was read the article
array:25 [ "pii" => "S2341287919301802" "issn" => "23412879" "doi" => "10.1016/j.anpede.2019.01.017" "estado" => "S300" "fechaPublicacion" => "2019-12-01" "aid" => "2606" "copyright" => "Asociación Española de Pediatría" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2019;91:410-1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 169 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 113 "PDF" => 37 ] ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S1695403319300694" "issn" => "16954033" "doi" => "10.1016/j.anpedi.2019.01.018" "estado" => "S300" "fechaPublicacion" => "2019-12-01" "aid" => "2606" "copyright" => "Asociación Española de Pediatría" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2019;91:410-1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1942 "formatos" => array:3 [ "EPUB" => 114 "HTML" => 1427 "PDF" => 401 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científica</span>" "titulo" => "Urticaria por frío y enfermedad celiaca en paciente pediátrico" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "410" "paginaFinal" => "411" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cold urticaria and coeliac disease in a paediatric patient" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alejandra Méndez Sánchez, Alicia Isabel Pascual Pérez, Maria Antonia Vázquez Piñera, Porfirio Fernández González" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Alejandra" "apellidos" => "Méndez Sánchez" ] 1 => array:2 [ "nombre" => "Alicia Isabel" "apellidos" => "Pascual Pérez" ] 2 => array:2 [ "nombre" => "Maria Antonia" "apellidos" => "Vázquez Piñera" ] 3 => array:2 [ "nombre" => "Porfirio" "apellidos" => "Fernández González" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2341287919301802" "doi" => "10.1016/j.anpede.2019.01.017" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919301802?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319300694?idApp=UINPBA00005H" "url" => "/16954033/0000009100000006/v2_201912170939/S1695403319300694/v2_201912170939/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2341287919301760" "issn" => "23412879" "doi" => "10.1016/j.anpede.2019.01.016" "estado" => "S300" "fechaPublicacion" => "2019-12-01" "aid" => "2598" "copyright" => "Asociación Española de Pediatría" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2019;91:411-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 175 "formatos" => array:3 [ "EPUB" => 30 "HTML" => 109 "PDF" => 36 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Takayasu arteritis of atypical presentation. Tocilizumab as an alternative therapeutic option" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "411" "paginaFinal" => "413" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Arteritis de Takayasu de presentación atípica. Tocilizumab como alternativa terapéutica" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 755 "Ancho" => 1500 "Tamanyo" => 127883 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Computed tomography angiogram. Stenosis of left subclavian and vertebral arteries, abdominal aorta and right renal arteries. (B) Arteriogram of the aorta. Right kidney with renal artery bifurcation and critical stenosis in the ostium, and left kidney with no signs of stenosis of the renal artery.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Zaira Cubiles Arillo, Esmeralda Núñez Cuadros, Verónica Martínez Rivera, José Manuel González Gómez, Victorio Cuenca Peiró" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Zaira" "apellidos" => "Cubiles Arillo" ] 1 => array:2 [ "nombre" => "Esmeralda" "apellidos" => "Núñez Cuadros" ] 2 => array:2 [ "nombre" => "Verónica" "apellidos" => "Martínez Rivera" ] 3 => array:2 [ "nombre" => "José Manuel" "apellidos" => "González Gómez" ] 4 => array:2 [ "nombre" => "Victorio" "apellidos" => "Cuenca Peiró" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1695403319300293" "doi" => "10.1016/j.anpedi.2019.01.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319300293?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919301760?idApp=UINPBA00005H" "url" => "/23412879/0000009100000006/v1_201912080648/S2341287919301760/v1_201912080648/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2341287919301838" "issn" => "23412879" "doi" => "10.1016/j.anpede.2018.12.010" "estado" => "S300" "fechaPublicacion" => "2019-12-01" "aid" => "2581" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "An Pediatr (Barc). 2019;91:408-10" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 145 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 97 "PDF" => 31 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Usefulness of a specialised primary immunodeficiencies clinic" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "408" "paginaFinal" => "410" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilidad de una consulta especializada en inmunodeficiencias primarias" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 732 "Ancho" => 1467 "Tamanyo" => 75549 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Personal and family history in children in who PID was confirmed and ruled out.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Claudia Millán-Longo, Paula Rodríguez Molino, Teresa del Rosal Rabes, Dolores Corral Sánchez, Ana Méndez Echevarría" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Claudia" "apellidos" => "Millán-Longo" ] 1 => array:2 [ "nombre" => "Paula" "apellidos" => "Rodríguez Molino" ] 2 => array:2 [ "nombre" => "Teresa" "apellidos" => "del Rosal Rabes" ] 3 => array:2 [ "nombre" => "Dolores" "apellidos" => "Corral Sánchez" ] 4 => array:2 [ "nombre" => "Ana" "apellidos" => "Méndez Echevarría" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1695403319300086" "doi" => "10.1016/j.anpedi.2018.12.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1695403319300086?idApp=UINPBA00005H" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919301838?idApp=UINPBA00005H" "url" => "/23412879/0000009100000006/v1_201912080648/S2341287919301838/v1_201912080648/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Cold urticaria and coeliac disease in a paediatric patient" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "410" "paginaFinal" => "411" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Alejandra Méndez Sánchez, Alicia Isabel Pascual Pérez, Maria Antonia Vázquez Piñera, Porfirio Fernández González" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Alejandra" "apellidos" => "Méndez Sánchez" "email" => array:1 [ 0 => "amendezarboleya@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Alicia Isabel" "apellidos" => "Pascual Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Maria Antonia" "apellidos" => "Vázquez Piñera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Porfirio" "apellidos" => "Fernández González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Alergia Infantil, Área de Gestión Clínica de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Gastroenterología Infantil, Área de Gestión Clínica de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Urticaria por frío y enfermedad celiaca en paciente pediátrico" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cold urticaria (CU) is a chronic form of urticaria that may be associated with various systemic disorders. Coeliac disease (CD) is also commonly associated with other disorders, usually of the immune system.</p><p id="par0010" class="elsevierStylePara elsevierViewall">To date, there have been several descriptions of the association between CD and chronic idiopathic urticaria in children,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> but we only found 1 case in the reviewed literature with diagnosis of CD in a patient with a previous history of CU where the cutaneous manifestations improved after excluding gluten from the diet.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Given the current scarcity in the literature of data on the association between these two conditions, we considered that the description of this case of diagnosis of CD in the context of CU would be of interest.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was a boy aged 5 years assessed due to episodes of urticaria in areas of the body exposed to environmental coldness with onset 2 months prior, manifesting with nasal itching in the absence of other mucosal, cutaneous, respiratory or gastrointestinal symptoms, and improving on returning to warmer settings. The episodes occurred in the absence of previous exercise, intake of drugs or intercurrent infection. The patient did not experience symptoms after bathing in the sea or a pool. The personal and family histories were unremarkable except for a history of rhinitis, hay fever and penicillin allergy in the mother.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient had a positive ice cube challenge and received a diagnosis of CU. Further tests included a complete blood count and chemistry panel, measurement of basal tryptase, C-reactive protein, thyroid-stimulating hormone, free thyroxine, anti-thyroid stimulating immunoglobulin and total IgE, total complement test (C3, C4 and C1 inhibitor) and determination of immunoglobulins, antinuclear antibodies, rheumatoid factor and cryoglobulins, all with normal results. The salient findings were serum levels of deamidated antigliadin (DMG) IgG antibodies of 7.3<span class="elsevierStyleHsp" style=""></span>AU/mL, anti-transglutaminase antibodies (ATA) IgA 11.6<span class="elsevierStyleHsp" style=""></span>AU/mL and anti-thyroid peroxidase (anti-TPO) antibodies of 63<span class="elsevierStyleHsp" style=""></span>IU/mL. The patient was instructed to take measures to avoid the cold and to maintain his usual diet without restrictions.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Three months later the patient remained free of gastrointestinal or systemic manifestations and occasionally exhibited very mild facial urticaria after exposure to cold. Laboratory tests revealed levels of DMG IgG of 58<span class="elsevierStyleHsp" style=""></span>AU/mL, ATA IgA of 66<span class="elsevierStyleHsp" style=""></span>AU/mL, ATA IgA greater than 200<span class="elsevierStyleHsp" style=""></span>AU/mL, with a positive result for detection of anti-endomysial antibodies (EMA) (titre of 1:160) and molecular detection of HLADQ2 (DQA1*05 B1*02) suggestive of sensitivity to gluten. The thyroid function was normal, with a negative result for anti-TSI and a level of anti-TPO of 54<span class="elsevierStyleHsp" style=""></span>IU/mL.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient received a diagnosis of CD and was prescribed a gluten-free diet, after which he exhibited a progressive decrease in the antibody levels, reaching normal values at 10 months, with improvement of cutaneous symptoms.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Cold urticaria is the fourth most frequent cause of chronic urticaria, with an estimated incidence of 0.05%. It can develop at any age, with a higher prevalence between ages 18 and 25 years and a predominance of the female sex (2:1). The diagnosis is based on a compatible history with development of symptoms on exposure to cold stimuli (environment, oral intake, contact) and a positive ice cube challenge. It can be inherited or acquired, and primary or secondary to systemic disorders (such as cryoglobulinemia, vasculitis, infection, hypothyroidism or blood disorders).<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Coeliac disease mainly affects individuals with a genetic predisposition (HLA DQ2/DQ8) and is frequently associated with other immune disorders, such as chronic idiopathic urticaria, diabetes type 1 or autoimmune thyroiditis, among others. In the case presented here, the diagnosis of CD was made based on the ESPGHAN5 criteria (presence of symptoms, HLA DQ2 haplotype, an ATA IgA value more than tenfold the upper limit of normal and a second positive marker [EMA]) without performance of a biopsy.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Our patient exhibited typical clinical features of CU without manifestations suggestive of CD. Subsequent follow-up evaluations detected a progressive increase in serum markers of CD, which improved after exclusion of gluten from the diet. The pattern of cutaneous symptoms paralleled the changes in serum markers of CD.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The immune mechanisms underlying chronic urticaria and CD are different (Th2 and Th1 responses, respectively).<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4,5</span></a> A hypothesis proposed to explain cases where both disorders are associated is that the increased bowel permeability secondary to inflammatory infiltration in CD would allow passage of antigens to the blood and the formation of circulating immune complexes believed to be involved in the pathogenesis of chronic urticaria. Additional mechanisms have been proposed, such as the formation of anaphylatoxins triggered by the production of antibodies, which in turn induce the degranulation of mast cells and basophils.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Recent reviews of cases of chronic urticaria have concluded that routine performance of a broad array of diagnostic tests offers a poor yield for diagnosis of associated diseases, and that performance of tests based on the findings of the history taking and/or the physical examination is more useful.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">This case study, along with other reported cases, encourage considering the addition of screening for CD in children with CU to the history taking and physical examination, and other diagnostic tests in case of suggestive findings.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Méndez Sánchez A, Pascual Pérez AI, Vázquez Piñera MA, Fernández González P. Urticaria por frío y enfermedad celiaca en paciente pediátrico. Arch Bronconeumol. 2019;91:410–411.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic urticaria and associated coeliac disease in children: A case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Caminiti" 1 => "G. Passalacqua" 2 => "G. Magazzù" 3 => "F. Comisi" 4 => "D. Vita" 5 => "G. Barberio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ped Allergy Immunol" "fecha" => "2005" "volumen" => "16" "paginaInicial" => "428" "paginaFinal" => "432" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cold urticaria and celiac disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Pedrosa Delgado" 1 => "F. Martin Muñoz" 2 => "I. Polanco Allué" 3 => "M. Martin Esteban" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Investig Allergol Clin Immunol" "fecha" => "2008" "volumen" => "18" "paginaInicial" => "123" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18447142" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cold-induced urticaria: challenges in diagnosis and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.F. Hochstadter" 1 => "M. Ben-Shoshan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bcr-2013-010441" "Revista" => array:3 [ "tituloSerie" => "BMJ Case Rep" "fecha" => "2013" "volumen" => "8" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European society for pediatric gastroenterology hepatology, and nutrition guidelines for the diagnosis of coeliac disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Husby" 1 => "S. Koletzko" 2 => "I.R. Korponay-Szabó" 3 => "M.L. Mearin" 4 => "A. Phillips" 5 => "R. Shamir" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0b013e31821a23d0" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2012" "volumen" => "54" "paginaInicial" => "136" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22197856" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic urticaria and celiac disease: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.G. Peroni" 1 => "G. Parola" 2 => "L. Tenero" 3 => "M. Fornaro" 4 => "A. Bodini" 5 => "F. Pollini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1525-1470.2009.01066.x" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol" "fecha" => "2010" "volumen" => "27" "paginaInicial" => "108" "paginaFinal" => "109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20199432" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laboratory tests and identified diagnoses in patients with physical and chronic urticaria and angioedema: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.M. Kozel" 1 => "P.M. Bossuyt" 2 => "J.R. Mekkes" 3 => "J.D. Bos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mjd.2003.142" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2003" "volumen" => "48" "paginaInicial" => "409" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12637921" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000009100000006/v1_201912080648/S2341287919301802/v1_201912080648/en/main.assets" "Apartado" => array:4 [ "identificador" => "38181" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000009100000006/v1_201912080648/S2341287919301802/v1_201912080648/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287919301802?idApp=UINPBA00005H" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 11 | 11 | 22 |
2024 October | 106 | 38 | 144 |
2024 September | 90 | 39 | 129 |
2024 August | 129 | 81 | 210 |
2024 July | 134 | 45 | 179 |
2024 June | 96 | 38 | 134 |
2024 May | 100 | 35 | 135 |
2024 April | 70 | 39 | 109 |
2024 March | 90 | 21 | 111 |
2024 February | 107 | 24 | 131 |
2024 January | 116 | 21 | 137 |
2023 December | 142 | 25 | 167 |
2023 November | 141 | 40 | 181 |
2023 October | 96 | 21 | 117 |
2023 September | 60 | 27 | 87 |
2023 August | 64 | 21 | 85 |
2023 July | 78 | 27 | 105 |
2023 June | 91 | 25 | 116 |
2023 May | 86 | 24 | 110 |
2023 April | 55 | 12 | 67 |
2023 March | 86 | 20 | 106 |
2023 February | 64 | 12 | 76 |
2023 January | 47 | 15 | 62 |
2022 December | 83 | 17 | 100 |
2022 November | 78 | 23 | 101 |
2022 October | 79 | 52 | 131 |
2022 September | 68 | 13 | 81 |
2022 August | 72 | 46 | 118 |
2022 July | 65 | 30 | 95 |
2022 June | 58 | 29 | 87 |
2022 May | 59 | 26 | 85 |
2022 April | 74 | 30 | 104 |
2022 March | 102 | 36 | 138 |
2022 February | 93 | 18 | 111 |
2022 January | 91 | 28 | 119 |
2021 December | 70 | 38 | 108 |
2021 November | 75 | 37 | 112 |
2021 October | 121 | 64 | 185 |
2021 September | 75 | 30 | 105 |
2021 August | 67 | 41 | 108 |
2021 July | 61 | 26 | 87 |
2021 June | 46 | 47 | 93 |
2021 May | 51 | 33 | 84 |
2021 April | 155 | 91 | 246 |
2021 March | 93 | 22 | 115 |
2021 February | 53 | 24 | 77 |
2021 January | 77 | 21 | 98 |
2020 December | 62 | 5 | 67 |
2020 November | 37 | 18 | 55 |
2020 October | 43 | 20 | 63 |
2020 September | 78 | 16 | 94 |
2020 August | 77 | 28 | 105 |
2020 July | 60 | 27 | 87 |
2020 June | 27 | 21 | 48 |
2020 May | 34 | 16 | 50 |
2020 April | 14 | 8 | 22 |
2020 March | 44 | 12 | 56 |
2020 February | 36 | 19 | 55 |
2020 January | 24 | 9 | 33 |
2019 December | 55 | 20 | 75 |
2019 November | 15 | 4 | 19 |