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or use of accessory muscles for breathing&#41;&#59; pneumonia &#40;presence of respiratory symptoms and evidence of lung consolidation in chest X-ray&#41;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> and&#47;or bronchiolitis &#40;rhinitis&#44; tachypnoea&#44; wheezing&#44; cough&#44; crepitus and&#47;or nasal flaring&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> A <span class="elsevierStyleItalic">confirmed case</span> was defined as a neonate admitted to the NU between October 2 and December 6 with a positive RSV antigen detection test of a nasopharyngeal wash sample and symptoms compatible with upper respiratory tract infection&#44; lower respiratory tract infection&#44; pneumonia and&#47;or bronchiolitis&#46; We defined <span class="elsevierStyleItalic">asymptomatic carrier</span> as a neonate admitted to the UN between October 2 and December 6&#44; with a positive RSV antigen detection test of a nasopharyngeal aspirate sample and no apparent symptoms of respiratory infection&#46; We calculated the length of stay in the NU for RSV cases as the number of days elapsed from admission to the day of microbiological diagnosis&#46; For those that did not become ill&#44; length of stay was calculated as the days elapsed from admission to the day they underwent screening&#46; We used the World Health Organisation &#40;WHO&#41; classification<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> of preterm birth and its subcategories based on gestational age &#40;GA&#41;&#44; thus defining <span class="elsevierStyleItalic">preterm birth</span> as a birth before 37 weeks&#8217; gestation&#44; <span class="elsevierStyleItalic">moderate to late preterm</span> as a birth between 32 and 37 weeks&#8217; gestation&#44; <span class="elsevierStyleItalic">very preterm</span> as a birth between 28 and 32 weeks&#8217; gestation&#44; and <span class="elsevierStyleItalic">extremely preterm</span> as a birth before 28 weeks&#8217; gestation&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Microbiological testing&#46;</span> The diagnosis of RSV was made based on the detection of the viral antigen in nasopharyngeal lavage samples by chromatographic immunoassay &#40;BD Directigen EZ RSV<span class="elsevierStyleSup">&#174;</span>&#59; New Jersey&#44; USA&#41;&#46; This test has a reproducibility of 99&#46;1&#37;&#44; a sensitivity of 80&#37; and a specificity of 91&#37;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Outbreak detection and measures for intervention&#46;</span> On October 9&#44; 2012&#44; the chief of the NU notified the department of preventive medicine of the presence of six cases of RSV infection in GN&#46; Subsequently&#44; a retrospective search and prospective surveillance for additional cases was initiated&#44; an interdisciplinary team was created to control the outbreak&#44; and the following preventive measures were implemented&#58; contact isolation of patients suspected to be infected by RSV based on their clinical presentation&#44; with particular emphasis on handwashing and strict compliance with the hand hygiene recommendations of the WHO&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">12</span></a> care of infected patients by exclusively-dedicated health care staff&#44; and visitation restrictions&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">On October 22 and November 5&#44; new cases were detected in the NICU and in GN&#44; respectively&#44; and further measures were implemented&#44; including RSV screening for identification of carriers&#44; prophylaxis with palivizumab&#44; and monitoring of hand hygiene and compliance with isolation measures in all three units&#46; <a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a> show the distribution of disease cases and infected patients in the affected units&#44; while <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> summarises the flow of events&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Study design&#46;</span> We studied the cohorts consisting of all the neonates hospitalised in the NU from the time the first case was diagnosed &#40;October 2&#44; 2012&#41; to the time the last two cases were detected &#40;November 6&#44; 2012&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Data collection&#46;</span> We used the protocolized individual questionnaire developed by the Department of Preventive Medicine &#40;see <a class="elsevierStyleCrossRef" href="#sec0035">Appendix A</a>&#41; to collect personal information and data for variables concerning the disease process&#44; medical history&#44; and interventions performed&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Statistical analysis&#46;</span> We calculated the overall RSV attack rate and the attack rate for each unit&#44; which corresponds to the probability that patients hospitalised in the unit get infected by RSV&#46; We defined <span class="elsevierStyleItalic">at-risk individual</span> as a neonate hospitalised in the NU during the outbreak&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">We performed a univariate descriptive statistical analysis&#44; summarising categorical variables as frequency distributions and quantitative variables as measures of central tendency and dispersion&#46; For the bivariate analysis&#44; we assessed the associations between variables using the chi square test or Fisher&#39;s exact test&#46; Statistical significance was defined as <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; We used the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test for independent samples to compare the medians of two groups&#46; We used logistic regression for the multivariate analysis of variables previously identified as risk factors for RSV infection&#46; We analysed the data using the Statistical Package for the Social Sciences &#40;SPSS&#41; version 20 &#40;IBM&#59; Armonk&#44; New York&#44; USA&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The variables described in the univariate and bivariate analyses were&#58; age at diagnosis of RSV infection&#59; length of stay in the unit until diagnosis of RSV infection&#59; birth weight &#40;in grams&#41;&#59; GA &#40;in weeks&#41;&#59; degree of prematurity&#59; and positive history of chronic lung disease&#44; heart disease&#44; patent ductus arteriosus&#44; neurologic disease&#44; congenital anomaly&#44; intrauterine growth restriction &#40;IUGR&#41; and malnutrition&#44; surgery prior to diagnosis of RSV infection&#44; mechanical ventilation prior to diagnosis of RSV infection&#44; and nosocomial infection in the seven days preceding the diagnosis of RSV infection&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The variables corresponding to <span class="elsevierStyleItalic">P</span> values of less than 0&#46;05 in the bivariate analysis that were included in the multivariate analysis were GA&#44; birth weight&#44; length of stay in the unit&#44; history of chronic lung disease&#44; prior nosocomial infection and degree of prematurity&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Outbreak characteristics</span><p id="par0085" class="elsevierStylePara elsevierViewall">The overall RSV attack rate was 42&#37;&#44; with attack rates of 38&#37; for GN&#44; 42&#37; for the ICN and 47&#37; for the NICU &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The outbreak comprised three epidemic waves and a total of 20 cases in the 48 hospitalised neonates &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; The first wave started on October 2 in GN and comprised 9 cases&#46; The first case occurred in a patient admitted to the ICU on August 6 and transferred to GN on September 28&#44; in whom testing of a nasopharyngeal aspirate sample detected the presence of RSV antigen on October 2&#46; The second wave affected the NICU and ICN&#44; occurred between October 20 and 25&#44; and comprised eight cases&#46; The third wave&#44; from December 3 to 6&#44; comprised the three remaining cases detected in the NICU and ICN&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Of the total number of cases&#44; twelve were reported by GN in the course of the three epidemic waves&#44; and the other eight cases were detected in the screening for carriers&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Of the 20 cases&#44; half corresponded to male and half to female patients&#44; with a median age at diagnosis of RSV infection of 36 days &#40;IQR&#44; 22&#8211;58&#41;&#44; a median gestational age of 29 weeks &#40;IQR&#44; 25&#46;5&#8211;33&#46;8&#41; and a median birth weight of 982<span class="elsevierStyleHsp" style=""></span>g &#40;IQR&#44; 797&#8211;1518&#41;&#46; The mean length of stay in the unit was 30&#46;5 days &#40;IQR&#44; 17&#46;25&#8211;54&#46;25&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; As for the clinical manifestations&#44; out of the 20 patients&#44; 15 developed symptoms &#40;75&#37;&#41;&#44; albeit mild ones&#44; and only 30&#37; of symptomatic patients developed a full case of bronchiolitis&#46; Radiologic findings were normal in most patients &#40;60&#37;&#41;&#59; there were signs of hyperinflation or perihilar infiltrates in 25&#37;&#44; and signs of lung consolidation or atelectasis in 15&#37;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The hospitalised neonates that were not infected by RSV were aged a median of 13&#46;50 days &#40;IQR&#44; 5&#46;5&#8211;24&#46;5&#41;&#44; with a median GA of 36 weeks &#40;IQR&#44; 32&#8211;38&#41;&#44; a median birth weight of 2785<span class="elsevierStyleHsp" style=""></span>g &#40;IQR&#44; 1966&#8211;3565&#41; and a length of stay in the unit of 8&#46;5 days &#40;IQR&#44; 4&#46;25&#8211;21&#41;&#46; The bivariate analysis showed that the differences in birth weight&#44; GA and length of stay between cases and patients that did not get infected were statistically significant for all three variables &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Eighty-five percent of cases were born preterm&#44; compared to fifty-seven percent of controls&#46; Twenty-five percent of cases were very preterm and forty-five percent extremely preterm&#44; and we found a statistically significant association between RSV infection and very preterm birth &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;029&#41;&#44; and between RSV infection and extremely preterm birth &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;013&#41;&#46; Sixty-five percent of cases had a history of chronic lung disease compared to twenty-nine percent of controls &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;012&#41;&#46; Forty percent of cases had another nosocomial infection in the week preceding the diagnosis of RSV infection compared to 3&#46;6&#37; of controls &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;002&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Fifty percent of cases received prophylactic treatment with monoclonal antibodies &#40;palivizumab&#41; compared to twenty-nine percent of controls&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">As for the clinical outcomes&#44; most patients were discharged after improving&#44; two of the cases &#40;10&#37;&#41; and one of the patients that was not infected by RSV &#40;3&#46;6&#37;&#41; died&#46; The cause of death was unrelated to RSV infection in all three&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">We did not find a statistically significant association between RSV infection and a positive history of heart disease&#44; patent ductus arteriosus&#44; neurologic disease&#44; congenital anomaly&#44; IUGR&#44; surgery prior to diagnosis of RSV infection or mechanical ventilation prior to diagnosis of RSV infection&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The multivariate logistic regression analysis &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; identified the following as independent risk factors for infection by RSV&#58; birth weight of less than 1000<span class="elsevierStyleHsp" style=""></span>g 1 &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#46;5&#59; 95&#37; CI&#44; 3&#46;26&#8211;169&#46;21&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;002&#41; and having had another nosocomial infection in the week preceding the diagnosis of RSV infection &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;98&#59; 95&#37; CI&#44; 1&#46;73&#8211;229&#46;79&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;016&#41;&#46; The resulting model classified 81&#46;3&#37; of the analysed cases correctly&#44; and the variability in infection by RSV virus &#40;independent variable&#41; predicted by the model ranged from 39&#46;7&#37; &#40;Cox and Snell R square&#41; to 53&#46;5&#37; &#40;Nagerkelke&#39;s R square&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">Respiratory syncytial virus is the leading cause of lower respiratory tract infection in infants younger than one year&#44;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">13&#44;14</span></a> it is one of the most frequent causative pathogens in outbreaks of nosocomial infection&#44; and is associated with a high morbidity and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15&#44;16</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In infants aged less than 6 months&#44; chronic lung disease&#44; birth before 35 weeks&#8217; gestation&#44; congenital heart disease and immunodeficiency are well-known risk factors for RSV infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">17&#44;18</span></a> Preterm newborns are most susceptible to infection by RSV due to the immaturity of their immune system and their low serum levels of maternal antibodies&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15&#44;19</span></a> In our study&#44; the average GA and birth weight of neonates infected by RSV were significantly lower than those of the neonates that were not infected&#44; which was consistent with the results of previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8&#44;20</span></a> We also found a significant association between RSV infection and chronic lung disease&#44; which has also been described in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15&#44;17</span></a> Infection by RSV was associated with a longer length of stay in the unit until diagnosis or screening&#44; but we did not find an association with other risk factors reported in previous studies&#44; such as underlying congenital heart disease&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> We also found a significant association between RSV infection and having had another nosocomial infection in the week prior to its diagnosis&#46; This could be explained by a weakened immune system in these children&#44; which would make them more susceptible to infection by another pathogen&#44; although we did not find data to support this hypothesis in the literature&#46; The multivariate logistic regression analysis only identified two independent risk factors for becoming infected by RSV&#44; which were birth weight of less than 1000<span class="elsevierStyleHsp" style=""></span>g and having had another nosocomial infection in the week preceding the diagnosis of RSV infection&#46; The degree of prematurity variable was a potential confounding factor due to its close association with birth weight&#44; and was therefore removed from the logistic regression model&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The mortality of patients with community-acquired RSV infection is negligible&#44; unlike that of patients with nosocomial infections&#44; which can be considerable&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a> The risk of death is higher in children of younger ages&#44; born preterm&#44; or with congenital heart disease&#44; bronchopulmonary dysplasia or immunodeficiency&#44; as they are more susceptible to severe disease&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> In our study&#44; the three deaths that occurred in the patients under study were unrelated to RSV infection&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Thirty percent of the cases required invasive mechanical ventilation&#44; but since all these patients had required it prior to the diagnosis of RSV infection&#44; we were unable to determine its association with RSV&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Early detection of cases is a crucial measure in outbreak control&#44; as it allows the timely implementation of appropriate isolation precautions and the containment of viral transmission&#46; Respiratory syncytial virus spreads through direct contact or indirectly through fomites&#44; and it can survive on inorganic surfaces for up to 12<span class="elsevierStyleHsp" style=""></span>h&#44; which prolongs the time span during which transmission is possible&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8&#44;21</span></a> In addition&#44; while the usual duration of viral shedding is two weeks&#44; this period can be longer in premature or immunocompromised infants&#44; and therefore all patients should be tested when an outbreak of RSV is suspected to detect potential asymptomatic cases of infection&#46; For all the above reasons&#44; preventive measures such as screening for virus carriage are not only important for the detection of new cases&#44; but can be helpful in estimating how long contact isolation precautions should be maintained&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">One of the limitations of our study was that the respiratory secretion samples of the patients were not analysed with polymerase chain reaction techniques&#46; This may have resulted in underdiagnosis of RSV infection&#44; as the sensitivity of the chromatographic immune assays that were used is lower&#46; Furthermore&#44; sequencing the gene products obtained by amplification would allow additional serogroup and molecular epidemiology analyses&#44; which could not be conducted in this study&#46; However&#44; the availability of PCR would not have changed the preventive measures used to control the outbreak in any significant way&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">It is worth highlighting the considerable number of cases detected in our study&#46; Some of the factors that may have contributed to it are the screening for carriers &#40;which identified 8 of the 20 diagnosed cases&#41;&#44; the delay in reporting &#40;there were already six cases of RSV infection at the time of the first report&#41;&#44; the early discontinuation of isolation precautions &#40;which were automatically discontinued seven days after their initiation&#41;&#44; and gaps in the adherence to hand hygiene measures&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Despite the delay in reporting&#44; which was due to flaws in the internal communication between the involved departments&#44; the creation of the interdisciplinary team helped address these issues and facilitated the quick implementation of preventive measures&#44; which was crucial in the management and containment of the outbreak&#46; These precautions&#44; such as the isolation of infected patients&#44; the screening for carrier detection&#44; the assignment of an exclusively-dedicated staff to the care of patients infected by RSV&#44; and the emphasis placed on the adherence to appropriate hand hygiene&#44; were measures that are generally recommended for infection control&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#44;21&#44;23&#8211;25</span></a> Furthermore&#44; following the recommendations given in different studies<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">26&#44;27</span></a> and clinical practice guidelines&#44;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">28&#44;29</span></a> adherence to hand hygiene was assessed by direct observation of the performance of health care workers during their shifts and the supervision of isolation precautions&#46; In our study&#44; the adherence of health care workers to hand hygiene measures was of 63&#37;&#44; a percentage that exceeded the 40&#37; reported in a recent systematic review&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> However&#44; we must take into account that the monitoring took place during the study of the outbreak&#44; which may have increased the motivation of health care workers to strictly adhere to hand hygiene measures&#46; Of all the measures that were implemented&#44; those that seemed to be most effective were the observation of hand hygiene and the supervision of isolation precautions&#44; as no further cases were detected after they started&#46; In contrast&#44; the screening for carriers did succeed in detecting new cases but did not lead to the end of the outbreak&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">In conclusion&#44; this was an outbreak with a large number of cases&#44; a fact that was associated with delayed reporting and the long duration of RSV carriage&#44; and further facilitated by flaws in the hand hygiene of the health care staff and in contact isolation precautions&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The experience gained during this outbreak allows us to conclude that the creation of interdisciplinary teams is key in the control of epidemic outbreaks&#44; as it leads to the quick and consistent implementation of preventive measures&#46; Furthermore&#44; we believe that such teams should be permanent in high-risk units&#44; as they provide effective channels of communication between the departments involved in the daily surveillance of health care-related infections&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Investigation and control of a respiratory syncytial virus &#40;RSV&#41; outbreak that affected the Neonatal Intensive Care Unit &#40;NICU&#41; of a university hospital from October to December 2012&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cohort study of children admitted to the NICU&#46; The infection attack rate was calculated&#46; A descriptive analysis of the cases and a multivariate analysis was performed using the variables that were shown to be risk factors for RSV infection&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Preventive measures taken were&#58; contact isolation&#59; hand hygiene training and observation&#59; exclusivity of a health team of nurses and physicians for positive cases&#44; restrictions on visitor numbers&#59; surveillance RSV testing&#44; and palivizumab prophylaxis&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The outbreak had three epidemic waves and 20 positive cases out of a total of 48 children admitted&#46; The overall attack rate was 42&#37;&#46; Half of positive cases were children&#44; with a median age of 36 days &#40;p25<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&#44; p75<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>58&#41;&#46; The independent risk factors for RSV infection were birth weight below 1000<span class="elsevierStyleHsp" style=""></span>g &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#46;5&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;002&#41; and to have another nosocomial infection the week before the diagnosis of RSV infection &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;98&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;016&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It was an outbreak with a high number of cases&#44; due to the delay in notification&#44; prolonged RSV carrier status&#44; and low adherence to hand hygiene practice&#44; which favoured the cross-transmission of infection&#46; The most effective preventive measures were direct observation of hand hygiene and supervision of isolation measures&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Patients and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Investigaci&#243;n y control de un brote por virus respiratorio sincitial &#40;VRS&#41; que afect&#243; a la Unidad de Neonatolog&#237;a &#40;UN&#41; de un hospital universitario de octubre a diciembre del 2012&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohortes de los ni&#241;os ingresados en la UN&#46; Se calcul&#243; la tasa de ataque de infecci&#243;n y se realizaron un an&#225;lisis descriptivo de los casos y un an&#225;lisis multivariante de aquellas variables que mostraron ser factores de riesgo de infecci&#243;n por VRS&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las medidas preventivas llevadas a cabo fueron&#58; aislamiento de contacto de casos&#59; formaci&#243;n y observaci&#243;n de higiene de manos&#59; exclusividad del personal sanitario para casos&#44; restricci&#243;n de visitas&#59; estudio de portadores de VRS y profilaxis con palivizumab&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El brote tuvo 3 ondas epid&#233;micas y un total de 20 casos&#44; de 48 ni&#241;os ingresados&#46; La tasa de ataque global fue del 42&#37;&#46; De los casos&#44; la mitad fueron ni&#241;os&#44; con una edad mediana de 36 d&#237;as &#40;p25<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&#44; p75<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>58&#41;&#46; El peso al nacimiento inferior a 1&#46;000<span class="elsevierStyleHsp" style=""></span>g &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#44;5&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; y tener otra infecci&#243;n nosocomial en la semana previa al diagn&#243;stico de infecci&#243;n por VRS &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#44;98&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;016&#41;&#44; fueron factores de riesgo independientes de infecci&#243;n por VRS&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Se trat&#243; de un brote epid&#233;mico con un elevado n&#250;mero de casos&#44; relacionado con el retraso en la notificaci&#243;n&#44; el tiempo prolongado del estado de portador del VRS y los fallos en el cumplimiento de la higiene de manos&#44; que favoreci&#243; la transmisi&#243;n cruzada de la infecci&#243;n&#46; Las medidas preventivas m&#225;s eficaces fueron la observaci&#243;n directa de higiene de manos y supervisi&#243;n de las medidas de aislamiento&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Pacientes y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Parejo CM&#44; Garc&#237;a AM&#44; Dom&#237;nguez CL&#44; Ochoa CC&#44; Mart&#237;n JA&#44; Herrera MC&#46; Brote por virus respiratorio sincitial en la Unidad de Neonatolog&#237;a de un hospital de tercer nivel&#46; An Pediatr &#40;Barc&#41;&#46; 2016&#59;85&#58;119&#8211;127&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Previous presentations&#58; This study was presented as an oral communication &#40;<span class="elsevierStyleItalic">Brote nosocomial de infecci&#243;n por virus respiratorio sincitial en una Unidad de Neonatolog&#237;a</span>&#41; at the Congreso Iberoamericano de Epidemiolog&#237;a y Salud P&#250;blica&#44; XXXI Reuni&#243;n Cient&#237;fica de la Sociedad Espa&#241;ola de Epidemiolog&#237;a&#59; September 4&#8211;6&#44; 2013&#59; Granada&#44; Spain&#46;</p>"
      ]
    ]
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            "apendice" => "<p id="par0190" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="201608250218571811"></elsevierMultimedia></p>"
            "etiqueta" => "Annex 1"
            "titulo" => "Epidemiologic survey on the nosocomial outbreak of respiratory syncytial virus"
            "identificador" => "sec0035"
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        ]
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Spatial distribution of cases and carriers of RSV infection in the General Neonatology Unit&#46;</p>"
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Epidemic curve of the outbreak &#40;by date of microbiological diagnosis of respiratory syncytial virus infection by testing of nasopharyngeal samples&#41;&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Unit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Attack rate<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> for each unit &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">General neonatology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Intermediate care nursery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NICU&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Overall attack rate<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Attack rate&#58; number of patients infected by RSV&#47;number of patients hospitalised in the unit&#46;</p>"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Respiratory syncytial virus attack rate&#44; overall and for each unit&#46;</p>"
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">BW&#44; birth weight&#59; Dx&#44; diagnosis&#59; F&#44; female&#59; GA&#44; gestational age&#59; HD&#44; heart disease&#59; IUGR-M&#44; intrauterine growth restriction-malnutrition&#59; LD&#44; lung disease&#59; LOS&#44; length of stay in the unit&#59; M&#44; male&#59; MM&#44; multiple malformation&#59; MV&#44; invasive mechanical ventilation prior to RSV infection&#59; ND&#44; neurologic disease&#59; ONI&#44; other nosocomial infection&#59; RSV&#44; respiratory syncytial virus&#59; Surg&#44; surgery prior to RSV infection&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">GA &#40;weeks&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">BW &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age at RSV Dx &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">LOS at Dx &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Underlying disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">927&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1443&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IUGR-M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2900&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1543&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1350&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;Ductus&#47;ND&#47;ONI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1780&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IUGR-M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">769&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ductus&#47;IUGR-M&#47;Surg&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3376&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Death&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1214&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">819&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3186&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Surg&#47;MM&#47;ONI&#47;Surg&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">820&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">153&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">144&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ND&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Death&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">588&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ductus&#47;ONI&#47;Surg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">964&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">680&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ductus&#47;ND&#47;Surg&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">794&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;IUGR-M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">806&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">791&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ductus&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;IUGR-M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Birth weight</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8805;1500<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>0&#8211;999<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;157&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;511&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1000&#8211;1499<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;246&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;737&#8211;229&#46;793&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Constant</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;618&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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Original Article
Respiratory syncytial virus outbreak in a tertiary hospital Neonatal Intensive Care Unit
Brote por virus respiratorio sincitial en la Unidad de Neonatología de un hospital de tercer nivel
Joaquín Carlos Moreno Parejoa,
Corresponding author
carlos.moreno.parejo@gmail.com

Corresponding author.
, Áurea Morillo Garcíaa, Carmen Lozano Domínguezb, Concepción Carreño Ochoaa, Javier Aznar Martínb, Manuel Conde Herreraa
a Servicio de Medicina Preventiva, Hospital Universitario Virgen del Rocío, Sevilla, Spain
b Servicio de Microbiología y Parasitología, Hospital Universitario Virgen del Rocío, Sevilla, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Respiratory syncytial virus &#40;RSV&#41; is a single-stranded RNA virus of the Paramyxoviridae family&#46; It is classified into A and B subtypes&#44; which may co-circulate&#44; although subtype A generally dominates&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Respiratory syncytial virus is the single most important cause of lower respiratory tract infections<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a> and the leading cause of acute bronchiolitis<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> in children&#46; It may cause upper respiratory tract infections&#44; lower respiratory tract infections and pneumonia&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> It causes seasonal outbreaks that vary by geographical area&#44; with its incidence peaking between November and February in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> It is one of the main causative agents in nosocomial respiratory tract infections in the paediatric population&#44; and causes outbreaks associated with considerable morbidity and mortality&#44; especially in patients with certain underlying diseases&#46; Prolonged viral shedding and the potential susceptibility of patients and health care staff&#44; since permanent immunity cannot be acquired&#44; make it difficult to control nosocomial spread&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The most frequent mode of transmission is direct contact&#44; as the virus can remain for hours in surfaces and the hands of health care workers&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this article&#44; we analyse an outbreak of RSV that affected 20 infants hospitalised in a neonatal unit &#40;NU&#41; and the measures taken to control the spread of infection&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">The NU was located in a tertiary care university hospital &#40;referral hospital&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> The paediatric department serves a catchment area with a population of 150&#44;619 children&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The NU&#44; which is the referral unit for the autonomous community of Andalusia&#44; is divided into General Neonatology &#40;GN&#41;&#44; which has 28 beds&#44; 5 doctors and a nurse-patient ratio of one nurse to six or seven patients&#59; the Intermediate Care Nursery &#40;ICN&#41;&#44; with 16 beds&#44; 6 doctors and a ratio of one nurse per three or four patients&#59; and the Neonatal Intensive Care Unit &#40;NICU&#41;&#44; with 12 beds&#44; 6 doctors and a ratio of one nurse per two patients&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Definitions&#46;</span> We defined a <span class="elsevierStyleItalic">suspected case</span> of RSV infection as a neonate admitted to the NU between October 2 and December 6 that exhibited symptoms compatible with one of the following&#58; upper respiratory tract infection &#40;presence of cough&#44; rhinorrhoea and&#47;or fever&#41;&#59; lower respiratory tract infection &#40;hypoxaemia&#44; stridor or wheezing on auscultation&#44; or use of accessory muscles for breathing&#41;&#59; pneumonia &#40;presence of respiratory symptoms and evidence of lung consolidation in chest X-ray&#41;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> and&#47;or bronchiolitis &#40;rhinitis&#44; tachypnoea&#44; wheezing&#44; cough&#44; crepitus and&#47;or nasal flaring&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> A <span class="elsevierStyleItalic">confirmed case</span> was defined as a neonate admitted to the NU between October 2 and December 6 with a positive RSV antigen detection test of a nasopharyngeal wash sample and symptoms compatible with upper respiratory tract infection&#44; lower respiratory tract infection&#44; pneumonia and&#47;or bronchiolitis&#46; We defined <span class="elsevierStyleItalic">asymptomatic carrier</span> as a neonate admitted to the UN between October 2 and December 6&#44; with a positive RSV antigen detection test of a nasopharyngeal aspirate sample and no apparent symptoms of respiratory infection&#46; We calculated the length of stay in the NU for RSV cases as the number of days elapsed from admission to the day of microbiological diagnosis&#46; For those that did not become ill&#44; length of stay was calculated as the days elapsed from admission to the day they underwent screening&#46; We used the World Health Organisation &#40;WHO&#41; classification<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> of preterm birth and its subcategories based on gestational age &#40;GA&#41;&#44; thus defining <span class="elsevierStyleItalic">preterm birth</span> as a birth before 37 weeks&#8217; gestation&#44; <span class="elsevierStyleItalic">moderate to late preterm</span> as a birth between 32 and 37 weeks&#8217; gestation&#44; <span class="elsevierStyleItalic">very preterm</span> as a birth between 28 and 32 weeks&#8217; gestation&#44; and <span class="elsevierStyleItalic">extremely preterm</span> as a birth before 28 weeks&#8217; gestation&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Microbiological testing&#46;</span> The diagnosis of RSV was made based on the detection of the viral antigen in nasopharyngeal lavage samples by chromatographic immunoassay &#40;BD Directigen EZ RSV<span class="elsevierStyleSup">&#174;</span>&#59; New Jersey&#44; USA&#41;&#46; This test has a reproducibility of 99&#46;1&#37;&#44; a sensitivity of 80&#37; and a specificity of 91&#37;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Outbreak detection and measures for intervention&#46;</span> On October 9&#44; 2012&#44; the chief of the NU notified the department of preventive medicine of the presence of six cases of RSV infection in GN&#46; Subsequently&#44; a retrospective search and prospective surveillance for additional cases was initiated&#44; an interdisciplinary team was created to control the outbreak&#44; and the following preventive measures were implemented&#58; contact isolation of patients suspected to be infected by RSV based on their clinical presentation&#44; with particular emphasis on handwashing and strict compliance with the hand hygiene recommendations of the WHO&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">12</span></a> care of infected patients by exclusively-dedicated health care staff&#44; and visitation restrictions&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">On October 22 and November 5&#44; new cases were detected in the NICU and in GN&#44; respectively&#44; and further measures were implemented&#44; including RSV screening for identification of carriers&#44; prophylaxis with palivizumab&#44; and monitoring of hand hygiene and compliance with isolation measures in all three units&#46; <a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a> show the distribution of disease cases and infected patients in the affected units&#44; while <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> summarises the flow of events&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Study design&#46;</span> We studied the cohorts consisting of all the neonates hospitalised in the NU from the time the first case was diagnosed &#40;October 2&#44; 2012&#41; to the time the last two cases were detected &#40;November 6&#44; 2012&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Data collection&#46;</span> We used the protocolized individual questionnaire developed by the Department of Preventive Medicine &#40;see <a class="elsevierStyleCrossRef" href="#sec0035">Appendix A</a>&#41; to collect personal information and data for variables concerning the disease process&#44; medical history&#44; and interventions performed&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Statistical analysis&#46;</span> We calculated the overall RSV attack rate and the attack rate for each unit&#44; which corresponds to the probability that patients hospitalised in the unit get infected by RSV&#46; We defined <span class="elsevierStyleItalic">at-risk individual</span> as a neonate hospitalised in the NU during the outbreak&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">We performed a univariate descriptive statistical analysis&#44; summarising categorical variables as frequency distributions and quantitative variables as measures of central tendency and dispersion&#46; For the bivariate analysis&#44; we assessed the associations between variables using the chi square test or Fisher&#39;s exact test&#46; Statistical significance was defined as <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; We used the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test for independent samples to compare the medians of two groups&#46; We used logistic regression for the multivariate analysis of variables previously identified as risk factors for RSV infection&#46; We analysed the data using the Statistical Package for the Social Sciences &#40;SPSS&#41; version 20 &#40;IBM&#59; Armonk&#44; New York&#44; USA&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The variables described in the univariate and bivariate analyses were&#58; age at diagnosis of RSV infection&#59; length of stay in the unit until diagnosis of RSV infection&#59; birth weight &#40;in grams&#41;&#59; GA &#40;in weeks&#41;&#59; degree of prematurity&#59; and positive history of chronic lung disease&#44; heart disease&#44; patent ductus arteriosus&#44; neurologic disease&#44; congenital anomaly&#44; intrauterine growth restriction &#40;IUGR&#41; and malnutrition&#44; surgery prior to diagnosis of RSV infection&#44; mechanical ventilation prior to diagnosis of RSV infection&#44; and nosocomial infection in the seven days preceding the diagnosis of RSV infection&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The variables corresponding to <span class="elsevierStyleItalic">P</span> values of less than 0&#46;05 in the bivariate analysis that were included in the multivariate analysis were GA&#44; birth weight&#44; length of stay in the unit&#44; history of chronic lung disease&#44; prior nosocomial infection and degree of prematurity&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Outbreak characteristics</span><p id="par0085" class="elsevierStylePara elsevierViewall">The overall RSV attack rate was 42&#37;&#44; with attack rates of 38&#37; for GN&#44; 42&#37; for the ICN and 47&#37; for the NICU &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The outbreak comprised three epidemic waves and a total of 20 cases in the 48 hospitalised neonates &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; The first wave started on October 2 in GN and comprised 9 cases&#46; The first case occurred in a patient admitted to the ICU on August 6 and transferred to GN on September 28&#44; in whom testing of a nasopharyngeal aspirate sample detected the presence of RSV antigen on October 2&#46; The second wave affected the NICU and ICN&#44; occurred between October 20 and 25&#44; and comprised eight cases&#46; The third wave&#44; from December 3 to 6&#44; comprised the three remaining cases detected in the NICU and ICN&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Of the total number of cases&#44; twelve were reported by GN in the course of the three epidemic waves&#44; and the other eight cases were detected in the screening for carriers&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Of the 20 cases&#44; half corresponded to male and half to female patients&#44; with a median age at diagnosis of RSV infection of 36 days &#40;IQR&#44; 22&#8211;58&#41;&#44; a median gestational age of 29 weeks &#40;IQR&#44; 25&#46;5&#8211;33&#46;8&#41; and a median birth weight of 982<span class="elsevierStyleHsp" style=""></span>g &#40;IQR&#44; 797&#8211;1518&#41;&#46; The mean length of stay in the unit was 30&#46;5 days &#40;IQR&#44; 17&#46;25&#8211;54&#46;25&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; As for the clinical manifestations&#44; out of the 20 patients&#44; 15 developed symptoms &#40;75&#37;&#41;&#44; albeit mild ones&#44; and only 30&#37; of symptomatic patients developed a full case of bronchiolitis&#46; Radiologic findings were normal in most patients &#40;60&#37;&#41;&#59; there were signs of hyperinflation or perihilar infiltrates in 25&#37;&#44; and signs of lung consolidation or atelectasis in 15&#37;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The hospitalised neonates that were not infected by RSV were aged a median of 13&#46;50 days &#40;IQR&#44; 5&#46;5&#8211;24&#46;5&#41;&#44; with a median GA of 36 weeks &#40;IQR&#44; 32&#8211;38&#41;&#44; a median birth weight of 2785<span class="elsevierStyleHsp" style=""></span>g &#40;IQR&#44; 1966&#8211;3565&#41; and a length of stay in the unit of 8&#46;5 days &#40;IQR&#44; 4&#46;25&#8211;21&#41;&#46; The bivariate analysis showed that the differences in birth weight&#44; GA and length of stay between cases and patients that did not get infected were statistically significant for all three variables &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Eighty-five percent of cases were born preterm&#44; compared to fifty-seven percent of controls&#46; Twenty-five percent of cases were very preterm and forty-five percent extremely preterm&#44; and we found a statistically significant association between RSV infection and very preterm birth &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;029&#41;&#44; and between RSV infection and extremely preterm birth &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;013&#41;&#46; Sixty-five percent of cases had a history of chronic lung disease compared to twenty-nine percent of controls &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;012&#41;&#46; Forty percent of cases had another nosocomial infection in the week preceding the diagnosis of RSV infection compared to 3&#46;6&#37; of controls &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;002&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Fifty percent of cases received prophylactic treatment with monoclonal antibodies &#40;palivizumab&#41; compared to twenty-nine percent of controls&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">As for the clinical outcomes&#44; most patients were discharged after improving&#44; two of the cases &#40;10&#37;&#41; and one of the patients that was not infected by RSV &#40;3&#46;6&#37;&#41; died&#46; The cause of death was unrelated to RSV infection in all three&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">We did not find a statistically significant association between RSV infection and a positive history of heart disease&#44; patent ductus arteriosus&#44; neurologic disease&#44; congenital anomaly&#44; IUGR&#44; surgery prior to diagnosis of RSV infection or mechanical ventilation prior to diagnosis of RSV infection&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The multivariate logistic regression analysis &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; identified the following as independent risk factors for infection by RSV&#58; birth weight of less than 1000<span class="elsevierStyleHsp" style=""></span>g 1 &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#46;5&#59; 95&#37; CI&#44; 3&#46;26&#8211;169&#46;21&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;002&#41; and having had another nosocomial infection in the week preceding the diagnosis of RSV infection &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;98&#59; 95&#37; CI&#44; 1&#46;73&#8211;229&#46;79&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;016&#41;&#46; The resulting model classified 81&#46;3&#37; of the analysed cases correctly&#44; and the variability in infection by RSV virus &#40;independent variable&#41; predicted by the model ranged from 39&#46;7&#37; &#40;Cox and Snell R square&#41; to 53&#46;5&#37; &#40;Nagerkelke&#39;s R square&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">Respiratory syncytial virus is the leading cause of lower respiratory tract infection in infants younger than one year&#44;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">13&#44;14</span></a> it is one of the most frequent causative pathogens in outbreaks of nosocomial infection&#44; and is associated with a high morbidity and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15&#44;16</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In infants aged less than 6 months&#44; chronic lung disease&#44; birth before 35 weeks&#8217; gestation&#44; congenital heart disease and immunodeficiency are well-known risk factors for RSV infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">17&#44;18</span></a> Preterm newborns are most susceptible to infection by RSV due to the immaturity of their immune system and their low serum levels of maternal antibodies&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15&#44;19</span></a> In our study&#44; the average GA and birth weight of neonates infected by RSV were significantly lower than those of the neonates that were not infected&#44; which was consistent with the results of previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8&#44;20</span></a> We also found a significant association between RSV infection and chronic lung disease&#44; which has also been described in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15&#44;17</span></a> Infection by RSV was associated with a longer length of stay in the unit until diagnosis or screening&#44; but we did not find an association with other risk factors reported in previous studies&#44; such as underlying congenital heart disease&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> We also found a significant association between RSV infection and having had another nosocomial infection in the week prior to its diagnosis&#46; This could be explained by a weakened immune system in these children&#44; which would make them more susceptible to infection by another pathogen&#44; although we did not find data to support this hypothesis in the literature&#46; The multivariate logistic regression analysis only identified two independent risk factors for becoming infected by RSV&#44; which were birth weight of less than 1000<span class="elsevierStyleHsp" style=""></span>g and having had another nosocomial infection in the week preceding the diagnosis of RSV infection&#46; The degree of prematurity variable was a potential confounding factor due to its close association with birth weight&#44; and was therefore removed from the logistic regression model&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The mortality of patients with community-acquired RSV infection is negligible&#44; unlike that of patients with nosocomial infections&#44; which can be considerable&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a> The risk of death is higher in children of younger ages&#44; born preterm&#44; or with congenital heart disease&#44; bronchopulmonary dysplasia or immunodeficiency&#44; as they are more susceptible to severe disease&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> In our study&#44; the three deaths that occurred in the patients under study were unrelated to RSV infection&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Thirty percent of the cases required invasive mechanical ventilation&#44; but since all these patients had required it prior to the diagnosis of RSV infection&#44; we were unable to determine its association with RSV&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Early detection of cases is a crucial measure in outbreak control&#44; as it allows the timely implementation of appropriate isolation precautions and the containment of viral transmission&#46; Respiratory syncytial virus spreads through direct contact or indirectly through fomites&#44; and it can survive on inorganic surfaces for up to 12<span class="elsevierStyleHsp" style=""></span>h&#44; which prolongs the time span during which transmission is possible&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8&#44;21</span></a> In addition&#44; while the usual duration of viral shedding is two weeks&#44; this period can be longer in premature or immunocompromised infants&#44; and therefore all patients should be tested when an outbreak of RSV is suspected to detect potential asymptomatic cases of infection&#46; For all the above reasons&#44; preventive measures such as screening for virus carriage are not only important for the detection of new cases&#44; but can be helpful in estimating how long contact isolation precautions should be maintained&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">One of the limitations of our study was that the respiratory secretion samples of the patients were not analysed with polymerase chain reaction techniques&#46; This may have resulted in underdiagnosis of RSV infection&#44; as the sensitivity of the chromatographic immune assays that were used is lower&#46; Furthermore&#44; sequencing the gene products obtained by amplification would allow additional serogroup and molecular epidemiology analyses&#44; which could not be conducted in this study&#46; However&#44; the availability of PCR would not have changed the preventive measures used to control the outbreak in any significant way&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">It is worth highlighting the considerable number of cases detected in our study&#46; Some of the factors that may have contributed to it are the screening for carriers &#40;which identified 8 of the 20 diagnosed cases&#41;&#44; the delay in reporting &#40;there were already six cases of RSV infection at the time of the first report&#41;&#44; the early discontinuation of isolation precautions &#40;which were automatically discontinued seven days after their initiation&#41;&#44; and gaps in the adherence to hand hygiene measures&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Despite the delay in reporting&#44; which was due to flaws in the internal communication between the involved departments&#44; the creation of the interdisciplinary team helped address these issues and facilitated the quick implementation of preventive measures&#44; which was crucial in the management and containment of the outbreak&#46; These precautions&#44; such as the isolation of infected patients&#44; the screening for carrier detection&#44; the assignment of an exclusively-dedicated staff to the care of patients infected by RSV&#44; and the emphasis placed on the adherence to appropriate hand hygiene&#44; were measures that are generally recommended for infection control&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#44;21&#44;23&#8211;25</span></a> Furthermore&#44; following the recommendations given in different studies<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">26&#44;27</span></a> and clinical practice guidelines&#44;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">28&#44;29</span></a> adherence to hand hygiene was assessed by direct observation of the performance of health care workers during their shifts and the supervision of isolation precautions&#46; In our study&#44; the adherence of health care workers to hand hygiene measures was of 63&#37;&#44; a percentage that exceeded the 40&#37; reported in a recent systematic review&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> However&#44; we must take into account that the monitoring took place during the study of the outbreak&#44; which may have increased the motivation of health care workers to strictly adhere to hand hygiene measures&#46; Of all the measures that were implemented&#44; those that seemed to be most effective were the observation of hand hygiene and the supervision of isolation precautions&#44; as no further cases were detected after they started&#46; In contrast&#44; the screening for carriers did succeed in detecting new cases but did not lead to the end of the outbreak&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">In conclusion&#44; this was an outbreak with a large number of cases&#44; a fact that was associated with delayed reporting and the long duration of RSV carriage&#44; and further facilitated by flaws in the hand hygiene of the health care staff and in contact isolation precautions&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The experience gained during this outbreak allows us to conclude that the creation of interdisciplinary teams is key in the control of epidemic outbreaks&#44; as it leads to the quick and consistent implementation of preventive measures&#46; Furthermore&#44; we believe that such teams should be permanent in high-risk units&#44; as they provide effective channels of communication between the departments involved in the daily surveillance of health care-related infections&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Investigation and control of a respiratory syncytial virus &#40;RSV&#41; outbreak that affected the Neonatal Intensive Care Unit &#40;NICU&#41; of a university hospital from October to December 2012&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cohort study of children admitted to the NICU&#46; The infection attack rate was calculated&#46; A descriptive analysis of the cases and a multivariate analysis was performed using the variables that were shown to be risk factors for RSV infection&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Preventive measures taken were&#58; contact isolation&#59; hand hygiene training and observation&#59; exclusivity of a health team of nurses and physicians for positive cases&#44; restrictions on visitor numbers&#59; surveillance RSV testing&#44; and palivizumab prophylaxis&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The outbreak had three epidemic waves and 20 positive cases out of a total of 48 children admitted&#46; The overall attack rate was 42&#37;&#46; Half of positive cases were children&#44; with a median age of 36 days &#40;p25<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&#44; p75<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>58&#41;&#46; The independent risk factors for RSV infection were birth weight below 1000<span class="elsevierStyleHsp" style=""></span>g &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#46;5&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;002&#41; and to have another nosocomial infection the week before the diagnosis of RSV infection &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;98&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;016&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It was an outbreak with a high number of cases&#44; due to the delay in notification&#44; prolonged RSV carrier status&#44; and low adherence to hand hygiene practice&#44; which favoured the cross-transmission of infection&#46; The most effective preventive measures were direct observation of hand hygiene and supervision of isolation measures&#46;</p></span>"
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            "titulo" => "Introduction"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Investigaci&#243;n y control de un brote por virus respiratorio sincitial &#40;VRS&#41; que afect&#243; a la Unidad de Neonatolog&#237;a &#40;UN&#41; de un hospital universitario de octubre a diciembre del 2012&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohortes de los ni&#241;os ingresados en la UN&#46; Se calcul&#243; la tasa de ataque de infecci&#243;n y se realizaron un an&#225;lisis descriptivo de los casos y un an&#225;lisis multivariante de aquellas variables que mostraron ser factores de riesgo de infecci&#243;n por VRS&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las medidas preventivas llevadas a cabo fueron&#58; aislamiento de contacto de casos&#59; formaci&#243;n y observaci&#243;n de higiene de manos&#59; exclusividad del personal sanitario para casos&#44; restricci&#243;n de visitas&#59; estudio de portadores de VRS y profilaxis con palivizumab&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El brote tuvo 3 ondas epid&#233;micas y un total de 20 casos&#44; de 48 ni&#241;os ingresados&#46; La tasa de ataque global fue del 42&#37;&#46; De los casos&#44; la mitad fueron ni&#241;os&#44; con una edad mediana de 36 d&#237;as &#40;p25<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&#44; p75<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>58&#41;&#46; El peso al nacimiento inferior a 1&#46;000<span class="elsevierStyleHsp" style=""></span>g &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#44;5&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; y tener otra infecci&#243;n nosocomial en la semana previa al diagn&#243;stico de infecci&#243;n por VRS &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#44;98&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;016&#41;&#44; fueron factores de riesgo independientes de infecci&#243;n por VRS&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Se trat&#243; de un brote epid&#233;mico con un elevado n&#250;mero de casos&#44; relacionado con el retraso en la notificaci&#243;n&#44; el tiempo prolongado del estado de portador del VRS y los fallos en el cumplimiento de la higiene de manos&#44; que favoreci&#243; la transmisi&#243;n cruzada de la infecci&#243;n&#46; Las medidas preventivas m&#225;s eficaces fueron la observaci&#243;n directa de higiene de manos y supervisi&#243;n de las medidas de aislamiento&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Parejo CM&#44; Garc&#237;a AM&#44; Dom&#237;nguez CL&#44; Ochoa CC&#44; Mart&#237;n JA&#44; Herrera MC&#46; Brote por virus respiratorio sincitial en la Unidad de Neonatolog&#237;a de un hospital de tercer nivel&#46; An Pediatr &#40;Barc&#41;&#46; 2016&#59;85&#58;119&#8211;127&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Previous presentations&#58; This study was presented as an oral communication &#40;<span class="elsevierStyleItalic">Brote nosocomial de infecci&#243;n por virus respiratorio sincitial en una Unidad de Neonatolog&#237;a</span>&#41; at the Congreso Iberoamericano de Epidemiolog&#237;a y Salud P&#250;blica&#44; XXXI Reuni&#243;n Cient&#237;fica de la Sociedad Espa&#241;ola de Epidemiolog&#237;a&#59; September 4&#8211;6&#44; 2013&#59; Granada&#44; Spain&#46;</p>"
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Epidemic curve of the outbreak &#40;by date of microbiological diagnosis of respiratory syncytial virus infection by testing of nasopharyngeal samples&#41;&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Unit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Attack rate<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> for each unit &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">General neonatology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Intermediate care nursery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NICU&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Overall attack rate<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">GA &#40;weeks&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">BW &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age at RSV Dx &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">LOS at Dx &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Underlying disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">927&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1443&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IUGR-M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2900&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1543&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1350&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;Ductus&#47;ND&#47;ONI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1780&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IUGR-M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">769&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ductus&#47;IUGR-M&#47;Surg&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3376&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Death&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1214&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">819&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3186&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Surg&#47;MM&#47;ONI&#47;Surg&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">820&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">153&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">144&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ND&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Death&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">588&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ductus&#47;ONI&#47;Surg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">964&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">680&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ductus&#47;ND&#47;Surg&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">794&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;IUGR-M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">806&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ONI&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">791&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;ductus&#47;MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LD&#47;IUGR-M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>0&#8211;999<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;157&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;511&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;267&#8211;169&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1000&#8211;1499<span class="elsevierStyleHsp" style=""></span>g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;797&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;946&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;031&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;944&#8211;38&#46;533&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Another nosocomial infection</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;995&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;246&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;737&#8211;229&#46;793&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Constant</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;618&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                          "etal" => true
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ISSN: 23412879
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Idiomas
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