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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Food protein-induced enterocolitis syndrome &#40;FPIES&#41; is the most serious form of enteropathy&#46; The pathophysiology of this syndrome is not completely understood&#44; but it is believed that ingestion of the triggering food is followed by T-lymphocyte activation&#44; resulting in a local inflammatory response&#44; increased gastrointestinal &#40;GI&#41; permeability and subsequent passage of fluids to the GI lumen&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A boy aged 4 months visited the emergency department &#40;ED&#41; with profuse vomiting and signs of hypovolaemic shock&#46; He had been breastfed until the age of three months&#44; when supplementation with one feed of cow&#39;s milk formula a day was introduced&#46; In the two days that followed&#44; he vomited once a day right after ingesting the cow&#39;s milk&#46; On day 3&#44; he developed persistent vomiting and bloody diarrhoea and became increasingly lethargic&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the ED&#44; he presented in shock&#44; with a blood pressure of 60&#47;25<span class="elsevierStyleHsp" style=""></span>mmHg&#44; poor peripheral perfusion with cold extremities&#44; and no other abnormalities in the physical examination&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The diagnoses considered at this point were sepsis and cow&#39;s milk protein allergy&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The blood tests showed absence of leucocytosis &#40;10&#44;990&#47;&#956;L&#41; with relative neutrophilia &#40;76&#46;2&#37; neutrophils&#41;&#44; thrombocytosis &#40;645&#44;000&#47;&#956;L platelets&#41;&#44; a negative result for C-reactive protein&#44; normal levels of serum electrolytes and normal renal function&#46; There were no abnormalities in the cerebrospinal fluid or the urine&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The boy was given a bolus of isotonic fluid &#40;20<span class="elsevierStyleHsp" style=""></span>mL&#47;kg&#41; to reverse the shock&#44; intramuscular adrenalin and methylprednisolone&#46; Antibiotic therapy was initiated with ceftriaxone&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient had normal total IgE levels&#44; and negative results for specific IgE against cow&#39;s milk protein&#46; The triptase value measured at the emergency department was also normal&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Once admitted to the paediatrics ward&#44; he was fed with breast milk or with an amino acid-based formula&#44; with complete resolution of symptoms in less than 12<span class="elsevierStyleHsp" style=""></span>h&#46; All the culture results were negative&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The compatible history and favourable clinical outcome allowed the conclusion that the patient had cow&#39;s milk protein-induced enterocolitis syndrome &#40;MPIES&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Two months after the acute event&#44; the patient underwent an oral food challenge &#40;OFC&#41; with extensively hydrolysed milk formula &#40;EHF&#41;&#44; with recurrence of symptoms&#44; but at the age of 12 months he tolerated this formula during a new OFC&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">At the age of 2&#44; under medical supervision&#44; the patient underwent oral tolerance induction&#46; The starting dose was 1<span class="elsevierStyleHsp" style=""></span>mL&#44; which was doubled weekly until reaching a 200<span class="elsevierStyleHsp" style=""></span>mL dose&#46; The patient exhibited good tolerance&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The clinical manifestations of FPIES and its severity are dose-dependent&#46; In this case&#44; the identification of cow&#39;s milk proteins as the trigger was confirmed by the previous history of exposure to small amounts followed by reactions of increasing severity&#46; The diagnosis of acute FPIES requires that a patient meets the major criterion<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a>&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Vomiting in the 1&#8211;4<span class="elsevierStyleHsp" style=""></span>h period after ingestion of the suspect food in the absence of classic IgE-mediated allergic skin or respiratory symptoms&#59;</p></li></ul></p><p id="par0070" class="elsevierStylePara elsevierViewall">and at least 3 minor criteria&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0075" class="elsevierStylePara elsevierViewall">A second &#40;or more&#41; episode of repetitive vomiting after eating the same suspect food</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0080" class="elsevierStylePara elsevierViewall">Episode of repetitive vomiting 1&#8211;4<span class="elsevierStyleHsp" style=""></span>h after eating a different food</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0085" class="elsevierStylePara elsevierViewall">Extreme lethargy with any suspected reaction</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0090" class="elsevierStylePara elsevierViewall">Marked pallor with any suspected reaction</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0095" class="elsevierStylePara elsevierViewall">Need for emergency room visit with any suspected reaction</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0100" class="elsevierStylePara elsevierViewall">Need for intravenous fluid support with any suspected reaction</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0105" class="elsevierStylePara elsevierViewall">Diarrhoea within 24<span class="elsevierStyleHsp" style=""></span>h</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">&#8226;</span><p id="par0110" class="elsevierStylePara elsevierViewall">Hypotension</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">&#8226;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Hypothermia</p></li></ul></p><p id="par0120" class="elsevierStylePara elsevierViewall">This infant fulfilled the major criterion and all of the minor criteria with the exception of hypothermia&#46; He also had thrombocytosis&#44; which has been reported in 65&#37; of patients with acute FPIES&#44; and relative neutrophilia&#44; a common laboratory finding in patients with positive oral food challenges &#40;OFC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In patients with a single documented episode&#44; performance of an OFC can be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> In this case&#44; we considered that the typical history made it unnecessary&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">As occurs in IgE-mediated cow&#39;s milk allergies&#44; where reactions may be triggered by an EHF&#44; about 10&#8211;40&#37; of patients with MPIES do not tolerate these formulas and require formulas based on amino acids&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> although their financial and nutritional impact must be taken into account&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">There are geographic and institutional variations in the timing of OFC in patients with FPIES&#46; Most authors defend that it should not be tried before 12&#8211;24 months have elapsed since the last acute episode&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> but good results have been observed after 10 months in patients with MFPIES&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> It is important to emphasize that regardless of the timing&#44; OFCs should always be performed in appropriate settings&#44; where resuscitation equipment and staff trained in the identification and treatment of these potentially severe reactions are always available&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; knowledge of this syndrome and the severity of its presentation allows the early removal of the trigger and prevents unnecessary testing and pharmacological treatment&#46; The follow-up and management of these patients can be challenging&#44; but the disorder has a favourable prognosis and resolves fully in most cases by age of 3&#8211;5 years&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p></span>"
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Scientific Letter
Cow's milk protein intolerance imitating septic shock in a young infant
Intolerancia a la proteína de la leche de vaca simulando shock séptico en un lactante pequeño
Sylvia Jacoba,
Corresponding author
sylviamhelder@gmail.com

Corresponding author.
, Artur Bonito Vitorb
a Departamento de Pediatría, Centro Hospitalar São João, Oporto, Portugal
b Departamento of de Inmunoalergología Pediátrica, Centro Hospitalar São João, Oporto, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Food protein-induced enterocolitis syndrome &#40;FPIES&#41; is the most serious form of enteropathy&#46; The pathophysiology of this syndrome is not completely understood&#44; but it is believed that ingestion of the triggering food is followed by T-lymphocyte activation&#44; resulting in a local inflammatory response&#44; increased gastrointestinal &#40;GI&#41; permeability and subsequent passage of fluids to the GI lumen&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A boy aged 4 months visited the emergency department &#40;ED&#41; with profuse vomiting and signs of hypovolaemic shock&#46; He had been breastfed until the age of three months&#44; when supplementation with one feed of cow&#39;s milk formula a day was introduced&#46; In the two days that followed&#44; he vomited once a day right after ingesting the cow&#39;s milk&#46; On day 3&#44; he developed persistent vomiting and bloody diarrhoea and became increasingly lethargic&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the ED&#44; he presented in shock&#44; with a blood pressure of 60&#47;25<span class="elsevierStyleHsp" style=""></span>mmHg&#44; poor peripheral perfusion with cold extremities&#44; and no other abnormalities in the physical examination&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The diagnoses considered at this point were sepsis and cow&#39;s milk protein allergy&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The blood tests showed absence of leucocytosis &#40;10&#44;990&#47;&#956;L&#41; with relative neutrophilia &#40;76&#46;2&#37; neutrophils&#41;&#44; thrombocytosis &#40;645&#44;000&#47;&#956;L platelets&#41;&#44; a negative result for C-reactive protein&#44; normal levels of serum electrolytes and normal renal function&#46; There were no abnormalities in the cerebrospinal fluid or the urine&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The boy was given a bolus of isotonic fluid &#40;20<span class="elsevierStyleHsp" style=""></span>mL&#47;kg&#41; to reverse the shock&#44; intramuscular adrenalin and methylprednisolone&#46; Antibiotic therapy was initiated with ceftriaxone&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient had normal total IgE levels&#44; and negative results for specific IgE against cow&#39;s milk protein&#46; The triptase value measured at the emergency department was also normal&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Once admitted to the paediatrics ward&#44; he was fed with breast milk or with an amino acid-based formula&#44; with complete resolution of symptoms in less than 12<span class="elsevierStyleHsp" style=""></span>h&#46; All the culture results were negative&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The compatible history and favourable clinical outcome allowed the conclusion that the patient had cow&#39;s milk protein-induced enterocolitis syndrome &#40;MPIES&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Two months after the acute event&#44; the patient underwent an oral food challenge &#40;OFC&#41; with extensively hydrolysed milk formula &#40;EHF&#41;&#44; with recurrence of symptoms&#44; but at the age of 12 months he tolerated this formula during a new OFC&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">At the age of 2&#44; under medical supervision&#44; the patient underwent oral tolerance induction&#46; The starting dose was 1<span class="elsevierStyleHsp" style=""></span>mL&#44; which was doubled weekly until reaching a 200<span class="elsevierStyleHsp" style=""></span>mL dose&#46; The patient exhibited good tolerance&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The clinical manifestations of FPIES and its severity are dose-dependent&#46; In this case&#44; the identification of cow&#39;s milk proteins as the trigger was confirmed by the previous history of exposure to small amounts followed by reactions of increasing severity&#46; The diagnosis of acute FPIES requires that a patient meets the major criterion<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a>&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Vomiting in the 1&#8211;4<span class="elsevierStyleHsp" style=""></span>h period after ingestion of the suspect food in the absence of classic IgE-mediated allergic skin or respiratory symptoms&#59;</p></li></ul></p><p id="par0070" class="elsevierStylePara elsevierViewall">and at least 3 minor criteria&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0075" class="elsevierStylePara elsevierViewall">A second &#40;or more&#41; episode of repetitive vomiting after eating the same suspect food</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0080" class="elsevierStylePara elsevierViewall">Episode of repetitive vomiting 1&#8211;4<span class="elsevierStyleHsp" style=""></span>h after eating a different food</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0085" class="elsevierStylePara elsevierViewall">Extreme lethargy with any suspected reaction</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0090" class="elsevierStylePara elsevierViewall">Marked pallor with any suspected reaction</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0095" class="elsevierStylePara elsevierViewall">Need for emergency room visit with any suspected reaction</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0100" class="elsevierStylePara elsevierViewall">Need for intravenous fluid support with any suspected reaction</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0105" class="elsevierStylePara elsevierViewall">Diarrhoea within 24<span class="elsevierStyleHsp" style=""></span>h</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">&#8226;</span><p id="par0110" class="elsevierStylePara elsevierViewall">Hypotension</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">&#8226;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Hypothermia</p></li></ul></p><p id="par0120" class="elsevierStylePara elsevierViewall">This infant fulfilled the major criterion and all of the minor criteria with the exception of hypothermia&#46; He also had thrombocytosis&#44; which has been reported in 65&#37; of patients with acute FPIES&#44; and relative neutrophilia&#44; a common laboratory finding in patients with positive oral food challenges &#40;OFC&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In patients with a single documented episode&#44; performance of an OFC can be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> In this case&#44; we considered that the typical history made it unnecessary&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">As occurs in IgE-mediated cow&#39;s milk allergies&#44; where reactions may be triggered by an EHF&#44; about 10&#8211;40&#37; of patients with MPIES do not tolerate these formulas and require formulas based on amino acids&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> although their financial and nutritional impact must be taken into account&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">There are geographic and institutional variations in the timing of OFC in patients with FPIES&#46; Most authors defend that it should not be tried before 12&#8211;24 months have elapsed since the last acute episode&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> but good results have been observed after 10 months in patients with MFPIES&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> It is important to emphasize that regardless of the timing&#44; OFCs should always be performed in appropriate settings&#44; where resuscitation equipment and staff trained in the identification and treatment of these potentially severe reactions are always available&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; knowledge of this syndrome and the severity of its presentation allows the early removal of the trigger and prevents unnecessary testing and pharmacological treatment&#46; The follow-up and management of these patients can be challenging&#44; but the disorder has a favourable prognosis and resolves fully in most cases by age of 3&#8211;5 years&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p></span>"
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