ficheroTamanyo" => 290 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Costs of hospitalization with respiratory syncytial virus illness among children aged <5 years and the financial impact on households in Bangladesh, 2010" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.U. 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