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In the twentieth century&#44; however&#44; questions began to be raised as to whether excessive consumption of sugars&#44; particularly associated with processed foods&#44; might be related to diabetes or obesity&#44; and research has continued up to the present&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Additives are substances deliberately added to foods to perform certain technological functions and the result is that both the additive itself and its byproducts become components of those foods&#46; Additives are not consumed as foods or used as typical ingredients in the diet&#44; regardless of whether or not they have nutritional value&#46; Monosaccharides&#44; disaccharides or oligosaccharides&#44; or foods containing them&#44; are not regarded as food additives&#46; The term <span class="elsevierStyleItalic">sweetener</span> refers to a substance used to impart a sweet taste to foods &#40;Regulation &#40;EC&#41; No 1333&#47;2008&#41;&#46; Thus foods such as honey or ordinary sugar&#44; fructose or glucose are not considered sweeteners&#44; since they have other functions apart from sweetening&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Low- or no-calorie sweeteners &#40;LNCSs&#41; have been used for years to replace all or part of the sugar content in foods and drinks&#44; but in the last few decades their consumption has increased both in adults and in children&#46; Their use is linked to dietary alternatives for weight control or diabetes&#44; but also to preventing tooth decay&#46; Although some studies question these possible benefits&#44; both in adults and in children&#44;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">7&#44;8</span></a> systematic reviews and meta-analyses on this subject conclude that the use of sweeteners is beneficial in weight-control and diabetes programmes associated with a healthy lifestyle&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The purpose of this document is to provide paediatricians with information on sweeteners and health-related issues&#44; in order to give appropriate advice to patients and their families&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Consumption of sugars and sweeteners and its relationship with health</span><p id="par0025" class="elsevierStylePara elsevierViewall">To assess this consumption we have to take into account not only added sugars and sweeteners&#44; but also sugar incorporated as an ingredient in precooked&#47;processed foods&#46; European adolescents consume some 384<span class="elsevierStyleHsp" style=""></span>kcal per day from drinks&#44; of which 30&#46;4&#37;&#44; 20&#46;7&#37; and 18&#46;1&#37; comes from sugar-sweetened beverages&#44; sweetened milk and fruit juice&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">10</span></a> Various cross-sectional studies have concluded that there is no association&#44; or even that there is a negative association&#44; between consumption of sugars and weight gain&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">11&#44;12</span></a> However&#44; there is a widespread debate on whether greater intake of sugars through sweetened beverages could have a significant effect on increase in body mass index &#40;BMI&#41; or about whether unsweetened diets may have an influence on control of obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">13</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Some observational studies have also related increase in BMI to consumption of non-caloric sweeteners&#44; although these data should not be interpreted as proof of a causal relationship&#44; but rather as a sign that the probability of consumption is higher in the obese and sedentary population &#40;reverse causality&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">8</span></a> Replacing sugar with sweeteners is not necessarily associated with a lower overall calorie intake&#44; and could encourage unbalanced dietary habits&#44; involving high consumption of low-calorie products with sweeteners and of others with excessive calories&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">6&#44;14</span></a> Some authors postulate that early consumption of sugar-sweetened products in infants and young children could affect self-regulation of eating and preference for sweet flavours&#44;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">7&#44;15</span></a> which may be maintained during childhood and adolescence&#46; It has even been suggested that consuming sweeteners and sugars together in the diet could give rise to a neuronal response that leads to more rapid absorption of sugars&#44; also increasing secretion of peptides related to glucagon&#44; or insulin&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">16</span></a> On this subject a highly controversial hypothesis has recently been put forward on the development of glucose intolerance through alterations to the intestinal microbiota in mice associated with consuming saccharin at maximum doses&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">17</span></a> However&#44; one must be very cautious in extrapolating conclusions from animal studies to humans&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">18</span></a> Nowadays diabetic patients can use non-caloric sweeteners as part of a balanced&#44; controlled diet&#44; and studies in adults indicate that they do not affect plasma glucose or lipid levels&#44; although this has not been sufficiently investigated in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">19&#44;20</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Fermentable CHs in the diet produce acidic materials which destroy hard tissues of the tooth&#44; giving rise to tooth decay&#46; In the child population dental caries is still common&#44; because of a general lack of adequate oral hygiene after consuming sugary foods&#44; as well as fluoride deficiency&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">21</span></a> In infants&#44; moreover&#44; prolonged use of fruit juices or other fructose- or sucrose-rich sweetened beverages in dummies increases the risk of damage to teeth&#46; Among sweeteners&#44; polyols &#40;sugar alcohols&#41; and sucralose&#44; among others&#44; have been declared to have healthy properties for avoiding this condition&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Recommendations for consumption</span><p id="par0040" class="elsevierStylePara elsevierViewall">All types of CHs must be represented in a healthy diet&#46; The FAO and WHO recommend an intake of sugars &#40;simple carbohydrates&#41; of less than 10&#37; of the total caloric value of the diet&#44; trying to make them part of a healthy diet with limited consumption of sugar-sweetened drinks&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">23</span></a> In 2005 it was established that the recommended daily intake in adults and children older than one year of age is 100<span class="elsevierStyleHsp" style=""></span>g&#47;day of CHs as an estimated mean requirement&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">24</span></a> In Spain&#44; adhering to a Mediterranean or similar diet would make it possible to maintain an appropriate energy intake without sacrificing its sweetening and pleasurable function&#46; In addition&#44; as a practical measure to achieve greater benefits&#44; it has been recommended that consumption of sugars or sugar-sweetened foods should be limited to less than 3 times per day&#44; not exceeding 6&#37; of total energy intake&#44;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">25</span></a> and that of sugar-sweetened drinks to occasional use&#46; It is also recommended that excessive consumption of high-fructose corn syrup &#40;55&#37; fructose&#41; should be reduced&#44; as it represents a health hazard&#44; especially for children&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">26</span></a> Indeed&#44; these syrups are not used in Spain&#44; where the maximum fructose content of manufactured products is approximately 50&#37;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The nutrition statements prescribed in Regulation &#40;EC&#41; No 1924&#47;2006 make it easy to ascertain the composition of foods in terms of sugars&#46; Thus according to the labelling we can find foods that are &#8220;low in sugar&#8221; &#40;no more than 5<span class="elsevierStyleHsp" style=""></span>g of sugars per 100<span class="elsevierStyleHsp" style=""></span>g for solids or 2&#46;5<span class="elsevierStyleHsp" style=""></span>g of sugars per 100<span class="elsevierStyleHsp" style=""></span>ml for liquids&#41;&#44; &#8220;sugar-free&#8221; &#40;no more than 0&#46;25<span class="elsevierStyleHsp" style=""></span>g per 100<span class="elsevierStyleHsp" style=""></span>g or 100<span class="elsevierStyleHsp" style=""></span>ml&#41;&#44; or &#8220;with no added sugar&#8221; &#40;a product with no added mono- or disaccharides nor any other food used for its sweetening properties&#41;&#46; In the last of these cases&#44; the food may &#8220;contain naturally occurring sugars&#8221; or &#8220;sugar&#40;s&#41; and sweetener&#40;s&#41;&#8221;&#44; and this information must appear on the nutrition information label&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">27</span></a> On a practical level&#44; the American Heart Association has suggested simple advice&#44; such as not having more than 6 teaspoonfuls of sugar per day for women &#40;25<span class="elsevierStyleHsp" style=""></span>g&#41; &#40;e&#46;g&#46;&#44; present in 250<span class="elsevierStyleHsp" style=""></span>ml of a sugar-sweetened beverage&#41; and 9 for men &#40;37<span class="elsevierStyleHsp" style=""></span>g&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">28</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">During pregnancy CH intake should not be restricted&#44; but intake of refined sugar or foods with added sugar should be controlled&#46; There is an increase in availability of glucose&#44; which is an essential substrate for the foetus&#46; In newborns&#44; because of pancreatic amylase deficiency&#44; it is advisable for infant milk formulae not to contain starch&#44; with lactose as the main CH&#44; as well as glucose polymers&#44; which can also be added&#44; since they are directly absorbable by the enterocyte&#46; On the other hand&#44; the infant&#39;s predisposition towards sweet taste makes it possible to introduce new foods with a relatively high starch content&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">29</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">As for sweeteners&#44; the European Food Safety Authority &#40;EFSA&#41; proposes acceptable daily intakes to ensure appropriate use without possible adverse effects&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">30</span></a> In the case of infants it is difficult to find sweeteners in the products they consume&#44; as they are prohibited in milk formulae&#44; cereals and baby foods&#46; At later ages&#44; foods such as soft drinks&#44; fruit juices or dairy products sweetened with sugar or sweeteners should be controlled&#46; Reducing the energy content in some foods through sweeteners does actually seem to have modest benefits in children&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">16</span></a> On the other hand&#44; it may lead to greater consumption of other more caloric foods&#44; and there is also the possibility that early exposure to sweeteners&#44; as mentioned previously&#44; could affect dietary habits later&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">31</span></a> In pre-school and school-aged children the recommendations already described should be maintained&#44; taking some additional factors into account&#44; such as physical activity&#44; which may mean that sugar intake has to be regulated with appropriate beverages rather than just drinking water&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">32</span></a> Indeed&#44; anaerobic or prolonged exercise causes a depletion of liver and muscle glycogen reserves&#44; leading to fatigue and cognitive abnormalities&#44;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">33</span></a> which sometimes have to be mitigated with sugars&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Types of sweeteners</span><p id="par0060" class="elsevierStylePara elsevierViewall">There are various ways of classifying sweeteners &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#41;&#46; Using the glycaemic index &#40;GI&#41; we can also make a classification of foods based on postprandial blood sugar response&#44; comparing them with a reference food &#40;GI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&#46; Sucrose is medium GI &#40;&#8776;65&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">34</span></a> Depending on their energy contribution they are classified as &#8220;caloric&#8221; or &#8220;low calorie&#47;non-caloric&#8221; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; or as &#8220;nutritive&#8221; or &#8220;non-nutritive&#8221;&#44; as established by the US Food and Drug Administration &#40;FDA&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">35</span></a> In some cases the term &#8220;natural origin&#8221; is used in the consumer information&#44; as with steviol glycoside&#44; or &#8220;artificial&#8221; origin when they are synthetic &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Natural caloric sweeteners include sucrose&#44; fructose&#44; glucose and maltose&#46; Fructose has classically been used as a substitute for sucrose in diabetic patients&#46; More recently&#44; however&#44; it has been found that high-fructose diets&#44; especially if the fructose is added to processed foods&#44; could induce hyperinsulinaemia&#44; hypertriglyceridaemia and insulin resistance&#44; and this has led to a recommendation to limit their use in diabetics&#46; In addition&#44; fructose dependence has been described&#44; leading to high consumption&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">36</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Fructooligosaccharides have a sweetening power relative to sucrose of 0&#46;3&#8211;0&#46;6&#46; Inulin is a fructan with a well-known prebiotic effect found naturally in the yacon or Peruvian ground apple&#44; a tuber native to the Andes&#44; considered a health food on account of being rich in various minerals&#44; vitamin C and B-group vitamins&#46; Coconut sugar is another traditional product with a low GI because of its sucrose content&#46; Polyols derived from sugar and also regarded as CHs are produced&#44; albeit in small quantities&#44; in plants and cereals&#46; They generally contain fewer calories than sugar&#44; with a very low GI&#44; and have not been associated with the development of tooth decay&#44; since they are non-fermentable&#59; they are used as sweeteners&#46; Their intestinal absorption is generally low&#44; and in moderate quantities &#40;more than 10<span class="elsevierStyleHsp" style=""></span>g of sorbitol&#41; they can produce flatulence&#44; colic or diarrhoea&#44; as they are fermented by the colonic microbiota&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Industrial processed foods use sugars converted from starch&#44; with a high GI and high calorie content&#46; Corn syrup is the prime example&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">There are also natural sweeteners &#40;stevia&#44; luo han guo&#44; thaumatin and brazzein&#41; with no significant calorie content in the quantities normally consumed for sweetening purposes&#46; These are not CHs&#44; and therefore have no GI&#46; They are regarded as high-intense sweeteners&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">&#8220;Artificial sweeteners&#8221; are characterised by being non-caloric&#44; with no glycaemic effect and high sweetening power &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Prominent among them is saccharin&#44; which has great sweetening capacity&#46; Sucralose and aspartame are also notable for their extensive worldwide use&#44; especially in beverages&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">37</span></a> Aspartame is made from a methyl ester of phenylalanine and aspartic acid&#46; Its use is approved by the FDA and the EFSA&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">38</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Safe use of sweeteners</span><p id="par0090" class="elsevierStylePara elsevierViewall">Society demands a market supply of high-quality food substances that are suitable for consumption by people with specific needs&#44; such as diabetics&#44; or that respond to the current demand for low-calorie products&#46; Although the object of using LNCSs is to reduce calorie intake in the diet and the presence of fermentable sugars in the mouth&#44; seeking beneficial effects&#44; such as promoting a decrease in body weight&#44; and preventing diabetes or tooth decay&#44; consumers have doubts about the health risks associated with their use&#44; depending on whether they are artificial or natural&#46; The fact that a sweetener is of natural origin does not imply greater safety or effectiveness&#46; Since a wide range of molecules is involved&#44; there are many potential sources of risk&#58; interference in absorption&#44; metabolism or excretion of nutrients or intermediate metabolites&#44; as well as allergic reactions&#44; accumulation in tissues&#44; effects on normal intestinal flora&#44; disruption of blood glucose regulation or interaction with other drugs or medications&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In research on safety and possible therapeutic uses in patients with diabetes or other specific health problems the focus of interest is on &#8220;artificial sweeteners&#8221;&#46; For this purpose the legal aspects of safety and efficacy in the use of sweeteners need to be constantly reviewed by the EFSA&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Regulation &#40;EC&#41; No 1333&#47;2008 lays down rules on the food additives used in foods to ensure the protection of consumers&#8217; health while upholding trade practices&#46; Annex II&#44; updated in 2013&#44; indicates that the following LNCSs are authorised&#58; acesulfame-K &#40;E-950&#41;&#44; aspartame &#40;E-951&#41;&#44; salt of aspartame-acesulfame &#40;E-962&#41;&#44; cyclamic acid and its Na and Ca salts &#40;E-952&#41;&#44; neohesperidine DC &#40;E-959&#41;&#44; saccharin and its Na&#44; K and Ca salts &#40;E-954&#41;&#44; sucralose &#40;E-955&#41;&#44; thaumatin &#40;E-957&#41; and neotame &#40;E-961&#41;&#46; Following the favourable verdict from the EFSA in 2010&#44; the use of stevia derivatives&#44; steviol glycosides &#40;E-960&#41;&#44; as natural non-caloric sweeteners was definitively approved throughout the European market&#44; and also sorbitol and xylitol&#46; In 2014 the use of advantame &#40;E-969&#41; as an intense sweetener was authorised&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">With regard to aspartame&#44; it does not represent a risk of toxicity for consumers at current exposure levels&#46; Because it is a source of phenylalanine it is not recommended in individuals with hyperphenylalaninaemia or phenylketonuria&#44; although in studies in patients with consumption at normal doses and long-term studies&#44; even in pregnant women&#44; no adverse effects have been found&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">37</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Information for correct use of these substances is based on knowing the differences between the information labels of commonly consumed products containing sweeteners&#46; The labelling of food additives must comply with the general conditions laid down in Directive 2000&#47;13&#47;EC&#46; Specifically&#44; if the product contains polyols&#44; the label must state&#58; &#8220;excessive consumption may produce laxative effects&#8221;&#44; or if it contains aspartame or salt of aspartame-acesulfame&#58; &#8220;contains a source of phenylalanine&#8221;&#46; In this regard&#44; however&#44; there is substantial room for improvement to ensure that this compulsory information appears on all products containing sweeteners&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Under European regulations &#40;Council Directive 89&#47;398&#47;EEC&#41;&#44; artificial sweeteners must not be used in infant formulae&#44; follow-on formulae&#44; cereals&#44; baby foods or dietary foods for very young children for special medical purposes&#44; unless expressly indicated&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">38</span></a> Sugars such as sucrose or fructose may be added in limited quantities&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Scientific research&#44; though still scarce in humans&#44; shows that sweeteners are safe in the general population&#44; including pregnant women<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">39</span></a> and children&#44; although in these populations they must be used in moderation&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">5&#44;16&#44;22</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">All the food additives approved in the European Union are considered safe in the specified doses and conditions of use&#46; In children&#44; however&#44; additives of this kind should only be used as an alternative when other forms of obesity prevention are not sufficient&#44; except for the use of sugar-free chewing gum to prevent tooth decay&#44; or use in pharmaceutical products&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">5</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Final comments</span><p id="par0130" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0135" class="elsevierStylePara elsevierViewall">In general&#44; an intake of simple CHs of less than 10&#37; of the caloric value of the diet is appropriate in the context of a healthy lifestyle&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Sweeteners&#44; especially &#8220;non-caloric&#8221; sweeteners&#44; can help to limit the intake of refined sugars in the diet and are useful for preventing diseases such as obesity and diabetes&#44; in association with a moderate&#44; balanced diet&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0145" class="elsevierStylePara elsevierViewall">In view of the recommendation not to add sweeteners to foods intended for infants and very young children&#44; their use is not advisable in children between the ages of 1 and 3 years&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">It is recommended that health care professionals acquire the appropriate knowledge to advise on and&#47;or choose a particular sweetener on the basis of its properties&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#46;</span><p id="par0155" class="elsevierStylePara elsevierViewall">There is a continuing need for specific research in order to make appropriate use of sweeteners in children&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of interest</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "titulo" => "Consumption of sugars and sweeteners and its relationship with health"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The term &#8220;sweetener&#8221; refers to a food additive that imparts a sweet flavour and usually provides no or very low energy&#46; It is used to sweeten foods&#44; medicines and food supplements with no nutritional purposes&#46; For years&#44; no-calorie sweeteners have been used as substitutes for all or part of the sugar content in foods and beverages&#46; In recent decades its consumption has risen to prevent tooth decay&#44; or as an aid in weight control&#44; obesity and diabetes and&#44; in general&#44; to achieve an optimal energy balance&#46; However&#44; consumption of sugary or sweetened food and soft drinks is high&#44; making this situation of special interest in calorie intake and in the poor behavioural pattern of eating habits in children&#46; In addition&#44; questions remain among consumers about the risks to health associated with their use&#44; whether they are artificial or natural&#46; The &#8220;artificial sweeteners&#8221; are the group of greatest interest in research in order to demonstrate their safety and to provide firm data on their possible therapeutic effects&#46; The aim of the present document is to increase information for paediatricians on the characteristics of different sweeteners&#44; and to advise on the choice of sweeteners&#44; based on their properties&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El t&#233;rmino edulcorante hace referencia a aquel aditivo alimentario que confiere un sabor dulce y que&#44; habitualmente&#44; no aporta o proporciona muy poca energ&#237;a&#46; Se utiliza para endulzar alimentos&#44; medicamentos y complementos alimenticios cuando se persiguen fines no nutritivos&#46; Desde hace a&#241;os&#44; se han empleado edulcorantes acal&#243;ricos como sustitutos de todo o parte del contenido en az&#250;cares en comidas y bebidas&#46; En las &#250;ltimas d&#233;cadas&#44; se ha incrementado su consumo para prevenir la caries y para el correcto cumplimiento de la dieta en casos de control del peso corporal&#44; obesidad y diabetes y&#44; en general&#44; como coadyuvantes para conseguir un balance energ&#233;tico adecuado&#46; No obstante&#44; el consumo de alimentos y de bebidas azucaradas y&#47;o edulcoradas es elevado&#44; reflejando o un aporte cal&#243;rico importante&#44; o un patr&#243;n de h&#225;bitos alimentarios inadecuados en los ni&#241;os&#46; Por otro lado&#44; sigue habiendo dudas entre los consumidores sobre los riesgos para la salud asociados al uso de edulcorantes&#44; ya sean artificiales o naturales&#46; El principal inter&#233;s en investigaci&#243;n sobre seguridad y los posibles usos terap&#233;uticos se centra en los &#171;edulcorantes artificiales&#187;&#46; El objetivo de este documento es proporcionar informaci&#243;n a los pediatras sobre las caracter&#237;sticas de los distintos edulcorantes para aconsejar en la elecci&#243;n de un determinado edulcorante sobre la base de sus propiedades&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:3 [
        "etiqueta" => "&#9674;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">The members of the Comit&#233; de Nutrici&#243;n de la AEP are presented in <a class="elsevierStyleCrossRef" href="#sec0040">Appendix A</a>&#46;</p>"
        "identificador" => "fn0005"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Gil-Campos M&#44; San Jos&#233; Gonz&#225;lez MA&#44; D&#237;az Mart&#237;n JJ&#46; Uso de az&#250;cares y edulcorantes en la alimentaci&#243;n del ni&#241;o&#46; Recomendaciones del Comit&#233; de Nutrici&#243;n de la Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a&#46; An Pediatr &#40;Barc&#41;&#46; 2015&#59;83&#58;353&#46;e1&#8211;353&#46;e7&#46;</p>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0165" class="elsevierStylePara elsevierViewall">Jos&#233; Manuel Moreno Villares &#40;coordinator&#41;&#44; Juan Jos&#233; D&#237;az Mart&#237;n&#44; Mercedes Gil Campos&#44; Ana Mor&#225;is L&#243;pez&#44; V&#237;ctor Manuel Navas L&#243;pez&#44; Susana Redecillas Ferreiro&#44; Miguel S&#225;enz de Pipa&#243;n&#44; Miguel &#193;ngel San Jos&#233; Gonz&#225;lez&#44; F&#233;lix S&#225;nchez-Valverde Visus&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "The members of the Nutrition Committee of the Spanish Association of Paediatrics"
            "identificador" => "sec0040"
          ]
        ]
      ]
    ]
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        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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        "mostrarDisplay" => false
        "fuente" => "<span class="elsevierStyleItalic">Source</span>&#58; Modified from Garc&#237;a-Almeida et al&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">37</span></a>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Natural</td><td class="td" title="table-entry  " align="left" valign="top">Caloric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sugars&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sucrose&#44; glucose&#44; galactose&#44; fructose&#44; lactose&#44; maltose&#44; trehalose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Honey&#44; maple syrup&#44; palm sugar&#44; coconut sugar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Non-caloric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Luo han guo&#44; stevia&#44; thaumatin&#44; pentadin&#44; monellin&#44; brazzein&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Artificial</td><td class="td" title="table-entry  " align="left" valign="top">Caloric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Modified sugars&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;High fructose&#41; corn syrup&#44; inverted sugar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sugar alcohols&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sorbitol&#44; xylitol&#44; mannitol&#44; lactitol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Non-caloric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Artificial sweeteners&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Aspartame&#44; sucralose&#44; saccharin&#44; neotame&#44; acesulfame K&#44; cyclamic acid&#44; alitame&#44; advantame&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "imagenFichero" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Classification of sugars and sweeteners&#46;</p>"
        ]
      ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sweeteners&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Classification by caloric contribution<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Classification by sweetening power<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Polyols</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bulk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sorbitol E-420&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&#8211;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mannitol E-421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Isomalt E-953&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;45&#8211;0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Maltitol E-965&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lactitol E-966&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Xylitol E-967&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Erythritol E-968&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Acesulfame K E-950</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;200&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Aspartame E-951</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;150&#8211;200&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Cyclamic acid E-952</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;50&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Saccharin E-954</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;300&#8211;400&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Thaumatin E-957</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;2500&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Neohesperidin DC E-959</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;250&#8211;2000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Neotame E-961</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;7000&#8211;13&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Sucralose E-955</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;600&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Steviol glycoside E-960</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;350&#8211;400&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">In intense sweeteners the energy contribution to the diet is insignificant&#44; because the amount of product consumed is very small&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">In parentheses&#44; sweetening power value relative to sucrose &#40;value 1&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Classification of sweeteners according to the US Food and Drug Administration &#40;FDA&#41; and the European Union&#44; and the sweetening power &#40;SP&#41; of each substance relative to sucrose &#40;table sugar&#41;&#58; degree of sweetness comparable with sugar &#40;bulk sweetener&#41; or much higher &#40;intense sweetener&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:39 [
            0 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbohydrates in human nutrition&#46; &#40;FAO Food and Nutrition Paper-66&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "FAO&#47;WHO &#40;Food and Agriculture Organization&#47;World Health Organization&#41;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1998"
                        "editorial" => "FAO"
                        "editorialLocalizacion" => "Rome"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scientific opinion on dietary reference values for carbohydrates and dietary fibre"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "EFSA Panel on Dietetic Products&#44; Nutrition&#44; and Allergies &#40;NDA&#41;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "EFSA J"
                        "fecha" => "2010"
                        "volumen" => "8"
                        "paginaInicial" => "1462"
                        "paginaFinal" => "1477"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
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Spanish Association of Paediatrics
Use of sugars and sweeteners in children's diets. Recommendations of the Nutrition Committee of the Spanish Association of Paediatrics
Uso de azúcares y edulcorantes en la alimentación del niño. Recomendaciones del Comité de Nutrición de la Asociación Española de Pediatría
M. Gil-Camposa,
Corresponding author
mercedes_gil_campos@yahoo.es

Corresponding author.
, M.A. San José Gonzálezb, J.J. Díaz Martínc, Comité de Nutrición de la Asociación Española de Pediatría
a Unidad de Metabolismo e Investigación Pediátrica, Hospital Universitario Reina Sofía, Universidad de Córdoba, IMIBIC, Córdoba, Spain
b Atención Primaria, Centro de Salud de Sarria, Lugo, Spain
c Sección de Gastroenterología y Nutrición Pediátrica, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Sugars and sweeteners&#58; concepts</span><p id="par0005" class="elsevierStylePara elsevierViewall">Carbohydrates &#40;CHs&#41; are the nutrients that constitute the main source of food energy&#46; They are notable for their structure and pleasant taste&#44; which in some cases&#44; such as sugars&#44; is sweet&#44; making other foods more palatable&#44; for their ability to satiate the appetite and&#44; in some&#44; for their high fibre content&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">1</span></a> CHs should provide between 45&#37; and 60&#37; of total dietary energy intake in children older than one year of age&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">2</span></a> CHs from food are presented in the form of complex molecules &#40;polymers or polysaccharides&#41;&#44; especially starches&#44; dextrins and fibre&#44; or simpler ones&#44; commonly called sugars&#46; The main dietary sources of sugars are fruit and fruit juices&#44; some vegetables&#44; milk&#44; and processed foods with added sugars&#44; especially sucrose or hydrolysed starch &#40;glucose or fructose syrups&#41;&#44; such as soft drinks&#44; pastries&#44; sweets and confectionery&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">1&#44;2</span></a> Sugars are used to sweeten or enhance the flavour of many of them&#44; to modify the freezing and melting point or to colour foods naturally&#44; and to preserve them&#46; Balanced intake of sugars in the daily diet has important properties&#44; as it facilitates the rapid supply of glucose&#44; an indispensable carbohydrate for the development of cognitive functions and physical activity&#44; to the brain and muscles&#46; Sugar should be consumed in a natural form with the foods that contain it&#44; since this also provides other micronutrients&#46; In the twentieth century&#44; however&#44; questions began to be raised as to whether excessive consumption of sugars&#44; particularly associated with processed foods&#44; might be related to diabetes or obesity&#44; and research has continued up to the present&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Additives are substances deliberately added to foods to perform certain technological functions and the result is that both the additive itself and its byproducts become components of those foods&#46; Additives are not consumed as foods or used as typical ingredients in the diet&#44; regardless of whether or not they have nutritional value&#46; Monosaccharides&#44; disaccharides or oligosaccharides&#44; or foods containing them&#44; are not regarded as food additives&#46; The term <span class="elsevierStyleItalic">sweetener</span> refers to a substance used to impart a sweet taste to foods &#40;Regulation &#40;EC&#41; No 1333&#47;2008&#41;&#46; Thus foods such as honey or ordinary sugar&#44; fructose or glucose are not considered sweeteners&#44; since they have other functions apart from sweetening&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Low- or no-calorie sweeteners &#40;LNCSs&#41; have been used for years to replace all or part of the sugar content in foods and drinks&#44; but in the last few decades their consumption has increased both in adults and in children&#46; Their use is linked to dietary alternatives for weight control or diabetes&#44; but also to preventing tooth decay&#46; Although some studies question these possible benefits&#44; both in adults and in children&#44;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">7&#44;8</span></a> systematic reviews and meta-analyses on this subject conclude that the use of sweeteners is beneficial in weight-control and diabetes programmes associated with a healthy lifestyle&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The purpose of this document is to provide paediatricians with information on sweeteners and health-related issues&#44; in order to give appropriate advice to patients and their families&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Consumption of sugars and sweeteners and its relationship with health</span><p id="par0025" class="elsevierStylePara elsevierViewall">To assess this consumption we have to take into account not only added sugars and sweeteners&#44; but also sugar incorporated as an ingredient in precooked&#47;processed foods&#46; European adolescents consume some 384<span class="elsevierStyleHsp" style=""></span>kcal per day from drinks&#44; of which 30&#46;4&#37;&#44; 20&#46;7&#37; and 18&#46;1&#37; comes from sugar-sweetened beverages&#44; sweetened milk and fruit juice&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">10</span></a> Various cross-sectional studies have concluded that there is no association&#44; or even that there is a negative association&#44; between consumption of sugars and weight gain&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">11&#44;12</span></a> However&#44; there is a widespread debate on whether greater intake of sugars through sweetened beverages could have a significant effect on increase in body mass index &#40;BMI&#41; or about whether unsweetened diets may have an influence on control of obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">13</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Some observational studies have also related increase in BMI to consumption of non-caloric sweeteners&#44; although these data should not be interpreted as proof of a causal relationship&#44; but rather as a sign that the probability of consumption is higher in the obese and sedentary population &#40;reverse causality&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">8</span></a> Replacing sugar with sweeteners is not necessarily associated with a lower overall calorie intake&#44; and could encourage unbalanced dietary habits&#44; involving high consumption of low-calorie products with sweeteners and of others with excessive calories&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">6&#44;14</span></a> Some authors postulate that early consumption of sugar-sweetened products in infants and young children could affect self-regulation of eating and preference for sweet flavours&#44;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">7&#44;15</span></a> which may be maintained during childhood and adolescence&#46; It has even been suggested that consuming sweeteners and sugars together in the diet could give rise to a neuronal response that leads to more rapid absorption of sugars&#44; also increasing secretion of peptides related to glucagon&#44; or insulin&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">16</span></a> On this subject a highly controversial hypothesis has recently been put forward on the development of glucose intolerance through alterations to the intestinal microbiota in mice associated with consuming saccharin at maximum doses&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">17</span></a> However&#44; one must be very cautious in extrapolating conclusions from animal studies to humans&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">18</span></a> Nowadays diabetic patients can use non-caloric sweeteners as part of a balanced&#44; controlled diet&#44; and studies in adults indicate that they do not affect plasma glucose or lipid levels&#44; although this has not been sufficiently investigated in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">19&#44;20</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Fermentable CHs in the diet produce acidic materials which destroy hard tissues of the tooth&#44; giving rise to tooth decay&#46; In the child population dental caries is still common&#44; because of a general lack of adequate oral hygiene after consuming sugary foods&#44; as well as fluoride deficiency&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">21</span></a> In infants&#44; moreover&#44; prolonged use of fruit juices or other fructose- or sucrose-rich sweetened beverages in dummies increases the risk of damage to teeth&#46; Among sweeteners&#44; polyols &#40;sugar alcohols&#41; and sucralose&#44; among others&#44; have been declared to have healthy properties for avoiding this condition&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Recommendations for consumption</span><p id="par0040" class="elsevierStylePara elsevierViewall">All types of CHs must be represented in a healthy diet&#46; The FAO and WHO recommend an intake of sugars &#40;simple carbohydrates&#41; of less than 10&#37; of the total caloric value of the diet&#44; trying to make them part of a healthy diet with limited consumption of sugar-sweetened drinks&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">23</span></a> In 2005 it was established that the recommended daily intake in adults and children older than one year of age is 100<span class="elsevierStyleHsp" style=""></span>g&#47;day of CHs as an estimated mean requirement&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">24</span></a> In Spain&#44; adhering to a Mediterranean or similar diet would make it possible to maintain an appropriate energy intake without sacrificing its sweetening and pleasurable function&#46; In addition&#44; as a practical measure to achieve greater benefits&#44; it has been recommended that consumption of sugars or sugar-sweetened foods should be limited to less than 3 times per day&#44; not exceeding 6&#37; of total energy intake&#44;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">25</span></a> and that of sugar-sweetened drinks to occasional use&#46; It is also recommended that excessive consumption of high-fructose corn syrup &#40;55&#37; fructose&#41; should be reduced&#44; as it represents a health hazard&#44; especially for children&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">26</span></a> Indeed&#44; these syrups are not used in Spain&#44; where the maximum fructose content of manufactured products is approximately 50&#37;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The nutrition statements prescribed in Regulation &#40;EC&#41; No 1924&#47;2006 make it easy to ascertain the composition of foods in terms of sugars&#46; Thus according to the labelling we can find foods that are &#8220;low in sugar&#8221; &#40;no more than 5<span class="elsevierStyleHsp" style=""></span>g of sugars per 100<span class="elsevierStyleHsp" style=""></span>g for solids or 2&#46;5<span class="elsevierStyleHsp" style=""></span>g of sugars per 100<span class="elsevierStyleHsp" style=""></span>ml for liquids&#41;&#44; &#8220;sugar-free&#8221; &#40;no more than 0&#46;25<span class="elsevierStyleHsp" style=""></span>g per 100<span class="elsevierStyleHsp" style=""></span>g or 100<span class="elsevierStyleHsp" style=""></span>ml&#41;&#44; or &#8220;with no added sugar&#8221; &#40;a product with no added mono- or disaccharides nor any other food used for its sweetening properties&#41;&#46; In the last of these cases&#44; the food may &#8220;contain naturally occurring sugars&#8221; or &#8220;sugar&#40;s&#41; and sweetener&#40;s&#41;&#8221;&#44; and this information must appear on the nutrition information label&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">27</span></a> On a practical level&#44; the American Heart Association has suggested simple advice&#44; such as not having more than 6 teaspoonfuls of sugar per day for women &#40;25<span class="elsevierStyleHsp" style=""></span>g&#41; &#40;e&#46;g&#46;&#44; present in 250<span class="elsevierStyleHsp" style=""></span>ml of a sugar-sweetened beverage&#41; and 9 for men &#40;37<span class="elsevierStyleHsp" style=""></span>g&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">28</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">During pregnancy CH intake should not be restricted&#44; but intake of refined sugar or foods with added sugar should be controlled&#46; There is an increase in availability of glucose&#44; which is an essential substrate for the foetus&#46; In newborns&#44; because of pancreatic amylase deficiency&#44; it is advisable for infant milk formulae not to contain starch&#44; with lactose as the main CH&#44; as well as glucose polymers&#44; which can also be added&#44; since they are directly absorbable by the enterocyte&#46; On the other hand&#44; the infant&#39;s predisposition towards sweet taste makes it possible to introduce new foods with a relatively high starch content&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">29</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">As for sweeteners&#44; the European Food Safety Authority &#40;EFSA&#41; proposes acceptable daily intakes to ensure appropriate use without possible adverse effects&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">30</span></a> In the case of infants it is difficult to find sweeteners in the products they consume&#44; as they are prohibited in milk formulae&#44; cereals and baby foods&#46; At later ages&#44; foods such as soft drinks&#44; fruit juices or dairy products sweetened with sugar or sweeteners should be controlled&#46; Reducing the energy content in some foods through sweeteners does actually seem to have modest benefits in children&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">16</span></a> On the other hand&#44; it may lead to greater consumption of other more caloric foods&#44; and there is also the possibility that early exposure to sweeteners&#44; as mentioned previously&#44; could affect dietary habits later&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">31</span></a> In pre-school and school-aged children the recommendations already described should be maintained&#44; taking some additional factors into account&#44; such as physical activity&#44; which may mean that sugar intake has to be regulated with appropriate beverages rather than just drinking water&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">32</span></a> Indeed&#44; anaerobic or prolonged exercise causes a depletion of liver and muscle glycogen reserves&#44; leading to fatigue and cognitive abnormalities&#44;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">33</span></a> which sometimes have to be mitigated with sugars&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Types of sweeteners</span><p id="par0060" class="elsevierStylePara elsevierViewall">There are various ways of classifying sweeteners &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#41;&#46; Using the glycaemic index &#40;GI&#41; we can also make a classification of foods based on postprandial blood sugar response&#44; comparing them with a reference food &#40;GI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&#46; Sucrose is medium GI &#40;&#8776;65&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">34</span></a> Depending on their energy contribution they are classified as &#8220;caloric&#8221; or &#8220;low calorie&#47;non-caloric&#8221; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; or as &#8220;nutritive&#8221; or &#8220;non-nutritive&#8221;&#44; as established by the US Food and Drug Administration &#40;FDA&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">35</span></a> In some cases the term &#8220;natural origin&#8221; is used in the consumer information&#44; as with steviol glycoside&#44; or &#8220;artificial&#8221; origin when they are synthetic &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Natural caloric sweeteners include sucrose&#44; fructose&#44; glucose and maltose&#46; Fructose has classically been used as a substitute for sucrose in diabetic patients&#46; More recently&#44; however&#44; it has been found that high-fructose diets&#44; especially if the fructose is added to processed foods&#44; could induce hyperinsulinaemia&#44; hypertriglyceridaemia and insulin resistance&#44; and this has led to a recommendation to limit their use in diabetics&#46; In addition&#44; fructose dependence has been described&#44; leading to high consumption&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">36</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Fructooligosaccharides have a sweetening power relative to sucrose of 0&#46;3&#8211;0&#46;6&#46; Inulin is a fructan with a well-known prebiotic effect found naturally in the yacon or Peruvian ground apple&#44; a tuber native to the Andes&#44; considered a health food on account of being rich in various minerals&#44; vitamin C and B-group vitamins&#46; Coconut sugar is another traditional product with a low GI because of its sucrose content&#46; Polyols derived from sugar and also regarded as CHs are produced&#44; albeit in small quantities&#44; in plants and cereals&#46; They generally contain fewer calories than sugar&#44; with a very low GI&#44; and have not been associated with the development of tooth decay&#44; since they are non-fermentable&#59; they are used as sweeteners&#46; Their intestinal absorption is generally low&#44; and in moderate quantities &#40;more than 10<span class="elsevierStyleHsp" style=""></span>g of sorbitol&#41; they can produce flatulence&#44; colic or diarrhoea&#44; as they are fermented by the colonic microbiota&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Industrial processed foods use sugars converted from starch&#44; with a high GI and high calorie content&#46; Corn syrup is the prime example&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">There are also natural sweeteners &#40;stevia&#44; luo han guo&#44; thaumatin and brazzein&#41; with no significant calorie content in the quantities normally consumed for sweetening purposes&#46; These are not CHs&#44; and therefore have no GI&#46; They are regarded as high-intense sweeteners&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">&#8220;Artificial sweeteners&#8221; are characterised by being non-caloric&#44; with no glycaemic effect and high sweetening power &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Prominent among them is saccharin&#44; which has great sweetening capacity&#46; Sucralose and aspartame are also notable for their extensive worldwide use&#44; especially in beverages&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">37</span></a> Aspartame is made from a methyl ester of phenylalanine and aspartic acid&#46; Its use is approved by the FDA and the EFSA&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">38</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Safe use of sweeteners</span><p id="par0090" class="elsevierStylePara elsevierViewall">Society demands a market supply of high-quality food substances that are suitable for consumption by people with specific needs&#44; such as diabetics&#44; or that respond to the current demand for low-calorie products&#46; Although the object of using LNCSs is to reduce calorie intake in the diet and the presence of fermentable sugars in the mouth&#44; seeking beneficial effects&#44; such as promoting a decrease in body weight&#44; and preventing diabetes or tooth decay&#44; consumers have doubts about the health risks associated with their use&#44; depending on whether they are artificial or natural&#46; The fact that a sweetener is of natural origin does not imply greater safety or effectiveness&#46; Since a wide range of molecules is involved&#44; there are many potential sources of risk&#58; interference in absorption&#44; metabolism or excretion of nutrients or intermediate metabolites&#44; as well as allergic reactions&#44; accumulation in tissues&#44; effects on normal intestinal flora&#44; disruption of blood glucose regulation or interaction with other drugs or medications&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In research on safety and possible therapeutic uses in patients with diabetes or other specific health problems the focus of interest is on &#8220;artificial sweeteners&#8221;&#46; For this purpose the legal aspects of safety and efficacy in the use of sweeteners need to be constantly reviewed by the EFSA&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Regulation &#40;EC&#41; No 1333&#47;2008 lays down rules on the food additives used in foods to ensure the protection of consumers&#8217; health while upholding trade practices&#46; Annex II&#44; updated in 2013&#44; indicates that the following LNCSs are authorised&#58; acesulfame-K &#40;E-950&#41;&#44; aspartame &#40;E-951&#41;&#44; salt of aspartame-acesulfame &#40;E-962&#41;&#44; cyclamic acid and its Na and Ca salts &#40;E-952&#41;&#44; neohesperidine DC &#40;E-959&#41;&#44; saccharin and its Na&#44; K and Ca salts &#40;E-954&#41;&#44; sucralose &#40;E-955&#41;&#44; thaumatin &#40;E-957&#41; and neotame &#40;E-961&#41;&#46; Following the favourable verdict from the EFSA in 2010&#44; the use of stevia derivatives&#44; steviol glycosides &#40;E-960&#41;&#44; as natural non-caloric sweeteners was definitively approved throughout the European market&#44; and also sorbitol and xylitol&#46; In 2014 the use of advantame &#40;E-969&#41; as an intense sweetener was authorised&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">With regard to aspartame&#44; it does not represent a risk of toxicity for consumers at current exposure levels&#46; Because it is a source of phenylalanine it is not recommended in individuals with hyperphenylalaninaemia or phenylketonuria&#44; although in studies in patients with consumption at normal doses and long-term studies&#44; even in pregnant women&#44; no adverse effects have been found&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">37</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Information for correct use of these substances is based on knowing the differences between the information labels of commonly consumed products containing sweeteners&#46; The labelling of food additives must comply with the general conditions laid down in Directive 2000&#47;13&#47;EC&#46; Specifically&#44; if the product contains polyols&#44; the label must state&#58; &#8220;excessive consumption may produce laxative effects&#8221;&#44; or if it contains aspartame or salt of aspartame-acesulfame&#58; &#8220;contains a source of phenylalanine&#8221;&#46; In this regard&#44; however&#44; there is substantial room for improvement to ensure that this compulsory information appears on all products containing sweeteners&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Under European regulations &#40;Council Directive 89&#47;398&#47;EEC&#41;&#44; artificial sweeteners must not be used in infant formulae&#44; follow-on formulae&#44; cereals&#44; baby foods or dietary foods for very young children for special medical purposes&#44; unless expressly indicated&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">38</span></a> Sugars such as sucrose or fructose may be added in limited quantities&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Scientific research&#44; though still scarce in humans&#44; shows that sweeteners are safe in the general population&#44; including pregnant women<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">39</span></a> and children&#44; although in these populations they must be used in moderation&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">5&#44;16&#44;22</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">All the food additives approved in the European Union are considered safe in the specified doses and conditions of use&#46; In children&#44; however&#44; additives of this kind should only be used as an alternative when other forms of obesity prevention are not sufficient&#44; except for the use of sugar-free chewing gum to prevent tooth decay&#44; or use in pharmaceutical products&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">5</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Final comments</span><p id="par0130" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0135" class="elsevierStylePara elsevierViewall">In general&#44; an intake of simple CHs of less than 10&#37; of the caloric value of the diet is appropriate in the context of a healthy lifestyle&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Sweeteners&#44; especially &#8220;non-caloric&#8221; sweeteners&#44; can help to limit the intake of refined sugars in the diet and are useful for preventing diseases such as obesity and diabetes&#44; in association with a moderate&#44; balanced diet&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0145" class="elsevierStylePara elsevierViewall">In view of the recommendation not to add sweeteners to foods intended for infants and very young children&#44; their use is not advisable in children between the ages of 1 and 3 years&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">It is recommended that health care professionals acquire the appropriate knowledge to advise on and&#47;or choose a particular sweetener on the basis of its properties&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#46;</span><p id="par0155" class="elsevierStylePara elsevierViewall">There is a continuing need for specific research in order to make appropriate use of sweeteners in children&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of interest</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "titulo" => "Palabras clave"
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          "identificador" => "sec0005"
          "titulo" => "Sugars and sweeteners&#58; concepts"
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          "titulo" => "Consumption of sugars and sweeteners and its relationship with health"
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          "titulo" => "Recommendations for consumption"
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          "titulo" => "Types of sweeteners"
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          "identificador" => "sec0025"
          "titulo" => "Safe use of sweeteners"
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          "titulo" => "Final comments"
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            0 => "Sweeteners"
            1 => "Children"
            2 => "Sugars"
            3 => "Obesity"
            4 => "Tooth decay"
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          "palabras" => array:5 [
            0 => "Edulcorantes"
            1 => "Infancia"
            2 => "Az&#250;cares"
            3 => "Obesidad"
            4 => "Caries"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The term &#8220;sweetener&#8221; refers to a food additive that imparts a sweet flavour and usually provides no or very low energy&#46; It is used to sweeten foods&#44; medicines and food supplements with no nutritional purposes&#46; For years&#44; no-calorie sweeteners have been used as substitutes for all or part of the sugar content in foods and beverages&#46; In recent decades its consumption has risen to prevent tooth decay&#44; or as an aid in weight control&#44; obesity and diabetes and&#44; in general&#44; to achieve an optimal energy balance&#46; However&#44; consumption of sugary or sweetened food and soft drinks is high&#44; making this situation of special interest in calorie intake and in the poor behavioural pattern of eating habits in children&#46; In addition&#44; questions remain among consumers about the risks to health associated with their use&#44; whether they are artificial or natural&#46; The &#8220;artificial sweeteners&#8221; are the group of greatest interest in research in order to demonstrate their safety and to provide firm data on their possible therapeutic effects&#46; The aim of the present document is to increase information for paediatricians on the characteristics of different sweeteners&#44; and to advise on the choice of sweeteners&#44; based on their properties&#46;</p></span>"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El t&#233;rmino edulcorante hace referencia a aquel aditivo alimentario que confiere un sabor dulce y que&#44; habitualmente&#44; no aporta o proporciona muy poca energ&#237;a&#46; Se utiliza para endulzar alimentos&#44; medicamentos y complementos alimenticios cuando se persiguen fines no nutritivos&#46; Desde hace a&#241;os&#44; se han empleado edulcorantes acal&#243;ricos como sustitutos de todo o parte del contenido en az&#250;cares en comidas y bebidas&#46; En las &#250;ltimas d&#233;cadas&#44; se ha incrementado su consumo para prevenir la caries y para el correcto cumplimiento de la dieta en casos de control del peso corporal&#44; obesidad y diabetes y&#44; en general&#44; como coadyuvantes para conseguir un balance energ&#233;tico adecuado&#46; No obstante&#44; el consumo de alimentos y de bebidas azucaradas y&#47;o edulcoradas es elevado&#44; reflejando o un aporte cal&#243;rico importante&#44; o un patr&#243;n de h&#225;bitos alimentarios inadecuados en los ni&#241;os&#46; Por otro lado&#44; sigue habiendo dudas entre los consumidores sobre los riesgos para la salud asociados al uso de edulcorantes&#44; ya sean artificiales o naturales&#46; El principal inter&#233;s en investigaci&#243;n sobre seguridad y los posibles usos terap&#233;uticos se centra en los &#171;edulcorantes artificiales&#187;&#46; El objetivo de este documento es proporcionar informaci&#243;n a los pediatras sobre las caracter&#237;sticas de los distintos edulcorantes para aconsejar en la elecci&#243;n de un determinado edulcorante sobre la base de sus propiedades&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">The members of the Comit&#233; de Nutrici&#243;n de la AEP are presented in <a class="elsevierStyleCrossRef" href="#sec0040">Appendix A</a>&#46;</p>"
        "identificador" => "fn0005"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Gil-Campos M&#44; San Jos&#233; Gonz&#225;lez MA&#44; D&#237;az Mart&#237;n JJ&#46; Uso de az&#250;cares y edulcorantes en la alimentaci&#243;n del ni&#241;o&#46; Recomendaciones del Comit&#233; de Nutrici&#243;n de la Asociaci&#243;n Espa&#241;ola de Pediatr&#237;a&#46; An Pediatr &#40;Barc&#41;&#46; 2015&#59;83&#58;353&#46;e1&#8211;353&#46;e7&#46;</p>"
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            "apendice" => "<p id="par0165" class="elsevierStylePara elsevierViewall">Jos&#233; Manuel Moreno Villares &#40;coordinator&#41;&#44; Juan Jos&#233; D&#237;az Mart&#237;n&#44; Mercedes Gil Campos&#44; Ana Mor&#225;is L&#243;pez&#44; V&#237;ctor Manuel Navas L&#243;pez&#44; Susana Redecillas Ferreiro&#44; Miguel S&#225;enz de Pipa&#243;n&#44; Miguel &#193;ngel San Jos&#233; Gonz&#225;lez&#44; F&#233;lix S&#225;nchez-Valverde Visus&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "The members of the Nutrition Committee of the Spanish Association of Paediatrics"
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        "fuente" => "<span class="elsevierStyleItalic">Source</span>&#58; Modified from Garc&#237;a-Almeida et al&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">37</span></a>"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Natural</td><td class="td" title="table-entry  " align="left" valign="top">Caloric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sugars&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sucrose&#44; glucose&#44; galactose&#44; fructose&#44; lactose&#44; maltose&#44; trehalose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Honey&#44; maple syrup&#44; palm sugar&#44; coconut sugar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Non-caloric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Luo han guo&#44; stevia&#44; thaumatin&#44; pentadin&#44; monellin&#44; brazzein&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Artificial</td><td class="td" title="table-entry  " align="left" valign="top">Caloric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Modified sugars&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;High fructose&#41; corn syrup&#44; inverted sugar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sugar alcohols&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sorbitol&#44; xylitol&#44; mannitol&#44; lactitol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Non-caloric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Artificial sweeteners&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Aspartame&#44; sucralose&#44; saccharin&#44; neotame&#44; acesulfame K&#44; cyclamic acid&#44; alitame&#44; advantame&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Classification of sugars and sweeteners&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sweeteners&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Classification by caloric contribution<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Classification by sweetening power<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Polyols</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bulk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sorbitol E-420&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&#8211;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mannitol E-421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Isomalt E-953&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;45&#8211;0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Maltitol E-965&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lactitol E-966&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Xylitol E-967&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Erythritol E-968&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Acesulfame K E-950</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;200&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Aspartame E-951</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;150&#8211;200&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Cyclamic acid E-952</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;50&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Saccharin E-954</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;300&#8211;400&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Thaumatin E-957</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;2500&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Neohesperidin DC E-959</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;250&#8211;2000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Neotame E-961</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;7000&#8211;13&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Sucralose E-955</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;600&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Steviol glycoside E-960</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-nutritive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Intense &#40;350&#8211;400&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">In intense sweeteners the energy contribution to the diet is insignificant&#44; because the amount of product consumed is very small&#46;</p>"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">In parentheses&#44; sweetening power value relative to sucrose &#40;value 1&#41;&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Classification of sweeteners according to the US Food and Drug Administration &#40;FDA&#41; and the European Union&#44; and the sweetening power &#40;SP&#41; of each substance relative to sucrose &#40;table sugar&#41;&#58; degree of sweetness comparable with sugar &#40;bulk sweetener&#41; or much higher &#40;intense sweetener&#41;&#46;</p>"
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        0 => array:2 [
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                  "contribucion" => array:1 [
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