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of 16 respiratory viruses in term and preterm neonates admitted to the NICU&#44; and to describe the associated clinical manifestations&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">We performed a prospective cohort study at the Hospital Severo Ochoa &#40;Legan&#233;s&#44; Madrid&#41; to assess the incidence&#44; aetiology and clinical characteristics of viral respiratory infections in neonates that required admission to the NICU for 2 or more weeks&#46; Patients were enrolled between November 2011 and May 2013&#46; The study was funded by grant number 09&#47;00246 of the Fondo de Investigaciones Sanitarias and approved by the Medical Ethics Committee of the Hospital Severo Ochoa&#46; The parents signed an informed consent form before patients were included in the study&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We collected a nasopharyngeal aspirate &#40;NPA&#41; sample the first day of life and weekly until discharge&#46; When infants developed respiratory symptoms such as cough&#44; respiratory distress&#44; rhinorrhoea and longer than usual apnoeic pauses with or without fever&#44; an additional NPA sample was collected at the moment&#46; The neonatologist filled out a clinical form for each episode&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The NPA specimens were sent to the Unidad de Virus Respiratorios y Gripe &#40;Unit of Respiratory Viruses and Influenza&#41; of the Centro Nacional de Gripe &#40;National Influenza Centre&#41; of the World Health Organisation&#44; the Instituto de Salud Carlos III&#44; in Madrid&#44; Spain&#46; This unit subjected the specimens to three nested real-time polymerase chain reaction &#40;RT-PCR&#41; assays for the detection of a total of 16 respiratory viruses&#44; as reported in previous publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">We have expressed discrete variables as percentages and continuous variables as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41;&#46; We compared the variables corresponding to clinical and laboratory characteristics by means of Student&#39;s <span class="elsevierStyleItalic">t</span> test&#44; the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#44; the &#967;<span class="elsevierStyleSup">2</span> test and Fisher&#39;s exact test&#46; We set the level of statistical significance &#40;for two-tailed tests&#41; at <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; The statistical analysis was performed using the Statistical Package for the Social Sciences &#40;SPSS&#41;&#44; version 13&#46;0&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">The study included 66 infants &#40;all but one born preterm&#41;&#44; six of which &#40;9&#37;&#41; were withdrawn from the study by their parents during followup&#46; We analysed the data for a total of 60 infants&#58; 33 &#40;55&#37;&#41; were female&#59; 30 &#40;50&#37;&#41; had a gestational age below 32 weeks&#59; and 36 &#40;60&#37;&#41; weighed less than 1500<span class="elsevierStyleHsp" style=""></span>g&#46; Mechanical ventilation was required by 41&#46;7&#37; of the patients &#40;mean duration<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#44; 2&#46;31<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;73 days&#41; and continuous positive airway pressure &#40;CPAP&#41; by 31&#46;7&#37; &#40;mean duration<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#44; 2&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;74<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A total of 256 NPA samples were collected&#44; and 24 tested positive &#40;9&#46;3&#37;&#41;&#59; none of the positive specimens had been collected in the first day of life&#46; The virus identified most frequently was RV&#44; detected in 19 &#40;79&#37;&#41; of the positive samples&#44; followed by adenovirus &#40;2 cases&#41;&#44; CoV &#40;3 cases&#41; and hMPV &#40;1 case&#41;&#46; One patient had a RV and CoV coinfection&#46; There were no cases of RSV or influenza&#46; The positive NPA specimens were obtained at a mean of 35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21 days &#40;range&#44; 8&#8211;68&#59; median&#44; 30&#41;&#46; We observed a higher frequency of samples positive for respiratory viruses in patients younger than 32 weeks and with weights below 1500<span class="elsevierStyleHsp" style=""></span>g &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;05 and <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#44; respectively&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The 24 positive samples corresponded to 13 infants &#40;21&#46;6&#37; of the patients&#41;&#44; of which 9 &#40;69&#37;&#41; developed symptoms&#44; with a total 11 infectious episodes &#40;2 patients had 2 separate episodes with a negative test result in between&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the clinical characteristics of the episodes of respiratory infection&#46; The symptoms found most frequently were the presence or greater number of apnoeic episodes &#40;75&#37;&#41; and the need for oxygen therapy&#46; None of the patients required mechanical ventilation&#44; and only one patient received noninvasive ventilation&#46; Fever occurred in 45&#37; of the infectious episodes&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Laboratory analyses were performed in 7 &#40;64&#37;&#41; of the 11 infectious episodes&#59; only one patient had leukocytosis &#40;32&#44;000&#47;mL&#41;&#46; Blood cultures were performed in 4 &#40;36&#37;&#41; cases&#44; and the results were negative for all&#46; Antibiotic therapy was initiated in one patient for suspected sepsis&#46; Five infants underwent chest radiographs&#44; and atelectasis was found in one&#46; All patients recovered&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Four of the children with positive samples did not develop clinical symptoms &#40;three had RV 3 and one CoV OC43&#41;&#46; One of the symptomatic infants had prolonged shedding of RV for 8 weeks&#46; No tests were performed on the healthcare staff or the parents&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> compares the clinical data of the patients&#44; &#40;symptomatic and asymptomatic&#41;&#44; with obtaining a positive result in the viral assays&#46; Of the 13 infants that had a positive viral isolate&#44; 5 &#40;38&#37;&#41; developed bronchopulmonary dysplasia&#46; One of them had an asymptomatic infection by CoV OC43 and the other 4 symptomatic infections by RV or adenovirus&#46; Of the children that did not have a positive viral isolate&#44; 3 &#40;6&#46;4&#37;&#41; were diagnosed with bronchopulmonary dysplasia &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>009&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Nosocomial infections are among the major causes of morbidity&#44; prolonged hospitalisation and mortality in neonates&#44; especially in those born preterm&#46; Most of the scientific literature focuses on bacterial or fungal infections and does not consider respiratory viruses&#44; except for RSV&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a> We present the results of a prospective cohort study in 16 viral respiratory infections conducted in the NICU of a secondary hospital&#46; Viral respiratory infections&#44; especially those by RV&#44; are fairly frequent in the neonatal unit and are associated with episodes of apnoea and the need for respiratory support&#44; especially in preterm newborns of less than 32 weeks of gestational age or with weights below 1500<span class="elsevierStyleHsp" style=""></span>g&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The advent of PCR techniques has revealed the involvement in lower respiratory tract infections in children&#44; and that this is one of the most important viruses overall in the epidemiology of respiratory infections&#46; Various groups have recently identified RV as the causative agent of respiratory infection outbreaks in neonatal units&#46; Reid et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> described an outbreak of infection by RV type C in 7 infants in a paediatric and neonatal intensive care unit&#44; 5 of which had clinically relevant episodes of apnoea and required respiratory support or oxygen therapy&#46; Van Piggelen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a> described 7 severe nosocomial infections associated to RV in the NICU over a period of 5 years&#44; all of which were associated with respiratory distress and required ventilatory support&#46; In both studies&#44; respiratory infections were suspected and a viral aetiology was actively explored&#46; The clinical data of these two studies are similar to those obtained in our cohort&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">However&#44; our data show that respiratory viruses are responsible for a considerable number of disease episodes that worsen respiratory status and that are attributed to prematurity when in fact they are due to viral infections&#46; We only found a similar study that focused on detecting unrecognised respiratory viral infections in preterm neonates admitted after delivery&#46; In this prospective study&#44; which had a design similar to ours&#44; Bennett et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a> observed that 52&#37; of the 60 preterm neonates tested for viral detection had positive results during their stay&#46; This group of neonates had longer lengths of stay&#44; prolonged respiratory support&#44; and a higher incidence of bronchopulmonary dysplasia&#46; In our patients&#44; the proportion of bronchopulmonary dysplasia was also greater in infants in whom a virus had been detected&#44; but the group of children that tested negative for viruses had a greater gestational age&#44; a circumstance that may lead to misinterpretation of the results&#46; The proportions of the viruses detected by Bennett et al&#46; differed somewhat from ours&#44; with a high prevalence of RSV&#44; parainfluenza virus and hMPV&#44; especially in the winter&#46; Rhinovirus was detected in only 27&#37; of the patients&#46; The lower incidence of viral infections by RSV or influenza in our group may have been due to our meticulous adherence to the preventive measures against nosocomial infections&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">We agree with Bennett in thinking that while there are descriptions of outbreaks of viral respiratory infections in NICUs&#44; these studies substantiate the importance of systematic surveillance for detecting infections that would otherwise not be recognised&#46; Preterm infants may present few or atypical symptoms&#44; and the detection of viral infections may have profound clinical consequences&#46; Our study was limited by the small number of patients included in it&#44; so it is important that other prospective studies are performed to elucidate the actual role of viral respiratory infections in neonatal units&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">We did not explore the sources of the infections&#44; but the infants only had contact with their parents and the healthcare staff&#46; And while we presumably adhere rigorously to preventive measures against nosocomial infections including the use of gloves&#44; handwashing before and after each contact with a patient&#44; and having any individual with respiratory symptoms wear a mask&#44; transmission of respiratory viruses does occur and we should explore new preventive strategies&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In short&#44; we found that RV may be the cause of respiratory infections in preterm neonates during their stay in the NICU&#44; and that preterm infants are at high risk of acquiring clinically significant infections of this kind&#46; Viral respiratory infections should be ruled out in infants with rhinorrhoea&#44; apnoea&#44; high oxygen requirements and clinical suspicion of sepsis&#46; We must apply rigorous measures for infection prevention and possibly introduce additional hygiene measures&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Funding</span><p id="par0105" class="elsevierStylePara elsevierViewall">This study has been funded by the <span class="elsevierStyleGrantSponsor" id="gs1">Instituto Nacional de Salud de Espa&#241;a</span> &#40;ISCIII&#44; Fondo de Investigaciones Sanitarias&#41;&#44; PI 09&#47;00246 and PI 12&#47;0129&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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    "fechaRecibido" => "2014-04-23"
    "fechaAceptado" => "2014-05-26"
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          "clase" => "keyword"
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          "palabras" => array:4 [
            0 => "Rhinovirus"
            1 => "Respiratory syncytial virus"
            2 => "Respiratory tract infections"
            3 => "Preterm infants"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:4 [
            0 => "Rinovirus"
            1 => "Virus respiratorio sincitial"
            2 => "Infecciones del tracto respiratorio"
            3 => "Pret&#233;rmino"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Viral respiratory infections cause major morbidity and mortality in preterm infants&#46; We have performed a prospective study in our neonatal intensive care unit &#40;NICU&#41; to determine the incidence of respiratory infections&#44; their impact and the epidemiology and outcome in high risk neonates&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">From September 2011 to May 2013 a prospective study was conducted in all preterm infants &#60;32 weeks gestational age and in all term newborns admitted to NICU for any pathology that was anticipated to have an admission exceeding two weeks&#46; A nasopharyngeal aspirate &#40;NPA&#41; was collected the first day of life and weekly until discharge for virologic study with polymerase chain reaction&#46; When these babies presented respiratory symptoms a new NPA was collected at this moment&#46; A clinical form was filled by the physician&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 60 infants were analysed&#58; 30 &#40;50&#37;&#41; had a gestational age &#60;32 weeks and 36 &#40;60&#37;&#41; weighed less than 1500<span class="elsevierStyleHsp" style=""></span>g&#46; We collected a total of 256 nasopharyngeal aspirate samples&#44; 24 of them being positive &#40;9&#46;3&#37;&#41;&#46; These 24 positive samples corresponded to 13 infants in our cohort &#40;21&#46;6&#37; of the patients&#41;&#46; Of them&#44; 9 were symptomatic and had 11 episodes of infection &#40;2 patients had two different episodes with negative control between them&#41;&#46; The most frequently identified virus was rhinovirus in &#40;19&#41; 79&#37; of cases&#46; The most frequent clinical data was the presence or increase in apneas &#40;75&#37;&#41; and the need for oxygenotherapy&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">HRV infections are prevalent in the NICU&#44; and preterm infants have a high risk of infections with clinical relevance&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Las infecciones virales respiratorias son causa de importante morbimortalidad en reci&#233;n nacidos prematuros&#46; Hemos realizado un estudio prospectivo en nuestra unidad de cuidados intensivos neonatales &#40;UCIN&#41; para determinar la incidencia de infecciones respiratorias&#44; su impacto&#44; epidemiolog&#237;a y pron&#243;stico en neonatos de alto riesgo&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo realizado entre septiembre del 2011 y mayo del 2013 entre todos los reci&#233;n nacidos &#60; 32 semanas de edad gestacional y aquellos ni&#241;os cuya patolog&#237;a pudiera dar lugar a pensar en un ingreso superior a las 2 semanas&#46; Se recogieron aspirados nasofar&#237;ngeos &#40;ANF&#41; el primer d&#237;a de vida y semanalmente hasta el alta para estudio virol&#243;gico mediante reacci&#243;n en cadena de polimerasa&#46; En los casos en los que los ni&#241;os presentaban s&#237;ntomas respiratorios&#44; se procedi&#243; a recoger un nuevo ANF&#46; El pediatra cumpliment&#243; un cuestionario con los datos cl&#237;nicos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 60 ni&#241;os&#59; 30 &#40;50&#37;&#41; de ellos con una edad gestacional &#60;32 semanas y 36 &#40;60&#37;&#41; con un peso &#60;1&#46;500<span class="elsevierStyleHsp" style=""></span>g&#46; Se recogi&#243; un total de 256 ANF&#44; 24 de los cuales resultaron positivos &#40;9&#44;3&#37;&#41;&#46; Estas 24 muestras positivas correspondieron solo a 13 ni&#241;os &#40;21&#44;6&#37; de los pacientes&#41;&#46; De ellos&#44; 9 resultaron sintom&#225;ticos y presentaron 11 episodios de infecci&#243;n &#40;2 pacientes experimentaron 2 episodios diferentes con control negativo entre ellos&#41;&#46; El virus m&#225;s frecuentemente identificado &#8211; el 79&#37; de las muestras &#40;19&#41; &#8211; fue el rinovirus &#40;RV&#41;&#46; El dato cl&#237;nico m&#225;s frecuente fue la presencia o incremento de apneas &#40;75&#37;&#41; y la necesidad de oxigenoterapia&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las infecciones por RV son frecuentes en la UCIN y los reci&#233;n nacidos pret&#233;rmino tienen un alto riesgo de presentar infecciones de relevancia cl&#237;nica&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gonzalez-Carrasco E&#44; Calvo C&#44; Garc&#237;a-Garc&#237;a ML&#44; Beato M&#44; Mu&#241;oz-Archidona C&#44; Pozo F&#44; et al&#46; Infecciones virales de las v&#237;as respiratorias en la Unidad de Cuidados Intensivos Neonatales&#46; An Pediatr &#40;Barc&#41;&#46; 2015&#59;82&#58;242&#8211;246&#46;</p>"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">CMV&#58; conventional mechanical ventilation&#59; CPAP&#58; continuous positive airway pressure&#59; NSD&#58; no significant differences&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Viral infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">No infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Male sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 &#40;46&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24 &#40;51&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1551<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>603&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;32&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Bronchopulmonary dysplasia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;6&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>03&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>171&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of patients with and without viral respiratory infection &#40;symptomatic or asymptomatic&#41;&#46;</p>"
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      "titulo" => "References"
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        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:13 [
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              "etiqueta" => "1"
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                  "contribucion" => array:1 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;L&#46; Garc&#237;a-Garc&#237;a"
                            1 => "C&#46; Calvo"
                            2 => "F&#46; Pozo"
                            3 => "P&#46; P&#233;rez-Bre&#241;a"
                            4 => "S&#46; Quevedo"
                            5 => "T&#46; Bracamonte"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1097/INF.0b013e3181626d2a"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Infect Dis J"
                        "fecha" => "2008"
                        "volumen" => "27"
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                            "web" => "Medline"
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              ]
            ]
            1 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of respiratory viruses in preterm infants submitted to mechanical ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;M&#46; Diniz"
                            1 => "R&#46;A&#46; Vieira"
                            2 => "M&#46;E&#46; Ceccon"
                            3 => "M&#46;A&#46; Ishida"
                            4 => "F&#46;A&#46; Vaz"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S0036-46652005000100007"
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                        "volumen" => "47"
                        "paginaInicial" => "37"
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                            "web" => "Medline"
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                        ]
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                    ]
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              ]
            ]
            2 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nosocomial respiratory syncytial virus infection in neonatal units in the United Kingdom"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "R&#46; Thwaites"
                            1 => "J&#46; Piercy"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Paediatr Suppl"
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              ]
            ]
            3 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coronavirus-related nosocomial viral respiratory infections in a neonatal and paediatric intensive care unit&#58; a prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Gagneur"
                            1 => "J&#46; Sizun"
                            2 => "S&#46; Vallet"
                            3 => "M&#46;C&#46; Legr"
                            4 => "B&#46; Picard"
                            5 => "P&#46;J&#46; Talbot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jhin.2002.1179"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hosp Infect"
                        "fecha" => "2002"
                        "volumen" => "51"
                        "paginaInicial" => "59"
                        "paginaFinal" => "64"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12009822"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            4 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An outbreak of human rhinovirus species C infections in a neonatal intensive care unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;B&#46; Reid"
                            1 => "T&#46;L&#46; Anderson"
                            2 => "L&#46; Cooley"
                            3 => "J&#46; Williamson"
                            4 => "A&#46;R&#46; Mcgregor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Infect Dis J"
                        "fecha" => "2011"
                        "volumen" => "30"
                        "paginaInicial" => "1095"
                        "paginaFinal" => "1096"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0095"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human bocavirus infection in a neonatal intensive care unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Calvo"
                            1 => "M&#46;L&#46; Garc&#237;a-Garc&#237;a"
                            2 => "C&#46; Blanco"
                            3 => "M&#46;J&#46; Santos"
                            4 => "F&#46; Pozo"
                            5 => "P&#46; P&#233;rez-Bre&#241;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jinf.2008.06.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect"
                        "fecha" => "2008"
                        "volumen" => "57"
                        "paginaInicial" => "269"
                        "paginaFinal" => "271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18649946"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
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              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variability of influenza AH1N1 infections in a Neonatal Unit in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Calvo"
                            1 => "E&#46; Gonzalez-Carrasco"
                            2 => "S&#46; Quevedo"
                            3 => "M&#46;L&#46; Garc&#237;a-Garc&#237;a"
                            4 => "A&#46; Rando"
                            5 => "J&#46; Ledesma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000324232"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neonatology"
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                        "volumen" => "100"
                        "paginaInicial" => "282"
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            7 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simultaneous detection of influenza A B&#44; and C viruses&#44; respiratory syncytial virus&#44; and adenoviruses in clinical samples by multiplex reverse transcription nested-PCR assay"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;T&#46; Coiras"
                            1 => "P&#46; P&#233;rez-Bre&#241;a"
                            2 => "M&#46;L&#46; Garc&#237;a"
                            3 => "I&#46; Casas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jmv.10255"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Virol"
                        "fecha" => "2003"
                        "volumen" => "69"
                        "paginaInicial" => "132"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12436489"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;T&#46; Coiras"
                            1 => "J&#46;C&#46; Aguilar"
                            2 => "M&#46;L&#46; Garc&#237;a"
                            3 => "I&#46; Casas"
                            4 => "P&#46; P&#233;rez-Bre&#241;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jmv.20008"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Virol"
                        "fecha" => "2004"
                        "volumen" => "72"
                        "paginaInicial" => "484"
                        "paginaFinal" => "495"
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Original Article
Viral respiratory tract infections in the neonatal intensive care unit
Infecciones virales de las vías respiratorias en la Unidad de Cuidados Intensivos Neonatales
E. Gonzalez-Carrascoa, C. Calvoa,
Corresponding author
ccalvorey@ono.com

Corresponding author.
, M.L. García-Garcíaa, M. Beatoa, C. Muñoz-Archidonaa, F. Pozob, I. Casasb
a Departamento de Neonatología y Pediatría, Hospital Severo Ochoa, Leganés, Madrid, Spain
b Laboratorio de Virus Respiratorios y Gripe, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain
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        "titulo" => "Infecciones virales de las v&#237;as respiratorias en la Unidad de Cuidados Intensivos Neonatales"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Viral respiratory infections are transmitted from person to person&#46; Many of the viruses that cause them are carried asymptomatically in the nasopharynx<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> and symptoms may not show until several days later&#46; Although these diseases are mild in most cases&#44; newborns&#44; and especially those born preterm or with low birth weight&#44; are at high risk of respiratory tract infection with severe symptoms such as respiratory distress&#44; apnoea or haemodynamic instability&#46; These symptoms often cannot be distinguished from symptoms caused by bacterial infections or other diseases associated to prematurity&#44; such as enterocolitis&#44; nosocomial sepsis or apnoea of prematurity&#44; so respiratory viruses are not the only causative agents under consideration&#46; Yet&#44; we know that common viral respiratory tract infections&#44; such as infection by respiratory syncytial virus &#40;RSV&#41;&#44; cause considerable morbidity and mortality in preterm patients as well as severe disease outbreaks in neonatal intensive care units &#40;NICUs&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">2&#44;3</span></a> In addition to classical viruses like RSV and influenza viruses&#44; rhinovirus &#40;RV&#41;&#44; human metapneumovirus &#40;hMPV&#41;&#44; coronavirus &#40;CoV&#41; and human bocavirus &#40;hBoV&#41; play an increasingly important role in respiratory tract infections in infants&#46; Very little is known about their role in neonatal units&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">4&#44;5</span></a> although we have demonstrated that they are associated with relevant pathology in our unit&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Neonatal units devote considerable effort to set up measures to prevent infection&#44; such as the use of hygiene measures of proved effectiveness by any staff that comes in contact with the infants&#58; applying alcohol gel before and after manipulating the child&#44; wearing gloves&#44; frequent handwashing&#44; prevention of catheter-related sepsis by monitoring the catheter and withdrawing it as early as possible&#44; and the prudent use of antibiotics&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Neonatal units have changed dramatically in recent years&#44; offering a more holistic care to the neonate and his or her family and a more humane approach that is manifested in the full participation of parents in the care of the child at any time of day or night&#59; that is&#44; an open-door policy&#46; Educating the parents on the hygiene protocols before and during their stay in the unit allows them to be part of the team that cares for the infant&#46; Our NICU &#40;which belongs to a secondary hospital that attends 1800 births a year&#41; has an open-door policy that allows parents to be involved in the infant&#39;s care&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our aim was to assess the presence &#40;symptomatic and asymptomatic&#41; of 16 respiratory viruses in term and preterm neonates admitted to the NICU&#44; and to describe the associated clinical manifestations&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">We performed a prospective cohort study at the Hospital Severo Ochoa &#40;Legan&#233;s&#44; Madrid&#41; to assess the incidence&#44; aetiology and clinical characteristics of viral respiratory infections in neonates that required admission to the NICU for 2 or more weeks&#46; Patients were enrolled between November 2011 and May 2013&#46; The study was funded by grant number 09&#47;00246 of the Fondo de Investigaciones Sanitarias and approved by the Medical Ethics Committee of the Hospital Severo Ochoa&#46; The parents signed an informed consent form before patients were included in the study&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We collected a nasopharyngeal aspirate &#40;NPA&#41; sample the first day of life and weekly until discharge&#46; When infants developed respiratory symptoms such as cough&#44; respiratory distress&#44; rhinorrhoea and longer than usual apnoeic pauses with or without fever&#44; an additional NPA sample was collected at the moment&#46; The neonatologist filled out a clinical form for each episode&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The NPA specimens were sent to the Unidad de Virus Respiratorios y Gripe &#40;Unit of Respiratory Viruses and Influenza&#41; of the Centro Nacional de Gripe &#40;National Influenza Centre&#41; of the World Health Organisation&#44; the Instituto de Salud Carlos III&#44; in Madrid&#44; Spain&#46; This unit subjected the specimens to three nested real-time polymerase chain reaction &#40;RT-PCR&#41; assays for the detection of a total of 16 respiratory viruses&#44; as reported in previous publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">We have expressed discrete variables as percentages and continuous variables as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41;&#46; We compared the variables corresponding to clinical and laboratory characteristics by means of Student&#39;s <span class="elsevierStyleItalic">t</span> test&#44; the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#44; the &#967;<span class="elsevierStyleSup">2</span> test and Fisher&#39;s exact test&#46; We set the level of statistical significance &#40;for two-tailed tests&#41; at <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; The statistical analysis was performed using the Statistical Package for the Social Sciences &#40;SPSS&#41;&#44; version 13&#46;0&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">The study included 66 infants &#40;all but one born preterm&#41;&#44; six of which &#40;9&#37;&#41; were withdrawn from the study by their parents during followup&#46; We analysed the data for a total of 60 infants&#58; 33 &#40;55&#37;&#41; were female&#59; 30 &#40;50&#37;&#41; had a gestational age below 32 weeks&#59; and 36 &#40;60&#37;&#41; weighed less than 1500<span class="elsevierStyleHsp" style=""></span>g&#46; Mechanical ventilation was required by 41&#46;7&#37; of the patients &#40;mean duration<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#44; 2&#46;31<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;73 days&#41; and continuous positive airway pressure &#40;CPAP&#41; by 31&#46;7&#37; &#40;mean duration<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#44; 2&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;74<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A total of 256 NPA samples were collected&#44; and 24 tested positive &#40;9&#46;3&#37;&#41;&#59; none of the positive specimens had been collected in the first day of life&#46; The virus identified most frequently was RV&#44; detected in 19 &#40;79&#37;&#41; of the positive samples&#44; followed by adenovirus &#40;2 cases&#41;&#44; CoV &#40;3 cases&#41; and hMPV &#40;1 case&#41;&#46; One patient had a RV and CoV coinfection&#46; There were no cases of RSV or influenza&#46; The positive NPA specimens were obtained at a mean of 35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21 days &#40;range&#44; 8&#8211;68&#59; median&#44; 30&#41;&#46; We observed a higher frequency of samples positive for respiratory viruses in patients younger than 32 weeks and with weights below 1500<span class="elsevierStyleHsp" style=""></span>g &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;05 and <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#44; respectively&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The 24 positive samples corresponded to 13 infants &#40;21&#46;6&#37; of the patients&#41;&#44; of which 9 &#40;69&#37;&#41; developed symptoms&#44; with a total 11 infectious episodes &#40;2 patients had 2 separate episodes with a negative test result in between&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the clinical characteristics of the episodes of respiratory infection&#46; The symptoms found most frequently were the presence or greater number of apnoeic episodes &#40;75&#37;&#41; and the need for oxygen therapy&#46; None of the patients required mechanical ventilation&#44; and only one patient received noninvasive ventilation&#46; Fever occurred in 45&#37; of the infectious episodes&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Laboratory analyses were performed in 7 &#40;64&#37;&#41; of the 11 infectious episodes&#59; only one patient had leukocytosis &#40;32&#44;000&#47;mL&#41;&#46; Blood cultures were performed in 4 &#40;36&#37;&#41; cases&#44; and the results were negative for all&#46; Antibiotic therapy was initiated in one patient for suspected sepsis&#46; Five infants underwent chest radiographs&#44; and atelectasis was found in one&#46; All patients recovered&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Four of the children with positive samples did not develop clinical symptoms &#40;three had RV 3 and one CoV OC43&#41;&#46; One of the symptomatic infants had prolonged shedding of RV for 8 weeks&#46; No tests were performed on the healthcare staff or the parents&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> compares the clinical data of the patients&#44; &#40;symptomatic and asymptomatic&#41;&#44; with obtaining a positive result in the viral assays&#46; Of the 13 infants that had a positive viral isolate&#44; 5 &#40;38&#37;&#41; developed bronchopulmonary dysplasia&#46; One of them had an asymptomatic infection by CoV OC43 and the other 4 symptomatic infections by RV or adenovirus&#46; Of the children that did not have a positive viral isolate&#44; 3 &#40;6&#46;4&#37;&#41; were diagnosed with bronchopulmonary dysplasia &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>009&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Nosocomial infections are among the major causes of morbidity&#44; prolonged hospitalisation and mortality in neonates&#44; especially in those born preterm&#46; Most of the scientific literature focuses on bacterial or fungal infections and does not consider respiratory viruses&#44; except for RSV&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a> We present the results of a prospective cohort study in 16 viral respiratory infections conducted in the NICU of a secondary hospital&#46; Viral respiratory infections&#44; especially those by RV&#44; are fairly frequent in the neonatal unit and are associated with episodes of apnoea and the need for respiratory support&#44; especially in preterm newborns of less than 32 weeks of gestational age or with weights below 1500<span class="elsevierStyleHsp" style=""></span>g&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The advent of PCR techniques has revealed the involvement in lower respiratory tract infections in children&#44; and that this is one of the most important viruses overall in the epidemiology of respiratory infections&#46; Various groups have recently identified RV as the causative agent of respiratory infection outbreaks in neonatal units&#46; Reid et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> described an outbreak of infection by RV type C in 7 infants in a paediatric and neonatal intensive care unit&#44; 5 of which had clinically relevant episodes of apnoea and required respiratory support or oxygen therapy&#46; Van Piggelen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a> described 7 severe nosocomial infections associated to RV in the NICU over a period of 5 years&#44; all of which were associated with respiratory distress and required ventilatory support&#46; In both studies&#44; respiratory infections were suspected and a viral aetiology was actively explored&#46; The clinical data of these two studies are similar to those obtained in our cohort&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">However&#44; our data show that respiratory viruses are responsible for a considerable number of disease episodes that worsen respiratory status and that are attributed to prematurity when in fact they are due to viral infections&#46; We only found a similar study that focused on detecting unrecognised respiratory viral infections in preterm neonates admitted after delivery&#46; In this prospective study&#44; which had a design similar to ours&#44; Bennett et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a> observed that 52&#37; of the 60 preterm neonates tested for viral detection had positive results during their stay&#46; This group of neonates had longer lengths of stay&#44; prolonged respiratory support&#44; and a higher incidence of bronchopulmonary dysplasia&#46; In our patients&#44; the proportion of bronchopulmonary dysplasia was also greater in infants in whom a virus had been detected&#44; but the group of children that tested negative for viruses had a greater gestational age&#44; a circumstance that may lead to misinterpretation of the results&#46; The proportions of the viruses detected by Bennett et al&#46; differed somewhat from ours&#44; with a high prevalence of RSV&#44; parainfluenza virus and hMPV&#44; especially in the winter&#46; Rhinovirus was detected in only 27&#37; of the patients&#46; The lower incidence of viral infections by RSV or influenza in our group may have been due to our meticulous adherence to the preventive measures against nosocomial infections&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">We agree with Bennett in thinking that while there are descriptions of outbreaks of viral respiratory infections in NICUs&#44; these studies substantiate the importance of systematic surveillance for detecting infections that would otherwise not be recognised&#46; Preterm infants may present few or atypical symptoms&#44; and the detection of viral infections may have profound clinical consequences&#46; Our study was limited by the small number of patients included in it&#44; so it is important that other prospective studies are performed to elucidate the actual role of viral respiratory infections in neonatal units&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">We did not explore the sources of the infections&#44; but the infants only had contact with their parents and the healthcare staff&#46; And while we presumably adhere rigorously to preventive measures against nosocomial infections including the use of gloves&#44; handwashing before and after each contact with a patient&#44; and having any individual with respiratory symptoms wear a mask&#44; transmission of respiratory viruses does occur and we should explore new preventive strategies&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In short&#44; we found that RV may be the cause of respiratory infections in preterm neonates during their stay in the NICU&#44; and that preterm infants are at high risk of acquiring clinically significant infections of this kind&#46; Viral respiratory infections should be ruled out in infants with rhinorrhoea&#44; apnoea&#44; high oxygen requirements and clinical suspicion of sepsis&#46; We must apply rigorous measures for infection prevention and possibly introduce additional hygiene measures&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Funding</span><p id="par0105" class="elsevierStylePara elsevierViewall">This study has been funded by the <span class="elsevierStyleGrantSponsor" id="gs1">Instituto Nacional de Salud de Espa&#241;a</span> &#40;ISCIII&#44; Fondo de Investigaciones Sanitarias&#41;&#44; PI 09&#47;00246 and PI 12&#47;0129&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Viral respiratory infections cause major morbidity and mortality in preterm infants&#46; We have performed a prospective study in our neonatal intensive care unit &#40;NICU&#41; to determine the incidence of respiratory infections&#44; their impact and the epidemiology and outcome in high risk neonates&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">From September 2011 to May 2013 a prospective study was conducted in all preterm infants &#60;32 weeks gestational age and in all term newborns admitted to NICU for any pathology that was anticipated to have an admission exceeding two weeks&#46; A nasopharyngeal aspirate &#40;NPA&#41; was collected the first day of life and weekly until discharge for virologic study with polymerase chain reaction&#46; When these babies presented respiratory symptoms a new NPA was collected at this moment&#46; A clinical form was filled by the physician&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 60 infants were analysed&#58; 30 &#40;50&#37;&#41; had a gestational age &#60;32 weeks and 36 &#40;60&#37;&#41; weighed less than 1500<span class="elsevierStyleHsp" style=""></span>g&#46; We collected a total of 256 nasopharyngeal aspirate samples&#44; 24 of them being positive &#40;9&#46;3&#37;&#41;&#46; These 24 positive samples corresponded to 13 infants in our cohort &#40;21&#46;6&#37; of the patients&#41;&#46; Of them&#44; 9 were symptomatic and had 11 episodes of infection &#40;2 patients had two different episodes with negative control between them&#41;&#46; The most frequently identified virus was rhinovirus in &#40;19&#41; 79&#37; of cases&#46; The most frequent clinical data was the presence or increase in apneas &#40;75&#37;&#41; and the need for oxygenotherapy&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">HRV infections are prevalent in the NICU&#44; and preterm infants have a high risk of infections with clinical relevance&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Las infecciones virales respiratorias son causa de importante morbimortalidad en reci&#233;n nacidos prematuros&#46; Hemos realizado un estudio prospectivo en nuestra unidad de cuidados intensivos neonatales &#40;UCIN&#41; para determinar la incidencia de infecciones respiratorias&#44; su impacto&#44; epidemiolog&#237;a y pron&#243;stico en neonatos de alto riesgo&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo realizado entre septiembre del 2011 y mayo del 2013 entre todos los reci&#233;n nacidos &#60; 32 semanas de edad gestacional y aquellos ni&#241;os cuya patolog&#237;a pudiera dar lugar a pensar en un ingreso superior a las 2 semanas&#46; Se recogieron aspirados nasofar&#237;ngeos &#40;ANF&#41; el primer d&#237;a de vida y semanalmente hasta el alta para estudio virol&#243;gico mediante reacci&#243;n en cadena de polimerasa&#46; En los casos en los que los ni&#241;os presentaban s&#237;ntomas respiratorios&#44; se procedi&#243; a recoger un nuevo ANF&#46; El pediatra cumpliment&#243; un cuestionario con los datos cl&#237;nicos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 60 ni&#241;os&#59; 30 &#40;50&#37;&#41; de ellos con una edad gestacional &#60;32 semanas y 36 &#40;60&#37;&#41; con un peso &#60;1&#46;500<span class="elsevierStyleHsp" style=""></span>g&#46; Se recogi&#243; un total de 256 ANF&#44; 24 de los cuales resultaron positivos &#40;9&#44;3&#37;&#41;&#46; Estas 24 muestras positivas correspondieron solo a 13 ni&#241;os &#40;21&#44;6&#37; de los pacientes&#41;&#46; De ellos&#44; 9 resultaron sintom&#225;ticos y presentaron 11 episodios de infecci&#243;n &#40;2 pacientes experimentaron 2 episodios diferentes con control negativo entre ellos&#41;&#46; El virus m&#225;s frecuentemente identificado &#8211; el 79&#37; de las muestras &#40;19&#41; &#8211; fue el rinovirus &#40;RV&#41;&#46; El dato cl&#237;nico m&#225;s frecuente fue la presencia o incremento de apneas &#40;75&#37;&#41; y la necesidad de oxigenoterapia&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las infecciones por RV son frecuentes en la UCIN y los reci&#233;n nacidos pret&#233;rmino tienen un alto riesgo de presentar infecciones de relevancia cl&#237;nica&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Pacientes y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gonzalez-Carrasco E&#44; Calvo C&#44; Garc&#237;a-Garc&#237;a ML&#44; Beato M&#44; Mu&#241;oz-Archidona C&#44; Pozo F&#44; et al&#46; Infecciones virales de las v&#237;as respiratorias en la Unidad de Cuidados Intensivos Neonatales&#46; An Pediatr &#40;Barc&#41;&#46; 2015&#59;82&#58;242&#8211;246&#46;</p>"
      ]
    ]
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        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">CMV&#58; conventional mechanical ventilation&#59; CPAP&#58; continuous positive airway pressure&#59; NSD&#58; no significant differences&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Viral infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">No infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Male sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 &#40;46&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NSD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;84&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24 &#40;51&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Weight &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1151<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>347&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1551<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>603&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>026&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Gestational age<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>31 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;61&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;32&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Gestational age &#40;weeks&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#46;4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Bronchopulmonary dysplasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;38&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;6&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Length of stay &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&#46;8<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>171&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top">Clinical data &#40;signs and symptoms&#41;</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Greater number of apnoea episodes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;72&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Rhinorrhoea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;63&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fever&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cough&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top">Respiratory support</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Environmental oxygen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;81&#37;&#41; &#40;maximum FiO<span class="elsevierStyleInf">2</span>&#44; 0&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nasal cannula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CPAP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CMV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;18&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of patients with and without viral respiratory infection &#40;symptomatic or asymptomatic&#41;&#46;</p>"
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      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:13 [
            0 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human bocavirus detection in nasopharyngeal aspirates of children without clinical symptoms of respiratory infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;L&#46; Garc&#237;a-Garc&#237;a"
                            1 => "C&#46; Calvo"
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/INF.0b013e3181626d2a"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Infect Dis J"
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                        "volumen" => "27"
                        "paginaInicial" => "358"
                        "paginaFinal" => "360"
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                            "web" => "Medline"
                          ]
                        ]
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                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of respiratory viruses in preterm infants submitted to mechanical ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;M&#46; Diniz"
                            1 => "R&#46;A&#46; Vieira"
                            2 => "M&#46;E&#46; Ceccon"
                            3 => "M&#46;A&#46; Ishida"
                            4 => "F&#46;A&#46; Vaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S0036-46652005000100007"
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                        "fecha" => "2005"
                        "volumen" => "47"
                        "paginaInicial" => "37"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15729473"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nosocomial respiratory syncytial virus infection in neonatal units in the United Kingdom"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Thwaites"
                            1 => "J&#46; Piercy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Paediatr Suppl"
                        "fecha" => "2004"
                        "volumen" => "93"
                        "paginaInicial" => "23"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15035458"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coronavirus-related nosocomial viral respiratory infections in a neonatal and paediatric intensive care unit&#58; a prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Gagneur"
                            1 => "J&#46; Sizun"
                            2 => "S&#46; Vallet"
                            3 => "M&#46;C&#46; Legr"
                            4 => "B&#46; Picard"
                            5 => "P&#46;J&#46; Talbot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jhin.2002.1179"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hosp Infect"
                        "fecha" => "2002"
                        "volumen" => "51"
                        "paginaInicial" => "59"
                        "paginaFinal" => "64"
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