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we considered that the description of this case of diagnosis of CD in the context of CU would be of interest&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was a boy aged 5 years assessed due to episodes of urticaria in areas of the body exposed to environmental coldness with onset 2 months prior&#44; manifesting with nasal itching in the absence of other mucosal&#44; cutaneous&#44; respiratory or gastrointestinal symptoms&#44; and improving on returning to warmer settings&#46; The episodes occurred in the absence of previous exercise&#44; intake of drugs or intercurrent infection&#46; The patient did not experience symptoms after bathing in the sea or a pool&#46; The personal and family histories were unremarkable except for a history of rhinitis&#44; hay fever and penicillin allergy in the mother&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient had a positive ice cube challenge and received a diagnosis of CU&#46; Further tests included a complete blood count and chemistry panel&#44; measurement of basal tryptase&#44; C-reactive protein&#44; thyroid-stimulating hormone&#44; free thyroxine&#44; anti-thyroid stimulating immunoglobulin and total IgE&#44; total complement test &#40;C3&#44; C4 and C1 inhibitor&#41; and determination of immunoglobulins&#44; antinuclear antibodies&#44; rheumatoid factor and cryoglobulins&#44; all with normal results&#46; The salient findings were serum levels of deamidated antigliadin &#40;DMG&#41; IgG antibodies of 7&#46;3<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#44; anti-transglutaminase antibodies &#40;ATA&#41; IgA 11&#46;6<span class="elsevierStyleHsp" style=""></span>AU&#47;mL and anti-thyroid peroxidase &#40;anti-TPO&#41; antibodies of 63<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#46; The patient was instructed to take measures to avoid the cold and to maintain his usual diet without restrictions&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Three months later the patient remained free of gastrointestinal or systemic manifestations and occasionally exhibited very mild facial urticaria after exposure to cold&#46; Laboratory tests revealed levels of DMG IgG of 58<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#44; ATA IgA of 66<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#44; ATA IgA greater than 200<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#44; with a positive result for detection of anti-endomysial antibodies &#40;EMA&#41; &#40;titre of 1&#58;160&#41; and molecular detection of HLADQ2 &#40;DQA1&#42;05 B1&#42;02&#41; suggestive of sensitivity to gluten&#46; The thyroid function was normal&#44; with a negative result for anti-TSI and a level of anti-TPO of 54<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient received a diagnosis of CD and was prescribed a gluten-free diet&#44; after which he exhibited a progressive decrease in the antibody levels&#44; reaching normal values at 10 months&#44; with improvement of cutaneous symptoms&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Cold urticaria is the fourth most frequent cause of chronic urticaria&#44; with an estimated incidence of 0&#46;05&#37;&#46; It can develop at any age&#44; with a higher prevalence between ages 18 and 25 years and a predominance of the female sex &#40;2&#58;1&#41;&#46; The diagnosis is based on a compatible history with development of symptoms on exposure to cold stimuli &#40;environment&#44; oral intake&#44; contact&#41; and a positive ice cube challenge&#46; It can be inherited or acquired&#44; and primary or secondary to systemic disorders &#40;such as cryoglobulinemia&#44; vasculitis&#44; infection&#44; hypothyroidism or blood disorders&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Coeliac disease mainly affects individuals with a genetic predisposition &#40;HLA DQ2&#47;DQ8&#41; and is frequently associated with other immune disorders&#44; such as chronic idiopathic urticaria&#44; diabetes type 1 or autoimmune thyroiditis&#44; among others&#46; In the case presented here&#44; the diagnosis of CD was made based on the ESPGHAN5 criteria &#40;presence of symptoms&#44; HLA DQ2 haplotype&#44; an ATA IgA value more than tenfold the upper limit of normal and a second positive marker &#91;EMA&#93;&#41; without performance of a biopsy&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Our patient exhibited typical clinical features of CU without manifestations suggestive of CD&#46; Subsequent follow-up evaluations detected a progressive increase in serum markers of CD&#44; which improved after exclusion of gluten from the diet&#46; The pattern of cutaneous symptoms paralleled the changes in serum markers of CD&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The immune mechanisms underlying chronic urticaria and CD are different &#40;Th2 and Th1 responses&#44; respectively&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;5</span></a> A hypothesis proposed to explain cases where both disorders are associated is that the increased bowel permeability secondary to inflammatory infiltration in CD would allow passage of antigens to the blood and the formation of circulating immune complexes believed to be involved in the pathogenesis of chronic urticaria&#46; Additional mechanisms have been proposed&#44; such as the formation of anaphylatoxins triggered by the production of antibodies&#44; which in turn induce the degranulation of mast cells and basophils&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Recent reviews of cases of chronic urticaria have concluded that routine performance of a broad array of diagnostic tests offers a poor yield for diagnosis of associated diseases&#44; and that performance of tests based on the findings of the history taking and&#47;or the physical examination is more useful&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">This case study&#44; along with other reported cases&#44; encourage considering the addition of screening for CD in children with CU to the history taking and physical examination&#44; 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Scientific Letter
Cold urticaria and coeliac disease in a paediatric patient
Urticaria por frío y enfermedad celiaca en paciente pediátrico
Alejandra Méndez Sáncheza,
Corresponding author
amendezarboleya@gmail.com

Corresponding author.
, Alicia Isabel Pascual Pérezb, Maria Antonia Vázquez Piñeraa, Porfirio Fernández Gonzáleza
a Unidad de Alergia Infantil, Área de Gestión Clínica de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Spain
b Unidad de Gastroenterología Infantil, Área de Gestión Clínica de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Spain
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    "titulo" => "Cold urticaria and coeliac disease in a paediatric patient"
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        "autoresLista" => "Alejandra M&#233;ndez S&#225;nchez, Alicia Isabel Pascual P&#233;rez, Maria Antonia V&#225;zquez Pi&#241;era, Porfirio Fern&#225;ndez Gonz&#225;lez"
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        "titulo" => "Urticaria por fr&#237;o y enfermedad celiaca en paciente pedi&#225;trico"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cold urticaria &#40;CU&#41; is a chronic form of urticaria that may be associated with various systemic disorders&#46; Coeliac disease &#40;CD&#41; is also commonly associated with other disorders&#44; usually of the immune system&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">To date&#44; there have been several descriptions of the association between CD and chronic idiopathic urticaria in children&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> but we only found 1 case in the reviewed literature with diagnosis of CD in a patient with a previous history of CU where the cutaneous manifestations improved after excluding gluten from the diet&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Given the current scarcity in the literature of data on the association between these two conditions&#44; we considered that the description of this case of diagnosis of CD in the context of CU would be of interest&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was a boy aged 5 years assessed due to episodes of urticaria in areas of the body exposed to environmental coldness with onset 2 months prior&#44; manifesting with nasal itching in the absence of other mucosal&#44; cutaneous&#44; respiratory or gastrointestinal symptoms&#44; and improving on returning to warmer settings&#46; The episodes occurred in the absence of previous exercise&#44; intake of drugs or intercurrent infection&#46; The patient did not experience symptoms after bathing in the sea or a pool&#46; The personal and family histories were unremarkable except for a history of rhinitis&#44; hay fever and penicillin allergy in the mother&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient had a positive ice cube challenge and received a diagnosis of CU&#46; Further tests included a complete blood count and chemistry panel&#44; measurement of basal tryptase&#44; C-reactive protein&#44; thyroid-stimulating hormone&#44; free thyroxine&#44; anti-thyroid stimulating immunoglobulin and total IgE&#44; total complement test &#40;C3&#44; C4 and C1 inhibitor&#41; and determination of immunoglobulins&#44; antinuclear antibodies&#44; rheumatoid factor and cryoglobulins&#44; all with normal results&#46; The salient findings were serum levels of deamidated antigliadin &#40;DMG&#41; IgG antibodies of 7&#46;3<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#44; anti-transglutaminase antibodies &#40;ATA&#41; IgA 11&#46;6<span class="elsevierStyleHsp" style=""></span>AU&#47;mL and anti-thyroid peroxidase &#40;anti-TPO&#41; antibodies of 63<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#46; The patient was instructed to take measures to avoid the cold and to maintain his usual diet without restrictions&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Three months later the patient remained free of gastrointestinal or systemic manifestations and occasionally exhibited very mild facial urticaria after exposure to cold&#46; Laboratory tests revealed levels of DMG IgG of 58<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#44; ATA IgA of 66<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#44; ATA IgA greater than 200<span class="elsevierStyleHsp" style=""></span>AU&#47;mL&#44; with a positive result for detection of anti-endomysial antibodies &#40;EMA&#41; &#40;titre of 1&#58;160&#41; and molecular detection of HLADQ2 &#40;DQA1&#42;05 B1&#42;02&#41; suggestive of sensitivity to gluten&#46; The thyroid function was normal&#44; with a negative result for anti-TSI and a level of anti-TPO of 54<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient received a diagnosis of CD and was prescribed a gluten-free diet&#44; after which he exhibited a progressive decrease in the antibody levels&#44; reaching normal values at 10 months&#44; with improvement of cutaneous symptoms&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Cold urticaria is the fourth most frequent cause of chronic urticaria&#44; with an estimated incidence of 0&#46;05&#37;&#46; It can develop at any age&#44; with a higher prevalence between ages 18 and 25 years and a predominance of the female sex &#40;2&#58;1&#41;&#46; The diagnosis is based on a compatible history with development of symptoms on exposure to cold stimuli &#40;environment&#44; oral intake&#44; contact&#41; and a positive ice cube challenge&#46; It can be inherited or acquired&#44; and primary or secondary to systemic disorders &#40;such as cryoglobulinemia&#44; vasculitis&#44; infection&#44; hypothyroidism or blood disorders&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Coeliac disease mainly affects individuals with a genetic predisposition &#40;HLA DQ2&#47;DQ8&#41; and is frequently associated with other immune disorders&#44; such as chronic idiopathic urticaria&#44; diabetes type 1 or autoimmune thyroiditis&#44; among others&#46; In the case presented here&#44; the diagnosis of CD was made based on the ESPGHAN5 criteria &#40;presence of symptoms&#44; HLA DQ2 haplotype&#44; an ATA IgA value more than tenfold the upper limit of normal and a second positive marker &#91;EMA&#93;&#41; without performance of a biopsy&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Our patient exhibited typical clinical features of CU without manifestations suggestive of CD&#46; Subsequent follow-up evaluations detected a progressive increase in serum markers of CD&#44; which improved after exclusion of gluten from the diet&#46; The pattern of cutaneous symptoms paralleled the changes in serum markers of CD&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The immune mechanisms underlying chronic urticaria and CD are different &#40;Th2 and Th1 responses&#44; respectively&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;5</span></a> A hypothesis proposed to explain cases where both disorders are associated is that the increased bowel permeability secondary to inflammatory infiltration in CD would allow passage of antigens to the blood and the formation of circulating immune complexes believed to be involved in the pathogenesis of chronic urticaria&#46; Additional mechanisms have been proposed&#44; such as the formation of anaphylatoxins triggered by the production of antibodies&#44; which in turn induce the degranulation of mast cells and basophils&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Recent reviews of cases of chronic urticaria have concluded that routine performance of a broad array of diagnostic tests offers a poor yield for diagnosis of associated diseases&#44; and that performance of tests based on the findings of the history taking and&#47;or the physical examination is more useful&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">This case study&#44; along with other reported cases&#44; encourage considering the addition of screening for CD in children with CU to the history taking and physical examination&#44; and other diagnostic tests in case of suggestive findings&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; M&#233;ndez S&#225;nchez A&#44; Pascual P&#233;rez AI&#44; V&#225;zquez Pi&#241;era MA&#44; Fern&#225;ndez Gonz&#225;lez P&#46; Urticaria por fr&#237;o y enfermedad celiaca en paciente pedi&#225;trico&#46; Arch Bronconeumol&#46; 2019&#59;91&#58;410&#8211;411&#46;</p>"
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