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Carlos Moreno Parejo, Áurea Morillo García, Carmen Lozano Domínguez, Concepción Carreño Ochoa, Javier Aznar Martín, Manuel Conde Herrera" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Joaquín Carlos" "apellidos" => "Moreno Parejo" "email" => array:1 [ 0 => "carlos.moreno.parejo@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Áurea" "apellidos" => "Morillo García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Carmen" "apellidos" => "Lozano Domínguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Concepción" "apellidos" => "Carreño Ochoa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Javier" "apellidos" => "Aznar Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Manuel" "apellidos" => "Conde Herrera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Preventiva, Hospital Universitario Virgen del Rocío, Sevilla, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Microbiología y Parasitología, Hospital Universitario Virgen del Rocío, Sevilla, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Brote por virus respiratorio sincitial en la Unidad de Neonatología de un hospital de tercer nivel" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2093 "Ancho" => 2916 "Tamanyo" => 266871 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Spatial distribution of cases and carriers of RSV infection in the Neonatal Intensive Care Unit and the Intermediate Care Nursery.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Respiratory syncytial virus (RSV) is a single-stranded RNA virus of the Paramyxoviridae family. It is classified into A and B subtypes, which may co-circulate, although subtype A generally dominates.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Respiratory syncytial virus is the single most important cause of lower respiratory tract infections<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a> and the leading cause of acute bronchiolitis<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> in children. It may cause upper respiratory tract infections, lower respiratory tract infections and pneumonia.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> It causes seasonal outbreaks that vary by geographical area, with its incidence peaking between November and February in Spain.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> It is one of the main causative agents in nosocomial respiratory tract infections in the paediatric population, and causes outbreaks associated with considerable morbidity and mortality, especially in patients with certain underlying diseases. Prolonged viral shedding and the potential susceptibility of patients and health care staff, since permanent immunity cannot be acquired, make it difficult to control nosocomial spread.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The most frequent mode of transmission is direct contact, as the virus can remain for hours in surfaces and the hands of health care workers.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this article, we analyse an outbreak of RSV that affected 20 infants hospitalised in a neonatal unit (NU) and the measures taken to control the spread of infection.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">The NU was located in a tertiary care university hospital (referral hospital).<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> The paediatric department serves a catchment area with a population of 150,619 children.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The NU, which is the referral unit for the autonomous community of Andalusia, is divided into General Neonatology (GN), which has 28 beds, 5 doctors and a nurse-patient ratio of one nurse to six or seven patients; the Intermediate Care Nursery (ICN), with 16 beds, 6 doctors and a ratio of one nurse per three or four patients; and the Neonatal Intensive Care Unit (NICU), with 12 beds, 6 doctors and a ratio of one nurse per two patients.</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Definitions.</span> We defined a <span class="elsevierStyleItalic">suspected case</span> of RSV infection as a neonate admitted to the NU between October 2 and December 6 that exhibited symptoms compatible with one of the following: upper respiratory tract infection (presence of cough, rhinorrhoea and/or fever); lower respiratory tract infection (hypoxaemia, stridor or wheezing on auscultation, or use of accessory muscles for breathing); pneumonia (presence of respiratory symptoms and evidence of lung consolidation in chest X-ray)<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> and/or bronchiolitis (rhinitis, tachypnoea, wheezing, cough, crepitus and/or nasal flaring).<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> A <span class="elsevierStyleItalic">confirmed case</span> was defined as a neonate admitted to the NU between October 2 and December 6 with a positive RSV antigen detection test of a nasopharyngeal wash sample and symptoms compatible with upper respiratory tract infection, lower respiratory tract infection, pneumonia and/or bronchiolitis. We defined <span class="elsevierStyleItalic">asymptomatic carrier</span> as a neonate admitted to the UN between October 2 and December 6, with a positive RSV antigen detection test of a nasopharyngeal aspirate sample and no apparent symptoms of respiratory infection. We calculated the length of stay in the NU for RSV cases as the number of days elapsed from admission to the day of microbiological diagnosis. For those that did not become ill, length of stay was calculated as the days elapsed from admission to the day they underwent screening. We used the World Health Organisation (WHO) classification<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> of preterm birth and its subcategories based on gestational age (GA), thus defining <span class="elsevierStyleItalic">preterm birth</span> as a birth before 37 weeks’ gestation, <span class="elsevierStyleItalic">moderate to late preterm</span> as a birth between 32 and 37 weeks’ gestation, <span class="elsevierStyleItalic">very preterm</span> as a birth between 28 and 32 weeks’ gestation, and <span class="elsevierStyleItalic">extremely preterm</span> as a birth before 28 weeks’ gestation.</p><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Microbiological testing.</span> The diagnosis of RSV was made based on the detection of the viral antigen in nasopharyngeal lavage samples by chromatographic immunoassay (BD Directigen EZ RSV<span class="elsevierStyleSup">®</span>; New Jersey, USA). This test has a reproducibility of 99.1%, a sensitivity of 80% and a specificity of 91%.</p><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Outbreak detection and measures for intervention.</span> On October 9, 2012, the chief of the NU notified the department of preventive medicine of the presence of six cases of RSV infection in GN. Subsequently, a retrospective search and prospective surveillance for additional cases was initiated, an interdisciplinary team was created to control the outbreak, and the following preventive measures were implemented: contact isolation of patients suspected to be infected by RSV based on their clinical presentation, with particular emphasis on handwashing and strict compliance with the hand hygiene recommendations of the WHO,<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">12</span></a> care of infected patients by exclusively-dedicated health care staff, and visitation restrictions.</p><p id="par0050" class="elsevierStylePara elsevierViewall">On October 22 and November 5, new cases were detected in the NICU and in GN, respectively, and further measures were implemented, including RSV screening for identification of carriers, prophylaxis with palivizumab, and monitoring of hand hygiene and compliance with isolation measures in all three units. <a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a> show the distribution of disease cases and infected patients in the affected units, while <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a> summarises the flow of events.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Study design.</span> We studied the cohorts consisting of all the neonates hospitalised in the NU from the time the first case was diagnosed (October 2, 2012) to the time the last two cases were detected (November 6, 2012).</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Data collection.</span> We used the protocolized individual questionnaire developed by the Department of Preventive Medicine (see <a class="elsevierStyleCrossRef" href="#sec0035">Appendix A</a>) to collect personal information and data for variables concerning the disease process, medical history, and interventions performed.</p><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Statistical analysis.</span> We calculated the overall RSV attack rate and the attack rate for each unit, which corresponds to the probability that patients hospitalised in the unit get infected by RSV. We defined <span class="elsevierStyleItalic">at-risk individual</span> as a neonate hospitalised in the NU during the outbreak.</p><p id="par0070" class="elsevierStylePara elsevierViewall">We performed a univariate descriptive statistical analysis, summarising categorical variables as frequency distributions and quantitative variables as measures of central tendency and dispersion. For the bivariate analysis, we assessed the associations between variables using the chi square test or Fisher's exact test. Statistical significance was defined as <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>.05. We used the Mann–Whitney <span class="elsevierStyleItalic">U</span> test for independent samples to compare the medians of two groups. We used logistic regression for the multivariate analysis of variables previously identified as risk factors for RSV infection. We analysed the data using the Statistical Package for the Social Sciences (SPSS) version 20 (IBM; Armonk, New York, USA).</p><p id="par0075" class="elsevierStylePara elsevierViewall">The variables described in the univariate and bivariate analyses were: age at diagnosis of RSV infection; length of stay in the unit until diagnosis of RSV infection; birth weight (in grams); GA (in weeks); degree of prematurity; and positive history of chronic lung disease, heart disease, patent ductus arteriosus, neurologic disease, congenital anomaly, intrauterine growth restriction (IUGR) and malnutrition, surgery prior to diagnosis of RSV infection, mechanical ventilation prior to diagnosis of RSV infection, and nosocomial infection in the seven days preceding the diagnosis of RSV infection.</p><p id="par0080" class="elsevierStylePara elsevierViewall">The variables corresponding to <span class="elsevierStyleItalic">P</span> values of less than 0.05 in the bivariate analysis that were included in the multivariate analysis were GA, birth weight, length of stay in the unit, history of chronic lung disease, prior nosocomial infection and degree of prematurity.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Outbreak characteristics</span><p id="par0085" class="elsevierStylePara elsevierViewall">The overall RSV attack rate was 42%, with attack rates of 38% for GN, 42% for the ICN and 47% for the NICU (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The outbreak comprised three epidemic waves and a total of 20 cases in the 48 hospitalised neonates (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). The first wave started on October 2 in GN and comprised 9 cases. The first case occurred in a patient admitted to the ICU on August 6 and transferred to GN on September 28, in whom testing of a nasopharyngeal aspirate sample detected the presence of RSV antigen on October 2. The second wave affected the NICU and ICN, occurred between October 20 and 25, and comprised eight cases. The third wave, from December 3 to 6, comprised the three remaining cases detected in the NICU and ICN.</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Of the total number of cases, twelve were reported by GN in the course of the three epidemic waves, and the other eight cases were detected in the screening for carriers.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Of the 20 cases, half corresponded to male and half to female patients, with a median age at diagnosis of RSV infection of 36 days (IQR, 22–58), a median gestational age of 29 weeks (IQR, 25.5–33.8) and a median birth weight of 982<span class="elsevierStyleHsp" style=""></span>g (IQR, 797–1518). The mean length of stay in the unit was 30.5 days (IQR, 17.25–54.25) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). As for the clinical manifestations, out of the 20 patients, 15 developed symptoms (75%), albeit mild ones, and only 30% of symptomatic patients developed a full case of bronchiolitis. Radiologic findings were normal in most patients (60%); there were signs of hyperinflation or perihilar infiltrates in 25%, and signs of lung consolidation or atelectasis in 15%.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The hospitalised neonates that were not infected by RSV were aged a median of 13.50 days (IQR, 5.5–24.5), with a median GA of 36 weeks (IQR, 32–38), a median birth weight of 2785<span class="elsevierStyleHsp" style=""></span>g (IQR, 1966–3565) and a length of stay in the unit of 8.5 days (IQR, 4.25–21). The bivariate analysis showed that the differences in birth weight, GA and length of stay between cases and patients that did not get infected were statistically significant for all three variables (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>.001).</p><p id="par0110" class="elsevierStylePara elsevierViewall">Eighty-five percent of cases were born preterm, compared to fifty-seven percent of controls. Twenty-five percent of cases were very preterm and forty-five percent extremely preterm, and we found a statistically significant association between RSV infection and very preterm birth (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.029), and between RSV infection and extremely preterm birth (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.013). Sixty-five percent of cases had a history of chronic lung disease compared to twenty-nine percent of controls (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.012). Forty percent of cases had another nosocomial infection in the week preceding the diagnosis of RSV infection compared to 3.6% of controls (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.002).</p><p id="par0115" class="elsevierStylePara elsevierViewall">Fifty percent of cases received prophylactic treatment with monoclonal antibodies (palivizumab) compared to twenty-nine percent of controls.</p><p id="par0120" class="elsevierStylePara elsevierViewall">As for the clinical outcomes, most patients were discharged after improving, two of the cases (10%) and one of the patients that was not infected by RSV (3.6%) died. The cause of death was unrelated to RSV infection in all three.</p><p id="par0125" class="elsevierStylePara elsevierViewall">We did not find a statistically significant association between RSV infection and a positive history of heart disease, patent ductus arteriosus, neurologic disease, congenital anomaly, IUGR, surgery prior to diagnosis of RSV infection or mechanical ventilation prior to diagnosis of RSV infection.</p><p id="par0130" class="elsevierStylePara elsevierViewall">The multivariate logistic regression analysis (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>) identified the following as independent risk factors for infection by RSV: birth weight of less than 1000<span class="elsevierStyleHsp" style=""></span>g 1 (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>23.5; 95% CI, 3.26–169.21; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.002) and having had another nosocomial infection in the week preceding the diagnosis of RSV infection (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19.98; 95% CI, 1.73–229.79; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.016). The resulting model classified 81.3% of the analysed cases correctly, and the variability in infection by RSV virus (independent variable) predicted by the model ranged from 39.7% (Cox and Snell R square) to 53.5% (Nagerkelke's R square).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">Respiratory syncytial virus is the leading cause of lower respiratory tract infection in infants younger than one year,<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">13,14</span></a> it is one of the most frequent causative pathogens in outbreaks of nosocomial infection, and is associated with a high morbidity and mortality.<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15,16</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In infants aged less than 6 months, chronic lung disease, birth before 35 weeks’ gestation, congenital heart disease and immunodeficiency are well-known risk factors for RSV infection.<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">17,18</span></a> Preterm newborns are most susceptible to infection by RSV due to the immaturity of their immune system and their low serum levels of maternal antibodies.<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15,19</span></a> In our study, the average GA and birth weight of neonates infected by RSV were significantly lower than those of the neonates that were not infected, which was consistent with the results of previous studies.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8,20</span></a> We also found a significant association between RSV infection and chronic lung disease, which has also been described in the literature.<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15,17</span></a> Infection by RSV was associated with a longer length of stay in the unit until diagnosis or screening, but we did not find an association with other risk factors reported in previous studies, such as underlying congenital heart disease.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> We also found a significant association between RSV infection and having had another nosocomial infection in the week prior to its diagnosis. This could be explained by a weakened immune system in these children, which would make them more susceptible to infection by another pathogen, although we did not find data to support this hypothesis in the literature. The multivariate logistic regression analysis only identified two independent risk factors for becoming infected by RSV, which were birth weight of less than 1000<span class="elsevierStyleHsp" style=""></span>g and having had another nosocomial infection in the week preceding the diagnosis of RSV infection. The degree of prematurity variable was a potential confounding factor due to its close association with birth weight, and was therefore removed from the logistic regression model.</p><p id="par0145" class="elsevierStylePara elsevierViewall">The mortality of patients with community-acquired RSV infection is negligible, unlike that of patients with nosocomial infections, which can be considerable.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a> The risk of death is higher in children of younger ages, born preterm, or with congenital heart disease, bronchopulmonary dysplasia or immunodeficiency, as they are more susceptible to severe disease.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> In our study, the three deaths that occurred in the patients under study were unrelated to RSV infection.</p><p id="par0150" class="elsevierStylePara elsevierViewall">Thirty percent of the cases required invasive mechanical ventilation, but since all these patients had required it prior to the diagnosis of RSV infection, we were unable to determine its association with RSV.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Early detection of cases is a crucial measure in outbreak control, as it allows the timely implementation of appropriate isolation precautions and the containment of viral transmission. Respiratory syncytial virus spreads through direct contact or indirectly through fomites, and it can survive on inorganic surfaces for up to 12<span class="elsevierStyleHsp" style=""></span>h, which prolongs the time span during which transmission is possible.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8,21</span></a> In addition, while the usual duration of viral shedding is two weeks, this period can be longer in premature or immunocompromised infants, and therefore all patients should be tested when an outbreak of RSV is suspected to detect potential asymptomatic cases of infection. For all the above reasons, preventive measures such as screening for virus carriage are not only important for the detection of new cases, but can be helpful in estimating how long contact isolation precautions should be maintained.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">One of the limitations of our study was that the respiratory secretion samples of the patients were not analysed with polymerase chain reaction techniques. This may have resulted in underdiagnosis of RSV infection, as the sensitivity of the chromatographic immune assays that were used is lower. Furthermore, sequencing the gene products obtained by amplification would allow additional serogroup and molecular epidemiology analyses, which could not be conducted in this study. However, the availability of PCR would not have changed the preventive measures used to control the outbreak in any significant way.</p><p id="par0165" class="elsevierStylePara elsevierViewall">It is worth highlighting the considerable number of cases detected in our study. Some of the factors that may have contributed to it are the screening for carriers (which identified 8 of the 20 diagnosed cases), the delay in reporting (there were already six cases of RSV infection at the time of the first report), the early discontinuation of isolation precautions (which were automatically discontinued seven days after their initiation), and gaps in the adherence to hand hygiene measures.</p><p id="par0170" class="elsevierStylePara elsevierViewall">Despite the delay in reporting, which was due to flaws in the internal communication between the involved departments, the creation of the interdisciplinary team helped address these issues and facilitated the quick implementation of preventive measures, which was crucial in the management and containment of the outbreak. These precautions, such as the isolation of infected patients, the screening for carrier detection, the assignment of an exclusively-dedicated staff to the care of patients infected by RSV, and the emphasis placed on the adherence to appropriate hand hygiene, were measures that are generally recommended for infection control.<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6,21,23–25</span></a> Furthermore, following the recommendations given in different studies<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">26,27</span></a> and clinical practice guidelines,<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">28,29</span></a> adherence to hand hygiene was assessed by direct observation of the performance of health care workers during their shifts and the supervision of isolation precautions. In our study, the adherence of health care workers to hand hygiene measures was of 63%, a percentage that exceeded the 40% reported in a recent systematic review.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> However, we must take into account that the monitoring took place during the study of the outbreak, which may have increased the motivation of health care workers to strictly adhere to hand hygiene measures. Of all the measures that were implemented, those that seemed to be most effective were the observation of hand hygiene and the supervision of isolation precautions, as no further cases were detected after they started. In contrast, the screening for carriers did succeed in detecting new cases but did not lead to the end of the outbreak.</p><p id="par0175" class="elsevierStylePara elsevierViewall">In conclusion, this was an outbreak with a large number of cases, a fact that was associated with delayed reporting and the long duration of RSV carriage, and further facilitated by flaws in the hand hygiene of the health care staff and in contact isolation precautions.</p><p id="par0180" class="elsevierStylePara elsevierViewall">The experience gained during this outbreak allows us to conclude that the creation of interdisciplinary teams is key in the control of epidemic outbreaks, as it leads to the quick and consistent implementation of preventive measures. Furthermore, we believe that such teams should be permanent in high-risk units, as they provide effective channels of communication between the departments involved in the daily surveillance of health care-related infections.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres721432" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec726520" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres721433" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Pacientes y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec726521" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Results" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Outbreak characteristics" ] ] ] 7 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interests" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-07-17" "fechaAceptado" => "2015-10-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec726520" "palabras" => array:5 [ 0 => "Respiratory syncytial viruses" 1 => "Cross infection" 2 => "Disease outbreaks" 3 => "Neonatal intensive care unit" 4 => "Hand hygiene" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec726521" "palabras" => array:5 [ 0 => "Virus respiratorio sincitial" 1 => "Infección nosocomial" 2 => "Brote epidémico" 3 => "Cuidados intensivos neonatales" 4 => "Higiene de manos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Investigation and control of a respiratory syncytial virus (RSV) outbreak that affected the Neonatal Intensive Care Unit (NICU) of a university hospital from October to December 2012.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cohort study of children admitted to the NICU. The infection attack rate was calculated. A descriptive analysis of the cases and a multivariate analysis was performed using the variables that were shown to be risk factors for RSV infection.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Preventive measures taken were: contact isolation; hand hygiene training and observation; exclusivity of a health team of nurses and physicians for positive cases, restrictions on visitor numbers; surveillance RSV testing, and palivizumab prophylaxis.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The outbreak had three epidemic waves and 20 positive cases out of a total of 48 children admitted. The overall attack rate was 42%. Half of positive cases were children, with a median age of 36 days (p25<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>22, p75<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>58). The independent risk factors for RSV infection were birth weight below 1000<span class="elsevierStyleHsp" style=""></span>g (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>23.5; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.002) and to have another nosocomial infection the week before the diagnosis of RSV infection (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19.98; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.016).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It was an outbreak with a high number of cases, due to the delay in notification, prolonged RSV carrier status, and low adherence to hand hygiene practice, which favoured the cross-transmission of infection. The most effective preventive measures were direct observation of hand hygiene and supervision of isolation measures.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Investigación y control de un brote por virus respiratorio sincitial (VRS) que afectó a la Unidad de Neonatología (UN) de un hospital universitario de octubre a diciembre del 2012.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y métodos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohortes de los niños ingresados en la UN. Se calculó la tasa de ataque de infección y se realizaron un análisis descriptivo de los casos y un análisis multivariante de aquellas variables que mostraron ser factores de riesgo de infección por VRS.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las medidas preventivas llevadas a cabo fueron: aislamiento de contacto de casos; formación y observación de higiene de manos; exclusividad del personal sanitario para casos, restricción de visitas; estudio de portadores de VRS y profilaxis con palivizumab.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El brote tuvo 3 ondas epidémicas y un total de 20 casos, de 48 niños ingresados. La tasa de ataque global fue del 42%. De los casos, la mitad fueron niños, con una edad mediana de 36 días (p25<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>22, p75<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>58). El peso al nacimiento inferior a 1.000<span class="elsevierStyleHsp" style=""></span>g (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>23,5; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,002) y tener otra infección nosocomial en la semana previa al diagnóstico de infección por VRS (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19,98; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,016), fueron factores de riesgo independientes de infección por VRS.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Se trató de un brote epidémico con un elevado número de casos, relacionado con el retraso en la notificación, el tiempo prolongado del estado de portador del VRS y los fallos en el cumplimiento de la higiene de manos, que favoreció la transmisión cruzada de la infección. Las medidas preventivas más eficaces fueron la observación directa de higiene de manos y supervisión de las medidas de aislamiento.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Pacientes y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as: Parejo CM, García AM, Domínguez CL, Ochoa CC, Martín JA, Herrera MC. Brote por virus respiratorio sincitial en la Unidad de Neonatología de un hospital de tercer nivel. An Pediatr (Barc). 2016;85:119–127.</p>" ] 1 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Previous presentations: This study was presented as an oral communication (<span class="elsevierStyleItalic">Brote nosocomial de infección por virus respiratorio sincitial en una Unidad de Neonatología</span>) at the Congreso Iberoamericano de Epidemiología y Salud Pública, XXXI Reunión Científica de la Sociedad Española de Epidemiología; September 4–6, 2013; Granada, Spain.</p>" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0190" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="201608250218571811"></elsevierMultimedia></p>" "etiqueta" => "Annex 1" "titulo" => "Epidemiologic survey on the nosocomial outbreak of respiratory syncytial virus" "identificador" => "sec0035" ] ] ] ] "multimedia" => array:8 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1841 "Ancho" => 2500 "Tamanyo" => 205203 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Spatial distribution of cases and carriers of RSV infection in the General Neonatology Unit.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2093 "Ancho" => 2916 "Tamanyo" => 266871 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Spatial distribution of cases and carriers of RSV infection in the Neonatal Intensive Care Unit and the Intermediate Care Nursery.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1887 "Ancho" => 3334 "Tamanyo" => 309347 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Flow chart.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1359 "Ancho" => 3326 "Tamanyo" => 242876 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Epidemic curve of the outbreak (by date of microbiological diagnosis of respiratory syncytial virus infection by testing of nasopharyngeal samples).</p>" ] ] 4 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">NICU, Neonatal Intensive Care Unit.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Unit \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Attack rate<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> for each unit (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">General neonatology \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Intermediate care nursery \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NICU \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">47 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Overall attack rate<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1185968.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Attack rate: number of patients infected by RSV/number of patients hospitalised in the unit.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Respiratory syncytial virus attack rate, overall and for each unit.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">BW, birth weight; Dx, diagnosis; F, female; GA, gestational age; HD, heart disease; IUGR-M, intrauterine growth restriction-malnutrition; LD, lung disease; LOS, length of stay in the unit; M, male; MM, multiple malformation; MV, invasive mechanical ventilation prior to RSV infection; ND, neurologic disease; ONI, other nosocomial infection; RSV, respiratory syncytial virus; Surg, surgery prior to RSV infection.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">GA (weeks) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">BW (g) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age at RSV Dx (days) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">LOS at Dx (days) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Underlying disease \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">927 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1443 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IUGR-M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2900 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1543 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1350 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/Ductus/ND/ONI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1780 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1122 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IUGR-M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">769 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">130 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/ductus/IUGR-M/Surg/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3376 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ND/ONI/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Death \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1214 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/ONI/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">819 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/ONI/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3186 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Surg/MM/ONI/Surg/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">820 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">153 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">144 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/ND/ONI/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Death \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">588 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/ductus/ONI/Surg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">964 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">680 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/ductus/ND/Surg/ONI/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">794 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/IUGR-M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">806 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/ONI/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">791 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/ductus/MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LD/IUGR-M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cure \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1185969.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients with tests positive for respiratory syncytial virus infection.</p>" ] ] 6 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">B</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SE \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Birth weight</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>≥1500<span class="elsevierStyleHsp" style=""></span>g \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ref) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>0–999<span class="elsevierStyleHsp" style=""></span>g \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.157 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.511 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.267–169.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1000–1499<span class="elsevierStyleHsp" style=""></span>g \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.797 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.946 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.031 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.944–38.533 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.058 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Another nosocomial infection</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ref) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.995 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.246 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19.98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.737–229.793 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Constant</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">–2.016 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.618 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1185970.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Multivariate logistic regression. 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2024 September | 48 | 39 | 87 |
2024 August | 75 | 68 | 143 |
2024 July | 60 | 41 | 101 |
2024 June | 49 | 25 | 74 |
2024 May | 63 | 46 | 109 |
2024 April | 65 | 34 | 99 |
2024 March | 74 | 32 | 106 |
2024 February | 86 | 39 | 125 |
2024 January | 70 | 31 | 101 |
2023 December | 99 | 18 | 117 |
2023 November | 83 | 22 | 105 |
2023 October | 91 | 30 | 121 |
2023 September | 49 | 23 | 72 |
2023 August | 37 | 19 | 56 |
2023 July | 65 | 39 | 104 |
2023 June | 80 | 31 | 111 |
2023 May | 70 | 22 | 92 |
2023 April | 43 | 21 | 64 |
2023 March | 92 | 30 | 122 |
2023 February | 69 | 21 | 90 |
2023 January | 60 | 22 | 82 |
2022 December | 72 | 27 | 99 |
2022 November | 88 | 30 | 118 |
2022 October | 63 | 64 | 127 |
2022 September | 43 | 30 | 73 |
2022 August | 49 | 43 | 92 |
2022 July | 42 | 32 | 74 |
2022 June | 38 | 33 | 71 |
2022 May | 38 | 40 | 78 |
2022 April | 60 | 65 | 125 |
2022 March | 58 | 75 | 133 |
2022 February | 51 | 44 | 95 |
2022 January | 73 | 37 | 110 |
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2021 November | 62 | 51 | 113 |
2021 October | 85 | 69 | 154 |
2021 September | 83 | 41 | 124 |
2021 August | 77 | 49 | 126 |
2021 July | 91 | 24 | 115 |
2021 June | 59 | 39 | 98 |
2021 May | 73 | 41 | 114 |
2021 April | 132 | 94 | 226 |
2021 March | 121 | 48 | 169 |
2021 February | 61 | 10 | 71 |
2021 January | 76 | 35 | 111 |
2020 December | 68 | 19 | 87 |
2020 November | 52 | 24 | 76 |
2020 October | 64 | 23 | 87 |
2020 September | 50 | 19 | 69 |
2020 August | 42 | 23 | 65 |
2020 July | 38 | 15 | 53 |
2020 June | 40 | 11 | 51 |
2020 May | 46 | 33 | 79 |
2020 April | 46 | 23 | 69 |
2020 March | 45 | 29 | 74 |
2020 February | 46 | 23 | 69 |
2020 January | 49 | 19 | 68 |
2019 December | 47 | 18 | 65 |
2019 November | 25 | 14 | 39 |
2019 October | 31 | 16 | 47 |
2019 September | 41 | 25 | 66 |
2019 August | 27 | 24 | 51 |
2019 July | 33 | 23 | 56 |
2019 June | 25 | 35 | 60 |
2019 May | 81 | 28 | 109 |
2019 April | 102 | 34 | 136 |
2019 March | 41 | 24 | 65 |
2019 February | 44 | 18 | 62 |
2019 January | 30 | 15 | 45 |
2018 December | 71 | 34 | 105 |
2018 November | 141 | 33 | 174 |
2018 October | 137 | 33 | 170 |
2018 September | 108 | 18 | 126 |
2018 August | 3 | 0 | 3 |
2018 July | 3 | 0 | 3 |
2018 June | 3 | 0 | 3 |
2018 May | 4 | 0 | 4 |
2018 April | 33 | 0 | 33 |
2018 March | 26 | 0 | 26 |
2018 February | 35 | 0 | 35 |
2018 January | 43 | 0 | 43 |
2017 December | 31 | 0 | 31 |
2017 November | 37 | 0 | 37 |
2017 October | 26 | 0 | 26 |
2017 September | 19 | 0 | 19 |
2017 August | 19 | 0 | 19 |
2017 July | 31 | 1 | 32 |
2017 June | 38 | 6 | 44 |
2017 May | 49 | 14 | 63 |
2017 April | 30 | 6 | 36 |
2017 March | 25 | 19 | 44 |
2017 February | 58 | 12 | 70 |
2017 January | 13 | 2 | 15 |
2016 December | 39 | 10 | 49 |
2016 November | 47 | 8 | 55 |
2016 October | 33 | 24 | 57 |
2016 September | 57 | 39 | 96 |
2016 August | 24 | 6 | 30 |
2016 July | 6 | 4 | 10 |