array:24 [
  "pii" => "S234128791930225X"
  "issn" => "23412879"
  "doi" => "10.1016/j.anpede.2018.12.011"
  "estado" => "S300"
  "fechaPublicacion" => "2020-02-01"
  "aid" => "2576"
  "copyright" => "Asociación Española de Pediatría"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "An Pediatr (Barc). 2020;92:104-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 82
    "formatos" => array:3 [
      "EPUB" => 8
      "HTML" => 58
      "PDF" => 16
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2341287920300053"
    "issn" => "23412879"
    "doi" => "10.1016/j.anpede.2018.10.014"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "2648"
    "copyright" => "Asociación Española de Pediatría"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "An Pediatr (Barc). 2020;92:105-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 48
      "formatos" => array:3 [
        "EPUB" => 5
        "HTML" => 34
        "PDF" => 9
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Advances in the diagnosis of ocular toxoplasmosis&#58; Use of optical coherence tomography"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "105"
          "paginaFinal" => "107"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Novedades para el diagn&#243;stico de la toxoplasmosis ocular&#58; uso de la tomograf&#237;a de coherencia &#243;ptica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 578
              "Ancho" => 1500
              "Tamanyo" => 65220
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0010"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#41; OCT image&#46; Cystic spaces in the inner layer of the retina&#46; Cystic spaces are a frequent finding in patients with toxoplasmosis and considered a complication &#40;parasite-filled cysts or signs of local inflammation or exudates&#41;&#46; B&#41; Photograph of the eye fundus showing the paramacular chorioretinal scar in the nasal fundus&#44; consistent with the OCT findings&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Tessie Ferrer Mellor, Bel&#233;n Sevilla P&#233;rez, Javier Lacorzana, Beatriz Bravo Manche&#241;o, Jose Lu&#237;s Garc&#237;a Serrano"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Tessie"
              "apellidos" => "Ferrer Mellor"
            ]
            1 => array:2 [
              "nombre" => "Bel&#233;n"
              "apellidos" => "Sevilla P&#233;rez"
            ]
            2 => array:2 [
              "nombre" => "Javier"
              "apellidos" => "Lacorzana"
            ]
            3 => array:2 [
              "nombre" => "Beatriz"
              "apellidos" => "Bravo Manche&#241;o"
            ]
            4 => array:2 [
              "nombre" => "Jose Lu&#237;s"
              "apellidos" => "Garc&#237;a Serrano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1695403319301754"
        "doi" => "10.1016/j.anpedi.2018.10.023"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319301754?idApp=UINPBA00005H"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300053?idApp=UINPBA00005H"
    "url" => "/23412879/0000009200000002/v2_202002150708/S2341287920300053/v2_202002150708/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2341287919302327"
    "issn" => "23412879"
    "doi" => "10.1016/j.anpede.2018.12.012"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "2582"
    "copyright" => "Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "An Pediatr &#40;Barc&#41;. 2020;92:102-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 42
      "formatos" => array:3 [
        "EPUB" => 3
        "HTML" => 31
        "PDF" => 8
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Percutaneous shunt closure in patients with nickel allergy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "102"
          "paginaFinal" => "104"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Cierre percut&#225;neo de shunts en pacientes al&#233;rgicos al n&#237;quel"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 839
              "Ancho" => 1250
              "Tamanyo" => 147579
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0045"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Photograph of the anterior region of the thorax and the abdomen demonstrating the lack of cutaneous reactions after contact with different percutaneous ASD closure devices&#58; Amplatzer Septal Occluder &#40;top left&#41;&#59; Figulla ASD Occluder &#40;top right&#41;&#59; Cardia Ultrasept &#40;bottom left&#41; and Gore Septal Occluder &#40;bottom right&#41;&#46; &#40;b&#41; Photograph illustrating the method used to affix the devices to the skin&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marc Figueras-Coll, Anna Sabat&#233;-Rot&#233;s, Gerard Mart&#237;-Aguasca, Marc Roguera-Sopena, Pedro Betri&#225;n-Blasco"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Marc"
              "apellidos" => "Figueras-Coll"
            ]
            1 => array:2 [
              "nombre" => "Anna"
              "apellidos" => "Sabat&#233;-Rot&#233;s"
            ]
            2 => array:2 [
              "nombre" => "Gerard"
              "apellidos" => "Mart&#237;-Aguasca"
            ]
            3 => array:2 [
              "nombre" => "Marc"
              "apellidos" => "Roguera-Sopena"
            ]
            4 => array:2 [
              "nombre" => "Pedro"
              "apellidos" => "Betri&#225;n-Blasco"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1695403319300098"
        "doi" => "10.1016/j.anpedi.2018.12.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319300098?idApp=UINPBA00005H"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919302327?idApp=UINPBA00005H"
    "url" => "/23412879/0000009200000002/v2_202002150708/S2341287919302327/v2_202002150708/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
    "titulo" => "Glucose and galactose malabsorption&#58; A new case in Spain"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "104"
        "paginaFinal" => "105"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Blanca Lodoso-Torrecilla, Guiomar Perez de Nanclares, Intza Garin, Ariane Calvo-Saez, Idoya Martinez-Fernandez de Pinedo"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "Blanca"
            "apellidos" => "Lodoso-Torrecilla"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Guiomar"
            "apellidos" => "Perez de Nanclares"
            "email" => array:1 [
              0 => "gnanclares@osakidetza.eus"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Intza"
            "apellidos" => "Garin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ariane"
            "apellidos" => "Calvo-Saez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Idoya"
            "apellidos" => "Martinez-Fernandez de Pinedo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Grupo de Investigaci&#243;n en Enfermedades Raras&#44; Unidad Neonatal&#44; Servicio de Pediatr&#237;a&#44; Instituto de Investigaci&#243;n Sanitaria BioAraba&#44; OSI Araba&#44; Vitoria-Gasteiz&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Grupo de Investigaci&#243;n de Enfermedades Raras&#44; Laboratorio de &#40;Epi&#41;Gen&#233;tica Molecular&#44; Instituto de Investigaci&#243;n Sanitaria BioAraba&#44; OSI Araba-Txagorritxu&#44; Vitoria-Gasteiz&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Laboratorio de Gen&#233;tica&#44; UGC Laboratorio&#44; OSI Araba&#44; Vitoria-Gasteiz&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Secci&#243;n de Gastroenterolog&#237;a&#44; Hepatolog&#237;a y Nutrici&#243;n Pedi&#225;trica&#44; OSI Araba&#44; Vitoria-Gasteiz&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Malabsorci&#243;n de glucosa y galactosa&#46; Nuevo caso en Espa&#241;a"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Congenital diarrhoea refers to a heterogeneous group of enteropathies that cause symptoms from the first few days of life&#44; and it may be the only manifestation or one of the symptoms of a systemic disease&#46; In most cases&#44; early treatment is necessary to prevent dehydration&#44; given the potential complications of the latter&#46; The first step in the differential diagnosis is to differentiate between secretory and osmotic diarrhoea&#58; in the former&#44; the diarrhoeal output does not improve with a nil per os trial&#44; whereas in the latter it does&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a male newborn aged 2 days admitted to the neonatal unit with hyperbilirubinaemia&#46; The parents were Pakistani and reported consanguinity&#46; The newborn was a product of a monochorionic-diamniotic twin pregnancy and had been born second at 36 weeks&#8217; gestation with a weight of 2460<span class="elsevierStyleHsp" style=""></span>g&#46; He was receiving artificial formula following the wishes of the mother&#46; On admission to the neonatal unit&#44; the physical examination revealed a 15&#37; weight loss&#44; jaundice extending to Kramer&#39;s zone 3 and a dry oral mucosa&#44; with no other abnormal findings&#46; Blood tests revealed hyperbilirubinaemia on account of elevation of indirect bilirubin and dehydration with hypernatraemia and hyperchloraemia &#40;urea&#44; 49<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; creatinine&#44; 1&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; sodium&#44; 163<span class="elsevierStyleHsp" style=""></span>mEq&#47;L&#59; chloride&#44; 132<span class="elsevierStyleHsp" style=""></span>mEq&#47;L&#41; and metabolic acidosis &#40;pH&#44; 7&#46;30&#59; bicarbonate&#44; 18&#46;7<span class="elsevierStyleHsp" style=""></span>mM&#59; base excess&#44; 7<span class="elsevierStyleHsp" style=""></span>mM&#59; lactate&#44; 3&#46;9<span class="elsevierStyleHsp" style=""></span>mM&#41;&#46; Phototherapy was initiated&#44; along with placement of a peripheral catheter for intravenous fluid replacement&#44; while the patient continued to receive artificial formula&#46; The diarrhoeal output continued to be very high&#44; leading to prescription of nil per os&#44; which achieved resolution of the diarrhoea&#46; The analysis of stool samples revealed an acidic pH and the presence of reducing bodies&#46; In the following days&#44; several attempts were made to reintroduce oral feedings&#44; first with elemental formula and later with a soy-based formula&#44; with diarrhoea recurring in both instances as the feeding volume increased&#46; Eventually&#44; the newborn was given a fructose-based formula with no other carbohydrates&#44; to which he responded favourably&#46; Increases in feeding volume did not create problems&#44; and the boy started producing normal stools and exhibiting adequate weight gain&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In this case&#44; since the patient improved with fasting&#44; the diarrhoea was classified as osmotic&#44; and the presence of reducing bodies in the stool suggested that the congenital diarrhoea could be due to carbohydrate malabsorption&#46; Since the patient did not improve with the soy formula&#44; we suspected glucose&#8211;galactose malabsorption&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> as soy formulas do not contain galactose but do contain glucose&#46; In fact&#44; upon switching to a formula in which the sole carbohydrate was fructose&#44; the newborn responded well&#44; which supported our clinical suspicion&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Congenital glucose&#8211;galactose malabsorption &#40;cGGM&#41; is a rare autosomal recessive disorder characterised by changes in the <span class="elsevierStyleItalic">SLC5A1</span> gene that encodes the protein SGLT1&#44; responsible for transporting glucose and galactose from the intestinal lumen into intestinal cells&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Sequencing of this gene in the patient revealed the homozygous mutation c&#46;875G&#62;A &#40;p&#46;C292Y&#41;&#44; previously described as a pathogenic variant&#44; as it impacts the location and function of the protein&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> thus confirming the diagnosis&#46; Microsatellite genotyping confirmed that the twins were dizygotic&#44; which explained the clinical differences between the two&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Congenital glucose&#8211;galactose malabsorption is characterised by severe diarrhoea and dehydration from the first day of life&#44; which can quickly result in the death of the infant if glucose&#44; galactose and the disaccharides that contain them are not removed from the diet&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Approximately 300 cases have been diagnosed worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Treatment consists in the elimination of glucose and galactose from the diet&#44; substituting a fructose-based formula&#44; which achieves resolution of diarrhoea&#46; Some authors have proposed that cGGM improves over time as the intestinal flora adapts&#44; and it appears that administration of <span class="elsevierStyleItalic">Lactobacillus acidophilus</span> helps shorten the time that carbohydrates need to be restricted&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> However&#44; there are no prospective studies in the literature establishing how to identify which patients will develop tolerance and which will remain intolerant for life&#44; so we currently recommend that older children and adults consume a diet where fructose is the sole source of carbohydrates until tolerance can be evaluated&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lodoso-Torrecilla B&#44; Perez de Nanclares G&#44; Garin I&#44; Calvo-Saez A&#44; Martinez-Fernandez de Pinedo I&#46; Malabsorci&#243;n de glucosa y galactosa&#46; Nuevo caso en Espa&#241;a&#46; An Pediatr &#40;Barc&#41;&#46; 2020&#59;92&#58;104&#8211;105&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advances in evaluation of chronic diarrhea in infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;R&#46; Thiagarajah"
                            1 => "D&#46;S&#46; Kamin"
                            2 => "S&#46; Acra"
                            3 => "J&#46;D&#46; Goldsmith"
                            4 => "J&#46;T&#46; Roland"
                            5 => "W&#46;I&#46; Lencer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2018"
                        "volumen" => "154"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic diarrhoea caused by monosaccharide malabsorption"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Lindquist&#46;F B"
                            1 => "Meeuwisse&#46;F G&#46;W"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1651-2227.1962.tb06600.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Paediatr"
                        "fecha" => "1962"
                        "volumen" => "51"
                        "paginaInicial" => "674"
                        "paginaFinal" => "685"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13930819"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defects in Na&#43;&#47;glucose cotransporter &#40;SGLT1&#41; trafficking and function cause glucose&#8211;galactose malabsorption"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;G&#46; Mart&#237;n"
                            1 => "E&#46; Turk"
                            2 => "M&#46;P&#46; Lostao"
                            3 => "C&#46; Kerner"
                            4 => "E&#46;M&#46; Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng0296-216"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1996"
                        "volumen" => "12"
                        "paginaInicial" => "216"
                        "paginaFinal" => "220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8563765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nutrition management of congenital glucose&#8211;galactose malabsorption&#58; a case study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Abad-Sinden"
                            1 => "S&#46; Borowitz"
                            2 => "R&#46; Meyers"
                            3 => "J&#46; Sutphen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0002-8223(97)00342-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Diet Assoc"
                        "fecha" => "1997"
                        "volumen" => "97"
                        "paginaInicial" => "1417"
                        "paginaFinal" => "1421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9404340"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human gene mutation database &#40;HGMD&#41;&#58; 2003 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;D&#46; Stenson"
                            1 => "E&#46;V&#46; Ball"
                            2 => "M&#46; Mort"
                            3 => "A&#46;D&#46; Phillips"
                            4 => "J&#46;A&#46; Shiel"
                            5 => "N&#46;S&#46;T&#46; Thomas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/humu.10212"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mutat"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "577"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12754702"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple sequence variations in SLC5A1 gene are associated with glucose&#8211;galactose malabsorption in a large cohort of Old Order Amish"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46; Xin"
                            1 => "H&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1399-0004.2010.01440.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Genet"
                        "fecha" => "2011"
                        "volumen" => "79"
                        "paginaInicial" => "86"
                        "paginaFinal" => "91"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20486940"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/23412879/0000009200000002/v2_202002150708/S234128791930225X/v2_202002150708/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "38181"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009200000002/v2_202002150708/S234128791930225X/v2_202002150708/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S234128791930225X?idApp=UINPBA00005H"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Scientific Letter
Glucose and galactose malabsorption: A new case in Spain
Malabsorción de glucosa y galactosa. Nuevo caso en España
Blanca Lodoso-Torrecillaa, Guiomar Perez de Nanclaresb,
Corresponding author
gnanclares@osakidetza.eus

Corresponding author.
, Intza Garinc, Ariane Calvo-Saezd, Idoya Martinez-Fernandez de Pinedoa
a Grupo de Investigación en Enfermedades Raras, Unidad Neonatal, Servicio de Pediatría, Instituto de Investigación Sanitaria BioAraba, OSI Araba, Vitoria-Gasteiz, Spain
b Grupo de Investigación de Enfermedades Raras, Laboratorio de (Epi)Genética Molecular, Instituto de Investigación Sanitaria BioAraba, OSI Araba-Txagorritxu, Vitoria-Gasteiz, Spain
c Laboratorio de Genética, UGC Laboratorio, OSI Araba, Vitoria-Gasteiz, Spain
d Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, OSI Araba, Vitoria-Gasteiz, Spain
Read
5565
Times
was read the article
1694
Total PDF
3871
Total HTML
Share statistics
 array:24 [
  "pii" => "S234128791930225X"
  "issn" => "23412879"
  "doi" => "10.1016/j.anpede.2018.12.011"
  "estado" => "S300"
  "fechaPublicacion" => "2020-02-01"
  "aid" => "2576"
  "copyright" => "Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "An Pediatr &#40;Barc&#41;. 2020;92:104-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 82
    "formatos" => array:3 [
      "EPUB" => 8
      "HTML" => 58
      "PDF" => 16
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2341287920300053"
    "issn" => "23412879"
    "doi" => "10.1016/j.anpede.2018.10.014"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "2648"
    "copyright" => "Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "An Pediatr &#40;Barc&#41;. 2020;92:105-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 48
      "formatos" => array:3 [
        "EPUB" => 5
        "HTML" => 34
        "PDF" => 9
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Advances in the diagnosis of ocular toxoplasmosis&#58; Use of optical coherence tomography"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "105"
          "paginaFinal" => "107"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Novedades para el diagn&#243;stico de la toxoplasmosis ocular&#58; uso de la tomograf&#237;a de coherencia &#243;ptica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 578
              "Ancho" => 1500
              "Tamanyo" => 65220
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0010"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#41; OCT image&#46; Cystic spaces in the inner layer of the retina&#46; Cystic spaces are a frequent finding in patients with toxoplasmosis and considered a complication &#40;parasite-filled cysts or signs of local inflammation or exudates&#41;&#46; B&#41; Photograph of the eye fundus showing the paramacular chorioretinal scar in the nasal fundus&#44; consistent with the OCT findings&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Tessie Ferrer Mellor, Bel&#233;n Sevilla P&#233;rez, Javier Lacorzana, Beatriz Bravo Manche&#241;o, Jose Lu&#237;s Garc&#237;a Serrano"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Tessie"
              "apellidos" => "Ferrer Mellor"
            ]
            1 => array:2 [
              "nombre" => "Bel&#233;n"
              "apellidos" => "Sevilla P&#233;rez"
            ]
            2 => array:2 [
              "nombre" => "Javier"
              "apellidos" => "Lacorzana"
            ]
            3 => array:2 [
              "nombre" => "Beatriz"
              "apellidos" => "Bravo Manche&#241;o"
            ]
            4 => array:2 [
              "nombre" => "Jose Lu&#237;s"
              "apellidos" => "Garc&#237;a Serrano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1695403319301754"
        "doi" => "10.1016/j.anpedi.2018.10.023"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319301754?idApp=UINPBA00005H"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287920300053?idApp=UINPBA00005H"
    "url" => "/23412879/0000009200000002/v2_202002150708/S2341287920300053/v2_202002150708/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2341287919302327"
    "issn" => "23412879"
    "doi" => "10.1016/j.anpede.2018.12.012"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "2582"
    "copyright" => "Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "An Pediatr &#40;Barc&#41;. 2020;92:102-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 42
      "formatos" => array:3 [
        "EPUB" => 3
        "HTML" => 31
        "PDF" => 8
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Percutaneous shunt closure in patients with nickel allergy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "102"
          "paginaFinal" => "104"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Cierre percut&#225;neo de shunts en pacientes al&#233;rgicos al n&#237;quel"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 839
              "Ancho" => 1250
              "Tamanyo" => 147579
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0045"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Photograph of the anterior region of the thorax and the abdomen demonstrating the lack of cutaneous reactions after contact with different percutaneous ASD closure devices&#58; Amplatzer Septal Occluder &#40;top left&#41;&#59; Figulla ASD Occluder &#40;top right&#41;&#59; Cardia Ultrasept &#40;bottom left&#41; and Gore Septal Occluder &#40;bottom right&#41;&#46; &#40;b&#41; Photograph illustrating the method used to affix the devices to the skin&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marc Figueras-Coll, Anna Sabat&#233;-Rot&#233;s, Gerard Mart&#237;-Aguasca, Marc Roguera-Sopena, Pedro Betri&#225;n-Blasco"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Marc"
              "apellidos" => "Figueras-Coll"
            ]
            1 => array:2 [
              "nombre" => "Anna"
              "apellidos" => "Sabat&#233;-Rot&#233;s"
            ]
            2 => array:2 [
              "nombre" => "Gerard"
              "apellidos" => "Mart&#237;-Aguasca"
            ]
            3 => array:2 [
              "nombre" => "Marc"
              "apellidos" => "Roguera-Sopena"
            ]
            4 => array:2 [
              "nombre" => "Pedro"
              "apellidos" => "Betri&#225;n-Blasco"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1695403319300098"
        "doi" => "10.1016/j.anpedi.2018.12.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319300098?idApp=UINPBA00005H"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919302327?idApp=UINPBA00005H"
    "url" => "/23412879/0000009200000002/v2_202002150708/S2341287919302327/v2_202002150708/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
    "titulo" => "Glucose and galactose malabsorption&#58; A new case in Spain"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "104"
        "paginaFinal" => "105"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Blanca Lodoso-Torrecilla, Guiomar Perez de Nanclares, Intza Garin, Ariane Calvo-Saez, Idoya Martinez-Fernandez de Pinedo"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "Blanca"
            "apellidos" => "Lodoso-Torrecilla"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Guiomar"
            "apellidos" => "Perez de Nanclares"
            "email" => array:1 [
              0 => "gnanclares@osakidetza.eus"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Intza"
            "apellidos" => "Garin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ariane"
            "apellidos" => "Calvo-Saez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Idoya"
            "apellidos" => "Martinez-Fernandez de Pinedo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Grupo de Investigaci&#243;n en Enfermedades Raras&#44; Unidad Neonatal&#44; Servicio de Pediatr&#237;a&#44; Instituto de Investigaci&#243;n Sanitaria BioAraba&#44; OSI Araba&#44; Vitoria-Gasteiz&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Grupo de Investigaci&#243;n de Enfermedades Raras&#44; Laboratorio de &#40;Epi&#41;Gen&#233;tica Molecular&#44; Instituto de Investigaci&#243;n Sanitaria BioAraba&#44; OSI Araba-Txagorritxu&#44; Vitoria-Gasteiz&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Laboratorio de Gen&#233;tica&#44; UGC Laboratorio&#44; OSI Araba&#44; Vitoria-Gasteiz&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Secci&#243;n de Gastroenterolog&#237;a&#44; Hepatolog&#237;a y Nutrici&#243;n Pedi&#225;trica&#44; OSI Araba&#44; Vitoria-Gasteiz&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Malabsorci&#243;n de glucosa y galactosa&#46; Nuevo caso en Espa&#241;a"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Congenital diarrhoea refers to a heterogeneous group of enteropathies that cause symptoms from the first few days of life&#44; and it may be the only manifestation or one of the symptoms of a systemic disease&#46; In most cases&#44; early treatment is necessary to prevent dehydration&#44; given the potential complications of the latter&#46; The first step in the differential diagnosis is to differentiate between secretory and osmotic diarrhoea&#58; in the former&#44; the diarrhoeal output does not improve with a nil per os trial&#44; whereas in the latter it does&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a male newborn aged 2 days admitted to the neonatal unit with hyperbilirubinaemia&#46; The parents were Pakistani and reported consanguinity&#46; The newborn was a product of a monochorionic-diamniotic twin pregnancy and had been born second at 36 weeks&#8217; gestation with a weight of 2460<span class="elsevierStyleHsp" style=""></span>g&#46; He was receiving artificial formula following the wishes of the mother&#46; On admission to the neonatal unit&#44; the physical examination revealed a 15&#37; weight loss&#44; jaundice extending to Kramer&#39;s zone 3 and a dry oral mucosa&#44; with no other abnormal findings&#46; Blood tests revealed hyperbilirubinaemia on account of elevation of indirect bilirubin and dehydration with hypernatraemia and hyperchloraemia &#40;urea&#44; 49<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; creatinine&#44; 1&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; sodium&#44; 163<span class="elsevierStyleHsp" style=""></span>mEq&#47;L&#59; chloride&#44; 132<span class="elsevierStyleHsp" style=""></span>mEq&#47;L&#41; and metabolic acidosis &#40;pH&#44; 7&#46;30&#59; bicarbonate&#44; 18&#46;7<span class="elsevierStyleHsp" style=""></span>mM&#59; base excess&#44; 7<span class="elsevierStyleHsp" style=""></span>mM&#59; lactate&#44; 3&#46;9<span class="elsevierStyleHsp" style=""></span>mM&#41;&#46; Phototherapy was initiated&#44; along with placement of a peripheral catheter for intravenous fluid replacement&#44; while the patient continued to receive artificial formula&#46; The diarrhoeal output continued to be very high&#44; leading to prescription of nil per os&#44; which achieved resolution of the diarrhoea&#46; The analysis of stool samples revealed an acidic pH and the presence of reducing bodies&#46; In the following days&#44; several attempts were made to reintroduce oral feedings&#44; first with elemental formula and later with a soy-based formula&#44; with diarrhoea recurring in both instances as the feeding volume increased&#46; Eventually&#44; the newborn was given a fructose-based formula with no other carbohydrates&#44; to which he responded favourably&#46; Increases in feeding volume did not create problems&#44; and the boy started producing normal stools and exhibiting adequate weight gain&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In this case&#44; since the patient improved with fasting&#44; the diarrhoea was classified as osmotic&#44; and the presence of reducing bodies in the stool suggested that the congenital diarrhoea could be due to carbohydrate malabsorption&#46; Since the patient did not improve with the soy formula&#44; we suspected glucose&#8211;galactose malabsorption&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> as soy formulas do not contain galactose but do contain glucose&#46; In fact&#44; upon switching to a formula in which the sole carbohydrate was fructose&#44; the newborn responded well&#44; which supported our clinical suspicion&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Congenital glucose&#8211;galactose malabsorption &#40;cGGM&#41; is a rare autosomal recessive disorder characterised by changes in the <span class="elsevierStyleItalic">SLC5A1</span> gene that encodes the protein SGLT1&#44; responsible for transporting glucose and galactose from the intestinal lumen into intestinal cells&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Sequencing of this gene in the patient revealed the homozygous mutation c&#46;875G&#62;A &#40;p&#46;C292Y&#41;&#44; previously described as a pathogenic variant&#44; as it impacts the location and function of the protein&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> thus confirming the diagnosis&#46; Microsatellite genotyping confirmed that the twins were dizygotic&#44; which explained the clinical differences between the two&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Congenital glucose&#8211;galactose malabsorption is characterised by severe diarrhoea and dehydration from the first day of life&#44; which can quickly result in the death of the infant if glucose&#44; galactose and the disaccharides that contain them are not removed from the diet&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Approximately 300 cases have been diagnosed worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Treatment consists in the elimination of glucose and galactose from the diet&#44; substituting a fructose-based formula&#44; which achieves resolution of diarrhoea&#46; Some authors have proposed that cGGM improves over time as the intestinal flora adapts&#44; and it appears that administration of <span class="elsevierStyleItalic">Lactobacillus acidophilus</span> helps shorten the time that carbohydrates need to be restricted&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> However&#44; there are no prospective studies in the literature establishing how to identify which patients will develop tolerance and which will remain intolerant for life&#44; so we currently recommend that older children and adults consume a diet where fructose is the sole source of carbohydrates until tolerance can be evaluated&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lodoso-Torrecilla B&#44; Perez de Nanclares G&#44; Garin I&#44; Calvo-Saez A&#44; Martinez-Fernandez de Pinedo I&#46; Malabsorci&#243;n de glucosa y galactosa&#46; Nuevo caso en Espa&#241;a&#46; An Pediatr &#40;Barc&#41;&#46; 2020&#59;92&#58;104&#8211;105&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advances in evaluation of chronic diarrhea in infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;R&#46; Thiagarajah"
                            1 => "D&#46;S&#46; Kamin"
                            2 => "S&#46; Acra"
                            3 => "J&#46;D&#46; Goldsmith"
                            4 => "J&#46;T&#46; Roland"
                            5 => "W&#46;I&#46; Lencer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2018"
                        "volumen" => "154"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic diarrhoea caused by monosaccharide malabsorption"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Lindquist&#46;F B"
                            1 => "Meeuwisse&#46;F G&#46;W"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1651-2227.1962.tb06600.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Paediatr"
                        "fecha" => "1962"
                        "volumen" => "51"
                        "paginaInicial" => "674"
                        "paginaFinal" => "685"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13930819"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defects in Na&#43;&#47;glucose cotransporter &#40;SGLT1&#41; trafficking and function cause glucose&#8211;galactose malabsorption"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;G&#46; Mart&#237;n"
                            1 => "E&#46; Turk"
                            2 => "M&#46;P&#46; Lostao"
                            3 => "C&#46; Kerner"
                            4 => "E&#46;M&#46; Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng0296-216"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1996"
                        "volumen" => "12"
                        "paginaInicial" => "216"
                        "paginaFinal" => "220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8563765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nutrition management of congenital glucose&#8211;galactose malabsorption&#58; a case study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Abad-Sinden"
                            1 => "S&#46; Borowitz"
                            2 => "R&#46; Meyers"
                            3 => "J&#46; Sutphen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0002-8223(97)00342-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Diet Assoc"
                        "fecha" => "1997"
                        "volumen" => "97"
                        "paginaInicial" => "1417"
                        "paginaFinal" => "1421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9404340"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human gene mutation database &#40;HGMD&#41;&#58; 2003 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;D&#46; Stenson"
                            1 => "E&#46;V&#46; Ball"
                            2 => "M&#46; Mort"
                            3 => "A&#46;D&#46; Phillips"
                            4 => "J&#46;A&#46; Shiel"
                            5 => "N&#46;S&#46;T&#46; Thomas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/humu.10212"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mutat"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "577"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12754702"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple sequence variations in SLC5A1 gene are associated with glucose&#8211;galactose malabsorption in a large cohort of Old Order Amish"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46; Xin"
                            1 => "H&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1399-0004.2010.01440.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Genet"
                        "fecha" => "2011"
                        "volumen" => "79"
                        "paginaInicial" => "86"
                        "paginaFinal" => "91"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20486940"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/23412879/0000009200000002/v2_202002150708/S234128791930225X/v2_202002150708/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "38181"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009200000002/v2_202002150708/S234128791930225X/v2_202002150708/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S234128791930225X?idApp=UINPBA00005H"
]
Article information
ISSN: 23412879
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 16 9 25
2024 October 56 45 101
2024 September 69 42 111
2024 August 82 62 144
2024 July 70 43 113
2024 June 58 31 89
2024 May 74 45 119
2024 April 59 27 86
2024 March 68 19 87
2024 February 83 37 120
2024 January 67 21 88
2023 December 105 32 137
2023 November 83 35 118
2023 October 85 46 131
2023 September 68 27 95
2023 August 69 37 106
2023 July 75 23 98
2023 June 86 26 112
2023 May 75 22 97
2023 April 41 12 53
2023 March 52 23 75
2023 February 71 9 80
2023 January 54 20 74
2022 December 71 26 97
2022 November 55 31 86
2022 October 65 49 114
2022 September 71 25 96
2022 August 84 45 129
2022 July 112 34 146
2022 June 43 28 71
2022 May 82 23 105
2022 April 40 23 63
2022 March 73 38 111
2022 February 50 20 70
2022 January 70 23 93
2021 December 47 35 82
2021 November 72 65 137
2021 October 115 49 164
2021 September 58 31 89
2021 August 108 35 143
2021 July 67 32 99
2021 June 74 31 105
2021 May 72 33 105
2021 April 160 61 221
2021 March 72 31 103
2021 February 53 23 76
2021 January 73 18 91
2020 December 60 21 81
2020 November 51 24 75
2020 October 49 15 64
2020 September 39 20 59
2020 August 29 13 42
2020 July 47 19 66
2020 June 34 11 45
2020 May 34 13 47
2020 April 39 8 47
2020 March 55 16 71
2020 February 52 23 75
2020 January 29 9 38
Show all

Follow this link to access the full text of the article

Idiomas
Anales de Pediatría (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?