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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Aeromonas</span> is a genus of gram-negative bacilli that are similar in morphology to the <span class="elsevierStyleItalic">Enterobacteriaceae</span>&#46; Numerous species have been described&#44; the most frequent of which are <span class="elsevierStyleItalic">A&#46; caviae</span>&#44; <span class="elsevierStyleItalic">A&#46; veronii</span> and&#44; above all&#44; <span class="elsevierStyleItalic">A&#46; hydrophila</span>&#46; These bacteria are transmitted through contaminated fresh and salt waters&#46; In humans&#44; they are most commonly involved in wound infections&#44; systemic disease &#40;usually in patients with underlying conditions&#41; and especially acute gastroenteritis &#40;AGE&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> In Spain&#44; <span class="elsevierStyleItalic">Aeromonas</span> is considered the third most frequent enteropathogenic bacterium identified in patients with AGE&#44; following <span class="elsevierStyleItalic">Campylobacter</span> and <span class="elsevierStyleItalic">Salmonella</span>&#44; accounting for 6&#8211;7&#37; of cases<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a>&#59; in the Valencian metropolitan area&#44; the incidence of AGE due to Aeromonas is of 20 cases per 1&#44;000&#44;000 inhabitants&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Recently&#44; the European Society for Paediatric Gastroenterology Hepatology and Nutrition &#40;ESPGHAN&#41; and the European Society for Paediatric Infectious Diseases &#40;ESPID&#41; have recommended oral azithromycin for the treatment of moderate to severe gastroenteritis based on the bacterial enteropathogens that are most commonly involved&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> However&#44; due to the lack of data on <span class="elsevierStyleItalic">Aeromonas</span> species&#44; we do not have any evidence of the actual usefulness of this antimicrobial&#46; The aim of our study was to assess the <span class="elsevierStyleItalic">in vitro</span> activity of azithromycin against clinical isolates of <span class="elsevierStyleItalic">Aeromonas</span>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We conducted a prospective descriptive study of clinical isolates of <span class="elsevierStyleItalic">A&#46; hydrophila</span> from patients with AGE during 2015&#46; We isolated the bacterial strains by culturing stool samples in selective CIN agar &#40;Becton-Dickinson&#41;&#46; Bacterial identification and antibiotic susceptibility testing were performed by means of standardised and widely used techniques&#44; specifically with NC70 panels of the commercially available MicroScan WalkAway<span class="elsevierStyleSup">&#174;</span> system &#40;Siemens&#41;&#46; Furthermore&#44; we used Etest<span class="elsevierStyleSup">&#174;</span> strips &#40;bioM&#233;rieux&#41; to determine the minimum inhibitory concentration &#40;MIC&#41; in a McFarland 0&#46;5 bacterial suspension&#59; and interpreted the results applying the epidemiological cut-off values established by the European Committee on Antimicrobial Susceptibility Testing &#40;EUCAST&#41; for <span class="elsevierStyleItalic">Shigella</span> and <span class="elsevierStyleItalic">Salmonella</span> &#40;sensitivity&#58; MIC<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>16<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#46; We analysed the cases by on time&#44; age and sex as well as the microbiological characteristics of the isolated strains&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">During the period under study&#44; <span class="elsevierStyleItalic">A&#46; hydrophila</span> was isolated from a total of 50 clinical samples&#46; The median age of the patients was 8 years &#40;range&#44; 0&#8211;89 years&#41;&#46; Fifty-four percent were children &#40;78&#37; aged less than 4 years&#41; and 32&#37; elderly&#46; Fifty-two percent were male&#46; All isolates came from patients in primary care&#44; and no patients reported having been hospitalised&#46; The isolates did not exhibit a significant seasonal pattern&#44; although 58&#37; of detections occurred in summer or spring&#46; The percentage of isolates that showed <span class="elsevierStyleItalic">in vitro</span> sensitivity to antibiotics commonly used to treat AGE were&#58; 0&#37; for ampicillin&#44; 10&#37; for amoxicillin&#47;clavulanic acid&#44; 92&#37; for cefuroxime&#44; 100&#37; for cefotaxime&#44; 100&#37; for ciprofloxacin&#44; 100&#37; for gentamicin and 96&#37; for cotrimoxazol&#46; All isolates were considered sensitive to azithromycin&#59; the determined MICs ranged between 0&#46;5 and 8&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#44; and the MIC50 &#40;concentration required to inhibit 50&#37; of bacterial strains&#41; 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hydrophila</span> showed a high sensitivity to azithromycin <span class="elsevierStyleItalic">in vitro</span>&#44; although it would be advisable to have international committees on microbiology to establish clinical breakpoints to determine the sensitivity or resistance to azithromycin&#44; as has been done for <span class="elsevierStyleItalic">Salmonella</span> and <span class="elsevierStyleItalic">Shigella</span>&#46; Given its easy dosage &#40;one dose a day&#41;&#44; low toxicity and evidence of the high sensitivity of <span class="elsevierStyleItalic">Campylobacter</span> and also <span class="elsevierStyleItalic">Salmonella</span><a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> to it&#44; azithromycin has been established as the empirical treatment of choice in cases of bacterial AGE that require antibiotherapy&#46;</p></span>"
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Scientific Letter
In vitro activity of azithromycin in faecal isolates of Aeromonas hydrophila
Actividad in vitro de azitromicina en aislados fecales de Aeromonas hydrophila
Jorge Jover-García, Virginia Pérez-Doñate, Javier Colomina-Rodríguez
Corresponding author
jcolomina@hospital-ribera.com

Corresponding author.
Servicio de Microbiología, Hospital Universitario de la Ribera, Alzira, Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Aeromonas</span> is a genus of gram-negative bacilli that are similar in morphology to the <span class="elsevierStyleItalic">Enterobacteriaceae</span>&#46; Numerous species have been described&#44; the most frequent of which are <span class="elsevierStyleItalic">A&#46; caviae</span>&#44; <span class="elsevierStyleItalic">A&#46; veronii</span> and&#44; above all&#44; <span class="elsevierStyleItalic">A&#46; hydrophila</span>&#46; These bacteria are transmitted through contaminated fresh and salt waters&#46; In humans&#44; they are most commonly involved in wound infections&#44; systemic disease &#40;usually in patients with underlying conditions&#41; and especially acute gastroenteritis &#40;AGE&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> In Spain&#44; <span class="elsevierStyleItalic">Aeromonas</span> is considered the third most frequent enteropathogenic bacterium identified in patients with AGE&#44; following <span class="elsevierStyleItalic">Campylobacter</span> and <span class="elsevierStyleItalic">Salmonella</span>&#44; accounting for 6&#8211;7&#37; of cases<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a>&#59; in the Valencian metropolitan area&#44; the incidence of AGE due to Aeromonas is of 20 cases per 1&#44;000&#44;000 inhabitants&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Recently&#44; the European Society for Paediatric Gastroenterology Hepatology and Nutrition &#40;ESPGHAN&#41; and the European Society for Paediatric Infectious Diseases &#40;ESPID&#41; have recommended oral azithromycin for the treatment of moderate to severe gastroenteritis based on the bacterial enteropathogens that are most commonly involved&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> However&#44; due to the lack of data on <span class="elsevierStyleItalic">Aeromonas</span> species&#44; we do not have any evidence of the actual usefulness of this antimicrobial&#46; The aim of our study was to assess the <span class="elsevierStyleItalic">in vitro</span> activity of azithromycin against clinical isolates of <span class="elsevierStyleItalic">Aeromonas</span>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We conducted a prospective descriptive study of clinical isolates of <span class="elsevierStyleItalic">A&#46; hydrophila</span> from patients with AGE during 2015&#46; We isolated the bacterial strains by culturing stool samples in selective CIN agar &#40;Becton-Dickinson&#41;&#46; Bacterial identification and antibiotic susceptibility testing were performed by means of standardised and widely used techniques&#44; specifically with NC70 panels of the commercially available MicroScan WalkAway<span class="elsevierStyleSup">&#174;</span> system &#40;Siemens&#41;&#46; Furthermore&#44; we used Etest<span class="elsevierStyleSup">&#174;</span> strips &#40;bioM&#233;rieux&#41; to determine the minimum inhibitory concentration &#40;MIC&#41; in a McFarland 0&#46;5 bacterial suspension&#59; and interpreted the results applying the epidemiological cut-off values established by the European Committee on Antimicrobial Susceptibility Testing &#40;EUCAST&#41; for <span class="elsevierStyleItalic">Shigella</span> and <span class="elsevierStyleItalic">Salmonella</span> &#40;sensitivity&#58; MIC<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>16<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#46; We analysed the cases by on time&#44; age and sex as well as the microbiological characteristics of the isolated strains&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">During the period under study&#44; <span class="elsevierStyleItalic">A&#46; hydrophila</span> was isolated from a total of 50 clinical samples&#46; The median age of the patients was 8 years &#40;range&#44; 0&#8211;89 years&#41;&#46; Fifty-four percent were children &#40;78&#37; aged less than 4 years&#41; and 32&#37; elderly&#46; Fifty-two percent were male&#46; All isolates came from patients in primary care&#44; and no patients reported having been hospitalised&#46; The isolates did not exhibit a significant seasonal pattern&#44; although 58&#37; of detections occurred in summer or spring&#46; The percentage of isolates that showed <span class="elsevierStyleItalic">in vitro</span> sensitivity to antibiotics commonly used to treat AGE were&#58; 0&#37; for ampicillin&#44; 10&#37; for amoxicillin&#47;clavulanic acid&#44; 92&#37; for cefuroxime&#44; 100&#37; for cefotaxime&#44; 100&#37; for ciprofloxacin&#44; 100&#37; for gentamicin and 96&#37; for cotrimoxazol&#46; All isolates were considered sensitive to azithromycin&#59; the determined MICs ranged between 0&#46;5 and 8&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#44; and the MIC50 &#40;concentration required to inhibit 50&#37; of bacterial strains&#41; and the MIC90 &#40;for inhibition of 90&#37; of strains&#41; were 3&#46;0&#8211;6&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#44; respectively&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Antibiotic treatment is not always indicated for AGE caused by <span class="elsevierStyleItalic">Aeromonas</span>&#44; so the use and choice of antimicrobials should be based on the symptoms and age of the patient&#44; the site of infection &#40;intestinal or extraintestinal&#41;&#44; the immune status of the patient and the local prevalence of different pathogens and patterns of drug resistance&#46; The antibiotic sensitivity of <span class="elsevierStyleItalic">Aeromonas</span> has been studied mainly in environmental bacterial strains&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> but few studies have analysed clinical isolates and the use of azithromycin&#46; In our experience&#44; <span class="elsevierStyleItalic">A&#46; hydrophila</span> showed a high sensitivity to azithromycin <span class="elsevierStyleItalic">in vitro</span>&#44; although it would be advisable to have international committees on microbiology to establish clinical breakpoints to determine the sensitivity or resistance to azithromycin&#44; as has been done for <span class="elsevierStyleItalic">Salmonella</span> and <span class="elsevierStyleItalic">Shigella</span>&#46; Given its easy dosage &#40;one dose a day&#41;&#44; low toxicity and evidence of the high sensitivity of <span class="elsevierStyleItalic">Campylobacter</span> and also <span class="elsevierStyleItalic">Salmonella</span><a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> to it&#44; azithromycin has been established as the empirical treatment of choice in cases of bacterial AGE that require antibiotherapy&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Jover-Garc&#237;a J&#44; P&#233;rez-Do&#241;ate V&#44; Colomina-Rodr&#237;guez J&#46; Actividad <span class="elsevierStyleItalic">in vitro</span> de azitromicina en aislados fecales de <span class="elsevierStyleItalic">Aeromonas hydrophila</span>&#46; An Pediatr &#40;Barc&#41;&#46; 2017&#59;86&#58;226&#8211;227&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Previous presentation&#58; This study was presented at the XX Congreso Nacional SEIMC&#59; May 26&#8211;28&#44; 2016&#59; Barcelona&#44; Spain&#46;</p>"
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Article information
ISSN: 23412879
Original language: English
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