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These symptoms are occasionally nonspecific such as persistent crying&#44; irritability&#44; sleeping disorders&#44; growth delays and respiratory complications&#44; and may potentially cause neonatal death&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">12</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">According to Tsoukali and Sifrim&#44;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">13</span></a> GERD is the most costly gastrointestinal disease with a prevalence ranging between 10&#37; and 20&#37; in the western world&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">14</span></a> Combined multiple intraluminal impedance-pH &#40;MII-pH&#41; monitoring allows for a more accurate detection of GER episodes and facilitates the study of symptom association &#40;SA&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">15&#8211;18</span></a> Particularly in preterm infants&#44; cardiorespiratory &#40;CR&#41; episodes such as apnea&#44; bradycardia or oxygen desaturation&#44; may be temporally related to GER if they occur within a given time interval around the onset of a GER episode&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">1&#44;7&#44;19</span></a> It has been a subject of extensive research since the mid-1980s&#46;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">20&#8211;22</span></a> Nevertheless&#44; in the second decade of the 21st century&#44; this discussion remains open&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">23&#8211;27</span></a> Different statistical indices have been proposed in order to quantify this relationship&#58; the symptom index &#40;SI&#41;&#44; the symptom sensitivity index &#40;SSI&#41; and the symptom association probability &#40;SAP&#41;&#46; However&#44; none of them seem to have solved this problem and therefore surgical treatments may be inappropriately recommended as the result of an overinterpretation of the current metrics&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">28</span></a> On the other hand&#44; the binomial symptom index &#40;BSI&#41;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">29</span></a> fell by the wayside due to its apparent mathematical complexity&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">17</span></a> However&#44; a recent computational analysis<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> has shown that an approximation of the BSI it can provide an optimal measurement of SA&#46; This paper highlights the shortcomings of SA in GER and presents the results of a clinical study of the evaluation of the temporal association between CR symptoms and GER in pediatric patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0015" class="elsevierStylePara elsevierViewall">Forty-three preterm neonates of gestational age varying between 24&#46;0 and 36&#46;0 weeks &#40;median 29&#46;0 weeks&#41; and weighing 0&#46;73&#8211;3&#46;18<span class="elsevierStyleHsp" style=""></span>kg &#40;median 1&#46;31<span class="elsevierStyleHsp" style=""></span>kg&#41; were considered for this study between 2004 and 2008&#46; At the time of recruitment&#44; their postnatal age varied between 13 and 119 days &#40;median 36&#46;5 days&#41;&#46; All showed recurrent CR symptoms&#44; potentially related to GER&#44; and were included in the study as recommended by Vandenplas and co-workers&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">1</span></a> Twenty-five of them &#40;11 females and 14 males&#41; developed symptoms during the study and were the subjects under research&#44; whereas the remaining 18 did not present any CR symptoms during and after the study&#46; Therefore these patients were not considered under this methodology&#46; This research was approved by the Ethics Committee of the Children&#39;s Hospital Virgen del Rocio &#40;CHVR&#41;&#44; Seville&#44; Spain&#46; Parents or legal guardians signed an informed consent form prior to enrolling&#46; Patients were hospitalized at the neonatal intensive care unit of the CHVR under oxygen-enriched atmosphere &#40;21&#8211;30&#37;&#41;&#46; One hour of nasogastric feeding was followed by a 2-h fasting period cyclically during hospitalization&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Instrumentation</span><p id="par0020" class="elsevierStylePara elsevierViewall">All patients underwent 24-h MII-pH and CR monitoring&#46; Six-french transnasal catheters were used to monitor MII-pH &#40;Femu&#44; Aachen&#44; Germany&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">5</span></a> The probe had seven impedance electrodes separated 10<span class="elsevierStyleHsp" style=""></span>mm from each other and two pH electrodes separated 5<span class="elsevierStyleHsp" style=""></span>cm from each other&#46; The pressure inversion point &#40;PIP&#41; was determined manometrically&#46; Thus&#44; the proximal pH electrode was placed at 20<span class="elsevierStyleHsp" style=""></span>mm from the PIP&#44; with the distal electrode located inside the stomach&#46; The distal impedance electrode was located at the position of the PIP&#46; On the other hand&#44; heart rate &#40;HR&#41;&#44; respiratory rate &#40;RR&#41; and oxygen saturation &#40;SpO<span class="elsevierStyleInf">2</span>&#41; were recorded using a bedside patient monitor&#46; MII-pH and CR signals were acquired and digitalized at 50<span class="elsevierStyleHsp" style=""></span>Hz per channel with a National Instruments DAQCard-700&#46; Synchronization was carried out by simultaneously sampling all channels every 20<span class="elsevierStyleHsp" style=""></span>ms&#46; GER events were identified according to the recommendations provided by the ESPGHAN and the NASPGHAN&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">1</span></a> that is&#44; a drop in the pH value below 4 and&#47;or a drop of 50&#37; of the impedance base line in two consecutive channels in the retrograde direction&#46; Then&#44; pathologic GER was determined when the reflux index was greater than 7&#37; or when the number of reflux episodes exceeded 70 episodes in 24<span class="elsevierStyleHsp" style=""></span>h&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">5</span></a> Similarly&#44; CR episodes were considered when the SpO<span class="elsevierStyleInf">2</span> fell below 80&#37;&#44; when breathing was suspended for at least 20<span class="elsevierStyleHsp" style=""></span>s or when the heart rate dropped below 80 systolic cycles per minute&#46; SA was analyzed computationally using numerical analysis software &#40;Matlab 2008&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Clinical methodology</span><p id="par0025" class="elsevierStylePara elsevierViewall">A total of 25 patients were evaluated for SA&#46; In doing so&#44; the SI&#44; the SSI and the SAP were calculated using a 2-minute window&#46; Those patients having none of these indices with a positive value &#40;SA&#8722;&#41; were studied for reflux only and excluded from SA analysis&#46; Patients with a positive value in at least one of the indices &#40;SA&#43;&#41; were carefully assessed&#44; adopting a conservative strategy at all times&#46; Patients were scheduled for laparoscopic Nissen fundoplication when the three estimators were positive&#44; as evidence of SA was proven&#46; However&#44; when only one or two indices were positive&#44; the patient underwent medical treatment and was controlled carefully&#46; All subjects with SA&#43; were followed up during five years as shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; At the time of the study&#44; the BSI was compared with the previous methodology recalculating all the indices using both a one-minute and a two-minute window of association&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">The three major metrics for SA were evaluated to determine the existence of a temporal relationship between GER and CR events&#58; the SI&#44; the SSI and the SAP&#46; Additionally&#44; the BSI<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> was added and compared retrospectively against anti-reflux surgery&#46; The indices were calculated varying the length of the window of association between 1 and 300<span class="elsevierStyleHsp" style=""></span>s&#46; In addition&#44; different temporal offsets were added to the start of the windowing to study the effect time shifts&#46; Although the current recommended width of the window of association is 120<span class="elsevierStyleHsp" style=""></span>s&#44;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">22&#44;25</span></a> a one-minute window of association was also studied&#46; Thus&#44; the Pearson&#39;s correlation coefficient &#40;<span class="elsevierStyleItalic">r</span>&#41; was applied to contrast agreement between 60 and 120<span class="elsevierStyleHsp" style=""></span>s windows with a level of confidence of 95&#37;&#46; The Cohen&#39;s kappa &#40;<span class="elsevierStyleItalic">&#954;</span>&#41; coefficient was used to evaluate agreement between the indices and the decision of anti-reflux surgery based on the combination of positive SI&#44; SSI and SAP&#46;</p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Symptom index</span><p id="par0035" class="elsevierStylePara elsevierViewall">The SI was first introduced by Ward et al&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">20</span></a> as the ratio between the number of symptoms that are related to a reflux episode &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf">RRS</span>&#41; and the total number of symptoms &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf">S</span>&#41; during time of study&#44; as in Eq&#46; <a class="elsevierStyleCrossRef" href="#eq0005">&#40;1&#41;</a>&#46; A positive association can be considered if SI<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>50&#37;&#44; according to studies conducted in adults&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">17</span></a><elsevierMultimedia ident="eq0005"></elsevierMultimedia></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Symptom sensitivity index</span><p id="par0040" class="elsevierStylePara elsevierViewall">The SSI represents the positive predictive value taking into account the total number of reflux episodes&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">17&#44;21</span></a> Eq&#46; <a class="elsevierStyleCrossRef" href="#eq0010">&#40;2&#41;</a> defines this index as the ratio of those symptom-related reflux episodes &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf">SRR</span>&#41; to the total number of reflux occurrences &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf">R</span>&#41;&#46; It is considered as positive if SSI<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>10&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">21</span></a><elsevierMultimedia ident="eq0010"></elsevierMultimedia></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Symptom association probability</span><p id="par0045" class="elsevierStylePara elsevierViewall">This index provides a measure of probability of association&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">17&#44;31</span></a> The study is divided into temporal windows to form a 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2 contingency array&#44; and then the Ficher&#39;s exact test is applied to obtain the probability of reflux and symptoms to occur by chance &#40;<span class="elsevierStyleItalic">p</span>&#41;&#46; Thus&#44; Eq&#46; <a class="elsevierStyleCrossRef" href="#eq0015">&#40;3&#41;</a> represents the degree of temporal association&#44; as a measure of probability&#44; in terms of the SAP&#58;<elsevierMultimedia ident="eq0015"></elsevierMultimedia>This index denotes a statistical temporal association when SAP<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>95&#37;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Binomial symptom index</span><p id="par0050" class="elsevierStylePara elsevierViewall">The BSI was first described by Ghillebert et al&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">29</span></a> to determine SA in esophageal pH studies and has been recently studied using computational methods&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> The BSI can be calculated according to Eq&#46; <a class="elsevierStyleCrossRef" href="#eq0020">&#40;4&#41;</a>&#44; where <span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">S</span></span> represents the total number of symptoms&#44; <span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">R</span></span> is the total number of ebbs&#44; <span class="elsevierStyleItalic">T</span> is the monitoring time&#44; <span class="elsevierStyleItalic">w</span> is the width of the window of association and <span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">A</span></span> represents the number of reflux-related symptoms&#46; The BSI was suggested to provide a positive assessment&#44; in a 24-h monitoring study&#44; when BSI<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>99&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a><elsevierMultimedia ident="eq0020"></elsevierMultimedia></p></span></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">The average monitoring time was 21&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;1<span class="elsevierStyleHsp" style=""></span>h&#46; The total number of reflux events ranged between 19 and 146 &#40;mean 77&#46;5&#41; whereas the total number of symptom episodes varied between 1 and 46 &#40;mean 15&#46;0&#41;&#46; In the first stage&#44; at least one of the three main indices under study determined a positive SA in 13&#47;25 patients as in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; All the indices were positive in 3&#47;25 subjects&#46; These patients were scheduled for anti-reflux surgery&#46; However&#44; one of them stopped having CR symptoms spontaneously a few days before surgery and therefore a conservative approach was adopted&#46; This patient had a good evolution and did not require surgery&#46; On the other hand&#44; 10&#47;25 patients had one or two indices with a positive value&#46; They were carefully studied and underwent eight weeks medical treatment&#44; including proton pump inhibitors and prokinetic drugs to treat reflux&#44; and theophylline and caffeine for the CR pathology&#46; Afterwards&#44; these patients were reevaluated for SA&#58; five of them were studied for reflux only for not having shown CR symptoms again&#44; whereas the other 5&#47;25 had a negative SA but still presented some CR episodes&#46; Therefore&#44; these subjects were included in the five year follow-up period&#46; After this time&#44; all patients were free from CR symptoms&#46; All subjects were operated by the same surgical team&#46; Detailed results on SA are provided in the supplementary table&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Dissimilarities were observed between the SI&#44; the SSI&#44; the SAP and the BSI&#44; as shown in the contingency matrix &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; This fact was previously reported by L&#252;hold et al&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">23</span></a> Note that <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> represents the number of positive values that occurred simultaneously for each two entries of the table&#46; These data were used to contrast the performance of all the indices to suggest anti-reflux therapy&#44; and in particular&#44; laparoscopic Nissen fundoplication&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">None of the patients had a positive association for all the indices considering both window sizes&#46; There was no perfect agreement between surgery and SA analysis&#46; However&#44; the BSI&#44; using the two-minute window of association&#44; showed the best agreement in terms of the Cohen&#39;s kappa &#40;0&#46;78&#41;&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">On the other hand&#44; there was a good linear correlation between the one-minute and the two-minute windows regarding the SI &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;91&#41;&#44; the SSI &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;94&#41; and the BSI &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;96&#41;&#46; However&#44; it was poor in the case of the SAP &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;67&#41; as shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> shows an example of the evolution of each index with the window length&#46; Clearly&#44; the wider the window of association the higher the value of the SI and the SSI&#46; Nevertheless&#44; the SAP showed chaotic behavior&#46; The SI and SSI curves exhibit an increasing non-linear profile when plotted against the window length whereas the SAP showed a random variability&#46; On the other hand&#44; the BSI was reported to show a maximum value when the window length matches the characteristic symptom-reflux lag&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> This can be appreciated in <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; although the typical value of this temporal lag remains under discussion&#44; and therefore the two-minute window is still considered as the optimal window of association&#46;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">22&#44;25</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Note that the effect of windowing the recording for the calculation of the SAP affects the results of the estimator&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">27</span></a> Therefore&#44; the value of the SAP depends&#44; at random&#44; on the starting time of the monitoring as shown in <a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#46; It is an example that represents the value of the SAP using a two-minute window when different time shifts were added to the onset of the windowing&#46; The standard deviation of the SAP index&#44; when varying the onset from zero to the width of the window&#44; ranged between 0&#37; and 46&#46;7&#37;&#46; On the contrary&#44; the other indices did not vary by altering the onset of the windowing&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">SA analysis is a mathematical technique to express temporal association between reflux and acute symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">17</span></a> The use of the SI&#44; the SSI and the SAP is still questioned and the need for new methods is claimed by the scientific community&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">27&#44;28&#44;32</span></a> This study shows disagreement between the three main metrics and presents the BSI as an optimal estimation of SA in pediatric patients with CR symptoms&#46; It is worth mentioning that the SI and the SSI can be calculated by hand whereas the SAP requires complex software&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">33</span></a> Although the BSI cannot be calculated by hand&#44; parameters involved in the formulation of this index can be accounted easily&#46; Then&#44; common software tools can be used to compute the results of the index&#46; This provides an alternative and more reliable method to calculate probability of association&#46; Note that the temporal window was defined to study association only in the same way that the previous indices do&#46; However&#44; if one aims to study causality&#44; latency between both events must be considered in one direction only as described in a previous study&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">The existence of a temporal association between CR and GER is controversial&#46; Both phenomena are common in preterm infants and are rarely related to each other&#46; Thus&#44; there are few recent scientific papers describing this problem<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">24&#44;25&#44;27</span></a> and include a scarce number of patients&#46; This pathology is known to have a good spontaneous evolution as the patient ages&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">34</span></a> The development of physiological barriers to GER with maturity explains these cases and supports the conservative approach adopted by the authors with regards to the use of anti-reflux surgery&#46; However&#44; due to the severity of these symptoms and the potential risk of neonatal death&#44; anti-reflux surgery was&#44; in some cases&#44; the elected treatment to ensure the patient&#39;s life&#46; Approximately half of the infants with recurrent apnea have a positive diagnosis of GERD&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">35</span></a> Further studies should consider the direction of the association to allow more reliable decisions in order to reduce hospital stays and to provide better therapies&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">It is important to mention that the impedance-pH monitoring was carried out along with a nasogastric probe&#46; This might have conditioned the results obtained in this study&#44; especially those related to the diagnosis of GERD&#46; Nevertheless&#44; the control values in pediatric patients<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">5</span></a> were obtained with nasogastric probe as well&#44; and therefore&#44; both studies were conducted in similar conditions&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The complex nature of recruiting patients regarding this pathology makes research in this area a difficult task&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">35</span></a> On the other hand&#44; there is only one control group for pediatric gastroesophageal reflux reported in the scientific literature&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">5</span></a> These two facts along with a poorly understood pathophysiology makes every contribution a valuable step&#46; Note the number of patients that underwent fundoplication in this study &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41; cannot fully support conclusions regarding clinical outcomes&#46; Anti-reflux surgery was decided based on a combination of a positive SI&#44; SSI and SAP&#46; That means the BSI predicts a combination of positive SI&#44; SSI and SAP&#46; Therefore&#44; there is still a need for further studies to investigate the BSI as a predictor of clinical outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">36</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">This work supports the existence of an important inconsistency between the three indices under study&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">23</span></a> Surgical treatments are often based on the evaluation of one&#44; or a combination&#44; of these indices &#40;probability of association plus effect of size&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A very critical parameter in SA analysis is the time window in which symptom and GER are considered to be related&#46; Lam et al&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">22</span></a> stated that the optimal window length was 120<span class="elsevierStyleHsp" style=""></span>s&#46; However&#44; this has not been validated in neonates until a recent study by Omari et al&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">25</span></a> It shows that two minutes is the optimal window length when calculating SAP in infants&#46; However&#44; the SAP was criticized on many occasions for being biased and affected by chance&#46;<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">26&#8211;28</span></a> In this study&#44; the 120-s window provided the best results for the BSI&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The study of the window of association concludes that the value of the SI and the SSI increase with the window size&#58; the larger the window the greater the index&#59; it occurs because the probability of a reflux to be symptom-related increases with the width of the window of association&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">27</span></a> However&#44; one cannot see the same behavior regarding the SAP&#44; as shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46; Small variations of the factors involved in the windowing &#40;onset and width&#41; produce strong oscillations in the value of the SAP&#46; On the contrary&#44; the BSI has its maximum accuracy when the window of association matches the characteristic reflux-symptom delay&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The BSI was resembled and proved computationally to be an optimal estimator of symptom association&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> Other authors<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">37</span></a> have considered the BSI as described by Ghillebert et al&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">29</span></a> and concluded it is a good test for SA analysis&#46; In this study the BSI seems to provide a good measurement of SA&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusion</span><p id="par0125" class="elsevierStylePara elsevierViewall">The evaluation of GER-CR association in infants remains an open problem&#46; Current statistical indices&#44; SI&#44; SSI and SAP&#44; do not provide a unique criterion for diagnosis&#58; the SAP index presents multiple deficiencies whereas the BSI represents a good measurement of probability and size of effect&#46; After having evaluated the BSI clinically against the decision of anti-reflux surgery&#44; this study concludes the BSI simplifies the evaluation of SA in pediatric patients with CR symptoms&#46; However&#44; further investigations are required to prove the BSI as an optimal predictor of clinical outcomes&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflict of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Funding</span><p id="par0130" class="elsevierStylePara elsevierViewall">This project &#40;PI-0434-2010&#41; was supported by the <span class="elsevierStyleGrantSponsor" id="gs1">Department of Health of the Regional Government of Andalusia</span>&#44; Spain&#46;</p></span></span>"
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          "titulo" => "Palabras clave"
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        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Instrumentation"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Clinical methodology"
            ]
            3 => array:3 [
              "identificador" => "sec0030"
              "titulo" => "Statistical analysis"
              "secciones" => array:4 [
                0 => array:2 [
                  "identificador" => "sec0035"
                  "titulo" => "Symptom index"
                ]
                1 => array:2 [
                  "identificador" => "sec0040"
                  "titulo" => "Symptom sensitivity index"
                ]
                2 => array:2 [
                  "identificador" => "sec0045"
                  "titulo" => "Symptom association probability"
                ]
                3 => array:2 [
                  "identificador" => "sec0050"
                  "titulo" => "Binomial symptom index"
                ]
              ]
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conclusion"
        ]
        9 => array:2 [
          "identificador" => "sec0085"
          "titulo" => "Conflict of interest"
        ]
        10 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Funding"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-07-02"
    "fechaAceptado" => "2015-09-07"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec749898"
          "palabras" => array:7 [
            0 => "Gastroesophageal reflux"
            1 => "Symptom association analysis"
            2 => "Binomial symptom index"
            3 => "Symptom association probability"
            4 => "Neonates"
            5 => "Cardiorespiratory"
            6 => "Anti-reflux surgery"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec749897"
          "palabras" => array:7 [
            0 => "Reflujo gastroesof&#225;gico"
            1 => "An&#225;lisis de asociaci&#243;n de s&#237;ntomas"
            2 => "&#205;ndice de s&#237;ntomas binomial"
            3 => "Probabilidad de asociaci&#243;n de s&#237;ntomas"
            4 => "Neonatos"
            5 => "Cardiorrespiratorio"
            6 => "Cirug&#237;a anti-reflujo"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The evaluation of symptom association between gastroesophageal reflux and cardiorespiratory events in preterm infants remains unclear&#46; This paper describes a conservative approach to decision-making of anti-reflux surgery through symptom association analysis&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Forty-three neonates with potentially reflux-related cardiorespiratory symptoms underwent synchronized esophageal impedance-pH and cardiorespiratory monitoring&#46; Three indices were considered to evaluate symptom association&#44; the symptom index &#40;SI&#41;&#44; the symptom sensitivity index &#40;SSI&#41; and the symptom association probability &#40;SAP&#41;&#46; A conservative strategy was adopted regarding the decision of anti-reflux surgery&#44; and therefore&#44; patients were scheduled for laparoscopic Nissen fundoplication if the three indices showed a positive assessment of symptom association&#46; Retrospectively&#44; these indices and the binomial symptom index &#40;BSI&#41; were contrasted against the decision of anti-reflux surgery using different windows of association&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Thirteen patients showed positive symptom association but only two underwent anti-reflux surgery&#46; The SI and the SSI showed an increasing trend with the width of the window of association&#46; The SAP was affected randomly by slightly altering the windowing parameters&#46; The BSI showed the best performance with the two-minute window &#40;<span class="elsevierStyleItalic">&#954;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;78&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The pathology under study is known to improve with maturity&#46; However&#44; the severity of cardiorespiratory symptoms may threaten the neonate&#39;s life and therefore&#44; on some occasions&#44; invasive treatments must be considered to protect life&#46; The BSI provides a good prediction of a combination of positive SI&#44; SSI and SAP&#44; which may improve clinical decisions&#46; However&#44; further clinical studies are required to prove the BSI as an optimal predictor of clinical outcomes&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La evaluaci&#243;n de la asociaci&#243;n de s&#237;ntomas entre el reflujo gastroesof&#225;gico y los eventos cardiorrespiratorios no est&#225; a&#250;n resuelta&#46; Este art&#237;culo describe una aproximaci&#243;n conservadora para la decisi&#243;n del tratamiento quir&#250;rgico anti-reflujo mediante el an&#225;lisis de la asociaci&#243;n de s&#237;ntomas&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cuarenta y tres neonatos con s&#237;ntomas cardiorrespiratorios potencialmente asociados al reflujo se sometieron a una monitorizaci&#243;n cardiorrespiratoria y de pH-impedancia esof&#225;gica&#46; Se consideraron tres &#237;ndices&#44; el &#237;ndice de s&#237;ntomas &#40;IS&#41;&#44; el &#237;ndice de sensibilidad de s&#237;ntomas &#40;ISS&#41; y la probabilidad de asociaci&#243;n de s&#237;ntomas &#40;PAS&#41;&#46; Asimismo&#44; se adopt&#243; una estrategia conservadora para la aplicaci&#243;n de cirug&#237;a anti-reflujo&#44; de manera que solo se consider&#243; el tratamiento quir&#250;rgico en aquellos pacientes con valor significativo en los tres &#237;ndices&#46; Se contrastaron retrospectivamente estos &#237;ndices y el &#237;ndice de s&#237;ntomas binomial &#40;ISB&#41; frente a la decisi&#243;n de cirug&#237;a anti-reflujo utilizando diferentes ventanas de asociaci&#243;n&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Trece pacientes mostraron alg&#250;n &#237;ndice con valor significativo pero solo dos se sometieron al tratamiento quir&#250;rgico&#46; Tanto el IS como el ISS mostraron una tendencia creciente al aumentar el ancho de la ventana de asociaci&#243;n&#46; El PAS sufri&#243; fuertes variaciones aleatorias frente a peque&#241;os cambios del enventanado&#46; El ISB present&#243; el mejor resultado con la ventana de dos minutos &#40;<span class="elsevierStyleItalic">&#954;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;78&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La patolog&#237;a bajo estudio mejora con la madurez del individuo&#46; Sin embargo&#44; la severidad de los s&#237;ntomas cardiorrespiratorios puede amenazar la vida del neonato y por lo tanto&#44; en algunas ocasiones se deben considerar tratamientos invasivos para proteger la vida&#46; El ISB proporciona una buena predicci&#243;n de la combinaci&#243;n de valores positivos del IS&#44; ISS y PAS&#44; lo que puede ayudar a mejorar las decisiones cl&#237;nicas&#46; Sin embargo&#44; son necesarios futuros estudios que prueben al ISB como un predictor &#243;ptimo de los eventos cl&#237;nicos&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Barriga-Rivera A&#44; Moya MJ&#44; Lopez-Alonso M&#46; El &#237;ndice de s&#237;ntomas binomial para la evaluaci&#243;n de la asociaci&#243;n temporal entre s&#237;ntomas cardiorespiratorios y reflujo gastroesof&#225;gico en neonatos&#46; An Pediatr &#40;Barc&#41;&#46; 2016&#59;85&#58;232&#8211;239&#46;</p>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0140" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0080"
          ]
        ]
      ]
    ]
    "multimedia" => array:11 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1646
            "Ancho" => 2336
            "Tamanyo" => 168793
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The figure shows the algorithm followed in this study&#46; Patients underwent synchronized multiple intraluminal impedance-pH and cardiorespiratory &#40;MII-pH<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>CR&#41; monitoring&#46; Symptom association &#40;SA&#41; was evaluated and considered positive if at least one of the indices was positive&#46; Otherwise&#44; patients underwent reflux study only&#46; Those having three indices with positive values were scheduled for anti-reflux surgery&#46; Al patients with SA&#43; were followed up for five years&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1771
            "Ancho" => 2284
            "Tamanyo" => 175311
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The scatter plots contrast the results of using one-minute and two-minute windows of association&#46; Panels A&#8211;D are referred to the SI&#44; the SSI&#44; the SAP and the BSI respectively&#46; Note that the numeric subscripts represent the length of the window of association in seconds&#46; The dashed line depicts the linear regression model&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1940
            "Ancho" => 2223
            "Tamanyo" => 213544
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The figure represents the value of each index against the width of the window&#46; The dashed line denotes the threshold to consider a positive association for each metric&#46; Panel A and B represent an increasing trend regarding the SI and the SSI respectively&#46; Panel C shows an example on how the SAP fluctuates randomly with small changes in the window length&#46; The BSI shows a peak that corresponds to the symptom-reflux characteristic temporal lag in this patient&#44; as in graph D&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1330
            "Ancho" => 1489
            "Tamanyo" => 74220
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">The graph shows an example of the evolution of the symptom association probability &#40;SAP&#41; index when the onset of the windowing varies between 0 and 120<span class="elsevierStyleHsp" style=""></span>s&#46; A two-minute window was used for the calculation of the index&#44; as denoted by the subscript&#46; The dashed line represents the 95&#37; threshold&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:3 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SSI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SAP<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">BSI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SURGERY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SSI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SAP<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BSI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SURGERY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1233419.png"
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            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SSI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SAP<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">BSI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SURGERY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
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                      "titulo" => "Pediatric gastroesophageal reflux clinical practice guidelines&#58; joint recommendations of the North American Society for Pediatric Gastroenterology&#44; Hepatology&#44; and Nutrition &#40;NASPGHAN&#41; and the European Society for Pediatric Gastroenterology&#44; Hepatology&#44; and Nutrition &#40;ESPGHAN&#41;"
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                        "volumen" => "49"
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                      "titulo" => "Esophageal impedance monitoring for gastroesophageal reflux"
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                            0 => "H&#46; Mousa"
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                            3 => "M&#46; Orsi"
                            4 => "D&#46; Armas"
                            5 => "C&#46; Faure"
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                        "fecha" => "2011"
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                        "paginaFinal" => "139"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2005-3140"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2006"
                        "volumen" => "118"
                        "paginaInicial" => "e299"
                        "paginaFinal" => "e308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16831894"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0215"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Twenty-four hour ambulatory simultaneous impedance and pH monitoring&#58; a multicenter report of normal values from 60 healthy volunteers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Shay"
                            1 => "R&#46; Tutuian"
                            2 => "D&#46; Sifrim"
                            3 => "M&#46; Vela"
                            4 => "J&#46; Wise"
                            5 => "N&#46; Balaji"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.2004.04172.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "2004"
                        "volumen" => "99"
                        "paginaInicial" => "1037"
                        "paginaFinal" => "1043"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15180722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myth&#58; gastroesophageal reflux is a pathological entity in the preterm infant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Poets"
                            1 => "P&#46; Brockmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Semin Fetal Neonatal Med"
                        "fecha" => "2011"
                        "volumen" => "16"
                        "paginaInicial" => "259e"
                        "paginaFinal" => "263e"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The lower oesophageal sphincter"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Boeckxstaens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2982.2005.00661.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Neurogastroenterol Motil"
                        "fecha" => "2005"
                        "volumen" => "17"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "13"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15836451"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transient lower esophageal sphincter relaxations and reflux&#58; mechanistic analysis using concurrent fluoroscopy and high-resolution manometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Pandol&#64257;no"
                            1 => "Q&#46; Zhang"
                            2 => "S&#46; Ghosh"
                            3 => "A&#46; Han"
                            4 => "C&#46; Boniquit"
                            5 => "P&#46;J&#46; Kahrilas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2006.09.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2006"
                        "volumen" => "131"
                        "paginaInicial" => "1725"
                        "paginaFinal" => "1733"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17087957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations confined to the gastro-oesophageal junction&#58; the relationship between low LOSP&#44; TLORS&#44; hiatus hernia and acid pocket"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Boeckxstaens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bpg.2010.08.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Best Pract Res Clin Gastroenterol"
                        "fecha" => "2010"
                        "volumen" => "24"
                        "paginaInicial" => "821"
                        "paginaFinal" => "829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21126696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of the multichannel intraluminal impedance technique in infants and children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Van Wijk"
                            1 => "M&#46; Benninga"
                            2 => "T&#46; Omari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MPG.0b013e31818f0902"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Gastroenterol Nutr"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "2"
                        "paginaFinal" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19172117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0245"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sudden infant death syndrome&#58; an update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Moon"
                            1 => "L&#46; Fu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/pir.33-7-314"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Rev"
                        "fecha" => "2012"
                        "volumen" => "33"
                        "paginaInicial" => "314"
                        "paginaFinal" => "320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22753789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of weakly acidic reflux in proton pump inhibitor failure&#44; has dust settled&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Tsoukali"
                            1 => "D&#46; Sifrim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5056/jnm.2010.16.3.258"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurogastroenterol Motil"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "258"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20680164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of gastro-oesophageal reflux disease&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Dent"
                            1 => "H&#46; El-Serag"
                            2 => "M&#46; Wallander"
                            3 => "S&#46; Johansson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/gut.2004.051821"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gut"
                        "fecha" => "2005"
                        "volumen" => "54"
                        "paginaInicial" => "710"
                        "paginaFinal" => "717"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15831922"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of esophageal pH and multichannel intraluminal impedance testing in pediatric patients with suspected gastroesophageal reflux"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Francavilla"
                            1 => "A&#46; Magista"
                            2 => "N&#46; Bucci"
                            3 => "A&#46; Villirillo"
                            4 => "G&#46; Boscarelli"
                            5 => "L&#46; Mappa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MPG.0b013e3181a4c1d8"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Gastroenterol Nutr"
                        "fecha" => "2010"
                        "volumen" => "50"
                        "paginaInicial" => "154"
                        "paginaFinal" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19680154"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Addition of pH-impedance monitoring to standard pH monitoring increases the yield of symptom association analysis in infants and children with gastroesophageal reflux"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Loots"
                            1 => "M&#46; Benninga"
                            2 => "G&#46; Davidson"
                            3 => "T&#46;I&#46; Omari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2008.08.019"
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                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2009"
                        "volumen" => "154"
                        "paginaInicial" => "248"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18823910"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Bredenoord"
                            1 => "B&#46; Weusten"
                            2 => "T&#46; Timmer"
                            3 => "J&#46;M&#46; Conchillo"
                            4 => "A&#46;J&#46; Smout"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.2006.00427.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "2006"
                        "volumen" => "101"
                        "paginaInicial" => "453"
                        "paginaFinal" => "459"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16464226"
                            "web" => "Medline"
                          ]
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                          "issn" => "07351097"
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                ]
              ]
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              "identificador" => "bib0275"
              "etiqueta" => "18"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esophageal impedance in children&#58; symptom-based results"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Salvatore"
                            1 => "S&#46; Arrigo"
                            2 => "C&#46; Luini"
                            3 => "Y&#46; Vandenplas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2010.07.029"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2010"
                        "volumen" => "157"
                        "paginaInicial" => "949"
                        "paginaFinal" => "954"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20828711"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0280"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Facts and fantasies in extra-oesophageal symptoms in GORD"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Labenz"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bpg.2010.08.012"
                      "Revista" => array:7 [
                        "tituloSerie" => "Best Pract Res Clin Gastroenterol"
                        "fecha" => "2010"
                        "volumen" => "24"
                        "paginaInicial" => "893"
                        "paginaFinal" => "904"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21126702"
                            "web" => "Medline"
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                  ]
                ]
              ]
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            19 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ambulatory 24-hour esophageal pH monitoring&#58; technology searching for a clinical application"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Ward"
                            1 => "W&#46; Wu"
                            2 => "J&#46; Richter"
                            3 => "K&#46;W&#46; Lui"
                            4 => "D&#46;O&#46; Castell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Gastroenterol"
                        "fecha" => "1986"
                        "volumen" => "8"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "59"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3734378"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The symptom sensitivity index&#58; a valuable additional parameter in 24-hour esophageal pH recording"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Breumelhof"
                            1 => "A&#46; Smout"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1991"
                        "volumen" => "86"
                        "paginaInicial" => "160"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1992627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0295"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "What is the optimal time window in symptom analysis of 24-hour esophageal pressure and pH data&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Lam"
                            1 => "R&#46; Breumelhof"
                            2 => "J&#46; Roelofs"
                            3 => "G&#46;P&#46; van Berge Henegouwen"
                            4 => "A&#46;J&#46; Smout"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "1994"
                        "volumen" => "39"
                        "paginaInicial" => "402"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8313825"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; L&#252;thold"
                            1 => "M&#46; Rochat"
                            2 => "P&#46; B&#228;hler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "World J Gastroenterol"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "2401"
                        "paginaFinal" => "2406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20480526"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0305"
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                            0 => "M&#46; Vaezi"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Gastroenterol Hepatol &#40;NY&#41;"
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                        "volumen" => "8"
                        "paginaInicial" => "185"
                        "paginaFinal" => "187"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Intraesophageal pressure recording improves the detection of cough during multichannel intraluminal impedance testing in children"
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                        "paginaFinal" => "26"
                        "link" => array:1 [
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                    0 => array:2 [
                      "titulo" => "The surgical treatment of gastro-esophageal reflux in neonates and infants"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "34"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Assessment of concordance of symptom reflux association tests in ambulatory pH monitoring"
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Original Article
The binomial symptom index for the evaluation of temporal association between cardiorespiratory symptoms and gastroesophageal reflux in neonates
El índice de síntomas binomial para la evaluación de la asociación temporal entre síntomas cardiorespiratorios y reflujo gastroesofágico en neonatos
Alejandro Barriga-Rivera, María José Moya, Manuel Lopez-Alonso
Corresponding author
Children's Hospital Virgen del Rocío, Sevilla, Spain
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These symptoms are occasionally nonspecific such as persistent crying&#44; irritability&#44; sleeping disorders&#44; growth delays and respiratory complications&#44; and may potentially cause neonatal death&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">12</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">According to Tsoukali and Sifrim&#44;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">13</span></a> GERD is the most costly gastrointestinal disease with a prevalence ranging between 10&#37; and 20&#37; in the western world&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">14</span></a> Combined multiple intraluminal impedance-pH &#40;MII-pH&#41; monitoring allows for a more accurate detection of GER episodes and facilitates the study of symptom association &#40;SA&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">15&#8211;18</span></a> Particularly in preterm infants&#44; cardiorespiratory &#40;CR&#41; episodes such as apnea&#44; bradycardia or oxygen desaturation&#44; may be temporally related to GER if they occur within a given time interval around the onset of a GER episode&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">1&#44;7&#44;19</span></a> It has been a subject of extensive research since the mid-1980s&#46;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">20&#8211;22</span></a> Nevertheless&#44; in the second decade of the 21st century&#44; this discussion remains open&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">23&#8211;27</span></a> Different statistical indices have been proposed in order to quantify this relationship&#58; the symptom index &#40;SI&#41;&#44; the symptom sensitivity index &#40;SSI&#41; and the symptom association probability &#40;SAP&#41;&#46; However&#44; none of them seem to have solved this problem and therefore surgical treatments may be inappropriately recommended as the result of an overinterpretation of the current metrics&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">28</span></a> On the other hand&#44; the binomial symptom index &#40;BSI&#41;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">29</span></a> fell by the wayside due to its apparent mathematical complexity&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">17</span></a> However&#44; a recent computational analysis<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> has shown that an approximation of the BSI it can provide an optimal measurement of SA&#46; This paper highlights the shortcomings of SA in GER and presents the results of a clinical study of the evaluation of the temporal association between CR symptoms and GER in pediatric patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0015" class="elsevierStylePara elsevierViewall">Forty-three preterm neonates of gestational age varying between 24&#46;0 and 36&#46;0 weeks &#40;median 29&#46;0 weeks&#41; and weighing 0&#46;73&#8211;3&#46;18<span class="elsevierStyleHsp" style=""></span>kg &#40;median 1&#46;31<span class="elsevierStyleHsp" style=""></span>kg&#41; were considered for this study between 2004 and 2008&#46; At the time of recruitment&#44; their postnatal age varied between 13 and 119 days &#40;median 36&#46;5 days&#41;&#46; All showed recurrent CR symptoms&#44; potentially related to GER&#44; and were included in the study as recommended by Vandenplas and co-workers&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">1</span></a> Twenty-five of them &#40;11 females and 14 males&#41; developed symptoms during the study and were the subjects under research&#44; whereas the remaining 18 did not present any CR symptoms during and after the study&#46; Therefore these patients were not considered under this methodology&#46; This research was approved by the Ethics Committee of the Children&#39;s Hospital Virgen del Rocio &#40;CHVR&#41;&#44; Seville&#44; Spain&#46; Parents or legal guardians signed an informed consent form prior to enrolling&#46; Patients were hospitalized at the neonatal intensive care unit of the CHVR under oxygen-enriched atmosphere &#40;21&#8211;30&#37;&#41;&#46; One hour of nasogastric feeding was followed by a 2-h fasting period cyclically during hospitalization&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Instrumentation</span><p id="par0020" class="elsevierStylePara elsevierViewall">All patients underwent 24-h MII-pH and CR monitoring&#46; Six-french transnasal catheters were used to monitor MII-pH &#40;Femu&#44; Aachen&#44; Germany&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">5</span></a> The probe had seven impedance electrodes separated 10<span class="elsevierStyleHsp" style=""></span>mm from each other and two pH electrodes separated 5<span class="elsevierStyleHsp" style=""></span>cm from each other&#46; The pressure inversion point &#40;PIP&#41; was determined manometrically&#46; Thus&#44; the proximal pH electrode was placed at 20<span class="elsevierStyleHsp" style=""></span>mm from the PIP&#44; with the distal electrode located inside the stomach&#46; The distal impedance electrode was located at the position of the PIP&#46; On the other hand&#44; heart rate &#40;HR&#41;&#44; respiratory rate &#40;RR&#41; and oxygen saturation &#40;SpO<span class="elsevierStyleInf">2</span>&#41; were recorded using a bedside patient monitor&#46; MII-pH and CR signals were acquired and digitalized at 50<span class="elsevierStyleHsp" style=""></span>Hz per channel with a National Instruments DAQCard-700&#46; Synchronization was carried out by simultaneously sampling all channels every 20<span class="elsevierStyleHsp" style=""></span>ms&#46; GER events were identified according to the recommendations provided by the ESPGHAN and the NASPGHAN&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">1</span></a> that is&#44; a drop in the pH value below 4 and&#47;or a drop of 50&#37; of the impedance base line in two consecutive channels in the retrograde direction&#46; Then&#44; pathologic GER was determined when the reflux index was greater than 7&#37; or when the number of reflux episodes exceeded 70 episodes in 24<span class="elsevierStyleHsp" style=""></span>h&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">5</span></a> Similarly&#44; CR episodes were considered when the SpO<span class="elsevierStyleInf">2</span> fell below 80&#37;&#44; when breathing was suspended for at least 20<span class="elsevierStyleHsp" style=""></span>s or when the heart rate dropped below 80 systolic cycles per minute&#46; SA was analyzed computationally using numerical analysis software &#40;Matlab 2008&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Clinical methodology</span><p id="par0025" class="elsevierStylePara elsevierViewall">A total of 25 patients were evaluated for SA&#46; In doing so&#44; the SI&#44; the SSI and the SAP were calculated using a 2-minute window&#46; Those patients having none of these indices with a positive value &#40;SA&#8722;&#41; were studied for reflux only and excluded from SA analysis&#46; Patients with a positive value in at least one of the indices &#40;SA&#43;&#41; were carefully assessed&#44; adopting a conservative strategy at all times&#46; Patients were scheduled for laparoscopic Nissen fundoplication when the three estimators were positive&#44; as evidence of SA was proven&#46; However&#44; when only one or two indices were positive&#44; the patient underwent medical treatment and was controlled carefully&#46; All subjects with SA&#43; were followed up during five years as shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; At the time of the study&#44; the BSI was compared with the previous methodology recalculating all the indices using both a one-minute and a two-minute window of association&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">The three major metrics for SA were evaluated to determine the existence of a temporal relationship between GER and CR events&#58; the SI&#44; the SSI and the SAP&#46; Additionally&#44; the BSI<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> was added and compared retrospectively against anti-reflux surgery&#46; The indices were calculated varying the length of the window of association between 1 and 300<span class="elsevierStyleHsp" style=""></span>s&#46; In addition&#44; different temporal offsets were added to the start of the windowing to study the effect time shifts&#46; Although the current recommended width of the window of association is 120<span class="elsevierStyleHsp" style=""></span>s&#44;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">22&#44;25</span></a> a one-minute window of association was also studied&#46; Thus&#44; the Pearson&#39;s correlation coefficient &#40;<span class="elsevierStyleItalic">r</span>&#41; was applied to contrast agreement between 60 and 120<span class="elsevierStyleHsp" style=""></span>s windows with a level of confidence of 95&#37;&#46; The Cohen&#39;s kappa &#40;<span class="elsevierStyleItalic">&#954;</span>&#41; coefficient was used to evaluate agreement between the indices and the decision of anti-reflux surgery based on the combination of positive SI&#44; SSI and SAP&#46;</p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Symptom index</span><p id="par0035" class="elsevierStylePara elsevierViewall">The SI was first introduced by Ward et al&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">20</span></a> as the ratio between the number of symptoms that are related to a reflux episode &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf">RRS</span>&#41; and the total number of symptoms &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf">S</span>&#41; during time of study&#44; as in Eq&#46; <a class="elsevierStyleCrossRef" href="#eq0005">&#40;1&#41;</a>&#46; A positive association can be considered if SI<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>50&#37;&#44; according to studies conducted in adults&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">17</span></a><elsevierMultimedia ident="eq0005"></elsevierMultimedia></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Symptom sensitivity index</span><p id="par0040" class="elsevierStylePara elsevierViewall">The SSI represents the positive predictive value taking into account the total number of reflux episodes&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">17&#44;21</span></a> Eq&#46; <a class="elsevierStyleCrossRef" href="#eq0010">&#40;2&#41;</a> defines this index as the ratio of those symptom-related reflux episodes &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf">SRR</span>&#41; to the total number of reflux occurrences &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf">R</span>&#41;&#46; It is considered as positive if SSI<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>10&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">21</span></a><elsevierMultimedia ident="eq0010"></elsevierMultimedia></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Symptom association probability</span><p id="par0045" class="elsevierStylePara elsevierViewall">This index provides a measure of probability of association&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">17&#44;31</span></a> The study is divided into temporal windows to form a 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2 contingency array&#44; and then the Ficher&#39;s exact test is applied to obtain the probability of reflux and symptoms to occur by chance &#40;<span class="elsevierStyleItalic">p</span>&#41;&#46; Thus&#44; Eq&#46; <a class="elsevierStyleCrossRef" href="#eq0015">&#40;3&#41;</a> represents the degree of temporal association&#44; as a measure of probability&#44; in terms of the SAP&#58;<elsevierMultimedia ident="eq0015"></elsevierMultimedia>This index denotes a statistical temporal association when SAP<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>95&#37;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Binomial symptom index</span><p id="par0050" class="elsevierStylePara elsevierViewall">The BSI was first described by Ghillebert et al&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">29</span></a> to determine SA in esophageal pH studies and has been recently studied using computational methods&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> The BSI can be calculated according to Eq&#46; <a class="elsevierStyleCrossRef" href="#eq0020">&#40;4&#41;</a>&#44; where <span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">S</span></span> represents the total number of symptoms&#44; <span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">R</span></span> is the total number of ebbs&#44; <span class="elsevierStyleItalic">T</span> is the monitoring time&#44; <span class="elsevierStyleItalic">w</span> is the width of the window of association and <span class="elsevierStyleItalic">N</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">A</span></span> represents the number of reflux-related symptoms&#46; The BSI was suggested to provide a positive assessment&#44; in a 24-h monitoring study&#44; when BSI<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>99&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a><elsevierMultimedia ident="eq0020"></elsevierMultimedia></p></span></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">The average monitoring time was 21&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;1<span class="elsevierStyleHsp" style=""></span>h&#46; The total number of reflux events ranged between 19 and 146 &#40;mean 77&#46;5&#41; whereas the total number of symptom episodes varied between 1 and 46 &#40;mean 15&#46;0&#41;&#46; In the first stage&#44; at least one of the three main indices under study determined a positive SA in 13&#47;25 patients as in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; All the indices were positive in 3&#47;25 subjects&#46; These patients were scheduled for anti-reflux surgery&#46; However&#44; one of them stopped having CR symptoms spontaneously a few days before surgery and therefore a conservative approach was adopted&#46; This patient had a good evolution and did not require surgery&#46; On the other hand&#44; 10&#47;25 patients had one or two indices with a positive value&#46; They were carefully studied and underwent eight weeks medical treatment&#44; including proton pump inhibitors and prokinetic drugs to treat reflux&#44; and theophylline and caffeine for the CR pathology&#46; Afterwards&#44; these patients were reevaluated for SA&#58; five of them were studied for reflux only for not having shown CR symptoms again&#44; whereas the other 5&#47;25 had a negative SA but still presented some CR episodes&#46; Therefore&#44; these subjects were included in the five year follow-up period&#46; After this time&#44; all patients were free from CR symptoms&#46; All subjects were operated by the same surgical team&#46; Detailed results on SA are provided in the supplementary table&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Dissimilarities were observed between the SI&#44; the SSI&#44; the SAP and the BSI&#44; as shown in the contingency matrix &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; This fact was previously reported by L&#252;hold et al&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">23</span></a> Note that <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> represents the number of positive values that occurred simultaneously for each two entries of the table&#46; These data were used to contrast the performance of all the indices to suggest anti-reflux therapy&#44; and in particular&#44; laparoscopic Nissen fundoplication&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">None of the patients had a positive association for all the indices considering both window sizes&#46; There was no perfect agreement between surgery and SA analysis&#46; However&#44; the BSI&#44; using the two-minute window of association&#44; showed the best agreement in terms of the Cohen&#39;s kappa &#40;0&#46;78&#41;&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">On the other hand&#44; there was a good linear correlation between the one-minute and the two-minute windows regarding the SI &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;91&#41;&#44; the SSI &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;94&#41; and the BSI &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;96&#41;&#46; However&#44; it was poor in the case of the SAP &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;67&#41; as shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> shows an example of the evolution of each index with the window length&#46; Clearly&#44; the wider the window of association the higher the value of the SI and the SSI&#46; Nevertheless&#44; the SAP showed chaotic behavior&#46; The SI and SSI curves exhibit an increasing non-linear profile when plotted against the window length whereas the SAP showed a random variability&#46; On the other hand&#44; the BSI was reported to show a maximum value when the window length matches the characteristic symptom-reflux lag&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> This can be appreciated in <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; although the typical value of this temporal lag remains under discussion&#44; and therefore the two-minute window is still considered as the optimal window of association&#46;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">22&#44;25</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Note that the effect of windowing the recording for the calculation of the SAP affects the results of the estimator&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">27</span></a> Therefore&#44; the value of the SAP depends&#44; at random&#44; on the starting time of the monitoring as shown in <a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#46; It is an example that represents the value of the SAP using a two-minute window when different time shifts were added to the onset of the windowing&#46; The standard deviation of the SAP index&#44; when varying the onset from zero to the width of the window&#44; ranged between 0&#37; and 46&#46;7&#37;&#46; On the contrary&#44; the other indices did not vary by altering the onset of the windowing&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">SA analysis is a mathematical technique to express temporal association between reflux and acute symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">17</span></a> The use of the SI&#44; the SSI and the SAP is still questioned and the need for new methods is claimed by the scientific community&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">27&#44;28&#44;32</span></a> This study shows disagreement between the three main metrics and presents the BSI as an optimal estimation of SA in pediatric patients with CR symptoms&#46; It is worth mentioning that the SI and the SSI can be calculated by hand whereas the SAP requires complex software&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">33</span></a> Although the BSI cannot be calculated by hand&#44; parameters involved in the formulation of this index can be accounted easily&#46; Then&#44; common software tools can be used to compute the results of the index&#46; This provides an alternative and more reliable method to calculate probability of association&#46; Note that the temporal window was defined to study association only in the same way that the previous indices do&#46; However&#44; if one aims to study causality&#44; latency between both events must be considered in one direction only as described in a previous study&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">The existence of a temporal association between CR and GER is controversial&#46; Both phenomena are common in preterm infants and are rarely related to each other&#46; Thus&#44; there are few recent scientific papers describing this problem<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">24&#44;25&#44;27</span></a> and include a scarce number of patients&#46; This pathology is known to have a good spontaneous evolution as the patient ages&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">34</span></a> The development of physiological barriers to GER with maturity explains these cases and supports the conservative approach adopted by the authors with regards to the use of anti-reflux surgery&#46; However&#44; due to the severity of these symptoms and the potential risk of neonatal death&#44; anti-reflux surgery was&#44; in some cases&#44; the elected treatment to ensure the patient&#39;s life&#46; Approximately half of the infants with recurrent apnea have a positive diagnosis of GERD&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">35</span></a> Further studies should consider the direction of the association to allow more reliable decisions in order to reduce hospital stays and to provide better therapies&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">It is important to mention that the impedance-pH monitoring was carried out along with a nasogastric probe&#46; This might have conditioned the results obtained in this study&#44; especially those related to the diagnosis of GERD&#46; Nevertheless&#44; the control values in pediatric patients<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">5</span></a> were obtained with nasogastric probe as well&#44; and therefore&#44; both studies were conducted in similar conditions&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The complex nature of recruiting patients regarding this pathology makes research in this area a difficult task&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">35</span></a> On the other hand&#44; there is only one control group for pediatric gastroesophageal reflux reported in the scientific literature&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">5</span></a> These two facts along with a poorly understood pathophysiology makes every contribution a valuable step&#46; Note the number of patients that underwent fundoplication in this study &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41; cannot fully support conclusions regarding clinical outcomes&#46; Anti-reflux surgery was decided based on a combination of a positive SI&#44; SSI and SAP&#46; That means the BSI predicts a combination of positive SI&#44; SSI and SAP&#46; Therefore&#44; there is still a need for further studies to investigate the BSI as a predictor of clinical outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">36</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">This work supports the existence of an important inconsistency between the three indices under study&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">23</span></a> Surgical treatments are often based on the evaluation of one&#44; or a combination&#44; of these indices &#40;probability of association plus effect of size&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A very critical parameter in SA analysis is the time window in which symptom and GER are considered to be related&#46; Lam et al&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">22</span></a> stated that the optimal window length was 120<span class="elsevierStyleHsp" style=""></span>s&#46; However&#44; this has not been validated in neonates until a recent study by Omari et al&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">25</span></a> It shows that two minutes is the optimal window length when calculating SAP in infants&#46; However&#44; the SAP was criticized on many occasions for being biased and affected by chance&#46;<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">26&#8211;28</span></a> In this study&#44; the 120-s window provided the best results for the BSI&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The study of the window of association concludes that the value of the SI and the SSI increase with the window size&#58; the larger the window the greater the index&#59; it occurs because the probability of a reflux to be symptom-related increases with the width of the window of association&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">27</span></a> However&#44; one cannot see the same behavior regarding the SAP&#44; as shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46; Small variations of the factors involved in the windowing &#40;onset and width&#41; produce strong oscillations in the value of the SAP&#46; On the contrary&#44; the BSI has its maximum accuracy when the window of association matches the characteristic reflux-symptom delay&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The BSI was resembled and proved computationally to be an optimal estimator of symptom association&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">30</span></a> Other authors<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">37</span></a> have considered the BSI as described by Ghillebert et al&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">29</span></a> and concluded it is a good test for SA analysis&#46; In this study the BSI seems to provide a good measurement of SA&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusion</span><p id="par0125" class="elsevierStylePara elsevierViewall">The evaluation of GER-CR association in infants remains an open problem&#46; Current statistical indices&#44; SI&#44; SSI and SAP&#44; do not provide a unique criterion for diagnosis&#58; the SAP index presents multiple deficiencies whereas the BSI represents a good measurement of probability and size of effect&#46; After having evaluated the BSI clinically against the decision of anti-reflux surgery&#44; this study concludes the BSI simplifies the evaluation of SA in pediatric patients with CR symptoms&#46; However&#44; further investigations are required to prove the BSI as an optimal predictor of clinical outcomes&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflict of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Funding</span><p id="par0130" class="elsevierStylePara elsevierViewall">This project &#40;PI-0434-2010&#41; was supported by the <span class="elsevierStyleGrantSponsor" id="gs1">Department of Health of the Regional Government of Andalusia</span>&#44; Spain&#46;</p></span></span>"
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    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The evaluation of symptom association between gastroesophageal reflux and cardiorespiratory events in preterm infants remains unclear&#46; This paper describes a conservative approach to decision-making of anti-reflux surgery through symptom association analysis&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Forty-three neonates with potentially reflux-related cardiorespiratory symptoms underwent synchronized esophageal impedance-pH and cardiorespiratory monitoring&#46; Three indices were considered to evaluate symptom association&#44; the symptom index &#40;SI&#41;&#44; the symptom sensitivity index &#40;SSI&#41; and the symptom association probability &#40;SAP&#41;&#46; A conservative strategy was adopted regarding the decision of anti-reflux surgery&#44; and therefore&#44; patients were scheduled for laparoscopic Nissen fundoplication if the three indices showed a positive assessment of symptom association&#46; Retrospectively&#44; these indices and the binomial symptom index &#40;BSI&#41; were contrasted against the decision of anti-reflux surgery using different windows of association&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Thirteen patients showed positive symptom association but only two underwent anti-reflux surgery&#46; The SI and the SSI showed an increasing trend with the width of the window of association&#46; The SAP was affected randomly by slightly altering the windowing parameters&#46; The BSI showed the best performance with the two-minute window &#40;<span class="elsevierStyleItalic">&#954;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;78&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The pathology under study is known to improve with maturity&#46; However&#44; the severity of cardiorespiratory symptoms may threaten the neonate&#39;s life and therefore&#44; on some occasions&#44; invasive treatments must be considered to protect life&#46; The BSI provides a good prediction of a combination of positive SI&#44; SSI and SAP&#44; which may improve clinical decisions&#46; However&#44; further clinical studies are required to prove the BSI as an optimal predictor of clinical outcomes&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La evaluaci&#243;n de la asociaci&#243;n de s&#237;ntomas entre el reflujo gastroesof&#225;gico y los eventos cardiorrespiratorios no est&#225; a&#250;n resuelta&#46; Este art&#237;culo describe una aproximaci&#243;n conservadora para la decisi&#243;n del tratamiento quir&#250;rgico anti-reflujo mediante el an&#225;lisis de la asociaci&#243;n de s&#237;ntomas&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cuarenta y tres neonatos con s&#237;ntomas cardiorrespiratorios potencialmente asociados al reflujo se sometieron a una monitorizaci&#243;n cardiorrespiratoria y de pH-impedancia esof&#225;gica&#46; Se consideraron tres &#237;ndices&#44; el &#237;ndice de s&#237;ntomas &#40;IS&#41;&#44; el &#237;ndice de sensibilidad de s&#237;ntomas &#40;ISS&#41; y la probabilidad de asociaci&#243;n de s&#237;ntomas &#40;PAS&#41;&#46; Asimismo&#44; se adopt&#243; una estrategia conservadora para la aplicaci&#243;n de cirug&#237;a anti-reflujo&#44; de manera que solo se consider&#243; el tratamiento quir&#250;rgico en aquellos pacientes con valor significativo en los tres &#237;ndices&#46; Se contrastaron retrospectivamente estos &#237;ndices y el &#237;ndice de s&#237;ntomas binomial &#40;ISB&#41; frente a la decisi&#243;n de cirug&#237;a anti-reflujo utilizando diferentes ventanas de asociaci&#243;n&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Trece pacientes mostraron alg&#250;n &#237;ndice con valor significativo pero solo dos se sometieron al tratamiento quir&#250;rgico&#46; Tanto el IS como el ISS mostraron una tendencia creciente al aumentar el ancho de la ventana de asociaci&#243;n&#46; El PAS sufri&#243; fuertes variaciones aleatorias frente a peque&#241;os cambios del enventanado&#46; El ISB present&#243; el mejor resultado con la ventana de dos minutos &#40;<span class="elsevierStyleItalic">&#954;</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;78&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La patolog&#237;a bajo estudio mejora con la madurez del individuo&#46; Sin embargo&#44; la severidad de los s&#237;ntomas cardiorrespiratorios puede amenazar la vida del neonato y por lo tanto&#44; en algunas ocasiones se deben considerar tratamientos invasivos para proteger la vida&#46; El ISB proporciona una buena predicci&#243;n de la combinaci&#243;n de valores positivos del IS&#44; ISS y PAS&#44; lo que puede ayudar a mejorar las decisiones cl&#237;nicas&#46; Sin embargo&#44; son necesarios futuros estudios que prueben al ISB como un predictor &#243;ptimo de los eventos cl&#237;nicos&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Barriga-Rivera A&#44; Moya MJ&#44; Lopez-Alonso M&#46; El &#237;ndice de s&#237;ntomas binomial para la evaluaci&#243;n de la asociaci&#243;n temporal entre s&#237;ntomas cardiorespiratorios y reflujo gastroesof&#225;gico en neonatos&#46; An Pediatr &#40;Barc&#41;&#46; 2016&#59;85&#58;232&#8211;239&#46;</p>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0140" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0080"
          ]
        ]
      ]
    ]
    "multimedia" => array:11 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1646
            "Ancho" => 2336
            "Tamanyo" => 168793
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The figure shows the algorithm followed in this study&#46; Patients underwent synchronized multiple intraluminal impedance-pH and cardiorespiratory &#40;MII-pH<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>CR&#41; monitoring&#46; Symptom association &#40;SA&#41; was evaluated and considered positive if at least one of the indices was positive&#46; Otherwise&#44; patients underwent reflux study only&#46; Those having three indices with positive values were scheduled for anti-reflux surgery&#46; Al patients with SA&#43; were followed up for five years&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1771
            "Ancho" => 2284
            "Tamanyo" => 175311
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The scatter plots contrast the results of using one-minute and two-minute windows of association&#46; Panels A&#8211;D are referred to the SI&#44; the SSI&#44; the SAP and the BSI respectively&#46; Note that the numeric subscripts represent the length of the window of association in seconds&#46; The dashed line depicts the linear regression model&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1940
            "Ancho" => 2223
            "Tamanyo" => 213544
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The figure represents the value of each index against the width of the window&#46; The dashed line denotes the threshold to consider a positive association for each metric&#46; Panel A and B represent an increasing trend regarding the SI and the SSI respectively&#46; Panel C shows an example on how the SAP fluctuates randomly with small changes in the window length&#46; The BSI shows a peak that corresponds to the symptom-reflux characteristic temporal lag in this patient&#44; as in graph D&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1330
            "Ancho" => 1489
            "Tamanyo" => 74220
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">The graph shows an example of the evolution of the symptom association probability &#40;SAP&#41; index when the onset of the windowing varies between 0 and 120<span class="elsevierStyleHsp" style=""></span>s&#46; A two-minute window was used for the calculation of the index&#44; as denoted by the subscript&#46; The dashed line represents the 95&#37; threshold&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:3 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SSI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SAP<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">BSI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SURGERY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SSI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SAP<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BSI<span class="elsevierStyleInf">60</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SURGERY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1233419.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SSI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SAP<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">BSI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SURGERY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SSI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SAP<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BSI<span class="elsevierStyleInf">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SURGERY&nbsp;\t\t\t\t\t\t\n
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                          "autores" => array:1 [
                            0 => "G&#46; Boeckxstaens"
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                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2982.2005.00661.x"
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                        "tituloSerie" => "Neurogastroenterol Motil"
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                        "numero" => "Suppl&#46; 1"
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                        "paginaFinal" => "21"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15836451"
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                          ]
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                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transient lower esophageal sphincter relaxations and reflux&#58; mechanistic analysis using concurrent fluoroscopy and high-resolution manometry"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Pandol&#64257;no"
                            1 => "Q&#46; Zhang"
                            2 => "S&#46; Ghosh"
                            3 => "A&#46; Han"
                            4 => "C&#46; Boniquit"
                            5 => "P&#46;J&#46; Kahrilas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2006.09.009"
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                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2006"
                        "volumen" => "131"
                        "paginaInicial" => "1725"
                        "paginaFinal" => "1733"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17087957"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "10"
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                    0 => array:2 [
                      "titulo" => "Alterations confined to the gastro-oesophageal junction&#58; the relationship between low LOSP&#44; TLORS&#44; hiatus hernia and acid pocket"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Boeckxstaens"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bpg.2010.08.011"
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                        "tituloSerie" => "Best Pract Res Clin Gastroenterol"
                        "fecha" => "2010"
                        "volumen" => "24"
                        "paginaInicial" => "821"
                        "paginaFinal" => "829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21126696"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0240"
              "etiqueta" => "11"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of the multichannel intraluminal impedance technique in infants and children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Van Wijk"
                            1 => "M&#46; Benninga"
                            2 => "T&#46; Omari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MPG.0b013e31818f0902"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Gastroenterol Nutr"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "2"
                        "paginaFinal" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19172117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0245"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sudden infant death syndrome&#58; an update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Moon"
                            1 => "L&#46; Fu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/pir.33-7-314"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Rev"
                        "fecha" => "2012"
                        "volumen" => "33"
                        "paginaInicial" => "314"
                        "paginaFinal" => "320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22753789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0250"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of weakly acidic reflux in proton pump inhibitor failure&#44; has dust settled&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Tsoukali"
                            1 => "D&#46; Sifrim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5056/jnm.2010.16.3.258"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurogastroenterol Motil"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "258"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20680164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            13 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of gastro-oesophageal reflux disease&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Dent"
                            1 => "H&#46; El-Serag"
                            2 => "M&#46; Wallander"
                            3 => "S&#46; Johansson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/gut.2004.051821"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gut"
                        "fecha" => "2005"
                        "volumen" => "54"
                        "paginaInicial" => "710"
                        "paginaFinal" => "717"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15831922"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0260"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of esophageal pH and multichannel intraluminal impedance testing in pediatric patients with suspected gastroesophageal reflux"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Francavilla"
                            1 => "A&#46; Magista"
                            2 => "N&#46; Bucci"
                            3 => "A&#46; Villirillo"
                            4 => "G&#46; Boscarelli"
                            5 => "L&#46; Mappa"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MPG.0b013e3181a4c1d8"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Gastroenterol Nutr"
                        "fecha" => "2010"
                        "volumen" => "50"
                        "paginaInicial" => "154"
                        "paginaFinal" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19680154"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0265"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Addition of pH-impedance monitoring to standard pH monitoring increases the yield of symptom association analysis in infants and children with gastroesophageal reflux"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Loots"
                            1 => "M&#46; Benninga"
                            2 => "G&#46; Davidson"
                            3 => "T&#46;I&#46; Omari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2008.08.019"
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                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2009"
                        "volumen" => "154"
                        "paginaInicial" => "248"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18823910"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            16 => array:3 [
              "identificador" => "bib0270"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Bredenoord"
                            1 => "B&#46; Weusten"
                            2 => "T&#46; Timmer"
                            3 => "J&#46;M&#46; Conchillo"
                            4 => "A&#46;J&#46; Smout"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.2006.00427.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "2006"
                        "volumen" => "101"
                        "paginaInicial" => "453"
                        "paginaFinal" => "459"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16464226"
                            "web" => "Medline"
                          ]
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              "etiqueta" => "18"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esophageal impedance in children&#58; symptom-based results"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Salvatore"
                            1 => "S&#46; Arrigo"
                            2 => "C&#46; Luini"
                            3 => "Y&#46; Vandenplas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2010.07.029"
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                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2010"
                        "volumen" => "157"
                        "paginaInicial" => "949"
                        "paginaFinal" => "954"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20828711"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0280"
              "etiqueta" => "19"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Facts and fantasies in extra-oesophageal symptoms in GORD"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Labenz"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bpg.2010.08.012"
                      "Revista" => array:7 [
                        "tituloSerie" => "Best Pract Res Clin Gastroenterol"
                        "fecha" => "2010"
                        "volumen" => "24"
                        "paginaInicial" => "893"
                        "paginaFinal" => "904"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21126702"
                            "web" => "Medline"
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              "identificador" => "bib0285"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ambulatory 24-hour esophageal pH monitoring&#58; technology searching for a clinical application"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Ward"
                            1 => "W&#46; Wu"
                            2 => "J&#46; Richter"
                            3 => "K&#46;W&#46; Lui"
                            4 => "D&#46;O&#46; Castell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Gastroenterol"
                        "fecha" => "1986"
                        "volumen" => "8"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "59"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3734378"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0290"
              "etiqueta" => "21"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The symptom sensitivity index&#58; a valuable additional parameter in 24-hour esophageal pH recording"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Breumelhof"
                            1 => "A&#46; Smout"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1991"
                        "volumen" => "86"
                        "paginaInicial" => "160"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1992627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "What is the optimal time window in symptom analysis of 24-hour esophageal pressure and pH data&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Lam"
                            1 => "R&#46; Breumelhof"
                            2 => "J&#46; Roelofs"
                            3 => "G&#46;P&#46; van Berge Henegouwen"
                            4 => "A&#46;J&#46; Smout"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "1994"
                        "volumen" => "39"
                        "paginaInicial" => "402"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8313825"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0300"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; L&#252;thold"
                            1 => "M&#46; Rochat"
                            2 => "P&#46; B&#228;hler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "World J Gastroenterol"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "2401"
                        "paginaFinal" => "2406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20480526"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Temporal association of polysomnographic cardiorespiratory events with GER detected by MII-pH probe in the premature infant at term"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            2 => "B&#46; McGinley"
                            3 => "R&#46; Katz"
                            4 => "D&#46;R&#46; Glen"
                            5 => "E&#46; Gauda"
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                      ]
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                  ]
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                    0 => array:2 [
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                      "Revista" => array:7 [
                        "tituloSerie" => "J Pediatr Gastroenterol Nutr"
                        "fecha" => "2011"
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                        "paginaFinal" => "531"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21502823"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0310"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Optimisation of the reflux-symptom association statistics for use in infants being investigated by 24-hour pH impedance"
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                          "etal" => true
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                            2 => "M&#46;P&#46; VanWijk"
                            3 => "M&#46;A&#46; Benninga"
                            4 => "L&#46; McCall"
                            5 => "S&#46; Kritas"
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                    0 => array:2 [
                      "doi" => "10.1097/MPG.0b013e3181f474c7"
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                        "tituloSerie" => "J Pediatr Gastroenterol Nutr"
                        "fecha" => "2011"
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                        "paginaInicial" => "408"
                        "paginaFinal" => "413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21240018"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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              "identificador" => "bib0315"
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                    0 => array:2 [
                      "titulo" => "Monte Carlo method for the evaluation of symptom association analysis"
                      "autores" => array:1 [
                        0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Symptom index <span class="elsevierStyleItalic">p</span>-value and symptom sensitivity index p-value to determine symptom association between apnea and reflux in premature infants at term"
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                        "paginaInicial" => "549"
                        "paginaFinal" => "556"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23163408"
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              ]
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                      "titulo" => "Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease"
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                          "etal" => true
                          "autores" => array:6 [
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                            3 => "A&#46;C&#46; Oranu"
                            4 => "J&#46;A&#46; Schneider"
                            5 => "C&#46;G&#46; Garrett"
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                    0 => array:2 [
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                        "tituloSerie" => "Clin Gastroenterol Hepatol"
                        "fecha" => "2011"
                        "volumen" => "9"
                        "paginaInicial" => "868"
                        "paginaFinal" => "874"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21782769"
                            "web" => "Medline"
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                        ]
                      ]
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                  ]
                ]
              ]
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              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ambulatory 24 hour intraoesophageal pH and pressure recordings v provocation tests in the diagnosis of chest pain of oesophageal origin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "J&#46; Janssens"
                            2 => "G&#46; Vantrappen"
                            3 => "F&#46; Nevens"
                            4 => "J&#46; Piessens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                        "tituloSerie" => "Gut"
                        "fecha" => "1990"
                        "volumen" => "31"
                        "paginaInicial" => "738"
                        "paginaFinal" => "744"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2370009"
                            "web" => "Medline"
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                    ]
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                ]
              ]
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The binomial symptom index&#44; an optimal method for the evaluation of symptom association in gastroesophageal reflux"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            1 => "M&#46; Elena"
                            2 => "M&#46; Moya"
                            3 => "M&#46; Lopez-Alonso"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/nmo.12143"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurogastroenterol Motil"
                        "fecha" => "2013"
                        "volumen" => "25"
                        "paginaInicial" => "664"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23638868"
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                      ]
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                  ]
                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The symptom-association probability&#58; an improved method for symptom analysis of 24-hour esophageal pH data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "J&#46; Roelofs"
                            2 => "L&#46; Akkermans"
                            3 => "G&#46;P&#46; Van Berge-Henegouwen"
                            4 => "A&#46;J&#46; Smout"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "1994"
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                        "paginaInicial" => "1741"
                        "paginaFinal" => "1745"
                        "link" => array:1 [
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                          "autores" => array:1 [
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                        "tituloSerie" => "Gastroenterol Hepatol &#40;NY&#41;"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Intraesophageal pressure recording improves the detection of cough during multichannel intraluminal impedance testing in children"
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                          "etal" => false
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                            4 => "S&#46; Nurko"
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                        "tituloSerie" => "J Pediatr Gastroenterol Nutr"
                        "fecha" => "2014"
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                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23942006"
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                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "The surgical treatment of gastro-esophageal reflux in neonates and infants"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "A&#46; Pierro"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Pediatr Surg"
                        "fecha" => "2005"
                        "volumen" => "14"
                        "paginaInicial" => "34"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15770586"
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                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Association between gastroesphageal reflux and pathologic apneas in infants&#58; a systematic review"
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                          "etal" => false
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                            4 => "M&#46; Tabbers"
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                    ]
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                    0 => array:2 [
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                        "fecha" => "2014"
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                        "link" => array:1 [
                          0 => array:2 [
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                ]
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23718322"
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                      ]
                    ]
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                ]
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            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of concordance of symptom reflux association tests in ambulatory pH monitoring"
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                          "etal" => false
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                            3 => "S&#46; Gaddam"
                            4 => "G&#46;S&#46; Sayuk"
                            5 => "C&#46;P&#46; Gyawali"
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