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The month before admission&#44; abundant stool production with decreased consistency associated to weight loss was present&#46; Coincidentally&#44; the decontamination protocol was not followed and 48<span class="elsevierStyleHsp" style=""></span>h prior to admission&#44; he developed a respiratory syncytial virus respiratory tract infection&#46; On admission&#44; the anthropometric data showed severe malnutrition&#58; weight 4&#46;41<span class="elsevierStyleHsp" style=""></span>kg &#40;<span class="elsevierStyleHsp" style=""></span>cm &#40;<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; and the anion GAP was increased &#40;27<span class="elsevierStyleHsp" style=""></span>mEq&#47;L&#41; with normal lactic levels &#40;0&#46;7<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41;&#46; Ketonuria was absent&#46; Correction therapy was started with intravenous fluids containing bicarbonate and oral metronidazole&#46; Prior to this&#44; a venous blood sample in a lithium heparin tube was immediately centrifuged&#46; Plasma was frozen and sent for <span class="elsevierStyleSmallCaps">d</span>-lactic acid analysis to a reference laboratory &#40;Birmingham Children&#39;s Hospital&#44; Birmingham&#44; through Reference Laboratory&#44; Barcelona&#41;&#44; confirming the suspected diagnosis &#40;<span class="elsevierStyleSmallCaps">d</span>-lactic acid<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41;&#46; The outcome was satisfactory with normalization of neurological symptoms and gradual improvement of the acid&#8211;base balance&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSmallCaps">d</span>-Lactic acidosis usually originates from an accumulation of <span class="elsevierStyleSmallCaps">d</span>-lactic secondary to an elevated synthesis by gastrointestinal tract bacteria&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> Production of <span class="elsevierStyleSmallCaps">d</span>-lactic is minimal under normal conditions and is easily metabolized by the mitochondrial <span class="elsevierStyleSmallCaps">d</span>-lactate dehydrogenase&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> However&#44; in the SBS&#44; a high carbohydrate intake may generate an increased production and subsequent accumulation of <span class="elsevierStyleSmallCaps">d</span>-lactate because of the bacterial overgrowth&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> This entity should be suspected in patients associating neurological symptoms and metabolic acidosis with elevated anion GAP without increasing <span class="elsevierStyleSmallCaps">l</span>-lactic acid&#44; as in our case&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;5</span></a> We could not find in the literature any report involving such a young infant&#46; We highlight that in our routine blood analysis&#44; only <span class="elsevierStyleSmallCaps">l</span>-lactic acid is detected&#46; When this condition is suspected&#44; it should be confirmed by a special measurement of serum or plasma <span class="elsevierStyleSmallCaps">d</span>-lactic concentration&#46; Normal values of <span class="elsevierStyleSmallCaps">d</span>-lactic acid in blood are undetectable&#44; being those above 3<span class="elsevierStyleHsp" style=""></span>mmol&#47;L pathological&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The treatment is based on pathogenic flora elimination &#40;administration of oral nonabsorbable antibiotics as metronidazole&#44; neomycin or vancomycin&#41;&#44; correction of the acidosis and carbohydrate restriction diet&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> Administration of probiotics is controversial&#46; <span class="elsevierStyleItalic">Bifidobacterium breve</span> and <span class="elsevierStyleItalic">Lactobacillus casei</span> are theoretically non <span class="elsevierStyleSmallCaps">d</span>-lactate producing flora and have been occasionally used as adjuvant therapy with antibiotics&#44; in order to replace the pathogenic flora&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> However&#44; two cases of <span class="elsevierStyleSmallCaps">d</span>-lactic acidosis in patients with SBS attributed to the administration of probiotics containing <span class="elsevierStyleSmallCaps">d</span>-lactate producing strains &#40;<span class="elsevierStyleItalic">Lactobacillus acidophilus</span>&#44; <span class="elsevierStyleItalic">Lactobacillus bulgaricus</span> and <span class="elsevierStyleItalic">Bifidobacterium infantis</span>&#41; have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Probiotics must be carefully selected in children with SBS&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> There are few data available related to the ideal maintenance therapy due to the lack of controlled studies&#46; Avoiding fast-acting carbohydrate diets&#44; periodical decontamination or the use of non <span class="elsevierStyleSmallCaps">d</span>-lactate producing probiotics are different options which should be individualized in patients at risk of developing <span class="elsevierStyleSmallCaps">d</span>-lactic acidosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3&#44;6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">This case is a reminder of the importance of suspecting this rare entity in SBS affected children presenting with neurological symptoms and metabolic acidosis where routine blood tests do not detect the increased anion&#46; In these situations an early treatment should be mandatory&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Pacheco PO&#44; L&#243;pez VMN&#44; Mac&#237;as RY&#44; Salinas CS&#46; Acidosis d-l&#225;ctica en un ni&#241;o de diez meses afecto de un s&#237;ndrome de intestino corto&#58; la r&#225;pida sospecha equivale a un r&#225;pido tratamiento&#46; An Pediatr &#40;Barc&#41;&#46; 2016&#59;84&#58;56&#8211;57&#46;</p>"
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Scientific Letter
d-Lactic acidosis in a ten months old infant with short bowel syndrome: Early suspicion equals early treatment
Acidosis d-láctica en un niño de diez meses afecto de un síndrome de intestino corto: la rápida sospecha equivale a un rápido tratamiento
P. Obando Pachecoa,
Corresponding author
pabobapac@gmail.com

Corresponding author.
, V.M. Navas Lópezb, R. Yahyaoui Macíasc, C. Sierra Salinasb
a Unidad de Gestión Clínica de Pediatría, Hospital Materno Infantil, Hospital Regional Universitario de Málaga, Spain
b Unidad de Gastroenterología y Nutrición Infantil, Unidad de Gestión Clínica de Pediatría, IBIMA, Hospital Materno Infantil, Hospital Regional Universitario de Málaga, Spain
c Laboratorio de Metabolopatías y Centro de Cribado Neonatal de Andalucía Oriental, Unidad de Gestión Clínica de Laboratorios, Hospital Materno Infantil, Hospital Regional Universitario de Málaga, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Metabolic acidosis is a disorder of the acid&#8211;base balance which may be due to bicarbonate losses&#44; deficient acid elimination by the kidney&#44; exogenous intake of acids or an endogenous increased acid production&#46; Within this last group&#44; lactic acidosis should be noted&#44; because of its frequency&#44; morbidity and potential mortality&#46; Lactic acidosis&#44; which is generally caused by accumulation of the <span class="elsevierStyleSmallCaps">l</span>-lactic isomer&#44; can be congenital or secondary&#44; the latter is in relation to tissue hypoxia &#40;type A&#41; or to hepatic&#44; renal or oncologic diseases&#44; intense exercise&#44; seizures or toxics &#40;type B&#41;&#46; Less common are the situations where the cumulative isomer is the <span class="elsevierStyleSmallCaps">d</span>-lactic&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> which have occasionally been reported in patients suffering from short bowel syndrome &#40;SBS&#41;&#44; presenting with a metabolic acidosis&#44; increased anion GAP and neurological symptoms&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of a ten month old infant with SBS secondary to gastroschisis and intestinal necrosis&#46; He had undergone surgery three times during the neonatal period with a remaining small bowel of 30<span class="elsevierStyleHsp" style=""></span>cm preserving the ileocecal valve&#46; The patient&#39;s diet was composed of extensively hydrolysed lactose-free formula&#44; gluten-free cereal&#44; vegetables and chicken&#46; Feeding was done mostly through nasogastric tube&#44; with some participation of oral feeding&#46; Metronidazole 20<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day and cefixime 8<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day were administered alternatively the first week of each month as intestinal decontamination protocol&#46; The month before admission&#44; abundant stool production with decreased consistency associated to weight loss was present&#46; Coincidentally&#44; the decontamination protocol was not followed and 48<span class="elsevierStyleHsp" style=""></span>h prior to admission&#44; he developed a respiratory syncytial virus respiratory tract infection&#46; On admission&#44; the anthropometric data showed severe malnutrition&#58; weight 4&#46;41<span class="elsevierStyleHsp" style=""></span>kg &#40;<span class="elsevierStyleHsp" style=""></span>cm &#40;<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; and the anion GAP was increased &#40;27<span class="elsevierStyleHsp" style=""></span>mEq&#47;L&#41; with normal lactic levels &#40;0&#46;7<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41;&#46; Ketonuria was absent&#46; Correction therapy was started with intravenous fluids containing bicarbonate and oral metronidazole&#46; Prior to this&#44; a venous blood sample in a lithium heparin tube was immediately centrifuged&#46; Plasma was frozen and sent for <span class="elsevierStyleSmallCaps">d</span>-lactic acid analysis to a reference laboratory &#40;Birmingham Children&#39;s Hospital&#44; Birmingham&#44; through Reference Laboratory&#44; Barcelona&#41;&#44; confirming the suspected diagnosis &#40;<span class="elsevierStyleSmallCaps">d</span>-lactic acid<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41;&#46; The outcome was satisfactory with normalization of neurological symptoms and gradual improvement of the acid&#8211;base balance&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSmallCaps">d</span>-Lactic acidosis usually originates from an accumulation of <span class="elsevierStyleSmallCaps">d</span>-lactic secondary to an elevated synthesis by gastrointestinal tract bacteria&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> Production of <span class="elsevierStyleSmallCaps">d</span>-lactic is minimal under normal conditions and is easily metabolized by the mitochondrial <span class="elsevierStyleSmallCaps">d</span>-lactate dehydrogenase&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> However&#44; in the SBS&#44; a high carbohydrate intake may generate an increased production and subsequent accumulation of <span class="elsevierStyleSmallCaps">d</span>-lactate because of the bacterial overgrowth&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> This entity should be suspected in patients associating neurological symptoms and metabolic acidosis with elevated anion GAP without increasing <span class="elsevierStyleSmallCaps">l</span>-lactic acid&#44; as in our case&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;5</span></a> We could not find in the literature any report involving such a young infant&#46; We highlight that in our routine blood analysis&#44; only <span class="elsevierStyleSmallCaps">l</span>-lactic acid is detected&#46; When this condition is suspected&#44; it should be confirmed by a special measurement of serum or plasma <span class="elsevierStyleSmallCaps">d</span>-lactic concentration&#46; Normal values of <span class="elsevierStyleSmallCaps">d</span>-lactic acid in blood are undetectable&#44; being those above 3<span class="elsevierStyleHsp" style=""></span>mmol&#47;L pathological&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The treatment is based on pathogenic flora elimination &#40;administration of oral nonabsorbable antibiotics as metronidazole&#44; neomycin or vancomycin&#41;&#44; correction of the acidosis and carbohydrate restriction diet&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> Administration of probiotics is controversial&#46; <span class="elsevierStyleItalic">Bifidobacterium breve</span> and <span class="elsevierStyleItalic">Lactobacillus casei</span> are theoretically non <span class="elsevierStyleSmallCaps">d</span>-lactate producing flora and have been occasionally used as adjuvant therapy with antibiotics&#44; in order to replace the pathogenic flora&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> However&#44; two cases of <span class="elsevierStyleSmallCaps">d</span>-lactic acidosis in patients with SBS attributed to the administration of probiotics containing <span class="elsevierStyleSmallCaps">d</span>-lactate producing strains &#40;<span class="elsevierStyleItalic">Lactobacillus acidophilus</span>&#44; <span class="elsevierStyleItalic">Lactobacillus bulgaricus</span> and <span class="elsevierStyleItalic">Bifidobacterium infantis</span>&#41; have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Probiotics must be carefully selected in children with SBS&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> There are few data available related to the ideal maintenance therapy due to the lack of controlled studies&#46; Avoiding fast-acting carbohydrate diets&#44; periodical decontamination or the use of non <span class="elsevierStyleSmallCaps">d</span>-lactate producing probiotics are different options which should be individualized in patients at risk of developing <span class="elsevierStyleSmallCaps">d</span>-lactic acidosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3&#44;6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">This case is a reminder of the importance of suspecting this rare entity in SBS affected children presenting with neurological symptoms and metabolic acidosis where routine blood tests do not detect the increased anion&#46; In these situations an early treatment should be mandatory&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Pacheco PO&#44; L&#243;pez VMN&#44; Mac&#237;as RY&#44; Salinas CS&#46; Acidosis d-l&#225;ctica en un ni&#241;o de diez meses afecto de un s&#237;ndrome de intestino corto&#58; la r&#225;pida sospecha equivale a un r&#225;pido tratamiento&#46; An Pediatr &#40;Barc&#41;&#46; 2016&#59;84&#58;56&#8211;57&#46;</p>"
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Article information
ISSN: 23412879
Original language: English
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Idiomas
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