Editorial
Paediatric Rheumatology: Where we are coming from and where we are going
Reumatología Pediátrica, de dónde venimos y a dónde vamos
a Sección de Reumatología Pediátrica, Servicio de Pediatría, Hospital Sant Joan de Déu, Barcelona, Spain
b Servicio de Infectología, Reumatología e Inmunología Pediátrica, Hospital Universitario Virgen del Rocío, Sevilla, Spain
c Unidad Reumatología Pediátrica, Hospital Regional Universitario de Málaga, Málaga, Spain
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The continuous line represents the time elapsed to discontinuation of MTX due to inactive disease in patients that did not experience adverse reactions, while the dotted line corresponds to the time elapsed to discontinuation of MTX in patients that experienced adverse reactions.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Estefanía Barral Mena, Luis Miguel García Cárdaba, Anna Canet Tarrés, Eugenia Enríquez Merayo, Alejandro Cruz Utrilla, Jaime de Inocencio Arocena" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Estefanía" "apellidos" => "Barral Mena" ] 1 => array:2 [ "nombre" => "Luis Miguel" "apellidos" => "García Cárdaba" ] 2 => array:2 [ "nombre" => "Anna" "apellidos" => "Canet Tarrés" ] 3 => array:2 [ "nombre" => "Eugenia" "apellidos" => "Enríquez Merayo" ] 4 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Cruz Utrilla" ] 5 => array:2 [ "nombre" => "Jaime" "apellidos" => "de Inocencio Arocena" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1695403319302012" "doi" => "10.1016/j.anpedi.2019.05.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319302012?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300120?idApp=UINPBA00005H" "url" => "/23412879/0000009200000003/v1_202003140714/S2341287920300120/v1_202003140714/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Paediatric Rheumatology: Where we are coming from and where we are going" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "123" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jordi Antón, Marisol Camacho Lovillo, Esmeralda Nuñez Cuadros" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Jordi" "apellidos" => "Antón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Marisol" "apellidos" => "Camacho Lovillo" "email" => array:1 [ 0 => "soledad.camacho.sspa@juntadeandalucia.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Esmeralda" "apellidos" => "Nuñez Cuadros" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Sección de Reumatología Pediátrica, Servicio de Pediatría, Hospital Sant Joan de Déu, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Infectología, Reumatología e Inmunología Pediátrica, Hospital Universitario Virgen del Rocío, Sevilla, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Unidad Reumatología Pediátrica, Hospital Regional Universitario de Málaga, Málaga, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Reumatología Pediátrica, de dónde venimos y a dónde vamos" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In 1483, Sandro Botticelli depicted what may be one of the earliest representations of juvenile idiopathic arthritis (JIA) in “Portrait of a Youth”, in which he showed the swelling of the wrist, metacarpophalangeal and proximal interphalangeal joints of one hand. But it was in 1897 that George Frederic Still, a paediatrician and pathologist at the Hospital for Sick Children at Great Ormond Street, London, published an article describing 22 children with chronic arthritis and highlighting that rheumatic manifestations in children differed from those in adults. Some of these patients had what years later came to be known as Still’s disease and is currently known as systemic-onset JIA. It was not until 1940 that the idea emerged again that children could have rheumatic diseases other than rheumatic fever.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Paediatric Rheumatology is a subspecialty of paediatrics focused on the diagnosis and management of a broad range of diseases: musculoskeletal disorders such as JIA, systemic autoimmune diseases such as systemic lupus erythematosus SLE, juvenile dermatomyositis or juvenile scleroderma, autoinflammatory diseases such as periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis PFAPA syndrome or hereditary periodic fever syndromes, disorders manifesting with increased pain such as fibromyalgia or chronic fatigue syndrome, or secondary osteoporosis, to name a few. To further knowledge in this field, in 1992 a group of paediatricians and rheumatologists in Spain created the Grupo Español de Reumatología Pediátrica (Spanish Group of Paediatric Rheumatology, GERP), which in 1995 became the Section of Paediatric Rheumatology of the Asociación Española de Pediatría (Spanish Association of Pediatrics, AEP) and in 1998 gave rise to the Sociedad Española de Reumatología Pediátrica (Spanish Society of Paediatric Rheumatology, SERPE).</p><p id="par0015" class="elsevierStylePara elsevierViewall">The most frequent chronic rheumatic disease in the paediatric population is JIA, formerly known as juvenile rheumatoid arthritis or juvenile chronic arthritis; JIA ultimately is a consensus-based term that encompasses several subtypes of disease. Few studies have been conducted in Spain to analyse its epidemiology, and a study conducted in Catalonia reported an incidence of 6.9 per 10 000 children aged less than 16 years and a prevalence of 39.7 per 10 000 children aged less than 16 years.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> On the other hand, it is estimated that 20% of cases of SLE have onset in childhood or adolescence, and most autoinflammatory disorders have onset in childhood. As physicians, we are all familiar with the saying that “one only diagnoses what one knows”, something that is particularly true in the field of paediatric rheumatology. The study published by Udaondo Gascón et al. in the current issue of <span class="elsevierStyleItalic">Anales de Pediatría</span> corroborates the perception that training in paediatric rheumatology must be improved at every level (undergraduate and postgraduate).<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It is essential that training programmes for medical students, residents in paediatrics and continuous education include not only information on this group of diseases but also on the evaluation of the musculoskeletal system. Nobody would think that it is acceptable for paediatricians not to know how to examine an ear or perform auscultation of the chest, but even the most recent evidence today shows that the physical examination often does not include a musculoskeletal evaluation and that many medical providers lack confidence in assessing joints.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Advances in imaging techniques along with the increased availability of ultrasound technicians in many clinics and in genetic diagnosis, which guides the management of newly recognised autoinflammatory diseases, combined with the development of new treatments, are some of the factors that have contributed to improvements in the management of these diseases that we would not even have dreamt of until a few years ago. Despite advances in treatment, methotrexate, which has been in use for more than 30 years, continues to be the main systemic drug used for the management of diseases like JIA. For this reason, we consider that the work of Barral Mena et al. analysing the factors associated with adverse reactions to methotrexate, published in this issue of <span class="elsevierStyleItalic">Anales de Pediatría</span>, is certainly relevant. It shows that despite its efficacy, up to one third of patients need to discontinue methotrexate due to adverse effects.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Fortunately, alternative options are available today, such as selective immunosuppressive agents (biologic drugs) or Janus kinase (JAK) inhibitors. The days when children frequently ended up with significant limitations or physical sequelae, or even dependent on a wheelchair, are behind us. Today, the vast majority of patients lead normal lives and participate in sports activities as do children of the same age.</p><p id="par0025" class="elsevierStylePara elsevierViewall">On the other hand, the follow-up of patients in specialty clinics has allowed participation in collaborative networks, registers, studies and clinical trials at the national and international levels. Institutions such as the Pediatric Rheumatology Trials Organization (PRINTO), the Pediatric Rheumatology Society (PReS) or SERPE have invested on promoting research and the establishment of working groups to join efforts and progress in the field. In 2013, the Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative was launched with the participation of European paediatric rheumatology networks with the aim of describing current needs for the optimal management of children and youth with rheumatic disease.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> This initiative has given rise to numerous publications in recent years with recommendations for the management of the most common paediatric rheumatic diseases, the performance of collaborative studies or the establishment of biobanks. Particular emphasis has been placed on the needs of adolescents with chronic disease and how to facilitate transitioning to adult care, which often involves a switch in the provider in charge of the patient.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">We ought to highlight the important and novel role taken in recent years by patient organizations. For instance, since 2015 and with the support of the SERPE, a yearly day-long “symposium for the families of children and adolescents with rheumatic diseases” is held simultaneously in several cities throughout Spain in collaboration with local patient organizations and the specialists that manage these patients. In these symposiums, health professionals, parents and children share experiences, questions and hopes. Starting this year, this symposium will be held on March to join the celebration in multiple countries of the World Young Rheumatic Diseases day (WORD). Furthermore, some of these organizations make altruistic contributions to research in paediatric rheumatology, offering research grants to further knowledge on these diseases.</p><p id="par0035" class="elsevierStylePara elsevierViewall">However, many challenges remain, for instance at the educational level, since, as is the case in other paediatric subspecialties, adequate training in the field needs to be guaranteed. In 1992, the American Board of Pediatrics held the first paediatric rheumatology subspecialty exam, and in 1994, specialist training was approved in the United Kingdom. Since then, numerous countries have recognised it as a specialty: Germany, the Netherlands, Italy, France, Austria, Sweden and Finland, among others. Furthermore, the European Union of Medical Specialists (UEMS) and its paediatric section, the European Academy of Paediatrics (EAP), have acknowledged this specialty and the specialty training curriculum at the European level. Spain should promptly recognise paediatric subspecialties officially, including paediatric rheumatology.</p><p id="par0040" class="elsevierStylePara elsevierViewall">At the level of care delivery, new communication technologies must be considered and applied to facilitate access of patients and their families to the providers involved in their care. In this regard, specialty nurses and case managers can play an essential role in contributing to the education, self-care and follow-up of these patients.</p><p id="par0045" class="elsevierStylePara elsevierViewall">When it comes to research objectives, it is important to continue to develop new drugs and to conduct trials with those that already exist, as well as to perform studies with the aim of identifying biomarkers (genetic, molecular, indicative of disease recurrence or treatment response) to aid prognosis and thus guide the selection of appropriate, individualised and targeted treatment, which not only would increase its effectiveness and decrease the probability of recurrence, but also improve the adverse reaction profile.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">As health care providers, we must strive to ensure access to all patients to the best possible care, to specialised care and to appropriate treatment for their disease. As paediatricians, we should be able to demand from our managers, coordinators, administrators and politicians that children with suspected non-infectious arthritis or autoimmune disease be assessed by a paediatric rheumatologist. There is still a long way to go, but the subspecialty of Paediatric Rheumatology is now a reality established on solid foundations.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-01-08" "fechaAceptado" => "2020-01-10" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Antón J, Camacho Lovillo M, Nuñez Cuadros E. Reumatología Pediátrica, de dónde venimos y a dónde vamos. An Pediatr (Barc). 2020;92:121–123.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence and prevalence of juvenile idiopathic arthritis in Catalonia (Spain)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Modesto" 1 => "J. Antón" 2 => "B. Rodriguez" 3 => "R. Bou" 4 => "C. Arnal" 5 => "J. 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Wedderburn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S2352-4642(19)30188-9" "Revista" => array:7 [ "tituloSerie" => "Lancet Child Adolesc Health" "fecha" => "2019" "volumen" => "3" "paginaInicial" => "725" "paginaFinal" => "733" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31331873" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0085253815562741" "estado" => "S300" "issn" => "00852538" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000009200000003/v1_202003140714/S2341287920300156/v1_202003140714/en/main.assets" "Apartado" => array:4 [ "identificador" => "25501" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Editorial" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009200000003/v1_202003140714/S2341287920300156/v1_202003140714/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300156?idApp=UINPBA00005H" ]
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|---|---|---|---|
| 2024 November | 3 | 7 | 10 |
| 2024 October | 48 | 29 | 77 |
| 2024 September | 47 | 33 | 80 |
| 2024 August | 53 | 50 | 103 |
| 2024 July | 29 | 26 | 55 |
| 2024 June | 43 | 19 | 62 |
| 2024 May | 40 | 35 | 75 |
| 2024 April | 31 | 28 | 59 |
| 2024 March | 29 | 18 | 47 |
| 2024 February | 23 | 27 | 50 |
| 2024 January | 21 | 21 | 42 |
| 2023 December | 19 | 18 | 37 |
| 2023 November | 25 | 29 | 54 |
| 2023 October | 29 | 27 | 56 |
| 2023 September | 21 | 23 | 44 |
| 2023 August | 19 | 13 | 32 |
| 2023 July | 29 | 20 | 49 |
| 2023 June | 21 | 34 | 55 |
| 2023 May | 36 | 20 | 56 |
| 2023 April | 18 | 9 | 27 |
| 2023 March | 25 | 20 | 45 |
| 2023 February | 28 | 11 | 39 |
| 2023 January | 18 | 18 | 36 |
| 2022 December | 42 | 21 | 63 |
| 2022 November | 38 | 23 | 61 |
| 2022 October | 45 | 33 | 78 |
| 2022 September | 22 | 19 | 41 |
| 2022 August | 31 | 41 | 72 |
| 2022 July | 23 | 35 | 58 |
| 2022 June | 28 | 25 | 53 |
| 2022 May | 31 | 33 | 64 |
| 2022 April | 17 | 22 | 39 |
| 2022 March | 39 | 43 | 82 |
| 2022 February | 37 | 23 | 60 |
| 2022 January | 35 | 31 | 66 |
| 2021 December | 30 | 33 | 63 |
| 2021 November | 33 | 41 | 74 |
| 2021 October | 64 | 53 | 117 |
| 2021 September | 32 | 34 | 66 |
| 2021 August | 33 | 35 | 68 |
| 2021 July | 38 | 16 | 54 |
| 2021 June | 29 | 27 | 56 |
| 2021 May | 50 | 32 | 82 |
| 2021 April | 89 | 83 | 172 |
| 2021 March | 84 | 24 | 108 |
| 2021 February | 53 | 19 | 72 |
| 2021 January | 60 | 19 | 79 |
| 2020 December | 60 | 13 | 73 |
| 2020 November | 33 | 13 | 46 |
| 2020 October | 48 | 18 | 66 |
| 2020 September | 42 | 19 | 61 |
| 2020 August | 94 | 17 | 111 |
| 2020 July | 92 | 21 | 113 |
| 2020 June | 37 | 10 | 47 |
| 2020 May | 36 | 20 | 56 |
| 2020 April | 35 | 16 | 51 |
| 2020 March | 69 | 25 | 94 |
| 2020 February | 37 | 21 | 58 |
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