Scientific Letter
Mitral valve replacement in infants less than 6 months-old
Prótesis mitral en pacientes de menos de 6 meses
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Colom Seguí, S. Escribà Bori, M.A. de la Fuente Sánchez, F. García Algas" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Colom Seguí" "email" => array:1 [ 0 => "marinacolomsegui@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "S." "apellidos" => "Escribà Bori" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M.A." "apellidos" => "de la Fuente Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "García Algas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Pediatría, Hospital Universitari Son Espases, Palma de Mallorca, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Cardiología, Servicio de Pediatría, Hospital Universitari Son Espases, Palma de Mallorca, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prótesis mitral en pacientes de menos de 6 meses" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Congenital mitral insufficiency (MI) is rare in children. It is usually associated with other heart malformations, and the isolated form occurs much less frequently.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> Mitral valve replacement (MVR) is an uncommon procedure in the paediatric age group, especially in infants. The most frequent indications for MVR are rheumatic disease, endocarditis, Shone syndrome or a failed atrioventricular canal repair. Despite surgical advances and the use of different materials, MVR is a complex surgery associated with a high rate of complications, and is the procedure for mitral repair that carries the highest mortality (5–52%) and the worst prognosis.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the cases of two patients that received care in our hospital and required MVR before age 12 months and reintervention shortly after, which by chance occurred while receiving maintenance treatment with heparin.</p><p id="par0015" class="elsevierStylePara elsevierViewall">A pregnant woman was referred to our hospital for foetal cardiomegaly at 36 weeks’ gestation. Assessment revealed global cardiomegaly, severe tricuspid insufficiency and moderate mitral insufficiency with normal ventricular function and a closed foramen ovale (FO). Premature closure of the FO was diagnosed that required urgent surgery. The neonatal echocardiogram confirmed these findings, with the most salient feature corresponding to a highly dysplastic mitral valve with pulmonary pressures exceeding systemic pressures. The patient did not respond well to treatment and was transferred to the surgical department at age 8 days. Conservative measures were attempted unsuccessfully, so at age 40 days the dysplastic (myxomatous) mitral valve was resected and a 16<span class="elsevierStyleHsp" style=""></span>mm mechanical prosthetic mitral valve placed in the supra-annular position (CarboMedics, Sorin Group<span class="elsevierStyleSup">®</span>). The patient had a cerebral infarction at the level of the middle cerebral artery as a complication of surgery. The patient was kept under anticoagulant therapy with heparin, administered by the subcutaneous route given his age. At age 3 months he developed a severe pulmonary oedema secondary to the immobilization of the leaflets by pannus formation, requiring a prosthesis exchange. At age 11 months he had a new episode and underwent surgery again for resection of the pannus and thrombi, and the prosthesis was cleaned and rotated after failure of treatment with fibrinolytic agents. Treatment with acenocoumarol and acetylsalicylic acid (ASA) was initiated after the surgery. The patient has remained asymptomatic since, and is currently 3 years old.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Infant aged 5 months with no relevant history referred by his paediatrician for investigation of a heart murmur and growth failure. The echocardiogram showed severe MI with a retracted posterior leaflet, thickening of the free edge, and significant dysplasia of the subvalvular apparatus with dysfunction of the left ventricle. It also revealed retrograde flow in the left coronary artery, suggestive of anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA syndrome). This suspicion led to transfer of the patient to the reference hospital, where the diagnosis was confirmed and coronary translocation from the pulmonary artery to the aorta performed along with a mitral valvuloplasty. At 24 days he showed clinical worsening, and underwent surgery again for placement of a mechanical mitral prosthesis (CarboMedics 18, Sorin Group<span class="elsevierStyleSup">®</span>). Treatment with heparin was initiated. Six months later, he had a sudden worsening of symptoms with signs of pulmonary oedema, and investigation confirmed the immobilization of the valve leaflets. A new intervention was performed, with resection of the pannus and cleaning and rotation of the prosthesis. The patient was subsequently put on acenocoumarol and ASA. The patient, currently aged 3 years, remains asymptomatic.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The surgical management of MI poses a challenge to the paediatric surgeon due to its considerable complexity.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a> Valve repair is the first-line treatment, as it has the best outcomes, although it is not always feasible. Biologic prostheses have the advantage of not requiring anticoagulant therapy, but they degenerate faster. When it comes to mechanical prostheses, the literature has identified the size of the ring and the position of the valve (supra-annular or annular) as factors that influence survival and the need for early reintervention (stenosis, endocarditis and thrombosis).<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a> It is imperative that patients are treated with vitamin K antagonist anticoagulants after the surgery.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In our patients, treatment with heparin was chosen because the adherence to oral administration is worse in children younger than 12 months. Pannus formation (a fibrous tissue overgrowth) was the reason for early reintervention in both patients. This complication is uncommon in the paediatric literature. Although it does not seem to be related to anticoagulant therapy, in both of our patients it developed while they were undergoing treatment with heparin, and did not recur when the patients were treated with a combination of a coumarin drug and ASA.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In short, MI in the paediatric age group continues to be a challenge. Mechanical prostheses have the disadvantage of requiring chronic anticoagulant therapy, which is difficult to adhere to, especially in infants.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Colom Seguí M, Escribà Bori S, de la Fuente Sánchez MA, García Algas F. Prótesis mitral en pacientes de menos de 6 meses. An Pediatr (Barc). 2016;84:170–171.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0025" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital malformations of the mitral valve" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.E. Séguéla" 1 => "L. Houyel" 2 => "P. Acar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.acvd.2011.06.004" "Revista" => array:6 [ "tituloSerie" => "Arch Cardiovasc Dis" "fecha" => "2011" "volumen" => "104" "paginaInicial" => "465" "paginaFinal" => "479" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21944149" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0030" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Valve replacement in children: a challenge for a whole life" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Henaine" 1 => "F. Roubertie" 2 => "M. Vergnat" 3 => "J. Ninet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Cardiovasc Dis" "fecha" => "2012" "volumen" => "105" "paginaInicial" => "17" "paginaFinal" => "28" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0035" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A standardized repair-oriented strategy for mitral insufficiency in infants and children: midterm functional outcomes and predictors of adverse events" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Kalfa" 1 => "M. Vergnat" 2 => "M. Ly" 3 => "B. Stos" 4 => "V. Lambert" 5 => "A. Baruteau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "2014" "volumen" => "148" "paginaInicial" => "459" "paginaFinal" => "466" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0040" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcomes and associated risk factors for mitral valve replacement in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Alsoufi" 1 => "C. Manlhiot" 2 => "M. Al-Ahmadi" 3 => "B.W. McCrindle" 4 => "A. Kalloghlian" 5 => "G. Siblini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejcts.2010.12.060" "Revista" => array:7 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2011" "volumen" => "40" "paginaInicial" => "543" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21353791" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0161642010007438" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:3 [ "titulo" => "Acknowledgments" "texto" => "<p id="par0040" class="elsevierStylePara elsevierViewall">We want to thank the family members of the patients for their cooperation.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/23412879/0000008400000003/v1_201602260011/S2341287916000041/v1_201602260011/en/main.assets" "Apartado" => array:4 [ "identificador" => "38181" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23412879/0000008400000003/v1_201602260011/S2341287916000041/v1_201602260011/en/main.pdf?idApp=UINPBA00005H&text.app=https://analesdepediatria.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2341287916000041?idApp=UINPBA00005H" ]
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| 2018 October | 119 | 38 | 157 |
| 2018 September | 61 | 18 | 79 |
| 2018 August | 5 | 0 | 5 |
| 2018 July | 2 | 0 | 2 |
| 2018 June | 5 | 0 | 5 |
| 2018 May | 16 | 0 | 16 |
| 2018 April | 26 | 0 | 26 |
| 2018 March | 35 | 0 | 35 |
| 2018 February | 23 | 0 | 23 |
| 2018 January | 14 | 0 | 14 |
| 2017 December | 36 | 0 | 36 |
| 2017 November | 13 | 0 | 13 |
| 2017 October | 15 | 0 | 15 |
| 2017 September | 16 | 0 | 16 |
| 2017 August | 17 | 0 | 17 |
| 2017 July | 12 | 1 | 13 |
| 2017 June | 18 | 7 | 25 |
| 2017 May | 19 | 6 | 25 |
| 2017 April | 14 | 6 | 20 |
| 2017 March | 7 | 3 | 10 |
| 2017 February | 7 | 3 | 10 |
| 2017 January | 6 | 2 | 8 |
| 2016 December | 21 | 9 | 30 |
| 2016 November | 23 | 4 | 27 |
| 2016 October | 24 | 5 | 29 |
| 2016 September | 23 | 5 | 28 |
| 2016 August | 33 | 3 | 36 |
| 2016 July | 13 | 3 | 16 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 2 | 0 | 2 |
Show all
